LOCUS       NM_001374672            2232 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibrous sheath-interacting protein 1 (Fsip1),
            transcript variant 1, mRNA.
ACCESSION   NM_001374672 XM_030252078
VERSION     NM_001374672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Gamallat,Y., Fang,X., Mai,H., Liu,X., Li,H., Zhou,P., Han,D.,
            Zheng,S., Liao,C., Yang,M., Li,Y., Zuo,L., Sun,L., Hu,H. and Li,N.
  TITLE     Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and
            attenuates flagellogenesis in mice
  JOURNAL   Redox Biol 43, 101969 (2021)
   PUBMED   33901807
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Brown,P.R., Miki,K., Harper,D.B. and Eddy,E.M.
  TITLE     A-kinase anchoring protein 4 binding proteins in the fibrous sheath
            of the sperm flagellum
  JOURNAL   Biol Reprod 68 (6), 2241-2248 (2003)
   PUBMED   12606363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845495.9.
            
            On Oct 8, 2019 this sequence version replaced XM_030252078.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.183383.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL845495.9         132775-132931       c
            158-290             AL845495.9         129261-129393       c
            291-471             AL845495.9         127614-127794       c
            472-626             AL845495.9         125781-125935       c
            627-723             AL845495.9         124270-124366       c
            724-816             AL845495.9         117618-117710       c
            817-974             AL845495.9         116367-116524       c
            975-1085            AL845495.9         112889-112999       c
            1086-1241           AL845495.9         108879-109034       c
            1242-1376           AL845495.9         98301-98435         c
            1377-1887           AL845495.9         12089-12599         c
            1888-2232           AL845495.9         6243-6587           c
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.38 cM"
     gene            1..2232
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /note="fibrous sheath-interacting protein 1"
                     /db_xref="GeneID:71313"
                     /db_xref="MGI:MGI:1918563"
     exon            1..157
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            158..290
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1940
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="fibrous sheath-interacting protein 1 isoform 1"
                     /protein_id="NP_001361601.1"
                     /db_xref="CCDS:CCDS89537.1"
                     /db_xref="GeneID:71313"
                     /db_xref="MGI:MGI:1918563"
                     /translation="MPMDIIKGNLDGISKPASSSRSRPGSRSSNGSLEVLTPEPGSVK
                     IDMVNKLNSGQEGHTSNSGVEERRNSNDAKWADDSKTKPAKESSDEDPDMPQPQATPE
                     HSDDPKLEETNAVLQNAIRKMHRLDKLLAKKQCREKEVKKQGLEMRVKLWEELKSAKN
                     TEDLENDEELGNTKKFLCLTSESAGKAAAEALHCEFEDALFSVFHTQIPPETYENLME
                     KDFTCDVEKNEPLIITEKQPFSNTEAIEPRSEDSQGFIRQNAEHSQDFIKRNIELAKH
                     SRSPVVMVEGEKKRLDELLQGLDDADSGLSSAEGDQCGWLVPGEGYTLAATESQQLAE
                     IDIKLQELSVDSPTIFSLESQSHKGDMECDANEERNTEPTPGEKILRDRKEQRDRESR
                     LRAIDGKLKELSEQLNSPTRLSEEQLKCLLDECVSKQKCIALGLSSERENKDTDTALG
                     SPQLCPSTLCDLPEEAGAKVQETQLDDANRLESEGCAYPADSYLTKALTGHYKPEALL
                     LEVETMKHLQFSKEEAFNDAVDYFMSKTIGIGRLKKPPFLDDPLDDVSVNSSSDDQEL
                     KTSLAEKSVVDDQEAGDAVKEIGEHEA"
     exon            291..471
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            472..626
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            627..723
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..816
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..974
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1085
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1241
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1376
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1887
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2232
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2045
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /note="major polyA site"
     polyA_site      2232
                     /gene="Fsip1"
                     /gene_synonym="1700012M13Rik; 4933432K11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagacagcgg tctcctgctg cctctttcat cttcacagag gaggcggtgg cgggaaaaac
       61 cggtcccctt cgaagggaag tggagagagt cagtgtctag gcgtccagct ttcttcccca
      121 ccgagaagtt gaggggccgc acgcaccacg ggcagaggat gccaatggat attataaagg
      181 ggaacctaga cggaatttca aaaccagcct caagttcaag atcacgtcct gggagccgaa
      241 gttcaaatgg ttctctggag gtgctcacac cagaaccagg gtctgtcaag attgacatgg
      301 taaacaagtt gaattctggc caagagggcc acacatcaaa cagtggtgtg gaagaaagaa
      361 ggaatagtaa tgatgctaag tgggcagacg actccaagac aaaaccagcc aaggagagct
      421 cagatgaaga cccggacatg cctcaacctc aggcgacccc tgagcattca gatgatccca
      481 aattagaaga gacgaatgct gtacttcaaa atgctattcg taagatgcac agactcgaca
      541 agctattggc caaaaaacaa tgtagagaaa aggaagttaa aaagcaaggt ctagaaatga
      601 gagttaagct gtgggaagag ctcaagtctg caaaaaacac tgaagactta gaaaatgacg
      661 aggagttggg aaacacaaaa aagtttttgt gcttgacttc agaatctgca gggaaagcag
      721 ctgcagaggc attgcattgt gagtttgaag acgccctttt ctcagtgttt catactcaga
      781 ttcctccaga aacttacgaa aatctcatgg agaaagattt tacctgtgat gtggagaaaa
      841 atgaaccatt gatcataaca gaaaagcaac cattttcaaa tacagaagcg attgagccta
      901 ggagtgaaga cagccagggt ttcattaggc agaacgctga acacagccag gattttatta
      961 agcgaaacat tgagttggcc aagcattcga gaagcccagt ggtcatggtt gaaggagaga
     1021 agaaaagact ggatgagctc ctgcaaggcc tggatgatgc agactcagga ctctccagtg
     1081 ccgagggcga tcagtgcggt tggctggttc caggagaagg ctataccctt gcagccactg
     1141 agtctcagca gcttgctgag attgacataa agcttcagga actctctgtt gactctccca
     1201 ccatcttcag ccttgaaagt cagagccata agggtgatat ggaatgtgat gccaatgaag
     1261 aaagaaatac ggaaccaact cccggagaga agatactccg ggaccgcaaa gagcaaaggg
     1321 accgggagtc tcggctgaga gccatcgatg gcaagctgaa agagctcagt gaacagctaa
     1381 actccccaac acgtctttct gaggaacagc tgaagtgtct tctggatgag tgtgtctcca
     1441 aacagaaatg cattgctctt ggtctttctt ctgaaagaga aaacaaagat actgatacag
     1501 cacttgggtc cccacagctt tgcccatcca ccctctgtga cttaccagaa gaggccggag
     1561 ccaaggtcca ggaaacccag ctagacgatg caaacaggct tgagagtgag ggatgtgcat
     1621 atcccgcaga ctcctatctt accaaagcct tgactggaca ctacaaaccc gaggctctgc
     1681 tcctcgaagt agagaccatg aaacacctcc agttctccaa ggaggaggct tttaatgatg
     1741 cagtagacta ttttatgtca aagaccattg gcattgggag actgaaaaag ccccctttct
     1801 tggatgatcc cctggatgac gtcagcgtga actcctcctc agatgaccaa gagttgaaaa
     1861 ccagccttgc agagaaatca gtagtagatg atcaggaggc tggggatgct gtgaaggaaa
     1921 taggagaaca tgaagcatga ctttctaggg tttaaggtta agaaagttga aaattaattt
     1981 gcattatatt ttttctgagt tttttgtatt cagtgaatgc aacatagaga tgattcctca
     2041 aatgatttca atatttgaat tcccttcttt gctgattgta tttctttaat gtttttgaaa
     2101 cttggggtgt aaatgttaga tttttttatc attgatattc ctaggaaatt tgtttacaac
     2161 tgtatcacta atctcacaat ctcaaggata ctttgtaaaa accaaagttg taacatatgc
     2221 ctgctgtgtt aa
//
