LOCUS       NM_172802               1718 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus fascin actin-bundling protein 2 (Fscn2), mRNA.
ACCESSION   NM_172802
VERSION     NM_172802.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Liu,X., Zhao,M., Xie,Y., Li,P., Wang,O., Zhou,B., Yang,L., Nie,Y.,
            Cheng,L., Song,X., Jin,C. and Han,F.
  TITLE     Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive
            Hearing Loss and Retinal Degeneration in C57BL/6J Mice
  JOURNAL   G3 (Bethesda) 8 (10), 3221-3230 (2018)
   PUBMED   30082328
  REMARK    GeneRIF: These results demonstrate that, in C57BL/6Jmice, Fscn2 is
            essential for maintaining ear and eye function and that a null
            mutation of Fscn2 leads to progressive hearing loss and retinal
            degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Wang,Q., Zhao,H., Zheng,T., Wang,W., Zhang,X., Wang,A., Li,B.,
            Wang,Y. and Zheng,Q.
  TITLE     Otoprotective effects of mouse nerve growth factor in DBA/2J mice
            with early-onset progressive hearing loss
  JOURNAL   J Neurosci Res 95 (10), 1937-1950 (2017)
   PUBMED   28345280
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Elizondo,D.M., Andargie,T.E., Kubhar,D.S., Gugssa,A. and
            Lipscomb,M.W.
  TITLE     CD40-CD40L cross-talk drives fascin expression in dendritic cells
            for efficient antigen presentation to CD4+ T cells
  JOURNAL   Int Immunol 29 (3), 121-131 (2017)
   PUBMED   28369442
  REMARK    GeneRIF: The results show that cross-talk through CD40-CD40L
            signaling drives elevated fascin expression in DCs to support
            acquisition of full T-cell responses.
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Krey,J.F., Krystofiak,E.S., Dumont,R.A., Vijayakumar,S., Choi,D.,
            Rivero,F., Kachar,B., Jones,S.M. and Barr-Gillespie,P.G.
  TITLE     Plastin 1 widens stereocilia by transforming actin filament packing
            from hexagonal to liquid
  JOURNAL   J Cell Biol 215 (4), 467-482 (2016)
   PUBMED   27811163
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Perrin,B.J., Strandjord,D.M., Narayanan,P., Henderson,D.M.,
            Johnson,K.R. and Ervasti,J.M.
  TITLE     beta-Actin and fascin-2 cooperate to maintain stereocilia length
  JOURNAL   J Neurosci 33 (19), 8114-8121 (2013)
   PUBMED   23658152
  REMARK    GeneRIF: The results of this study demonistrated that fascin-2
            crosslinks function to slow actin depolymerization at stereocilia
            tips to maintain stereocilia length.
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Shin,J.B., Longo-Guess,C.M., Gagnon,L.H., Saylor,K.W., Dumont,R.A.,
            Spinelli,K.J., Pagana,J.M., Wilmarth,P.A., David,L.L.,
            Gillespie,P.G. and Johnson,K.R.
  TITLE     The R109H variant of fascin-2, a developmentally regulated actin
            crosslinker in hair-cell stereocilia, underlies early-onset hearing
            loss of DBA/2J mice
  JOURNAL   J Neurosci 30 (29), 9683-9694 (2010)
   PUBMED   20660251
  REMARK    GeneRIF: Mutation in the Fscn2 gene underlies the early onset
            progressive hearing loss of DBA/2J mice attributed to the ahl8
            locus.
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Yamakita,Y., Matsumura,F. and Yamashiro,S.
  TITLE     Fascin1 is dispensable for mouse development but is favorable for
            neonatal survival
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 524-534 (2009)
   PUBMED   19343791
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Johnson,K.R., Longo-Guess,C., Gagnon,L.H., Yu,H. and Zheng,Q.Y.
  TITLE     A locus on distal chromosome 11 (ahl8) and its interaction with
            Cdh23 ahl underlie the early onset, age-related hearing loss of
            DBA/2J mice
  JOURNAL   Genomics 92 (4), 219-225 (2008)
   PUBMED   18662770
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Yokokura,S., Wada,Y., Nakai,S., Sato,H., Yao,R., Yamanaka,H.,
            Ito,S., Sagara,Y., Takahashi,M., Nakamura,Y., Tamai,M. and Noda,T.
  TITLE     Targeted disruption of FSCN2 gene induces retinopathy in mice
  JOURNAL   Invest Ophthalmol Vis Sci 46 (8), 2905-2915 (2005)
   PUBMED   16043865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050002.1, BC109356.1 and BB279997.2.
            
            On Nov 11, 2009 this sequence version replaced NM_172802.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050002.1, BC109356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1358              AK050002.1         2-1359
            1359-1700           BC109356.1         1320-1661
            1701-1718           BB279997.2         665-682
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.08 cM"
     gene            1..1718
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /note="fascin actin-bundling protein 2"
                     /db_xref="GeneID:238021"
                     /db_xref="MGI:MGI:2443337"
     exon            1..1001
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1654
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /note="retinal fascin; fascin homolog 2, actin-bundling
                     protein, retinal"
                     /codon_start=1
                     /product="fascin-2"
                     /protein_id="NP_766390.2"
                     /db_xref="CCDS:CCDS25731.1"
                     /db_xref="GeneID:238021"
                     /db_xref="MGI:MGI:2443337"
                     /translation="MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQ
                     IWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVL
                     QSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDE
                     MAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGK
                     LAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQG
                     INVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMF
                     EIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEDELFTLKLINRPLLVLRGLDGF
                     VCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFL
                     FEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY"
     exon            1002..1158
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1280
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1448
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1718
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1713
                     /gene="Fscn2"
                     /gene_synonym="A930022G03; Ahl8; C630046B20Rik"
                     /note="major polyA site"
ORIGIN      
        1 acaagacaga gggaggcagc attggagcag gtagcgtcca tgtcgctggc taggcttggg
       61 agccaagggt cagataaaca gatctgggcc tcaggggggg ctacaggccc cctgaacaga
      121 acacttagag agagttcctt cccaggcccc tgaagcaacg tggctagcct caaagatgcc
      181 aaccaacggt ctgcaccagg tgctgaagat ccagtttggc cttgttaacg atgccgaccg
      241 ctacctgact gcagagagct ttggcttcaa ggtcaacgcc tccgcagcca gcctcaagag
      301 gaagcagatc tgggtcctgg agcctgaccc ggggcagggc actgccgtgc tgttccgaag
      361 cagtcaccta ggccgctacc tgtcagcaga agaagatgga cgtgtggcct gtgagatgga
      421 tcagccgggc cgtgactgcc gcttcctggt cttgccgcag cctgatgggc gctgggtgct
      481 gcagtcagag ccacacggcc gcttcttcgg tggcattgag gaccgactgt cctgctttgc
      541 cacggccatt tccccggcag agctgtggac tgtgcacctg gccatccacc cacaggctca
      601 tttgctgagt gtgagccgtc ggcgctacgt gcacctgtgc cttcaggaag atgagatggc
      661 agcagacggt gacatgccat ggggtgtgga cgcactagtc accctcattt tccagagcag
      721 gcggtactgc ctcaagtctt atgacagccg ctaccttcgc agcgatggcc gccttgtctg
      781 ggaacctgaa gcccatgcct gctacacgct ggagttcaag gcaggcaagc tggccttcaa
      841 ggactgtgac ggccggtacc tggcacctgt ggggcctgct ggcacactca aggctggtcg
      901 caacacgagg cccagcaagg atgaactctt cgacctggag caaagtcacc cacaggtggt
      961 gctggtagct gccaaccggc gctacatctc tgtgaggcaa ggaatcaatg tctcagccaa
     1021 tcaggatgaa gaactgggtc atgagacatt cctgatgcaa atcgaccagg agacaaagaa
     1081 gtgtactttc tattccagca ctgggggcta ctggaccttg gtcacccatg ggggcattca
     1141 ggccacagcc acacaagtct ctgccaacac catgtttgaa atagaatggc atggccggcg
     1201 ggtggcactt aaagccagca acgggcgttt tgtgtgcatg aagaaaaacg ggcagctggc
     1261 cgccatcagc gactttgtgg gcgaggacga gctatttacc ctcaagctca tcaatcgacc
     1321 cctcctggtg ctgcgtggcc tggatggctt tgtgtgccac cgccggggct ccaaccagct
     1381 ggacaccaac cgttccactt acgacgtctt ccacttgagc ttcagggatg gcgcctatca
     1441 gattagaggc cgtggaggtg ggttctggta cacaggcagc catggaagcg tgtgcagcga
     1501 cggtgacttg gcggaagatt tcctctttga gttccgagag cgtggccgtc tggccatccg
     1561 agccctcagc ggcaagtacc tgcgtggagg agcctcaggg ctcctgcgtg ctgatgcaga
     1621 cctgcctgtg ggggaagctc tctgggaata ctgaggactc acagggggtc aaccccagag
     1681 cccaccgacc cagcattaaa cctttgttgc ggagttgc
//
