LOCUS       NM_178673               4820 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus follistatin-like 5 (Fstl5), transcript variant 1,
            mRNA.
ACCESSION   NM_178673
VERSION     NM_178673.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4820)
  AUTHORS   Markenscoff-Papadimitriou,E., Binyameen,F., Whalen,S., Price,J.,
            Lim,K., Ypsilanti,A.R., Catta-Preta,R., Pai,E.L., Mu,X., Xu,D.,
            Pollard,K.S., Nord,A.S., State,M.W. and Rubenstein,J.L.
  TITLE     Autism risk gene POGZ promotes chromatin accessibility and
            expression of clustered synaptic genes
  JOURNAL   Cell Rep 37 (10), 110089 (2021)
   PUBMED   34879283
REFERENCE   2  (bases 1 to 4820)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4820)
  AUTHORS   Khanshour,A.M., Kidane,Y.H., Kozlitina,J., Cornelia,R., Rafipay,A.,
            De Mello,V., Weston,M., Paria,N., Khalid,A., Hecht,J.T.,
            Dobbs,M.B., Richards,B.S., Vargesson,N., Hamra,F.K., Wilson,M.,
            Wise,C., Gurnett,C.A. and Rios,J.J.
  TITLE     Genetic association and characterization of FSTL5 in isolated
            clubfoot
  JOURNAL   Hum Mol Genet 29 (22), 3717-3728 (2021)
   PUBMED   33105483
REFERENCE   4  (bases 1 to 4820)
  AUTHORS   Masuda,T., Sakuma,C., Nagaoka,A., Yamagishi,T., Ueda,S., Nagase,T.
            and Yaginuma,H.
  TITLE     Follistatin-like 5 is expressed in restricted areas of the adult
            mouse brain: Implications for its function in the olfactory system
  JOURNAL   Congenit Anom (Kyoto) 54 (1), 63-66 (2014)
   PUBMED   24588779
  REMARK    GeneRIF: Restricted expression in the olfactory system suggests a
            possible role for Fstl5 in maintaining odor perception
REFERENCE   5  (bases 1 to 4820)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   6  (bases 1 to 4820)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   7  (bases 1 to 4820)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   8  (bases 1 to 4820)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 4820)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646895.1 and BC075640.1.
            
            On Dec 1, 2011 this sequence version replaced NM_178673.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075640.1, SRR1660813.179472.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BB646895.1         1-37
            38-4820             BC075640.1         1-4783
FEATURES             Location/Qualifiers
     source          1..4820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 34.04 cM"
     gene            1..4820
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /note="follistatin-like 5"
                     /db_xref="GeneID:213262"
                     /db_xref="MGI:MGI:2442179"
     exon            1..414
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..556
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2974
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /note="ollistatin-like 5; follistatin-related protein 5;
                     m-D/Bsp120I 1-2; follistatin-like protein 5"
                     /codon_start=1
                     /product="follistatin-related protein 5 precursor"
                     /protein_id="NP_848788.2"
                     /db_xref="CCDS:CCDS38455.1"
                     /db_xref="GeneID:213262"
                     /db_xref="MGI:MGI:2442179"
                     /translation="MFRCWSAILILGFIFLASEGRPTKESGYGLKSYQPLTRLRHKQE
                     KSQESSRIKEFLIHDGPFGSCENKYCGLGRHCVINRETRHAECACMDLCKQHYKPVCG
                     SDGEFYENHCEVHRAACLKKQKITIVHNEDCFFEGDNCMAIEYSKMKSMLLDLQNQKY
                     ITQENENPNSDDISRKKPLVDQMFKYFDADSNGLVDINELTQVIKQEELNKDLSDCTL
                     YDLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQRVSITAATVGQSAVLSCAIVGTL
                     RPPIIWKRNNIVLNNLDLEDINDFGDDGSLYITKVTTVHMGNYTCYADGYENVRQTHI
                     FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPDPQLGWLKNGIDITPKLSKQLTLQ
                     ANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISSLFVEDSARKTLANILWREEGLGI
                     GNMFYVFYEDGIKVIQPTECEFQRHIKPSEKLLGYQDEVCPKAEEDEVQRCVWASAVN
                     VKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEK
                     TSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDES
                     ALHKIDLETMSYIKTINLKDSRCIPLSLAYTHLGGYYFISCKADITGATPPQLVVDSV
                     TDSIIGFNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLHIS
                     DLAFQPSFTEAHQYNIYGSSSQQTDVLFVELSSGKVKMIKSLKEPLKTEDWPWSQKNR
                     HIQGSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVQKGNTVVWVGDA"
     exon            557..590
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..839
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1036
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1157
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1324
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1445
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1607
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1742
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1769
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1888
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2038
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2146
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2271
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..4802
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4783..4788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4802
                     /gene="Fstl5"
                     /gene_synonym="9130207J01Rik"
                     /note="major polyA site"
ORIGIN      
        1 atcctggttc agtgactgag acaaactgga cgtgagcgga gctggtgctg tccacagagt
       61 gtcggtgctg aaccccgggt gtaagggatc gcctgcttgg gcacctggag gcaacgccca
      121 ctggaaccct atgtgcccag tgggacccgc ttcaccacag gacccaattt aacttgacaa
      181 aggagtgcga ctcggacgtg ggagagactc ctatgtttgc aatctgggcg cccactcagg
      241 cgtgactttg gagattctgt agttctaact caaagtattt ggattttttt tccaacctaa
      301 gaggatcttt tcatcgttat tatttttctt ttttcttttt tacactgtga ctcatatttt
      361 cacatcattt agaaatcttt ttggaggact tttttgtttt ttacttcaaa taaggtgaaa
      421 atcaataaag atgtttaggt gctggtctgc cattttgatt cttggattca tctttctggc
      481 atctgaaggg aggccaacaa aagaatcagg atatggcctt aaatcctatc aacctcttac
      541 aagattgcga cataagcagg aaaaaagtca agaaagttca agaatcaaag aatttctaat
      601 tcatgatgga ccatttggat cttgtgaaaa taagtactgt ggcttgggga ggcactgtgt
      661 tatcaacaga gagacaaggc atgcggagtg tgcctgcatg gacctttgta aacagcacta
      721 caaacctgtg tgtggatctg atggggaatt ctatgaaaac cactgtgaag tgcacagagc
      781 tgcctgtctt aaaaagcaaa agatcaccat cgttcacaat gaagactgct tctttgaagg
      841 ggacaactgc atggccattg aatacagcaa gatgaaaagt atgcttttag acttacaaaa
      901 tcaaaagtat attacacaag aaaatgagaa tcccaacagt gatgacatat ctaggaagaa
      961 gccgttggtg gatcaaatgt tcaagtattt tgatgcagac agtaatggac ttgtagatat
     1021 taatgaacta actcaggtga ttaaacagga ggaattgaac aaggaccttt ctgactgtac
     1081 tttgtatgat ctgctcaagt atgatgactt caacgctgac aagcacctgg ctcttgaaga
     1141 attctacaga gcatttcagg tgatccagtt gagtctgcct gaagatcaga gagtaagcat
     1201 taccgcagcc actgtggggc agagtgctgt tctgagctgt gccattgtgg gaacgctgag
     1261 accccctatc atatggaaga ggaacaacat tgttctaaat aatttagatt tggaagacat
     1321 caatgacttt ggtgatgatg ggtccctgta tattaccaag gttaccacag ttcacatggg
     1381 aaattataca tgctatgcag atggctatga aaatgtccgt cagacacaca tcttccaagt
     1441 gaatgttcct ccagttatcc gagtgtatcc agagagtcag gccagagaac ctggtgtaac
     1501 tgcaagcctt aggtgccatg ccgagggcat tccagaccct cagcttggct ggctgaagaa
     1561 tgggattgac attacaccga agctctccaa acagctcaca cttcaagcaa atggcagtga
     1621 ggtccacata agcaatgtcc gttatgaaga tacaggagca tacacgtgca ttgctaggaa
     1681 tgaagccggt gtggatgaag acatctcttc tctttttgtg gaagattctg ctaggaagac
     1741 actagctaac atattatgga gagaagaagg tctgggaatt gggaacatgt tctatgtttt
     1801 ttatgaagat ggaatcaaag tgatacaacc cacggaatgt gaatttcaga ggcacattaa
     1861 gcccagtgaa aagctccttg gatatcagga tgaagtctgt cccaaagcag aagaggatga
     1921 agtgcagaga tgtgtgtggg catctgctgt taatgtcaaa gacaagttca tttatgtcgc
     1981 tcagccaact ttggacagaa tcttgattgt tgatgtgcaa tcccaaaagg ttgttcaggc
     2041 agtgagtaca gatcctgtac cagttaaatt acactacgac aagtcacatg accaagtctg
     2101 ggtgctgagc tggggcagca tggagaagac atcaccaact ctacaggtga tcactctggc
     2161 cagcgggaat gtgccacacc acaccatcca cactcagcca gttgggaaac agtttgacag
     2221 agtggacgat ttttttattc caactccaac acttattatt actcacatga gatttgggtt
     2281 tattcttcat aaagatgaat ctgcactaca caaaattgat ctcgaaacca tgtcctacat
     2341 caaaacaatt aacctgaagg actcacgatg cattcctcta tccttggcat acacccatct
     2401 gggaggatac tacttcataa gctgcaaggc tgacatcacc ggagctactc caccacagct
     2461 cgtggtagac agtgtgactg actctatcat tggcttcaat agcgatgtga cgggcactcc
     2521 ttatgtctct ccagacggac actatcttgt cagtgttaat gacgtgaaag gtcttgtcag
     2581 agtccaatat atcaccatcc gaggagagat tctggatgct tttgacatcc acaccaacct
     2641 acatatatct gacctggcct tccagccatc cttcacagaa gcccaccagt acaacatcta
     2701 tggcagctca agccaacaaa cagatgtact ctttgtggag ctttcctctg ggaaggtcaa
     2761 gatgatcaaa agcctcaaag aacctctcaa gacagaagac tggccctgga gccagaaaaa
     2821 caggcacatc caaggcagtg gcctgtttgg acagtacctg atgacacctt ccaaagattc
     2881 tctcttcatc ctggatggtc gccttaataa attaaactgt gagatcactg aggttcagaa
     2941 aggaaataca gttgtttggg ttggcgatgc ctaaggagcc ctcttaccta attatgaaag
     3001 aagagtttta cagtacattg cacttcatcc atatttaaat tacaacttaa cttttccaaa
     3061 tttatattct agtcaaatcc cctctgtttg ttcaaataag atagattttt ttttacaatg
     3121 ataattggct agttagaaac atttcataca atatttaatt ggaaattaca gcactcacaa
     3181 gaatcaaaca tgtagctata ttttaaacca atgaaatgag atttaaatta tttaaaaaaa
     3241 aaatacactg cagggaattt cagatgacct aagcatcatg tcattcttta cggcattttt
     3301 ttttcctctg ttattttgct atgcttaaat cagaaataaa aggtcgtgtt aaaccttaaa
     3361 attcttaatt caaaatactc tgtcccgtcc actgtttaaa atcttttgtg ccttgaagga
     3421 aatgtcatgg aaggaaaaaa aaaaaaggaa ggctaagctc tgcatattgg acaacctcat
     3481 aagcaatgaa tctactgtca ttaagaaatg tttatatctt gcgccaaatc ctgccttcag
     3541 gcatttgttt gaccttcaat gaaatgtcat gtgaaggcat aatttggcct tgggctgtat
     3601 acagatgaga agctatccaa cattcactgt actatgtcca ttgtgctata gaaaatggac
     3661 aggaagggag aaaaatttgt atggtaaaaa tgtttgcaat gtattgtgtc cacattttgc
     3721 tttcattcac tagagtgcat tatattattg gtgtatgatt atctgggaat tcaactgctt
     3781 acagaaggtt tccttcttta gtatcaagat tgattctttt gtgtagccta atgttacata
     3841 agtcaggagc tttctcagtt ctgaaaaagg agcatgactg tgtctgcaca gaaagaacca
     3901 cttctaggga aattgacagt gagacaaagc tgaaaccact ctctgtagtg cggtggccta
     3961 tatcctcttc agacaacatt cacttggttg gtccaaagaa ggtgaatggg ttttagcaga
     4021 aaacagtaac atgagcccac agtagagatt gggaagtgaa ctccactgct tttgcgattt
     4081 agatgtatct attaaataaa tccatccttt attaatggtc aagatgactt ctactcctgc
     4141 atattctaaa ccaccctctc tttaactgtg tgctctagct gtaacccaac ggagtctctt
     4201 gagatatagt agagaagtaa aagtgactgc ctttatcctt tttcctacag gagaaaacag
     4261 aaaaacagta gaaatagatt aataccaata gtttggttat tggaataaaa gaaaacaatc
     4321 caggtgtaag ggaatagcat acatggtttg aaaatctttt ctacttattt ttcttcttat
     4381 tgttgctaaa actcgtgata agctattgaa ctaatgccca tttgctgaag gtaatccagt
     4441 aagatctttt tttaaataca aattgggtaa aactgcatag aaacttggga ttttatagtg
     4501 tgcactctct tttgtgtata tagcaccatg ggctgtgtga taatagattt cttcttagct
     4561 taaggataca ttaagggaaa tagatttaat aaacaacaga aatcagccta catttttact
     4621 gattgagtct gttttactct ttagtaactt cgtcccctgg gaacatgaat catgcagtgt
     4681 ctttgtgtta atgatttcgt gtaagtctat cctgtacacg tacatcttct tttagaagct
     4741 tttactatgt ggatgctgtc tgttatcatt gcttgataaa agaataaacc tcttatgttt
     4801 taaaaaaaaa aaaaaaaaaa
//
