LOCUS       NM_011356               2920 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus frizzled-related protein (Frzb), mRNA.
ACCESSION   NM_011356
VERSION     NM_011356.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Baxi,A., Jourdeuil,K., Cox,T.C., Clouthier,D.E. and Tavares,A.L.P.
  TITLE     Transcriptomic analysis reveals the role of SIX1 in mouse cranial
            neural crest patterning and bone development
  JOURNAL   Dev Dyn 252 (10), 1303-1315 (2023)
   PUBMED   37183792
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Gu,Y., Ding,Y., Zhang,X., Li,Y. and Shang,Z.
  TITLE     Secreted frizzled-related protein 3 alleviated cardiac remodeling
            induced by angiotensin II via inhibiting oxidative stress and
            apoptosis in mice
  JOURNAL   Eur J Pharmacol 934, 175303 (2022)
   PUBMED   36174667
  REMARK    GeneRIF: Secreted frizzled-related protein 3 alleviated cardiac
            remodeling induced by angiotensin II via inhibiting oxidative
            stress and apoptosis in mice.
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Tang,S., Cope,D.I., Vasquez,Y.M. and Monsivais,D.
  TITLE     BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential
            for Receptivity and Early Pregnancy
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35383354
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Hoang,B.H., Thomas,J.T., Abdul-Karim,F.W., Correia,K.M.,
            Conlon,R.A., Luyten,F.P. and Ballock,R.T.
  TITLE     Expression pattern of two Frizzled-related genes, Frzb-1 and
            Sfrp-1, during mouse embryogenesis suggests a role for modulating
            action of Wnt family members
  JOURNAL   Dev Dyn 212 (3), 364-372 (1998)
   PUBMED   9671940
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Peichel,C.L., Kozak,C.A., Luyten,F.P. and Vogt,T.F.
  TITLE     Evaluation of mouse Sfrp3/Frzb1 as a candidate for the lst, Ul, and
            Far mutants on chromosome 2
  JOURNAL   Mamm Genome 9 (5), 385-387 (1998)
   PUBMED   9545497
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Mayr,T., Deutsch,U., Kuhl,M., Drexler,H.C., Lottspeich,F.,
            Deutzmann,R., Wedlich,D. and Risau,W.
  TITLE     Fritz: a secreted frizzled-related protein that inhibits Wnt
            activity
  JOURNAL   Mech Dev 63 (1), 109-125 (1997)
   PUBMED   9178261
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Leyns,L., Bouwmeester,T., Kim,S.H., Piccolo,S. and De Robertis,E.M.
  TITLE     Frzb-1 is a secreted antagonist of Wnt signaling expressed in the
            Spemann organizer
  JOURNAL   Cell 88 (6), 747-756 (1997)
   PUBMED   9118218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928578.6.
            
            On Apr 28, 2007 this sequence version replaced NM_011356.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029941.1, BC016884.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AL928578.6         44299-45332         c
            1035-1082           AL928578.6         36431-36478         c
            1083-1148           AL928578.6         22535-22600         c
            1149-1353           AL928578.6         16248-16452         c
            1354-1417           AL928578.6         15829-15892         c
            1418-2920           AL928578.6         9906-11408          c
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 48.13 cM"
     gene            1..2920
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /note="frizzled-related protein"
                     /db_xref="GeneID:20378"
                     /db_xref="MGI:MGI:892032"
     exon            1..1034
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..1528
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /note="secreted frizzled-related protein 3;
                     frizzled-related protein 1; secreted frizzled-related
                     sequence protein 3"
                     /codon_start=1
                     /product="secreted frizzled-related protein 3 precursor"
                     /protein_id="NP_035486.1"
                     /db_xref="CCDS:CCDS16176.1"
                     /db_xref="GeneID:20378"
                     /db_xref="MGI:MGI:892032"
                     /translation="MVCCGPGRMLLGWAGLLVLAALCLLQVPGAQAAACEPVRIPLCK
                     SLPWNMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQH
                     EPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVYDRGVCISPEAIVTADGAD
                     FPMDSSTGHCRGASSERCKCKPVRATQKTYFRNNYNYVIRAKVKEVKMKCHDVTAVVE
                     VKEILKASLVNIPRDTVNLYTTSGCLCPPLTVNEEYVIMGYEDEERSRLLLVEGSIAE
                     KWKDRLGKKVKRWDMKLRHLGLGKTDASDSTQNQKSGRNSNPRPARS"
     exon            1035..1082
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1148
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1353
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1417
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2920
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2723
                     /gene="Frzb"
                     /gene_synonym="frezzled; fritz; Frp; frzb-1; Sfrp3"
                     /note="major polyA site"
ORIGIN      
        1 gctgacctcc tctgagctcc tctggccgct cgcaggatct tcccgaccct gcaggacttg
       61 gcaaactccc acctccgctc ccattagtcc tcccaccccc accaaatctc ctccctcgga
      121 ggtcccctat ccatctcact ttgcagaatt tatcgcttct tccaacacct ttttgcaaca
      181 ccccagaact ccgagtccct taactgaatt tgacttttgt ttttatttct ctctggcttc
      241 ctcttctgcc ccctcatctg attgatgtgc taaggctgat gtctctgcca gagcgagagg
      301 aataaataga tgctgcctcg cctagaggct tagacgcttg ggaagagcag ccggcgcagc
      361 gaggcaccgg gctccgccaa gctagtggac cggacctggg agcacttgga tccaagagaa
      421 ctgtgattgt cccaggggtg ggggcagctc cccaggtcgt tgggatcacc cctcggaacc
      481 gcagggggag acttcggaac gaaagtgtct cccgcgtccg tcgctcggct gcgccctgcc
      541 ccatcctgct gggaccatgg tctgctgcgg cccgggacgg atgctgctag gatgggccgg
      601 gttgctagtc ctggctgctc tctgcctgct ccaggtgccc ggagctcagg ctgcagcctg
      661 tgagcctgtc cgcatcccgc tgtgcaagtc ccttccctgg aacatgacca agatgcccaa
      721 ccacctgcac cacagcaccc aggctaacgc catcctggcc atggaacagt tcgaagggct
      781 gctgggcacc cactgcagcc cggatcttct cttcttcctc tgtgcaatgt acgcacccat
      841 ttgcaccatc gacttccagc acgagcccat caagccctgc aagtctgtgt gtgagcgcgc
      901 ccgacagggc tgcgagccca ttctcatcaa gtaccgccac tcgtggccgg aaagcttggc
      961 ctgcgacgag ctgccggtgt acgaccgcgg cgtgtgcatc tctcctgagg ccatcgtcac
     1021 cgcggacgga gcggattttc ctatggattc aagtactgga cactgcagag gggcaagcag
     1081 cgaacgttgc aaatgtaagc ctgtcagagc tacacagaag acctatttcc ggaacaatta
     1141 caactatgtc atccgggcta aagttaaaga ggtaaagatg aaatgtcatg atgtgaccgc
     1201 cgttgtggaa gtgaaggaaa ttctaaaggc atcactggta aacattccaa gggacaccgt
     1261 caatctttat accacctctg gctgcctctg tcctccactt actgtcaatg aggaatatgt
     1321 catcatgggc tatgaagacg aggaacgttc caggttactc ttggtagaag gctctatagc
     1381 tgagaagtgg aaggatcggc ttggtaagaa agtcaagcgc tgggatatga aactccgaca
     1441 ccttggactg ggtaaaactg atgctagcga ttccactcag aatcagaagt ctggcaggaa
     1501 ctctaatccc cggccagcac gcagctaaat cctgaaatgt aaaaggccac acccacggac
     1561 tcccttctaa gactggcgct gctggactaa caaaggaaaa ccgcacagtt gtgctcgtga
     1621 ccgattgttt accgcagaca ccgcgtggct accgaagtta cttccggtcc cctttctcct
     1681 gcttcttaat ggcctggggt tagatccttt aatatgttat atattctgtt tcatcaatca
     1741 cgtggggact gttcttttgc aaccagaata gtaaattaaa tatgttgatg ctaaggtttc
     1801 tgtactggac tccctgggtt taatttggtg ttctgtaccc tgattgagaa tgcaatgttt
     1861 catgtaaaga gagaatcctg gtcatatctc aagaactaga tattgctgta agacagcctc
     1921 tgctgctgcg cttatagtct tgtgtttgta tgcctttggc catttccctc atgctgtgaa
     1981 agttatacat gtttataaag gtagaacggc attttgaaat cagacactgc acaagcagag
     2041 tagcccaaca ccaggaagca tttatgagga aacgccacac agcatgactt attttcaaga
     2101 ttggcaggca gcaaaataaa tagtgttggg agccaagaaa agaatatttt gcctggttaa
     2161 ggggcacact ggaatcagta gcccttgagc cattaacagc agtgttcttc tggcaacgtt
     2221 tttgatttgt tcataaatgt attcacgagc attagagatg aacttataac tagacatctg
     2281 ttgttatcac tatagctctg cttccttcta aatcaaaccc attgttggat gctccctctc
     2341 cattcataaa taaatttggc ttgctgtatt ggccaggaaa agaaagtatt aaagtatgca
     2401 tgcatgtgca ccagggtgtt atttaacaga ggtatgtaac tctataaaag actataattt
     2461 acaggacacg gaaatgtgca catttgttta ctttttttct tccttttgct ttgggcttgt
     2521 gattttggtt tttggtgtgt ttatgtctgt attttggggg gtgggtaggt ttaagccatt
     2581 gcacattcaa gttgaactag attagagtag actaggctca ttggcctaga cattatgatt
     2641 tgaatttgtg ttgtttaatg ctccatcaag atgtctaata aaaggaatat ggttgtcaac
     2701 agagacgaca acaacaacaa aaatgttttt cttatgtgtg ctgcactgag accccaacaa
     2761 cccatgggtg ggggggaacc cacgatgcct tttcttcctt ccctgcagca gggatgtgcc
     2821 catcacctga aagtctcatt ccctgaaatt tacacatgtg gtagtagtag gtccagattc
     2881 ctaagttaca gtgtgctgaa aaataaaaca ggtatgaagc
//
