LOCUS       NM_013523               2360 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus follicle stimulating hormone receptor (Fshr), mRNA.
ACCESSION   NM_013523
VERSION     NM_013523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Hsieh,T.B. and Jin,J.P.
  TITLE     Loss of Calponin 2 causes premature ovarian insufficiency in mice
  JOURNAL   J Ovarian Res 17 (1), 37 (2024)
   PUBMED   38336796
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Cheng,Y., Zhu,H., Ren,J., Wu,H.Y., Yu,J.E., Jin,L.Y., Pang,H.Y.,
            Pan,H.T., Luo,S.S., Yan,J., Dong,K.X., Ye,L.Y., Zhou,C.L.,
            Pan,J.X., Meng,Z.X., Yu,T., Jin,L., Lin,X.H., Wu,Y.T., Yang,H.B.,
            Liu,X.M., Sheng,J.Z., Ding,G.L. and Huang,H.F.
  TITLE     Follicle-stimulating hormone orchestrates glucose-stimulated
            insulin secretion of pancreatic islets
  JOURNAL   Nat Commun 14 (1), 6991 (2023)
   PUBMED   37914684
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Liu,L., Hao,M., Zhang,J., Chen,Z., Zhou,J., Wang,C., Zhang,H. and
            Wang,J.
  TITLE     FSHR-mTOR-HIF1 signaling alleviates mouse follicles from
            AMPK-induced atresia
  JOURNAL   Cell Rep 42 (10), 113158 (2023)
   PUBMED   37733588
  REMARK    GeneRIF: FSHR-mTOR-HIF1 signaling alleviates mouse follicles from
            AMPK-induced atresia.
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Kotlar,T.J., Young,R.H., Albanese,C., Crowley,W.F. Jr., Scully,R.E.
            and Jameson,J.L.
  TITLE     A mutation in the follicle-stimulating hormone receptor occurs
            frequently in human ovarian sex cord tumors
  JOURNAL   J Clin Endocrinol Metab 82 (4), 1020-1026 (1997)
   PUBMED   9100567
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Kumar,T.R., Wang,Y., Lu,N. and Matzuk,M.M.
  TITLE     Follicle stimulating hormone is required for ovarian follicle
            maturation but not male fertility
  JOURNAL   Nat Genet 15 (2), 201-204 (1997)
   PUBMED   9020850
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Aittomaki,K., Herva,R., Stenman,U.H., Juntunen,K., Ylostalo,P.,
            Hovatta,O. and de la Chapelle,A.
  TITLE     Clinical features of primary ovarian failure caused by a point
            mutation in the follicle-stimulating hormone receptor gene
  JOURNAL   J Clin Endocrinol Metab 81 (10), 3722-3726 (1996)
   PUBMED   8855829
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Wang,X.J., Greenhalgh,D.A., Eckhardt,J.N., Rothnagel,J.A. and
            Roop,D.R.
  TITLE     Epidermal expression of transforming growth factor-alpha in
            transgenic mice: induction of spontaneous and
            12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a
            mechanism independent of Ha-ras activation or overexpression
  JOURNAL   Mol Carcinog 10 (1), 15-22 (1994)
   PUBMED   8185825
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Huhtaniemi,I.T., Eskola,V., Pakarinen,P., Matikainen,T. and
            Sprengel,R.
  TITLE     The murine luteinizing hormone and follicle-stimulating hormone
            receptor genes: transcription initiation sites, putative promoter
            sequences and promoter activity
  JOURNAL   Mol Cell Endocrinol 88 (1-3), 55-66 (1992)
   PUBMED   1459341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165082.2, BC137990.1 and CT009630.16.
            
            On Jul 1, 2009 this sequence version replaced NM_013523.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016635.1, BC137990.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC165082.2         157991-157993       c
            4-2222              BC137990.1         1-2219
            2223-2360           CT009630.16        39265-39402
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 58.76 cM"
     gene            1..2360
                     /gene="Fshr"
                     /note="follicle stimulating hormone receptor"
                     /db_xref="GeneID:14309"
                     /db_xref="MGI:MGI:95583"
     exon            1..215
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            216..287
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            288..362
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            363..437
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            438..509
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            510..587
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            588..656
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            657..731
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            732..917
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            918..2360
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fshr"
                     /note="hexamer: ATTAAA"
     polyA_site      2357
                     /gene="Fshr"
                     /note="major polyA site"
ORIGIN      
        1 ggggaatccg tggaggtttt cgctgctgga gcaggcagaa agcaggtgga tggataaata
       61 agcatggcct tgctcctggt ctccttgctg gcattcttgg gctcgggatc tggatgtcat
      121 cactggctgt gtcattgctc taacagggtc ttcctctgcc aagatagcaa ggtgaccgag
      181 attccgcccg acctcccccg gaacgccatt gaactgagat ttgtgctcac caagcttcga
      241 gtcattccaa aaggatcatt ttctggattt ggggacctgg agaaaataga gatctctcag
      301 aatgatgtct tggaggtaat agaggcagat gtgttctcca acctacccaa cttgcatgaa
      361 attaggattg aaaaggctaa caatctgctg tacatcaacc ctgaggcctt ccagaatctt
      421 cccagtctcc gatatctgtt aatatccaac acaggcatta aacacttgcc agcctttcac
      481 aagatccagt ctctccaaaa ggttttatta gacattcaag ataacataaa catccacatc
      541 attgccagga actccttcat gggactgagc tttgaaagtg taattctatg gctgaataag
      601 aatgggattc aagaaataca caactgtgca ttcaacggaa cccagctaga tgaactgaat
      661 ctaagcgata acaataattt ggaagaattg cctgatgatg ttttccaggg agcctctggg
      721 ccagtcgttt tagacatctc aaggacaaag gtctattccc tgcccaacca tggcttagaa
      781 aatctgaaga agttgagggc caggtcaaca taccgcttga aaaagctccc tagtctagac
      841 aagtttgtca tgctcattga ggccagcctt acctacccca gtcactgctg tgcctttgca
      901 aactggaggc ggcaaacctc tgaacttcat ccaatttgca acaagtctat ttcaaggcaa
      961 gatattgatg atatgactca gcctggggat cagagagtct ctctcgtaga tgatgaaccc
     1021 agttatggaa aaggatctga catgttgtat agtgaatttg actatgactt atgcaatgaa
     1081 tttgttgatg tgacctgctc gccaaagcca gatgcattta atccatgtga agacatcatg
     1141 gggtacaaca tcctcagagt cttgatatgg tttatcagca tcctggccat cactgggaac
     1201 accacagtgc tggtggtcct gaccacaagc caatacaaac tcactgtgcc ccggttcctt
     1261 atgtgtaacc tcgcctttgc tgatctttgc attgggatct acttgctact tatagcctca
     1321 gttgatatcc atactaagag ccagtaccac aattacgcca ttgactggca aacaggagca
     1381 ggctgcgatg ccgctggctt tttcactgtc tttgccagtg aactgtcagt ctacacattg
     1441 gcagccataa ccctagaaag atggcatacc atcacacatg ccatgcaact ggaatgcaag
     1501 gtacagctct gccatgctgc cagcatcatg gtgctgggct gggcctttgc ctttgcggct
     1561 gctctcttcc ccatctttgg catcagtagc tacatgaaag tgagcatctg cctgcccatg
     1621 gatatcgaca gccctttgtc gcagctgtat gttatggccc tcctcgtact caacgccctg
     1681 gcctttgtgg tcatctgtgg ttgctacacc cacatctacc tcacagtgag gaatcctaac
     1741 attgtgtcct cgtcaagaga caccaagatt gccaagcgca tggccacact catcttcacg
     1801 gactttctct gcatggcccc aattttattc tttgccattt ccgcctccct caaggtgccc
     1861 ctcatcactg tgtccaaggc caagatcctc ctagttctgt tctaccccat caattcttgt
     1921 gccaatcctt tcctctatgc cattttcacc aagaacttcc gcagggactt cttcgtcctg
     1981 atgagcaagt ttggctgtta tgaggtgcaa gcccagattt acaagacaga aacctcatct
     2041 attacccaca acttccactc cagaaagaat ccctgttcct cggctcccag agtcaccaat
     2101 agttacgtgc ttgtccctct aaatcattca gtccagaact aaaaatcaat gtgaaaatgg
     2161 atcctcacct tgaaagacaa gtgtgacttc tttctggaga gagggctatg gaagagctgg
     2221 cagtgttgct acatatttca tctaatttaa tctttctagg tatgtgcatg gcagataggt
     2281 cagggaccat taatatctca tgtgactcat ctaagaactg aattattggt aaccgcaatt
     2341 aaaatagtgc aacactgctg
//
