LOCUS       NM_008045               1749 bp    mRNA    linear   ROD 25-FEB-2024
DEFINITION  Mus musculus follicle stimulating hormone beta (Fshb), mRNA.
ACCESSION   NM_008045
VERSION     NM_008045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Wang,H., Liu,Z., Larsen,M., Hastings,R., Gunewardena,S. and
            Kumar,T.R.
  TITLE     Identification of follicle-stimulating hormone-responsive genes in
            Sertoli cells during early postnatal mouse testis development
  JOURNAL   Andrology 11 (5), 860-871 (2023)
   PUBMED   37208854
  REMARK    GeneRIF: Identification of follicle-stimulating hormone-responsive
            genes in Sertoli cells during early postnatal mouse testis
            development.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Huang,C., Zhao,S., Yang,Y., Guo,T., Ke,H., Mi,X., Qin,Y., Chen,Z.J.
            and Zhao,S.
  TITLE     TP63 gain-of-function mutations cause premature ovarian
            insufficiency by inducing oocyte apoptosis
  JOURNAL   J Clin Invest 133 (5), e162315 (2023)
   PUBMED   36856110
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Gonzalez-Meljem,J.M., Ivins,S., Andoniadou,C.L., Le Tissier,P.,
            Scambler,P. and Martinez-Barbera,J.P.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Lin,Y.F., Schang,G., Buddle,E.R.S., Schultz,H., Willis,T.L.,
            Ruf-Zamojski,F., Zamojski,M., Mendelev,N., Boehm,U., Sealfon,S.C.,
            Andoniadou,C.L. and Bernard,D.J.
  TITLE     Steroidogenic Factor 1 Regulates Transcription of the Inhibin B
            Coreceptor in Pituitary Gonadotrope Cells
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   35957608
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Soejima,Y., Iwata,N., Nakayama,N., Hirata,S., Nakano,Y.,
            Yamamoto,K., Suyama,A., Oguni,K., Nada,T., Fujisawa,S. and
            Otsuka,F.
  TITLE     Mutual Effects of Orexin and Bone Morphogenetic Proteins on
            Gonadotropin Expression by Mouse Gonadotrope Cells
  JOURNAL   Int J Mol Sci 23 (17), 9782 (2022)
   PUBMED   36077179
  REMARK    GeneRIF: Mutual Effects of Orexin and Bone Morphogenetic Proteins
            on Gonadotropin Expression by Mouse Gonadotrope Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Oettinger,M.A., Stanger,B., Schatz,D.G., Glaser,T., Call,K.,
            Housman,D. and Baltimore,D.
  TITLE     The recombination activating genes, RAG 1 and RAG 2, are on
            chromosome 11p in humans and chromosome 2p in mice
  JOURNAL   Immunogenetics 35 (2), 97-101 (1992)
   PUBMED   1735560
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Lawler,J., Duquette,M., Ferro,P., Copeland,N.G., Gilbert,D.J. and
            Jenkins,N.A.
  TITLE     Characterization of the murine thrombospondin gene
  JOURNAL   Genomics 11 (3), 587-600 (1991)
   PUBMED   1774063
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Siracusa,L.D., Alvord,W.G., Bickmore,W.A., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Interspecific backcross mice show sex-specific differences in
            allelic inheritance
  JOURNAL   Genetics 128 (4), 813-821 (1991)
   PUBMED   1916246
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Hediger,R., Johnson,S.E. and Hetzel,D.J.
  TITLE     Localization of the beta-subunit of follicle stimulating hormone in
            cattle and sheep by in situ hybridization
  JOURNAL   Anim Genet 22 (3), 237-244 (1991)
   PUBMED   1928829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC061159.1, BB026460.1 and
            BB020786.1.
            
            On Aug 21, 2015 this sequence version replaced NM_008045.2.
            
            Summary: The pituitary glycoprotein hormone family includes
            follicle-stimulating hormone, luteinizing hormone, chorionic
            gonadotropin, and thyroid-stimulating hormone. All of these
            glycoproteins consist of an identical alpha subunit and a
            hormone-specific beta subunit. This gene encodes the beta subunit
            of follicle-stimulating hormone. In conjunction with luteinizing
            hormone, follicle-stimulating hormone induces egg and sperm
            production. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061159.1, AK017593.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1595              BC061159.1         1-1595
            1596-1662           BB026460.1         172-238
            1663-1749           BB020786.1         204-290
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.02 cM"
     gene            1..1749
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
                     /note="follicle stimulating hormone beta"
                     /db_xref="GeneID:14308"
                     /db_xref="MGI:MGI:95582"
     exon            1..37
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            38..224
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..455
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
                     /note="follitropin subunit beta; follitropin beta chain;
                     follicle-stimulating hormone beta subunit"
                     /codon_start=1
                     /product="follitropin subunit beta precursor"
                     /protein_id="NP_032071.1"
                     /db_xref="CCDS:CCDS16504.1"
                     /db_xref="GeneID:14308"
                     /db_xref="MGI:MGI:95582"
                     /translation="MMKLIQLCILFWCWRAICCHSCELTNITISVEKEECRFCISINT
                     TWCAGYCYTRDLVYKDPARPNTQKVCTFKELVYETVRLPGCARHSDSLYTYPVATECH
                     CGKCDSDSTDCTVRGLGPSYCSFSEMKE"
     exon            225..1749
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
     polyA_site      1595
                     /gene="Fshb"
                     /gene_synonym="FSH; FSH-B; FSH-beta; Fshbeta"
ORIGIN      
        1 gttcagcttt ccccagaaga gacagctgac tgcacaggac gtagctgttt acttcccaga
       61 ccatgatgaa gttgatccag ctttgcatct tattctggtg ctggagagca atctgctgcc
      121 atagctgtga attgaccaac atcaccatct cagtagagaa ggaagagtgc cgtttctgca
      181 taagcatcaa taccacttgg tgtgcgggct actgctacac tagggatctg gtgtataagg
      241 acccagctcg gcccaatacc cagaaagtat gtaccttcaa ggagctggta tacgagaccg
      301 taagattgcc tggctgtgcc cgccactcag actccctcta cacatatcca gtagccactg
      361 aatgtcactg tggcaagtgt gacagcgaca gcactgactg caccgtgagg ggcctaggac
      421 ccagctactg ctccttcagt gaaatgaagg aataaacgac gatggacatt gccgttcgcc
      481 cacccttgtc ctgaaggacc atgatatcca aaaagtctgt gacttcttag tgctgggact
      541 gcaaaccact ggcttgggga ccatcagacc cactgttgtc cgctgtcctg acagataggg
      601 agaaggaact caggactagg agtgccaggg ccaggactct acaccactca tccctccatc
      661 catactgttg gttatctaac tcattcactc atagctctca gcttggtgtg gggggctttc
      721 ctgttcaact atcttaagaa ccttctagag caatcccttc cttttagaca gaggcatgca
      781 tgagtctaga gggaggaaag gaaagtggaa atctgtgaaa gagctaaaac tagcacaatc
      841 gtctgccttt tagagccatc agactttgga gactctggca tgattgcaaa cttaaggcct
      901 aaagtctgca tggaattcaa tgagaaactc aatggcttcc ttaagaaaaa gaaaggtgag
      961 aaatatccga gaaatgctga tgaagctggc tgaggaaagc tggcccccac aaggttaggc
     1021 tgctcaactc ctctgaagag cgtggagtat tgagacagga tcaaacatct atggattgtt
     1081 ccaggcagac aggacaggag gtagtaacca agctcagaat ttcccaaggt attgccacca
     1141 agttctttag ttaaaggaaa aaaattaatt tggaactgtg aatattagtc cacatttatt
     1201 cattacttta agaaatgatc aaatgctgct agaattcttc aaaactccct gatctcacca
     1261 gctttccctc acatgcagtg agagaaggtt ttgaagtggg tttcaaagaa atttcagtga
     1321 ttaattaaat acatttagct tgcctacaaa cacacctgta taaattaatg gttatataaa
     1381 atgaaccatg aagggaaaaa cttctgtttt ctaggacccc ctacttctct ttcgcctatc
     1441 tatgttctcc taaagctttt gttcctttca aatacatcat gagttgaatt cttttaaaga
     1501 tgttaaccct tttcatcatg tacttatttc acagttatga tgcttgatta atttatttaa
     1561 atcttatttt tttaataaaa atgctactaa tgaaagtcaa agtttaattg ttttctatac
     1621 aaacagataa cctacatgtt gatatgttta taatattgcc acaaaagtca ttaagtacgg
     1681 ttcctagtgt ttctacaaaa attacctatt ttcatctttg gaaatattaa atatggtttt
     1741 tttcattcc
//
