LOCUS       NM_001256142            4572 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fibrinogen silencer binding protein (Fsbp), mRNA.
ACCESSION   NM_001256142
VERSION     NM_001256142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Lau,K.F., Perkinton,M.S., Rodriguez,L., McLoughlin,D.M. and
            Miller,C.C.
  TITLE     An X11alpha/FSBP complex represses transcription of the GSK3beta
            gene promoter
  JOURNAL   Neuroreport 21 (11), 761-766 (2010)
   PUBMED   20531236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147819.1, AK053419.1, AL732538.6 and BX527911.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147819.1, SRR7345562.4511604.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AK147819.1         2-572
            572-1557            AK053419.1         571-1556
            1558-4054           AL732538.6         98044-100540
            4055-4572           BX527911.1         1-518
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     gene            1..4572
                     /gene="Fsbp"
                     /note="fibrinogen silencer binding protein"
                     /db_xref="GeneID:100503583"
                     /db_xref="MGI:MGI:5301008"
     exon            1..446
                     /gene="Fsbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..972
                     /gene="Fsbp"
                     /codon_start=1
                     /product="fibrinogen silencer-binding protein"
                     /protein_id="NP_001243071.1"
                     /db_xref="CCDS:CCDS57263.1"
                     /db_xref="GeneID:100503583"
                     /db_xref="MGI:MGI:5301008"
                     /translation="MVGKARSSNFTLSEKLDLLNLVKPYVKILEEHTNKNSVIVEKNR
                     CWDVIAVNYNAIGVDRPPRTAQGLRSLYKRLKEYAKQELLQQKEAQSEFKSSVSEPTK
                     QVMEMIPQIASFGLIRDRSHIQSANLDETAQAGTSSLQVMVDHHPVAITVEVKQEEDI
                     KPSPPLVSNPQLSDTLEQREEHELMHVVEGSESPSLSSVDMRMTSSPSSVPRRDEIFH
                     QESGEHFRSLLRCDPQVLQMLKEEHQIILENQKNFGLYVQEKRDGLRRRQRLEEELLR
                     AKIEVEKLKATRLRRDLPEYSSL"
     exon            447..4572
                     /gene="Fsbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: AATAAA"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: TATAAA"
     polyA_site      2520
                     /gene="Fsbp"
                     /note="major polyA site"
     polyA_site      2529
                     /gene="Fsbp"
     regulatory      4195..4200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: ATTAAA"
     polyA_site      4215
                     /gene="Fsbp"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: CATAAA"
     polyA_site      4262
                     /gene="Fsbp"
     regulatory      4344..4349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: AATAAA"
     polyA_site      4375
                     /gene="Fsbp"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fsbp"
                     /note="hexamer: AGTAAA"
     polyA_site      4416
                     /gene="Fsbp"
ORIGIN      
        1 gtgaaaagag ctgagcagag ctgaaggctg catggtggtt tcagaaacgg cctacttaat
       61 tccaaaagaa caatggtagg aaaggctaga tcttccaatt ttaccttatc tgaaaagctt
      121 gatttgctaa accttgtgaa gccatatgtg aaaattctcg aagagcacac taataaaaat
      181 tcagtaatag tggaaaagaa tagatgttgg gatgtcatag cagttaacta taatgcgatt
      241 ggagtagacc gccctcctcg cacagctcag ggcctacgca gcctttacaa aaggctcaaa
      301 gaatatgcca aacaggagct attgcagcaa aaggaggccc agtctgagtt taaaagcagt
      361 gtttcggagc ccaccaagca agtcatggaa atgattcccc agattgccag cttcggcctc
      421 ataagagaca ggagccacat acagagtgca aacttggatg agactgccca agctggtacc
      481 agttcgctgc aggtaatggt ggatcaccat cctgttgcta tcactgtaga ggtgaagcaa
      541 gaagaggaca ttaagccatc tcctcccctg gtttcaaatc ctcaactcag tgatacttta
      601 gagcaaagag aagaacatga gttaatgcat gttgtggagg gatccgagtc tccatcactt
      661 tcttctgttg atatgagaat gacatcatct ccatcttctg tcccaaggag agatgagatt
      721 tttcatcagg aaagtggaga acactttagg tctctgctaa gatgtgaccc tcaggtcctg
      781 caaatgttaa aagaggaaca ccagataatt ttagaaaatc agaagaattt tggattgtat
      841 gttcaggaga agagggatgg gttgagaaga aggcagcggc ttgaggagga gctgctaaga
      901 gcaaagattg aagtggagaa gctgaaagcg actcgcttac ggcgtgatct gcctgaatac
      961 agtagtctct gagatggttc cagcctgggg tcgtgataat cttaattttg ccagaattat
     1021 tttcattttg gagcatcatg aagctcagca cacgtcctat aaaaatgtta atctctctta
     1081 taaaaaagct tttaacacga ttttcttctt ttcttaacct tcctgtttta tttttctgag
     1141 acagggtttc tctgtgtagc cctggctgtc ttggaactag ctctgtagac caggctggcc
     1201 ttgaacctat tttctttttg aacatagttt tctaagtatt tagttactct ttaaatactg
     1261 tcatttattg attggctgac atggtaatct agtttgttgc cttccctcaa ttgttttcta
     1321 agacatttaa ttgttggcct catgtaagat cttttatttt gattataaaa aataatgcaa
     1381 agagaattgc atttgttgca taagcttgta acctcagccc ttgggaggta gaggcagatg
     1441 agaagatgca ggccagcctt ggctaccttc caatttcaag gtcagcctgt gctatgtgaa
     1501 atcctatgtc aaataacaaa attcacaaaa ttgtatgaat tgcatacata ttactttaaa
     1561 gaactgaatt tttaacagtt ttagttacga ctttaaaagt tagagttaaa agagaaaaag
     1621 agagagtgtt ggaagctacc taatgagtgg taagcacata cttttactgt tgacctatat
     1681 ccatccccat tcctagtttt tcttttttgg agacaagatc tcactatgta gcccaggcta
     1741 gcctgtgata taagtttctc ctgccccagc ttctgaatac tgagattata agtttatgtt
     1801 aaactaacag taacaaaaga cttgtgtgca tgacattggc attgtcctta tcctttgaaa
     1861 gagtggtggt agaacttaca gttggaagat atttggaaaa gtcttaaaac agtttagcga
     1921 gcggagggag gtccagggag ggcaccataa tttattctag gtatctgctt tttatggcag
     1981 agcaagttat gagtacttag ttttttggag gagagggttg ggggcagcag ggggtggtgg
     2041 tgatagtttt tattccttat ttattctata gaaataaaga tttaggagaa tttatttaat
     2101 taaaaccacc ttttggttgg agatgtagct caaggataga acattgcttg gcctgtttga
     2161 ggtgcctgcc gtcccctggt gacaaagaaa gctgactttt acacattgtt gggttacaaa
     2221 acccagggaa ttgtatctac cccacgctcc cctctttttt gttctgccaa aagagatcag
     2281 gtatttttat ttaaaatatt acatattttc accatgtaag taagattatc ttaattcatt
     2341 ttaaatgtct ttctgggaaa tacttccttc ataggaaact tagaataaaa caaaataaaa
     2401 attacttaga atgaaaataa caaagatcat gttcacataa atatataact tgtagatttt
     2461 ttaagaatga tttttttgta aatattgtag tattcatgga aataaaatct ttataaagta
     2521 tatattgaat ttatgttatg tatttaatgt atgtcttaca tagttgattt ccattttttc
     2581 tggaattttg atgaggaagg actttaaaat tcaggctttc ttttggattg ggcagttaga
     2641 gtttcagaag tactggggat caagcgagct tggggtcaga ataaacttgt gaaaacatag
     2701 aaagtgggtg aactggatca gggtgtccac gcataggcac gctgagccag gggggatagg
     2761 tagaaagctt tgagtaacgt caacaaggac aatgacctgg gacacactat gtagatcaga
     2821 ctgccctcag tctcacagag atcattcccc tccagagtgc tgggattaaa tgtttgcaag
     2881 tcattcagaa tgcttttaaa acagagtttg ggcatgcccc tggccctgcc agttagcacc
     2941 aggcttctag ctggtggtct ttagagtaaa aaggtcagga aaggccgtgg ctgggaccca
     3001 ggactctcct ggcgtaactg aggcttagag tccatccacg gtagcacaca tacaatagag
     3061 ttacaacagt agtgtcagtc ctgatgagaa accagggctg gggtccagca gtctgctcat
     3121 agtgatgctc gctgaagggt aacaagtgaa cttggtgctt aaatcagctt ctcaacagtt
     3181 actgttgaag agtaatgtgg gcgaagtgaa attgagcggg tgtcaactgg atgccagttg
     3241 tcaccaagtt atggattaca ttaaacgcta tttttaagga ctcagattga actgaatgta
     3301 aagtgagaag ccattgatgg ctttttaatt atagagatga catgattaaa gatgtgattt
     3361 attttaaatt tagtggtaca agttatggtt atcgaaatag aaaaagtaaa tcgagtggat
     3421 tcttagggca ttaggttagt ttatttaatt tccttagttg aatcacaaaa cattttgtac
     3481 tttatacttg cataagtaaa aatgtgtact gtgaaatgtc ttgaggcctg aggaggtagc
     3541 tcagctcagg tgatagatgc ttgcctagtg cccaggaggc actgggttag atagattgcc
     3601 aacactccat gaacctgtgt gtgggtgtag tgcatctcta atcctagcac ttggcactgc
     3661 agggtcagga catcaaggtt atgacgtact cttcttcccc ccccaccccc ccaagacggg
     3721 gtttctctat gtagctttgg ctgtcctgga actccctctg tagatcaggc tggctttgag
     3781 ttcacagaga tccacctgcc cctgcctctg cttcctgtcc tgagtgctaa gattaaagac
     3841 gtggccacca tggccctgcc tttatggcaa tttatctttg taatctgtgc taactttcat
     3901 ttgaaatgca acgaatcttc taatttgagg tagcatattt tgtaatatga tttgagtaaa
     3961 tatatctgtt ttgaaatttt acaagttaag atatgcagta taattaatgt tataatttca
     4021 gcatgctacc attcatactt aataatagag tattgacttt gtatagcaaa acccatttta
     4081 taagtgtttc tgtgaaaaat taatcctgtg aaatatttct agaaaagaac tcagttttaa
     4141 agtatttaaa gtactttttt tttttgatgg gttggttcta taatcagtgt ggaaattaaa
     4201 atagatgtga aattaccttt gaaaaattct tttgttgtac ataaaatagt attataatca
     4261 catttttctc tggcattgtt taactttgct gttttcctat atcaagtgac acaatttggt
     4321 agcagttaag ggctgtgtag aataataaac ttaatttttc ttagttttaa atccagaatt
     4381 ccattcgtca gagtaaactc actgaagttt ttatgagtca atattgtttt aattgtaaaa
     4441 cataattctg ccacattctt ttaattcttt cccctgtgta accatcattt tagagcatgg
     4501 ttcatgagaa ttcccgaata aggcaaaaaa ttagtcattt gaccacaaac ccttcttgac
     4561 ccccttctcc ca
//
