LOCUS       NM_019569               1802 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus fascin actin-bundling protein 3 (Fscn3), transcript
            variant 1, mRNA.
ACCESSION   NM_019569
VERSION     NM_019569.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Ali,H., Unar,A., Dil,S., Ali,I., Khan,K., Khan,I. and Shi,Q.
  TITLE     Testis-specific fascin component FSCN3 is dispensable for mouse
            spermatogenesis and fertility
  JOURNAL   Mol Biol Rep 49 (7), 6261-6268 (2022)
   PUBMED   35449315
  REMARK    GeneRIF: Testis-specific fascin component FSCN3 is dispensable for
            mouse spermatogenesis and fertility.
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Yamakita,Y., Matsumura,F. and Yamashiro,S.
  TITLE     Fascin1 is dispensable for mouse development but is favorable for
            neonatal survival
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 524-534 (2009)
   PUBMED   19343791
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Tubb,B., Mulholland,D.J., Vogl,W., Lan,Z.J., Niederberger,C.,
            Cooney,A. and Bryan,J.
  TITLE     Testis fascin (FSCN3): a novel paralog of the actin-bundling
            protein fascin expressed specifically in the elongate spermatid
            head
  JOURNAL   Exp Cell Res 275 (1), 92-109 (2002)
   PUBMED   11925108
  REMARK    GeneRIF: This is a novel, spermatid-specific murine paralog of the
            actin-binding protein fascin FSCN1.  Its expression is restricted
            to the elongated spermatid head.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068608.5.
            
            On Aug 23, 2022 this sequence version replaced NM_019569.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050759.1, AF176024.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC068608.5         63291-63561
            272-968             AC068608.5         65379-66075
            969-1087            AC068608.5         66915-67033
            1088-1247           AC068608.5         69790-69949
            1248-1418           AC068608.5         70902-71072
            1419-1624           AC068608.5         71400-71605
            1625-1802           AC068608.5         73847-74024
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.99 cM"
     gene            1..1802
                     /gene="Fscn3"
                     /note="fascin actin-bundling protein 3"
                     /db_xref="GeneID:56223"
                     /db_xref="MGI:MGI:1890386"
     exon            1..271
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1624
                     /gene="Fscn3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fascin (testis); fascin-3; testis fascin; fascin homolog
                     3, actin-bundling protein, testicular"
                     /codon_start=1
                     /product="fascin-3 isoform 1"
                     /protein_id="NP_062515.2"
                     /db_xref="CCDS:CCDS39446.1"
                     /db_xref="GeneID:56223"
                     /db_xref="MGI:MGI:1890386"
                     /translation="MAEVDWIHRHPKAEDLRVGLISWAGTYLTFEAYKSSVTASAKSL
                     GRRQTWELLVSNEHESQAVIRLKSLQGLYLLCEADGTVCYGRPRTSHHGCFLLRFHRN
                     GKWTLQCIISGRYLESDGEDVFCNSRVLSAYHMWTPRPALHVHVILYSPIYHSYARAD
                     HTVGRIWVDAAIPCLEECGFLLHFQDGCYHLETSTHHFLSRVDRLVPQRSSQTAFHMQ
                     VRPRGLVALCDGEGGTLYPQGSHLLLGMGSAPMKGEEWFVLQHFPTWVSLKSKSRRFL
                     SVIYDAEVCAASERLTQMSLFQYECDSETPTLQLRSANGYYLAQRRHRAIIADGHPME
                     SDTFFRVHWNCGKITLQSPNGRFLGIASDGLLMANVTIPGPNEELGIRFANRPFLVLR
                     GRYGYVGSSSDHDLLKCNMDQPDCIQLLPCRQGIYHFQAQGGSFWSITSFGTFRPWGK
                     FALNFCIELQGSSLLTVLAPNGFYLRADRSGTLLADSEEITKECIWEF"
     exon            272..968
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1087
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1247
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1418
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1624
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1802
                     /gene="Fscn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fscn3"
                     /note="hexamer: AATACA"
     polyA_site      1802
                     /gene="Fscn3"
                     /note="major polyA site"
ORIGIN      
        1 aaagttttct ctgggaacag cttctggtgg gtactacggg ccatattccc ggccatatgg
       61 cctgtgggac cttaccactg gggggaagcc tgggccggac agagtcatca cttgtggcac
      121 cagccgcatg gctgaggtgg actggataca cagacatcca aaggcggagg acctaagggt
      181 tgggctcatc agctgggcag gaacctacct cacctttgaa gcatataaga gttcagtcac
      241 agcttctgca aagagtttgg gcaggagaca gacctgggag ctcctggtga gcaatgaaca
      301 tgaatcacag gctgtgatac gactaaagag cttgcagggc ctctacctgc tgtgcgaagc
      361 agatggtact gtgtgctatg gcaggccaag aactagtcac cacggatgct tcctgctccg
      421 cttccaccga aacggcaaat ggaccctcca gtgcatcatc tctggtcgct atcttgagtc
      481 cgatggggag gatgtattct gcaactccag ggttctttca gcttaccata tgtggactcc
      541 caggccagcc ttgcatgtcc acgtgatcct ctacagcccc atctaccaca gctatgcccg
      601 agcagaccac actgtgggcc gaatctgggt agacgcagca atcccctgcc tagaggaatg
      661 tggtttcctg ttacatttcc aagatggatg ttaccatctg gagacttcta cacaccattt
      721 cttgtctcga gtagaccgtc tggtccctca acgctcatca cagacagctt ttcacatgca
      781 agtacggcct cgaggactcg tggccctatg tgatggagaa ggcggcacat tgtatccgca
      841 gggttcacat cttctactgg gcatgggctc tgctcccatg aagggcgagg agtggtttgt
      901 cctacagcac ttcccgacct gggtcagcct gaagtccaag tctcggaggt tcctctcagt
      961 catctatgat gctgaggtgt gtgctgcttc tgagcgtttg acccagatgt ccttgttcca
     1021 gtacgaatgt gacagtgaga ctcctacctt gcaacttcgt tcagccaatg gctactacct
     1081 agctcagagg aggcatcggg caatcatcgc tgacggacac cccatggagt ctgacacctt
     1141 cttccgagtg cactggaatt gtgggaaaat caccctgcag tcccccaatg ggcggttcct
     1201 gggcatagcc tctgatggcc tgctaatggc aaatgtcacc atcccaggcc ctaacgagga
     1261 gctggggatt cgatttgcca atcgcccctt tctcgtctta cgcggtcgat atgggtatgt
     1321 gggctcctcc tccgaccacg acctgctgaa gtgcaacatg gatcaacctg actgtattca
     1381 gctattgccc tgtcgccagg gcatctatca ctttcaggca cagggtggat ccttctggtc
     1441 aataacatcc tttggcacct tccgcccttg gggaaaattt gccctcaact tctgcataga
     1501 actacagggg agcagcttgc tcacggtgct ggcacccaat ggcttctacc tccgagccga
     1561 ccggagtggc acactattgg cagacagtga agaaattacc aaagaatgta tctgggaatt
     1621 ttaggtcaat gggatgtcac ctgccaaact gtcaatcctc caggaacaac ctctgaacta
     1681 aacagggcag gagccccaga gtcacgatcc acgaggaggc tgtgtgctgt gcgatttttc
     1741 ctacctagtt tagcaaaaca actgcttgga gtgacaatac atcacaaaag gctacccccc
     1801 aa
//
