LOCUS       NM_001408284            7579 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor receptor substrate 2 (Frs2),
            transcript variant 4, mRNA.
ACCESSION   NM_001408284 XM_036155854
VERSION     NM_001408284.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7579)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     FRS2-independent GRB2 interaction with FGFR2 is not required for
            embryonic development
  JOURNAL   Biol Open 12 (7) (2023)
   PUBMED   37421147
  REMARK    GeneRIF: FRS2-independent GRB2 interaction with FGFR2 is not
            required for embryonic development.
REFERENCE   3  (bases 1 to 7579)
  AUTHORS   Huang,J.Y., Krebs,B.B., Miskus,M.L., Russell,M.L., Duffy,E.P.,
            Graf,J.M. and Lu,H.C.
  TITLE     Enhanced FGFR3 activity in postmitotic principal neurons during
            brain development results in cortical dysplasia and axonal tract
            abnormality
  JOURNAL   Sci Rep 10 (1), 18508 (2020)
   PUBMED   33116259
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7579)
  AUTHORS   Chen,D., Zhu,X., Kofler,N., Wang,Y., Zhou,B. and Simons,M.
  TITLE     FRS2alpha-dependent cell fate transition during endocardial cushion
            morphogenesis
  JOURNAL   Dev Biol 458 (1), 88-97 (2020)
   PUBMED   31669335
  REMARK    GeneRIF: FRS2alpha-dependent cell fate transition during
            endocardial cushion morphogenesis.
REFERENCE   5  (bases 1 to 7579)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7579)
  AUTHORS   Ong,S.H., Guy,G.R., Hadari,Y.R., Laks,S., Gotoh,N., Schlessinger,J.
            and Lax,I.
  TITLE     FRS2 proteins recruit intracellular signaling pathways by binding
            to diverse targets on fibroblast growth factor and nerve growth
            factor receptors
  JOURNAL   Mol Cell Biol 20 (3), 979-989 (2000)
   PUBMED   10629055
REFERENCE   7  (bases 1 to 7579)
  AUTHORS   Hadari,Y.R., Kouhara,H., Lax,I. and Schlessinger,J.
  TITLE     Binding of Shp2 tyrosine phosphatase to FRS2 is essential for
            fibroblast growth factor-induced PC12 cell differentiation
  JOURNAL   Mol Cell Biol 18 (7), 3966-3973 (1998)
   PUBMED   9632781
REFERENCE   8  (bases 1 to 7579)
  AUTHORS   White,J.K., Auerbach,W., Duyao,M.P., Vonsattel,J.P., Gusella,J.F.,
            Joyner,A.L. and MacDonald,M.E.
  TITLE     Huntingtin is required for neurogenesis and is not impaired by the
            Huntington's disease CAG expansion
  JOURNAL   Nat Genet 17 (4), 404-410 (1997)
   PUBMED   9398841
REFERENCE   9  (bases 1 to 7579)
  AUTHORS   Kouhara,H., Hadari,Y.R., Spivak-Kroizman,T., Schilling,J.,
            Bar-Sagi,D., Lax,I. and Schlessinger,J.
  TITLE     A lipid-anchored Grb2-binding protein that links FGF-receptor
            activation to the Ras/MAPK signaling pathway
  JOURNAL   Cell 89 (5), 693-702 (1997)
   PUBMED   9182757
REFERENCE   10 (bases 1 to 7579)
  AUTHORS   Ong,S.H., Goh,K.C., Lim,Y.P., Low,B.C., Klint,P.,
            Claesson-Welsh,L., Cao,X., Tan,Y.H. and Guy,G.R.
  TITLE     Suc1-associated neurotrophic factor target (SNT) protein is a major
            FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds
            to the SH2 domain of GRB2
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1021-1026 (1996)
   PUBMED   8780727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589661.21.
            
            On Jun 15, 2022 this sequence version replaced XM_036155854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.112388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL589661.21        25474-25606
            134-219             AL589661.21        71800-71885
            220-262             AL589661.21        73330-73372
            263-287             AL589661.21        74031-74055
            288-573             AL589661.21        85621-85906
            574-665             AL589661.21        88875-88966
            666-1516            AL589661.21        89399-90249
            1517-1608           AL589661.21        92885-92976
            1609-1795           AL589661.21        95052-95238
            1796-1954           AL589661.21        96328-96486
            1955-2118           AL589661.21        97024-97187
            2119-7579           AL589661.21        99119-104579
FEATURES             Location/Qualifiers
     source          1..7579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.09 cM"
     gene            1..7579
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="fibroblast growth factor receptor substrate 2"
                     /db_xref="GeneID:327826"
                     /db_xref="MGI:MGI:1100860"
     exon            1..133
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..219
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..262
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..287
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..573
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..665
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..1516
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1608
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1543..3069
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="isoform 1 is encoded by transcript variant 4; FGFR
                     substrate 2; FGFR-signaling adaptor SNT; suc1-associated
                     neurotrophic factor target 1"
                     /codon_start=1
                     /product="fibroblast growth factor receptor substrate 2
                     isoform 1"
                     /protein_id="NP_001395213.1"
                     /db_xref="GeneID:327826"
                     /db_xref="MGI:MGI:1100860"
                     /translation="MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTE
                     LILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQ
                     EIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDAS
                     SHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHVPPEA
                     RVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGKDPV
                     SGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQ
                     NINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNY
                     VNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNP
                     QTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
                     "
     exon            1609..1795
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1954
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2118
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..7579
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6851..6856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6871
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="major polyA site"
     regulatory      7539..7544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     regulatory      7550..7555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      7573
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
                     /note="major polyA site"
     polyA_site      7579
                     /gene="Frs2"
                     /gene_synonym="C330018A15Rik; FRS2-alpha; Frs2alpha;
                     SNT-1; SNT1"
ORIGIN      
        1 gtctagggtt cgggctggag agaggccttg tagacacagg cgccgaggct ccgagcaggg
       61 ggtcaggtcg cggggagagt gaggagctcc gcggctgcca ccccgcgccc ctcgcagcgc
      121 cttcgcgccg acgaaatggc taccaagaag taaatgccca gacgtaatgg tgatgcaggt
      181 gtcatgaagt aagatgcagt atagcatcca tccagattag gacaaaatta tatctgtttt
      241 tctcagaaaa gaattccaaa agactttttg aaggaagaca tcatcgagtc tgagtcattc
      301 atcagtggag agaaaccaaa gagatttaag aagtcacaca gagggctgga gagatggctc
      361 agtggttaag agcactgact gctcttgcag aggtcctgag ctcaattccc agcaaccaca
      421 tggtggctca caaccatctg tgatgggatc tgatgccctc ttctgatgtc tgaagacagc
      481 tacactgtgc tcacatacat aaaataaatg tttaaaaaga aagtcacaca gaagatctga
      541 atcaaatcaa atgcccacga cacccatggt ccagttaaag taccaaacga agacctggta
      601 ttttgaaata tgattaatct cctgatgcag catcagaggc taacaatatt aatggccaga
      661 tctaggcagt gcacagccgt tagaaccaag acctcggcat ggcacctccg gatgtccaca
      721 tgtgaatggg ctccgcaaca gcaggcacat gtgcgggagg actcagggca ccggacccct
      781 cattgcagaa ccgtgcggac cacaactgcc agcgttcatc agctggagtt cctcactcgt
      841 gctgagctgc tgctttcatg ctgaaaccct tgtccttcgt cctctgcttt gcttctttcc
      901 tgaccagaac atcctgtaat atctgtctct tctaccctca gaccctagat caattaaatc
      961 agtcaggccc tctaactgcc gagtgcagaa tcctgactct catcttctgc tgaggtcctc
     1021 gaatctaaaa atcttcttgg gcactcagtt atttaccagt ctcttcagtt ccctcatttt
     1081 gcaacccgtg tcttgtattt tataagatgg gagatgccat caacttcagc ttatttgcta
     1141 ttatcactcg tctgcccttt agtacgtgtg tgtacatatg tgtatatatg cacatgcgtg
     1201 tgtatgtgtg tgcatgtgtg ctgtacaggt aactataggg gccagaagaa gacacctaat
     1261 cctctggacc tgaagtcacc tctctagtcc cttccgttct tatgttttct cttgcctcag
     1321 agtctgccac ctctcggtag gcgccacagt ctggtcactg tacccatctc cccttcttta
     1381 ggttctcagc ccactctgtt agttaggctc ccccctccat gcttcctctc tgtgctttaa
     1441 aaaaggaaag aaaaaccctt tttctgccca ttgattgaag atctgcttct ttaattacgt
     1501 gacacctaag acggtgtgct cacatggtct tctgaagaag ccatgggtag ctgttgtagc
     1561 tgtccagata aagacactgt cccagataac catcggaaca agtttaaggt cattaatgtg
     1621 gatgatgatg ggaatgagct aggctctggt gtgatggaac tcacagacac agagctgatt
     1681 ctgtacaccc ggaaacggga ctcggtaaaa tggcactacc tctgcctacg acgatacggc
     1741 tatgactcaa atctgttttc ttttgaaagt ggtcgaaggt gtcagactgg acaaggaatt
     1801 tttgctttta agtgtgcccg tgcagaagaa ttatttaaca tgttgcaaga gattatgcaa
     1861 aataatagta taaatgtggt ggaagagccg gttgtagaaa ggagtagtca tcagacagag
     1921 ctggaagtcc ctaggacacc tcggacacct acaactccag ggctcggtgc tcagaactta
     1981 cctaatgggt atccccgcta cccctcgttt ggagacgctt catcccaccc ctcaagccgg
     2041 catccttcgg tgggaagtgc tcgcttacct tcagtcggtg aagagtccac acaccctttg
     2101 ctcgtggctg aggaacaagt acatacttat gttaacacta caggtgtgca agaggagcga
     2161 aaaaaccgtg caagtgtgca tgttccccca gaggcaaggg tttctaatgc tgagagcaac
     2221 acaccaaaag aagagccgag taaccccgag gacagggacc cgcaagtgct tcttaagcct
     2281 gaaggagtca ggtttgtgct aggaccaacc cctgtccaga agcagttaat ggaaaaggag
     2341 aaactggagc aactgggaaa agacccagtc agtgggagtg gagcgggcaa cacggagtgg
     2401 gacaccggct atgacagtga cgagcgcaga gatgtgcccc ctgtcaacaa actggtgtat
     2461 gaaaatataa acgggctatc tattcccagt gcctcagggg tcaggagagg tcgtctgaca
     2521 tctaccagca cctcagacac ccagaatatc aacaactcag cgcagagaag acctgcacta
     2581 ttaaactatg aaaatttacc atctttgcct cctgtttggg aagcccgcaa gctcagtagg
     2641 gatgaagatg acaatttagg accaaagacc ccatctctaa atggctacca taataatcta
     2701 gatccaatgc ataactatgt taatacagag aatgtaacag tgccggcaag tgctcacaaa
     2761 atagactatt cgaagcgcag ggattgtaca ccgacagtct ttaactttga tatcaggcga
     2821 cccagtttag aacataggca actcaattat atacaggtgg atttggaagg gggcagtgac
     2881 tctgacaacc ctcagactcc aaaaacgccg accactcccc tcccgcaaac ccccacgcgg
     2941 cgcacagagc tgtacgctgt gatagacatt gagagaactg ctgctatgtc caacttgcag
     3001 aaagcgctgc ctcgagacga cggtacatct cggaagacga ggcacaatag tactgacctg
     3061 cccatgtgag ccgggaagca ctgcgtcctt ctccgcaagg cgttcagagc gaagatgcag
     3121 tgcctcctct tcatgtctac actagctcct ttatagactg gtcttctgct ctgaatattt
     3181 catctttaaa gggaattgat gcagagcagg cactccttag aacactaatc tcctgatagc
     3241 tactcactgt ccagcagcac cccattctca cagtgcctac ttaccacgag aattgaagtg
     3301 aatgccgtgc tgggtgacct gtcctcagca tcctggggga tgcatagctt tcatgtctga
     3361 gttgtggttg gcgtttgaac cttttataaa gtctcttgat aatgcgcatt gctaacataa
     3421 ctctgggccc tgagaggaac cctcatagat cactgttcac agggtatggt cgccagcatg
     3481 gaacgtgagg attttatttc attagttaaa ggctttttgt cttgggccaa attcgtgtca
     3541 aagaacaagg agaaccacac ttccttttgt accagtcagc acctctgtct tgagtgtgct
     3601 gtgattggaa ggcagccagg agacagctct gtgtccccac ctcctggtgt catctgaagg
     3661 gcgtgtccag atagcatctt actcagagtt aggatgggct taggagtcag tctcaggtca
     3721 ctttacccaa aagcatttga aagtctaccc ctgatctctc ggtgtgtctg cggtagatta
     3781 ctgacagcac acatgtgtct gcagacactc gtgccattca gtcccatgga gcttcagttt
     3841 cccctttggt ctttgggttg tcttaccttg tatgtaatgc ttttttcaat ttacaacaca
     3901 atgtttgtgt atcgtcttgg aataggattg tgtgtttgct gttactactt aggctgcgtt
     3961 tttgttgtta cggtcctgaa ggtccatttg ggactgactg ttattctcta gctgggttgc
     4021 ccttgtccag tatttattta tctcctgctt gcttttcaag ttgatgaaaa aaatcgacgt
     4081 ttgggtttta aagttcattt gtgtccatgg gtgatctctt tagtagctga gaaggaaagg
     4141 aagagactct taaacatgtg agtccccgaa ggtcctgtcc tcgctggggc gccctgcgct
     4201 gcactttagc aggggttgtc tcagctccat ggctgcaggc ccgctctccc tgctctgctg
     4261 tcctcccacg tggagctggg ctctgattac cctgtgatgc tggtgagctg ttaatattgt
     4321 tgccagcata acaggaacag ggaagtctta aagaggcgcc gttatgtcat agcgtgaagt
     4381 gaagaaaggc cactcagact gatgtgctcc cagaccgacc actggacagt acagggaggg
     4441 gcagcctgcg ggataggtta tcttttctct aaagttggag acattcctgg ttatgatctg
     4501 gatataccag gtcaagaaaa gggttcagtc atcggcaggc agtgtattta ggaactcatc
     4561 cagagcagcg gctggatttg cagaacagta gtgcggggcc ataatatcta gatgtttcat
     4621 catcttcagc gccattgctt catagcatag cagacgcttc ctttcctttc cctctgcgaa
     4681 ctaaaatgtt tgctgttctc ttcaagagaa tagtggatac atgtgcagtt tacatattta
     4741 atacactgtt ccattcgtcc tttcttctga gtagcttgct aattgtgcca aatttcagtg
     4801 gtggttttgt ggtgtggggt aaggacgctt atgggaaggg cgcaggtcca gacagaatta
     4861 gccctccacc tcagagggct ggtctgcgcg gccgtctgca ggctgggtgc tttgttcttt
     4921 ctctgtactc ttcacttttc ccttcagatt tgaattagat tttatatttt ttagctgact
     4981 aatatcatca ttacagctat gctttaagta gtatatggct taagaatgca aatgggacca
     5041 atttgtctgc taagaatttg attttagggt acaatatgaa tattaggaag aggtaaacag
     5101 gtgtgttaat ttctagatat cttctggaaa ccacctttgt ttctgtttaa ccagtcctgt
     5161 agaatccctg tgtcctttac agtcgtctca tgatgggcat ttagctctgt cctggaagaa
     5221 tgtacctgct actatttggt gaattttaga gtgagatatt ttattggcat atttgtagcc
     5281 atatgtctca gattttctga atcaaaccta atgtcagatc attggttttg ttggttagac
     5341 catgttaccc cactttctgg ttttggaaat ataatccttg ctccctcctt ttctccccag
     5401 ataaaaaccc ttgcttagtc catatagtcc atatagatcc taacacttct acagaccagg
     5461 gctggagact gatagggcat cactagtgtt tcctgactgt tgtgtcccag tttcatcttc
     5521 ctttgaaaag tgaaaatatg gtgccttccc tccctccctt cctccctccc tctctccctt
     5581 ctttctccct cccttcctct ctccctccaa gaagacgggc aaatcgttcc ttgttctccc
     5641 actgctgtgg agtgatgaga cacgcacttt actcttgaag actcagcaaa aagactcact
     5701 tctcagcata tccataatag accacatttc ggacttagga aactttgcca agcagtctct
     5761 gtcattacag atattaatgt tgcctccccc acccccccac actatgttgt aagtcaaact
     5821 gtgtttgtct gtgctcccca ctgcgcctac cctaaatctg tgggtgtgca cagcatataa
     5881 aatgtacctc actaaagttc tattgcaaat gggacggggc cttatgtgtt catcatttcc
     5941 cagcaatgtg ccaccatgta tttgcctcaa ggcaaaggtt taacaagcta acaagtactt
     6001 cccagttccc ctgtgctgtt ttctacccac aatacccaag tgttttgtgc aatgtgtagt
     6061 gtgtatgtat aaatatatat atatatattc tttagagaca tcattcagaa gtaatgtatt
     6121 ggcatctcat tcatatttct gatgtgaagt atatggtact atttactttt tccttaatgt
     6181 ttgccaaatt agaatcaaga cgttggtacg aaattacagc atgtgtagaa accattttgg
     6241 cttgaagagt taacctgaaa tcctttcccc cgtcagtgtg ccctgcacag actagtgccc
     6301 tgccggctcg ctgcctggtt cccaaccctg cgtcctcaat gttcagggtg taacacagtt
     6361 ctctcatagc atcctatcat tgaaattgtc tgacagttgg acaatgaagc ctggaaacag
     6421 gctggtacag tgtacaatag tcaccagggg ccgagtttgc attagtaaat gcaaaataga
     6481 tgttttataa aggacagact ttgtgttatg tttctatttt cattacattg tataataatg
     6541 taagattatt gtatgttcta atttgcatta taaatgtttt tttcctacat aaaggcataa
     6601 atatagcaac tttgtataaa ggtagcttat tagattttaa tttttctttt ataaaagttg
     6661 tctacagtgg gactaccatt gccaaattgt atatgagata tgaatcttcc cctatggtta
     6721 atttcttttc taaacattcc atatttctct aatgaaagac gtgatactgt actatgcata
     6781 aattgtgttt taatgctgtt tcatatcagc aggttaatct tgggttggca aacgtaacca
     6841 ctgttattac aataaaacct tgtgtgtgta acggcgtcac tggccctctg gcccctctgt
     6901 ctttgttctt gctaccccat cagtgccaat gtcagacacc ctgtagcatg gcaataaaac
     6961 agaccgtcta cactgaggcc gagtgtggct ttgtggagga agtgtgggtg ggaggaccac
     7021 cccacagttg tcatagtgtg ggcctcttgc catgtcagcc gtgttgtcag gcataaggag
     7081 ttatctacga tgtaaacatg ctttaaggac aagtgtgcga gtgcttggaa gctttgcttt
     7141 tgatgtaaca ggtaataact agttgttaat ctttggaaaa gtcagagtcc ttgaagtaca
     7201 atcaagcctt tattaactgg agtacttaaa gaataagcta ataatggaat tttgttccac
     7261 aagggctaag caacactttt aaaattctct tacttattgt attagtatac tttcctatcc
     7321 taaaattaga atgtgtaaaa tgtggctcca tcttagactg tagcatctcg cgaggccttc
     7381 ctgtcagcat ccgggcgtaa atacccatga tgggtacaag gtgatactga agctgagctg
     7441 acacacactg accttcagcg ttcaggaaaa ctgctctgtg gaatcaaatc tgatgagttc
     7501 ttatggtcac ttctccctta ttgccaaaag tagatcgcaa taaaacccaa ataaaagttt
     7561 ggttggatac ttacgtaaa
//
