LOCUS       NM_172904               2976 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fibronectin type III and SPRY domain containing 2
            (Fsd2), mRNA.
ACCESSION   NM_172904
VERSION     NM_172904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Tyser,R.C.V., Ibarra-Soria,X., McDole,K., Arcot Jayaram,S.,
            Godwin,J., van den Brand,T.A.H., Miranda,A.M.A., Scialdone,A.,
            Keller,P.J., Marioni,J.C. and Srinivas,S.
  TITLE     Characterization of a common progenitor pool of the epicardium and
            myocardium
  JOURNAL   Science 371 (6533) (2021)
   PUBMED   33414188
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Benson,M.A., Tinsley,C.L., Waite,A.J., Carlisle,F.A., Sweet,S.M.M.,
            Ehler,E., George,C.H., Lai,F.A., Martin-Rendon,E. and Blake,D.J.
  TITLE     Ryanodine receptors are part of the myospryn complex in cardiac
            muscle
  JOURNAL   Sci Rep 7 (1), 6312 (2017)
   PUBMED   28740084
  REMARK    GeneRIF: Data identify a novel muscle-expressed TRIM-related
            protein minispryn, encoded by Fsd2, that has extensive sequence
            similarity with the C-terminus of Cmya5. They appear to have
            originated by a chromosomal duplication and are found within
            evolutionarily-conserved gene clusters on different chromosomes.
            Both proteins co-localize with RyR2 at the junctional sarcoplasmic
            reticulum of isolated cardiomyocytes.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY067791.1, AK028142.1 and AK036674.1.
            
            On Oct 12, 2006 this sequence version replaced NM_172904.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036674.1, SRR10223969.7480.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               BY067791.1         2-142
            142-1073            AK028142.1         134-1065
            1074-2976           AK036674.1         1040-2942
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..2976
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /note="fibronectin type III and SPRY domain containing 2"
                     /db_xref="GeneID:244091"
                     /db_xref="MGI:MGI:2444310"
     exon            1..141
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..723
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2334
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /note="SPRY domain-containing protein 1; SPRY domain
                     containing 1; minispryn"
                     /codon_start=1
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2"
                     /protein_id="NP_766492.2"
                     /db_xref="CCDS:CCDS80743.1"
                     /db_xref="GeneID:244091"
                     /db_xref="MGI:MGI:2444310"
                     /translation="MEEEAEEESGLGRSAAPKDFHFYHMDLYDSEDRLQLFPGDSSRI
                     RREVTQAEDDRELGDEFVDEHRLGTLGYPSYGMRRRDPGREPRDWGEAAEAEDLGYGG
                     GQGPLDQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEPADVFCITCKTPVRTVEKD
                     FDTHKEHEVTPISKALEHAKDEVHKNMCKLEQQIIEMENFASHLEEVFITVEENFGRQ
                     EQNFECHYNGILETLAQKYEEKIQALGEKKREKLEALYGQLVSCGENLDACRELMETV
                     EEMCHEEKVEFLKDAVAMTDRLGKFLKTKTDVELSAQPEFEDQTLDFSDVEQLMDAIN
                     TIPAPSAPVINPQAPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSSGKDRAEFT
                     MMVKETYCSVTNLEPNTQYEFWVIAQNRTGPSPCSEHAVYMTAPSPPSIKTEAIRSCE
                     EAVLICWESGNLNPVDSYTVELIQAETPEASGVTESVVGIPTCESLIQLQPRHSYTIY
                     VRALNVGGTSARSEPATVHTTGSYFQLNKDTCHPWLTISEDGFTVVRSEKKSFRKELP
                     PSKTQFTRCVAVMGNLIPVRGRHYWEVEVAEHLDYTVGVACEDVPKQEDLGANSLSWC
                     MRHTFVSKRHRYEFLHNKMTPDIRITVAPRKIGVLLDYENAKLSFFNVDIAQHLYTFS
                     CQLHQFVHPCFSLEKSGCLKICNGISMPKHVTFF"
     exon            724..819
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1050
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1073
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1195
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1351
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1486
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1637
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1771
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1904
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2081
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2976
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /note="hexamer: AATAAA"
     polyA_site      2919
                     /gene="Fsd2"
                     /gene_synonym="9830160G03Rik; Spryd1"
                     /note="major polyA site"
ORIGIN      
        1 agggtgaact aggcatggcc agcttgcagc gcactcagag gtcaccggga aggggagctg
       61 gccagacaga aatccaactt tccagcagaa acctaggatg ttggagttaa aagacgcatt
      121 tatgggcctt taaaaaagca ggactcagaa catccactga ctgagaaggg ctgccctgtg
      181 tcaatggagg aggaagcaga ggaggaatcc gggctgggca ggtcggcagc ccccaaagac
      241 ttccactttt atcacatgga cctgtatgac tctgaagata gactgcagct cttcccagga
      301 gacagcagca gaatcaggag ggaagtaacc caagccgaag atgaccgtga attaggggat
      361 gaatttgtgg atgaacacag actggggact ctggggtatc cttcttacgg gatgaggagg
      421 agggacccag gcagggagcc gagagactgg ggtgaggcag ctgaggcgga ggacctgggc
      481 tacggaggag ggcaaggccc tcttgaccag tgccaagacc tccgggaagc ctacaggtac
      541 acacatggcc gtgccagcga ggagtatgaa tgctatgtca tcccagagga ggaagacgaa
      601 gaagagcctg ctgatgtctt ctgcatcact tgcaaaactc cagtaagaac tgttgagaag
      661 gattttgata cacacaagga acacgaagta accccaatca gcaaagctct ggaacatgcc
      721 aaggatgagg ttcacaaaaa tatgtgcaaa ttggaacagc agataattga gatggaaaat
      781 ttcgctagcc acctggaaga agtgttcatt actgtggagg agaattttgg aagacaggaa
      841 caaaactttg agtgccatta caatgggatc ttggaaaccc tcgctcaaaa gtatgaagaa
      901 aaaattcaag ctctggggga gaaaaagaga gagaaactgg aagccttata cggacaactg
      961 gtcagctgtg gagagaacct cgatgcctgc agggagctga tggaaaccgt agaggagatg
     1021 tgtcatgagg aaaaggtgga gttcttaaag gatgcagtgg ctatgactga cagactgggg
     1081 aaattcctga aaaccaaaac tgatgtggag ctctctgcac aacctgagtt tgaagaccag
     1141 accttggact tctctgatgt ggagcagctg atggacgcca tcaataccat tccagcgccc
     1201 tctgctccag tgataaatcc ccaggcaccc aactccgcca ccggctcctc agtgcgtgta
     1261 tgctggagct tatattctga cgacaccgtg gagagctacc agctgtccta taggccggtg
     1321 caggacagct catctggcaa ggaccgagca gaattcacca tgatggtcaa agaaacatat
     1381 tgctcagtga caaatcttga gccaaatact cagtatgagt tttgggtcat agctcagaac
     1441 aggactggcc ccagcccctg cagtgagcac gcagtgtata tgacagcccc ctctcccccc
     1501 tctataaaaa ccgaggcaat cagaagctgt gaagaggctg tgctgatttg ctgggagtct
     1561 gggaacctga atccggtgga ctcctacacg gtggagctaa tccaggcaga gacgccagaa
     1621 gcctcggggg taactgaatc tgtcgtaggc atcccaacct gtgaatccct gatacagctg
     1681 cagcctagac acagctatac catctatgtg cgagccctca acgtgggagg caccagtgcc
     1741 agaagtgagc ctgctacagt gcacaccaca ggaagctact tccaattgaa caaagacacc
     1801 tgccatccct ggctgaccat ttctgaagat gggtttacgg tagttcgaag tgagaagaaa
     1861 agtttcagaa aggagctgcc gccgagcaag acgcaattta ccaggtgtgt tgctgtcatg
     1921 gggaatctga ttccggtccg agggcgccat tactgggaag tggaggtggc tgagcatttg
     1981 gactacactg tgggtgtggc ctgtgaagat gtccctaagc aggaagacct gggagcaaac
     2041 tccttgtcct ggtgcatgag gcatacattt gtttccaaaa ggcaccggta tgagtttctg
     2101 cacaacaaga tgactccaga catcaggatc acagttgctc cgaggaagat tggcgtgctg
     2161 ctggactatg agaacgccaa gctgtccttt ttcaatgtgg acattgctca gcacctgtac
     2221 acatttagct gtcagctcca ccagtttgtg catccctgct tttccctgga aaagtctgga
     2281 tgcctaaaga tctgcaatgg catttcaatg ccaaagcatg tcactttctt ttaggccctt
     2341 ctggtatttc cactctttct tccttcctgt ccctcagcca ccctcccctc cctggctgaa
     2401 cttggtattc aaggttccta ctgctagccg aagctaaagc tcacggtagt gtcagtagat
     2461 ggtgtactgg agcccttttc acctgtgtgc tgtgccctgc tgaagctagg gggagccctt
     2521 atcgggctgt taaatgaggg ctcttgtggg gtcgaattct tggagtgtta aattgcagtt
     2581 tgtgatatgt aaagtatttt gagtctccta aacttataga cctagggaga gggtcaggga
     2641 agtcatgatg gcatcagcag cccctgtaca tttgtgacat ttcactgttt accaagatca
     2701 gactaggaaa ggcaagaaat tacagaaaaa gaaggaagtc aggtgcccat ctcaaggcca
     2761 tcgtggacac tgagtaagaa tggttcccgt aggctcacat atttgaatgc ttagtcatgg
     2821 gtggaggcgg ggctaggagt ggcactactt gaaaaggatt agacttatta ggagatgtgg
     2881 ctttgatgat cagaataaac ctctccacta ccgctcccat gcagtgagtg ctgccatgct
     2941 tcctgccata ataaagggct taacctctca aactat
//
