LOCUS       NM_001408310            6813 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor receptor substrate 2 (Frs2),
            transcript variant 20, mRNA.
ACCESSION   NM_001408310
VERSION     NM_001408310.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6813)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     FRS2-independent GRB2 interaction with FGFR2 is not required for
            embryonic development
  JOURNAL   Biol Open 12 (7) (2023)
   PUBMED   37421147
  REMARK    GeneRIF: FRS2-independent GRB2 interaction with FGFR2 is not
            required for embryonic development.
REFERENCE   3  (bases 1 to 6813)
  AUTHORS   Huang,J.Y., Krebs,B.B., Miskus,M.L., Russell,M.L., Duffy,E.P.,
            Graf,J.M. and Lu,H.C.
  TITLE     Enhanced FGFR3 activity in postmitotic principal neurons during
            brain development results in cortical dysplasia and axonal tract
            abnormality
  JOURNAL   Sci Rep 10 (1), 18508 (2020)
   PUBMED   33116259
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6813)
  AUTHORS   Chen,D., Zhu,X., Kofler,N., Wang,Y., Zhou,B. and Simons,M.
  TITLE     FRS2alpha-dependent cell fate transition during endocardial cushion
            morphogenesis
  JOURNAL   Dev Biol 458 (1), 88-97 (2020)
   PUBMED   31669335
  REMARK    GeneRIF: FRS2alpha-dependent cell fate transition during
            endocardial cushion morphogenesis.
REFERENCE   5  (bases 1 to 6813)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6813)
  AUTHORS   Ong,S.H., Guy,G.R., Hadari,Y.R., Laks,S., Gotoh,N., Schlessinger,J.
            and Lax,I.
  TITLE     FRS2 proteins recruit intracellular signaling pathways by binding
            to diverse targets on fibroblast growth factor and nerve growth
            factor receptors
  JOURNAL   Mol Cell Biol 20 (3), 979-989 (2000)
   PUBMED   10629055
REFERENCE   7  (bases 1 to 6813)
  AUTHORS   Hadari,Y.R., Kouhara,H., Lax,I. and Schlessinger,J.
  TITLE     Binding of Shp2 tyrosine phosphatase to FRS2 is essential for
            fibroblast growth factor-induced PC12 cell differentiation
  JOURNAL   Mol Cell Biol 18 (7), 3966-3973 (1998)
   PUBMED   9632781
REFERENCE   8  (bases 1 to 6813)
  AUTHORS   White,J.K., Auerbach,W., Duyao,M.P., Vonsattel,J.P., Gusella,J.F.,
            Joyner,A.L. and MacDonald,M.E.
  TITLE     Huntingtin is required for neurogenesis and is not impaired by the
            Huntington's disease CAG expansion
  JOURNAL   Nat Genet 17 (4), 404-410 (1997)
   PUBMED   9398841
REFERENCE   9  (bases 1 to 6813)
  AUTHORS   Kouhara,H., Hadari,Y.R., Spivak-Kroizman,T., Schilling,J.,
            Bar-Sagi,D., Lax,I. and Schlessinger,J.
  TITLE     A lipid-anchored Grb2-binding protein that links FGF-receptor
            activation to the Ras/MAPK signaling pathway
  JOURNAL   Cell 89 (5), 693-702 (1997)
   PUBMED   9182757
REFERENCE   10 (bases 1 to 6813)
  AUTHORS   Ong,S.H., Goh,K.C., Lim,Y.P., Low,B.C., Klint,P.,
            Claesson-Welsh,L., Cao,X., Tan,Y.H. and Guy,G.R.
  TITLE     Suc1-associated neurotrophic factor target (SNT) protein is a major
            FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds
            to the SH2 domain of GRB2
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1021-1026 (1996)
   PUBMED   8780727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589661.21.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.3241902.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164137,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL589661.21        25474-25606
            134-219             AL589661.21        71800-71885
            220-262             AL589661.21        73330-73372
            263-399             AL589661.21        74031-74167
            400-491             AL589661.21        88875-88966
            492-587             AL589661.21        92885-92980
            588-842             AL589661.21        94699-94953
            843-1029            AL589661.21        95052-95238
            1030-1188           AL589661.21        96328-96486
            1189-1352           AL589661.21        97024-97187
            1353-6813           AL589661.21        99119-104579
FEATURES             Location/Qualifiers
     source          1..6813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.09 cM"
     gene            1..6813
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="fibroblast growth factor receptor substrate 2"
                     /db_xref="GeneID:327826"
                     /db_xref="MGI:MGI:1100860"
     exon            1..133
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..219
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..262
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..399
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..491
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..587
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..842
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1029
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             888..2303
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="isoform 2 is encoded by transcript variant 20; FGFR
                     substrate 2; FGFR-signaling adaptor SNT; suc1-associated
                     neurotrophic factor target 1"
                     /codon_start=1
                     /product="fibroblast growth factor receptor substrate 2
                     isoform 2"
                     /protein_id="NP_001395239.1"
                     /db_xref="GeneID:327826"
                     /db_xref="MGI:MGI:1100860"
                     /translation="MELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQ
                     TGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTP
                     GLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYV
                     NTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGP
                     TPVQKQLMEKEKLEQLGKDPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLS
                     IPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDN
                     LGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSL
                     EHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQK
                     ALPRDDGTSRKTRHNSTDLPM"
     exon            1030..1188
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1352
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..6813
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6085..6090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6105
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="major polyA site"
     regulatory      6773..6778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     regulatory      6784..6789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6807
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="major polyA site"
     polyA_site      6813
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
ORIGIN      
        1 gtctagggtt cgggctggag agaggccttg tagacacagg cgccgaggct ccgagcaggg
       61 ggtcaggtcg cggggagagt gaggagctcc gcggctgcca ccccgcgccc ctcgcagcgc
      121 cttcgcgccg acgaaatggc taccaagaag taaatgccca gacgtaatgg tgatgcaggt
      181 gtcatgaagt aagatgcagt atagcatcca tccagattag gacaaaatta tatctgtttt
      241 tctcagaaaa gaattccaaa agactttttg aaggaagaca tcatcgagtg agtagaaact
      301 atctttgttt gtttgttaac tgtgtaccaa ctacttggat tcaattgctg ggcaacttta
      361 aaaagtcact gtggtcatat ttcctcagga acattggagg ttaaagtacc aaacgaagac
      421 ctggtatttt gaaatatgat taatctcctg atgcagcatc agaggctaac aatattaatg
      481 gccagatcta gtgctcacat ggtcttctga agaagccatg ggtagctgtt gtagctgtcc
      541 agataaagac actgtcccag ataaccatcg gaacaagttt aaggtcacat cgtgccttcg
      601 tgctgtgccg tgcatcttgt gagccacccg atttcctctg taaagttagt cctactccgg
      661 cctaaaggag gggccgtggt ttttttcatc caccttaggc taccgtcgcc accttgtgcg
      721 ggctgtgttg cattcatttg tcaacaatca aaccgtctga cttggtgttt gtgtcttatt
      781 aagtgggaat gtaaattctc tatcttactg ggacatagtc cattcctcta cacacactgg
      841 tggtcattaa tgtggatgat gatgggaatg agctaggctc tggtgtgatg gaactcacag
      901 acacagagct gattctgtac acccggaaac gggactcggt aaaatggcac tacctctgcc
      961 tacgacgata cggctatgac tcaaatctgt tttcttttga aagtggtcga aggtgtcaga
     1021 ctggacaagg aatttttgct tttaagtgtg cccgtgcaga agaattattt aacatgttgc
     1081 aagagattat gcaaaataat agtataaatg tggtggaaga gccggttgta gaaaggagta
     1141 gtcatcagac agagctggaa gtccctagga cacctcggac acctacaact ccagggctcg
     1201 gtgctcagaa cttacctaat gggtatcccc gctacccctc gtttggagac gcttcatccc
     1261 acccctcaag ccggcatcct tcggtgggaa gtgctcgctt accttcagtc ggtgaagagt
     1321 ccacacaccc tttgctcgtg gctgaggaac aagtacatac ttatgttaac actacaggtg
     1381 tgcaagagga gcgaaaaaac cgtgcaagtg tgcatgttcc cccagaggca agggtttcta
     1441 atgctgagag caacacacca aaagaagagc cgagtaaccc cgaggacagg gacccgcaag
     1501 tgcttcttaa gcctgaagga gtcaggtttg tgctaggacc aacccctgtc cagaagcagt
     1561 taatggaaaa ggagaaactg gagcaactgg gaaaagaccc agtcagtggg agtggagcgg
     1621 gcaacacgga gtgggacacc ggctatgaca gtgacgagcg cagagatgtg ccccctgtca
     1681 acaaactggt gtatgaaaat ataaacgggc tatctattcc cagtgcctca ggggtcagga
     1741 gaggtcgtct gacatctacc agcacctcag acacccagaa tatcaacaac tcagcgcaga
     1801 gaagacctgc actattaaac tatgaaaatt taccatcttt gcctcctgtt tgggaagccc
     1861 gcaagctcag tagggatgaa gatgacaatt taggaccaaa gaccccatct ctaaatggct
     1921 accataataa tctagatcca atgcataact atgttaatac agagaatgta acagtgccgg
     1981 caagtgctca caaaatagac tattcgaagc gcagggattg tacaccgaca gtctttaact
     2041 ttgatatcag gcgacccagt ttagaacata ggcaactcaa ttatatacag gtggatttgg
     2101 aagggggcag tgactctgac aaccctcaga ctccaaaaac gccgaccact cccctcccgc
     2161 aaacccccac gcggcgcaca gagctgtacg ctgtgataga cattgagaga actgctgcta
     2221 tgtccaactt gcagaaagcg ctgcctcgag acgacggtac atctcggaag acgaggcaca
     2281 atagtactga cctgcccatg tgagccggga agcactgcgt ccttctccgc aaggcgttca
     2341 gagcgaagat gcagtgcctc ctcttcatgt ctacactagc tcctttatag actggtcttc
     2401 tgctctgaat atttcatctt taaagggaat tgatgcagag caggcactcc ttagaacact
     2461 aatctcctga tagctactca ctgtccagca gcaccccatt ctcacagtgc ctacttacca
     2521 cgagaattga agtgaatgcc gtgctgggtg acctgtcctc agcatcctgg gggatgcata
     2581 gctttcatgt ctgagttgtg gttggcgttt gaacctttta taaagtctct tgataatgcg
     2641 cattgctaac ataactctgg gccctgagag gaaccctcat agatcactgt tcacagggta
     2701 tggtcgccag catggaacgt gaggatttta tttcattagt taaaggcttt ttgtcttggg
     2761 ccaaattcgt gtcaaagaac aaggagaacc acacttcctt ttgtaccagt cagcacctct
     2821 gtcttgagtg tgctgtgatt ggaaggcagc caggagacag ctctgtgtcc ccacctcctg
     2881 gtgtcatctg aagggcgtgt ccagatagca tcttactcag agttaggatg ggcttaggag
     2941 tcagtctcag gtcactttac ccaaaagcat ttgaaagtct acccctgatc tctcggtgtg
     3001 tctgcggtag attactgaca gcacacatgt gtctgcagac actcgtgcca ttcagtccca
     3061 tggagcttca gtttcccctt tggtctttgg gttgtcttac cttgtatgta atgctttttt
     3121 caatttacaa cacaatgttt gtgtatcgtc ttggaatagg attgtgtgtt tgctgttact
     3181 acttaggctg cgtttttgtt gttacggtcc tgaaggtcca tttgggactg actgttattc
     3241 tctagctggg ttgcccttgt ccagtattta tttatctcct gcttgctttt caagttgatg
     3301 aaaaaaatcg acgtttgggt tttaaagttc atttgtgtcc atgggtgatc tctttagtag
     3361 ctgagaagga aaggaagaga ctcttaaaca tgtgagtccc cgaaggtcct gtcctcgctg
     3421 gggcgccctg cgctgcactt tagcaggggt tgtctcagct ccatggctgc aggcccgctc
     3481 tccctgctct gctgtcctcc cacgtggagc tgggctctga ttaccctgtg atgctggtga
     3541 gctgttaata ttgttgccag cataacagga acagggaagt cttaaagagg cgccgttatg
     3601 tcatagcgtg aagtgaagaa aggccactca gactgatgtg ctcccagacc gaccactgga
     3661 cagtacaggg aggggcagcc tgcgggatag gttatctttt ctctaaagtt ggagacattc
     3721 ctggttatga tctggatata ccaggtcaag aaaagggttc agtcatcggc aggcagtgta
     3781 tttaggaact catccagagc agcggctgga tttgcagaac agtagtgcgg ggccataata
     3841 tctagatgtt tcatcatctt cagcgccatt gcttcatagc atagcagacg cttcctttcc
     3901 tttccctctg cgaactaaaa tgtttgctgt tctcttcaag agaatagtgg atacatgtgc
     3961 agtttacata tttaatacac tgttccattc gtcctttctt ctgagtagct tgctaattgt
     4021 gccaaatttc agtggtggtt ttgtggtgtg gggtaaggac gcttatggga agggcgcagg
     4081 tccagacaga attagccctc cacctcagag ggctggtctg cgcggccgtc tgcaggctgg
     4141 gtgctttgtt ctttctctgt actcttcact tttcccttca gatttgaatt agattttata
     4201 ttttttagct gactaatatc atcattacag ctatgcttta agtagtatat ggcttaagaa
     4261 tgcaaatggg accaatttgt ctgctaagaa tttgatttta gggtacaata tgaatattag
     4321 gaagaggtaa acaggtgtgt taatttctag atatcttctg gaaaccacct ttgtttctgt
     4381 ttaaccagtc ctgtagaatc cctgtgtcct ttacagtcgt ctcatgatgg gcatttagct
     4441 ctgtcctgga agaatgtacc tgctactatt tggtgaattt tagagtgaga tattttattg
     4501 gcatatttgt agccatatgt ctcagatttt ctgaatcaaa cctaatgtca gatcattggt
     4561 tttgttggtt agaccatgtt accccacttt ctggttttgg aaatataatc cttgctccct
     4621 ccttttctcc ccagataaaa acccttgctt agtccatata gtccatatag atcctaacac
     4681 ttctacagac cagggctgga gactgatagg gcatcactag tgtttcctga ctgttgtgtc
     4741 ccagtttcat cttcctttga aaagtgaaaa tatggtgcct tccctccctc ccttcctccc
     4801 tccctctctc ccttctttct ccctcccttc ctctctccct ccaagaagac gggcaaatcg
     4861 ttccttgttc tcccactgct gtggagtgat gagacacgca ctttactctt gaagactcag
     4921 caaaaagact cacttctcag catatccata atagaccaca tttcggactt aggaaacttt
     4981 gccaagcagt ctctgtcatt acagatatta atgttgcctc ccccaccccc ccacactatg
     5041 ttgtaagtca aactgtgttt gtctgtgctc cccactgcgc ctaccctaaa tctgtgggtg
     5101 tgcacagcat ataaaatgta cctcactaaa gttctattgc aaatgggacg gggccttatg
     5161 tgttcatcat ttcccagcaa tgtgccacca tgtatttgcc tcaaggcaaa ggtttaacaa
     5221 gctaacaagt acttcccagt tcccctgtgc tgttttctac ccacaatacc caagtgtttt
     5281 gtgcaatgtg tagtgtgtat gtataaatat atatatatat attctttaga gacatcattc
     5341 agaagtaatg tattggcatc tcattcatat ttctgatgtg aagtatatgg tactatttac
     5401 tttttcctta atgtttgcca aattagaatc aagacgttgg tacgaaatta cagcatgtgt
     5461 agaaaccatt ttggcttgaa gagttaacct gaaatccttt cccccgtcag tgtgccctgc
     5521 acagactagt gccctgccgg ctcgctgcct ggttcccaac cctgcgtcct caatgttcag
     5581 ggtgtaacac agttctctca tagcatccta tcattgaaat tgtctgacag ttggacaatg
     5641 aagcctggaa acaggctggt acagtgtaca atagtcacca ggggccgagt ttgcattagt
     5701 aaatgcaaaa tagatgtttt ataaaggaca gactttgtgt tatgtttcta ttttcattac
     5761 attgtataat aatgtaagat tattgtatgt tctaatttgc attataaatg tttttttcct
     5821 acataaaggc ataaatatag caactttgta taaaggtagc ttattagatt ttaatttttc
     5881 ttttataaaa gttgtctaca gtgggactac cattgccaaa ttgtatatga gatatgaatc
     5941 ttcccctatg gttaatttct tttctaaaca ttccatattt ctctaatgaa agacgtgata
     6001 ctgtactatg cataaattgt gttttaatgc tgtttcatat cagcaggtta atcttgggtt
     6061 ggcaaacgta accactgtta ttacaataaa accttgtgtg tgtaacggcg tcactggccc
     6121 tctggcccct ctgtctttgt tcttgctacc ccatcagtgc caatgtcaga caccctgtag
     6181 catggcaata aaacagaccg tctacactga ggccgagtgt ggctttgtgg aggaagtgtg
     6241 ggtgggagga ccaccccaca gttgtcatag tgtgggcctc ttgccatgtc agccgtgttg
     6301 tcaggcataa ggagttatct acgatgtaaa catgctttaa ggacaagtgt gcgagtgctt
     6361 ggaagctttg cttttgatgt aacaggtaat aactagttgt taatctttgg aaaagtcaga
     6421 gtccttgaag tacaatcaag cctttattaa ctggagtact taaagaataa gctaataatg
     6481 gaattttgtt ccacaagggc taagcaacac ttttaaaatt ctcttactta ttgtattagt
     6541 atactttcct atcctaaaat tagaatgtgt aaaatgtggc tccatcttag actgtagcat
     6601 ctcgcgaggc cttcctgtca gcatccgggc gtaaataccc atgatgggta caaggtgata
     6661 ctgaagctga gctgacacac actgaccttc agcgttcagg aaaactgctc tgtggaatca
     6721 aatctgatga gttcttatgg tcacttctcc cttattgcca aaagtagatc gcaataaaac
     6781 ccaaataaaa gtttggttgg atacttacgt aaa
//
