LOCUS       NM_008047               3609 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus follistatin-like 1 (Fstl1), mRNA.
ACCESSION   NM_008047
VERSION     NM_008047.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3609)
  AUTHORS   Xu,H., Guo,H., Tang,Z., Hao,R., Wang,S. and Jin,P.
  TITLE     Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway
  JOURNAL   Cell Biol Int 48 (6), 795-807 (2024)
   PUBMED   38436106
  REMARK    GeneRIF: Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway.
REFERENCE   2  (bases 1 to 3609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3609)
  AUTHORS   Sun,W., Yang,X., Chen,L., Guo,L., Huang,H., Liu,X., Yang,Y. and
            Xu,Z.
  TITLE     FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary
            fibrosis by affecting SENP1-mediated DeSUMOylation
  JOURNAL   Cell Biol Int 47 (10), 1716-1727 (2023)
   PUBMED   37369969
  REMARK    GeneRIF: FSTL1 promotes alveolar epithelial cell aging and worsens
            pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
REFERENCE   4  (bases 1 to 3609)
  AUTHORS   Liu,H., Wen,J., Tian,X., Li,T., Zhao,J., Cheng,J., Huang,L.,
            Zhao,Y., Cao,Q. and Jiang,J.
  TITLE     miR-125a-3p regulates the expression of FSTL1, a pro-inflammatory
            factor, during adipogenic differentiation, and inhibits
            adipogenesis in mice
  JOURNAL   FASEB J 37 (9), e23146 (2023)
   PUBMED   37584664
  REMARK    GeneRIF: miR-125a-3p regulates the expression of FSTL1, a
            pro-inflammatory factor, during adipogenic differentiation, and
            inhibits adipogenesis in mice.
REFERENCE   5  (bases 1 to 3609)
  AUTHORS   Zhang,S., Mo,X., Jin,Y., Niu,Z., Yao,M., Zhang,Y., Li,L., Hu,G. and
            Ning,W.
  TITLE     Single-cell transcriptome analysis reveals cellular heterogeneity
            and highlights Fstl1-regulated alveolar myofibroblasts in mouse
            lung at birth
  JOURNAL   Genomics 115 (5), 110677 (2023)
   PUBMED   37406975
  REMARK    GeneRIF: Single-cell transcriptome analysis reveals cellular
            heterogeneity and highlights Fstl1-regulated alveolar
            myofibroblasts in mouse lung at birth.
REFERENCE   6  (bases 1 to 3609)
  AUTHORS   De Groot,E., Feijen,A., Eib,D., Zwijsen,A., Sugino,H., Martens,G.
            and Van Den Eijnden-Van Raaij,A.J.
  TITLE     Expression patterns of follistatin and two follistatin-related
            proteins during mouse development
  JOURNAL   Int J Dev Biol 44 (3), 327-330 (2000)
   PUBMED   10853830
REFERENCE   7  (bases 1 to 3609)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   8  (bases 1 to 3609)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 3609)
  AUTHORS   Zwijsen,A., Blockx,H., Van Arnhem,W., Willems,J., Fransen,L.,
            Devos,K., Raymackers,J., Van de Voorde,A. and Slegers,H.
  TITLE     Characterization of a rat C6 glioma-secreted follistatin-related
            protein (FRP). Cloning and sequence of the human homologue
  JOURNAL   Eur J Biochem 225 (3), 937-946 (1994)
   PUBMED   7957230
REFERENCE   10 (bases 1 to 3609)
  AUTHORS   Shibanuma,M., Mashimo,J., Mita,A., Kuroki,T. and Nose,K.
  TITLE     Cloning from a mouse osteoblastic cell line of a set of
            transforming-growth-factor-beta 1-regulated genes, one of which
            seems to encode a follistatin-related polypeptide
  JOURNAL   Eur J Biochem 217 (1), 13-19 (1993)
   PUBMED   7901004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC129539.11.
            
            On Oct 19, 2007 this sequence version replaced NM_008047.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049440.1, BC028921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC129539.11        60912-61009         c
            99-155              AC129539.11        60714-60770         c
            156-260             AC129539.11        22254-22358         c
            261-390             AC129539.11        19031-19160         c
            391-423             AC129539.11        16876-16908         c
            424-554             AC129539.11        15333-15463         c
            555-673             AC129539.11        11220-11338         c
            674-786             AC129539.11        9245-9357           c
            787-897             AC129539.11        8840-8950           c
            898-974             AC129539.11        6431-6507           c
            975-3609            AC129539.11        1548-4182           c
FEATURES             Location/Qualifiers
     source          1..3609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.48 cM"
     gene            1..3609
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /note="follistatin-like 1"
                     /db_xref="GeneID:14314"
                     /db_xref="MGI:MGI:102793"
     exon            1..98
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            99..155
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            156..260
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            261..390
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            391..423
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            424..554
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            674..786
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            787..897
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            898..974
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     exon            975..3609
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
                     /note="hexamer: AATAAA"
     polyA_site      1207
                     /gene="Fstl1"
                     /gene_synonym="Fstl; TSC-36"
ORIGIN      
        1 ttcctcggag cctggtgata agcgacgctc ccaccttcgc ctctaactcg ctgccgccac
       61 cctgcccagt gtcctccgga gtcccggacc cgagcacgat gtggaaacga tggctggcgc
      121 tctcgctggt gaccatcgcc ctggtccacg gcgaggagga acctagaagc aaatccaaga
      181 tctgcgccaa tgtgttttgt ggagctggca gggaatgtgc cgtcacagag aagggggagc
      241 ccacgtgcct ctgcattgag caatgcaaac ctcacaagag gcctgtgtgt ggcagtaatg
      301 gcaagaccta cctcaaccac tgtgaacttc atagagatgc ctgcctcact ggatccaaga
      361 tccaggttga ttatgatggg cactgcaaag aaaagaagtc tgcgagtcca tctgccagcc
      421 cagttgtctg ctatcaagct aaccgcgatg agctccgacg gcgcctcatc cagtggctgg
      481 aagctgagat cattccagat ggctggttct ctaaaggcag taactacagt gagatcctag
      541 acaagtactt taagagcttt gataatggcg actctcacct ggactccagt gaattcctga
      601 aattcgtgga gcagaatgaa acagccatca acatcaccac ttatgcagat caggagaaca
      661 acaaactgct cagaagcctc tgtgttgacg ccctcattga actgtctgat gagaacgctg
      721 actggaaact cagcttccaa gagttcctca agtgcctcaa cccatccttc aaccctcctg
      781 agaagaagtg tgccctggag gacgaaacct atgcagatgg agctgagact gaggtggact
      841 gcaatcgctg tgtctgttcc tgtggccact gggtctgcac agcaatgacc tgtgatggaa
      901 agaatcagaa gggggtccag acccacacag aggaggagaa gacaggatat gtccaggaac
      961 tccagaagca ccagggcaca gcagaaaaga ccaagaaggt gaacaccaaa gagatctaag
     1021 aagaggcaca gagcaccgtg tccggagccc agcgcctcct cttcagcgct gagcccagta
     1081 cacacagagt ctgcagcaat caccaaatca ctagtatttg cttgtatggc agcgaatctt
     1141 attttgtttg ttttgcaata aaggaaatga gggtggccag cctagcgagg gaaggccaca
     1201 accttcacct gtaggaatgc tttaagagaa actaaaggac accttgggac gagaggcaac
     1261 taaggaaaca gcatcgggtt ggcagaggag cagaggcagg tttgaatgaa gcctttctgg
     1321 ggtcacagca gctgcgagga gaatacagga aaagcataga gaaacattga actagccctg
     1381 ctggaggaag tggggggagc tttgtaggga ggaaccctgc tgctttgacc cttgtcacca
     1441 ctgtcagcat gacagacctg cagcaagtct gcttctcctt ttggtcccaa caatcacctg
     1501 aacacacagc cgcccaacta gttacctgtg tccctcagcc ttgcatggag tttcctggag
     1561 gaggtgttta aatgatgcag acacttatgt acttcaagcg ccatggagac ctaaccaaat
     1621 ttttaaaata catttttctt tttttttttt ttttgttaac caaaggtgct atttctctgt
     1681 aaaagacttt tttccaagct gacttcattc ctcagttatt accgttatat tattgttgtt
     1741 ttttaatatt tcattttttg actagatatt aagcttttgt aattattttt tcattagtcc
     1801 tactatttca gaagtgaagg tgaagggggt ttgggcattt ttccaggtac agggaactct
     1861 gtaacacaaa cagcccatac cctgtcacat attagaccgg ttgcagttcg gagctgcacc
     1921 ccaacccaga gcttctagaa aatcagctcc atgccacgaa gcacaagagg cccctcagac
     1981 agaagccaca ggacaaagca tcttcataga cagctgttga gatccaaaca gttaatttgc
     2041 ttttgtttct tgtaagaagt tccaaggatg gacgctcagg ctatcccagc ctgccagcct
     2101 gctgtgatct gtggctaact ggcagagtca gccactgtgg tccttagctg ctcctgtttc
     2161 taggtgtcag tttacttagt aaactggtaa gaatgaatct tggaatttaa taaatggtag
     2221 tttgtggttt agccaactgg tccagaggga gctaccttct ccttaggata gatgaatcta
     2281 caccataaga aaaaccagcc aggaatagca tggatgggtt ttgctttggt tgaaatgatc
     2341 ctagcaggtg actgggtatg aggacttcat ggtcactctg cccaggaaga gagcgtgaag
     2401 gacaactagc agcttcctta gggatggtac acatgagtgt gatctctgga gtcagaggtt
     2461 tccccacaca catgatgata aaacttttca gatttagagc ggttaaaact ggagatcgaa
     2521 tctggattga gaatcagcac tgggggagaa actgttattg aaagtcaatc ctttctttga
     2581 gcctccgaat aaactatgga gattttcctg cataggaaag tgtggaatgt tgagctattg
     2641 agatgggagt ggaattcgtc ctaaatagtt tttcctggtc tcatctgaac aagacaattt
     2701 ggctctgcct agtgttctgt gccctccctt tcaaaagctc tgagccccgc tcatgcagtc
     2761 cagatttcat ccccctctcc aagtgccttg gagagctcac agcagcaatg ccatcatcaa
     2821 aagttttgct gctgggaaga aaaaaaaaaa aaaaaaagaa aaaaaaagtt ttgctggttc
     2881 ttggaggtga tgggagaggg caggagtatc aatttgttca agtagctgca gtgtctgttg
     2941 gccaatcatc tttagaaccc tgtaacactg agtaccagag ggcaagccca cattcctctt
     3001 ctgctacttc agtgtaacta gggcagctgt tgtctgaagc accatagatt caggtgatcc
     3061 tccatagatt caggtgatcc tccatagatt caggtgatcc ttgaaccgtt catgaaaagc
     3121 tgctaagtag cctggtttgg gagacttggg ttgagatttg catgggacca acacgcagga
     3181 ttacatcttc ttcagttcct agagtcctct agaagcctat agaacaagac ggcaagctct
     3241 ctgggcttgc tctggggttt tgttctgtgg ttttatgttg ttcttgttgt tttattaaca
     3301 tcagtgtctc ttaagatcca ggacccaggg aggtcttttc acatacatat accaggactc
     3361 ttgggtacta ctgtcagtct tggggaagca ggctcctcca tcggcaacca aatccatgtg
     3421 agcactccga atgccttggt tagtcctatg acctaaatag ttaaacttca gaaaatggtt
     3481 tcaacagatt tctgtgccga gtggttttga aattgcattt gtatttgctg tgcttctgta
     3541 ttccatttaa ctgggttttt tgttacttct gatttttgtt actattaata aataaaaata
     3601 aaataaaat
//
