LOCUS       NM_031380               1953 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus follistatin-like 3 (Fstl3), mRNA.
ACCESSION   NM_031380
VERSION     NM_031380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1953)
  AUTHORS   Khanshour,A.M., Kidane,Y.H., Kozlitina,J., Cornelia,R., Rafipay,A.,
            De Mello,V., Weston,M., Paria,N., Khalid,A., Hecht,J.T.,
            Dobbs,M.B., Richards,B.S., Vargesson,N., Hamra,F.K., Wilson,M.,
            Wise,C., Gurnett,C.A. and Rios,J.J.
  TITLE     Genetic association and characterization of FSTL5 in isolated
            clubfoot
  JOURNAL   Hum Mol Genet 29 (22), 3717-3728 (2021)
   PUBMED   33105483
REFERENCE   3  (bases 1 to 1953)
  AUTHORS   Xu,Y., Xie,J., Wan,L., Wang,M., Xu,Y., Wang,H. and Dong,M.
  TITLE     Follistatin-like 3, an activin A binding protein, is involved in
            early pregnancy loss
  JOURNAL   Biomed Pharmacother 121, 109577 (2020)
   PUBMED   31810141
  REMARK    GeneRIF: FSTL3 plays a biological role in the establishment and
            maintenance of normal pregnancy.
REFERENCE   4  (bases 1 to 1953)
  AUTHORS   Liu,T.Y., Chen,Y.C., Jong,Y.J., Tsai,H.J., Lee,C.C., Chang,Y.S.,
            Chang,J.G. and Chang,Y.F.
  TITLE     Muscle developmental defects in heterogeneous nuclear
            Ribonucleoprotein A1 knockout mice
  JOURNAL   Open Biol 7 (1) (2017)
   PUBMED   28077597
REFERENCE   5  (bases 1 to 1953)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1953)
  AUTHORS   Hill,J.J., Qiu,Y., Hewick,R.M. and Wolfman,N.M.
  TITLE     Regulation of myostatin in vivo by growth and differentiation
            factor-associated serum protein-1: a novel protein with protease
            inhibitor and follistatin domains
  JOURNAL   Mol Endocrinol 17 (6), 1144-1154 (2003)
   PUBMED   12595574
REFERENCE   7  (bases 1 to 1953)
  AUTHORS   Nakatani,M., Yamakawa,N., Matsuzaki,T., Shimasaki,S., Sugino,H. and
            Tsuchida,K.
  TITLE     Genomic organization and promoter analysis of mouse
            follistatin-related gene (FLRG)
  JOURNAL   Mol Cell Endocrinol 189 (1-2), 117-123 (2002)
   PUBMED   12039070
  REMARK    GeneRIF: genomic organization and promoter analysis
REFERENCE   8  (bases 1 to 1953)
  AUTHORS   Wankell,M., Kaesler,S., Zhang,Y.Q., Florence,C., Werner,S. and
            Duan,R.
  TITLE     The activin binding proteins follistatin and follistatin-related
            protein are differentially regulated in vitro and during cutaneous
            wound repair
  JOURNAL   J Endocrinol 171 (3), 385-395 (2001)
   PUBMED   11739004
REFERENCE   9  (bases 1 to 1953)
  AUTHORS   Tortoriello,D.V., Sidis,Y., Holtzman,D.A., Holmes,W.E. and
            Schneyer,A.L.
  TITLE     Human follistatin-related protein: a structural homologue of
            follistatin with nuclear localization
  JOURNAL   Endocrinology 142 (8), 3426-3434 (2001)
   PUBMED   11459787
REFERENCE   10 (bases 1 to 1953)
  AUTHORS   Tsuchida,K., Arai,K.Y., Kuramoto,Y., Yamakawa,N., Hasegawa,Y. and
            Sugino,H.
  TITLE     Identification and characterization of a novel follistatin-like
            protein as a binding protein for the TGF-beta family
  JOURNAL   J Biol Chem 275 (52), 40788-40796 (2000)
   PUBMED   11010968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061052.1, AK082898.1, AK079286.1 and BQ840331.1.
            
            On Apr 22, 2009 this sequence version replaced NM_031380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061052.1, AK082898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-734               BC061052.1         1-734
            735-1543            AK082898.1         737-1545
            1544-1930           AK079286.1         1164-1550
            1931-1953           BQ840331.1         151-173
FEATURES             Location/Qualifiers
     source          1..1953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1953
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /note="follistatin-like 3"
                     /db_xref="GeneID:83554"
                     /db_xref="MGI:MGI:1890391"
     exon            1..124
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..798
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /note="follistatin-related protein 3; follistatin-like
                     protein 3; follistatin-related gene protein"
                     /codon_start=1
                     /product="follistatin-related protein 3 precursor"
                     /protein_id="NP_113557.1"
                     /db_xref="CCDS:CCDS23990.1"
                     /db_xref="GeneID:83554"
                     /db_xref="MGI:MGI:1890391"
                     /translation="MRSGALWPLLWGALVWTVGSVGAVMGSEDSVPGGVCWLQQGREA
                     TCSLVLKTRVSREECCASGNINTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVEC
                     GPGKACRMLGGRPHCECVPNCEGLPAGFQVCGSDGATYRDECELRTARCRGHPDLRVM
                     YRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPSNPGQELCGNNNVTYIS
                     SCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV"
     exon            125..310
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            311..526
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            527..754
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1953
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="Fstl3"
                     /gene_synonym="E030038F23Rik; Flrg"
                     /note="major polyA site"
ORIGIN      
        1 agtccccgct gctgcccaac actcgccatg cgttctgggg cactgtggcc gctgctttgg
       61 ggagccctgg tctggacagt gggatccgtg ggcgccgtga tgggctccga ggattctgtg
      121 cccggtggcg tgtgctggct ccagcagggc agagaggcca cctgcagtct ggtgctgaag
      181 actcgtgtca gccgggagga gtgctgtgct tccggcaaca tcaacaccgc ctggtccaac
      241 ttcacccacc caggcaataa aatcagcctg ctagggttcc tgggcctcgt ccactgcctc
      301 ccctgcaaag attcctgcga cggagtggag tgcggccccg gcaaggcgtg ccgcatgctg
      361 gggggccgtc cacactgcga gtgcgtgccc aactgcgagg ggcttcccgc gggcttccag
      421 gtctgcggct ctgatggcgc cacctaccgg gacgaatgcg aactgcgcac cgcgcgctgt
      481 cgcggacacc cagacttgcg cgtcatgtac cgcggccgct gtcaaaagtc ttgcgctcag
      541 gtagtgtgcc cgcgtcccca gtcgtgcctt gtggatcaga ccggcagcgc acactgcgtg
      601 gtgtgtcgcg ctgcgccctg cccagtacct tccaaccccg gccaagaact ctgtggcaac
      661 aacaacgtta cctacatctc gtcgtgtcac ctgcgccagg ccacttgctt cctgggccgc
      721 tccattgggg ttcggcaccc aggcatctgc acaggtggcc ccaaagtacc agcagaggag
      781 gaagagaact tcgtgtgagc tgcagccact gggcctggca tttgacgcca tcccgatttt
      841 atttattgtt atagaaaata ttctaattta tgtcacatgg acatttccca aacctggcct
      901 ggaaccactt ggggatcccc ctgggatcct gagcacgtat cacaaggact gaagggagat
      961 ttttataata gttggtatgt gccatcaccc aggtactggg atcaaagtta gaacccaaga
     1021 cccctgctgc ccagggatgg cagctgcatg gagatccccc tgctatgatc tccccacctg
     1081 ctttctaggc tggagctgtc gcagggcaca gccgatgagt tggtgtttgc atatggctgg
     1141 cctcagacca gagcgggcaa catcaggtca gagaaacact gggctcattc ctgtttggtc
     1201 cactcagggt gaaacctggt agaaacattg gaccctggct gactcacagg cccaggacag
     1261 ccagtggaca ctaggattca ctgtgcccag agcacccaga gtcactctag cacccactgc
     1321 cctgtaccct gcacacccac attagttttt acgcagttcc ccaccagccc cactcgtccc
     1381 caagcccagc tgcaggtggt gacaccagcc agatgctgtt tggggccaga ctgaattact
     1441 gccttcactc tgacagctgc tgctgcaact tgcccacacc cacaagtgcc ttcaaggaag
     1501 ccaaaagggg gagctgcaat gcatttaggt agagagtgct tttctagtgt tcaccgagcc
     1561 cgggctccat ccccagcacc gcataaacag acatgttggc tcaggcccct catcccagta
     1621 cttagaaagt agaggcaagg gcatcaggag tttaagttca tccttggcca cattatgagt
     1681 tcaaggccag cctgggctat ataagatctt atctttgaaa aaagaaaaaa aaaaaactta
     1741 aaaggtgtca gaccacaaca gaagactatg ggaaggtgcc caaccctcca gtttgggggc
     1801 aaggagttcc cagggtcttt ctcaccaccc tccagttctc agctgtgcct ttcttgtaat
     1861 atccccaaaa gtgtccttag caggggagct atggtagcct cccctaccct ggagttctgc
     1921 ctcaccaagg aaataaaaga caatagaaac cac
//
