LOCUS       NM_001142965            3854 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus ferric-chelate reductase 1 like (Frrs1l), mRNA.
ACCESSION   NM_001142965 XR_001563 XR_001596
VERSION     NM_001142965.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Wang R, Liu C, Guo W, Wang L, Chen S, Zhao J, Qin X, Bai W, Yang Z,
            Kong D, Jia Z, Liu S and Zhang W.
  TITLE     Movement disorder caused by FRRS1L deficiency may be associated
            with morphological and functional disorders in Purkinje cells
  JOURNAL   Brain Res Bull 191, 93-106 (2022)
   PUBMED   36330921
  REMARK    GeneRIF: Movement disorder caused by FRRS1L deficiency may be
            associated with morphological and functional disorders in Purkinje
            cells.
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T,
            Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A,
            Roeper J, Schulte U and Fakler B.
  TITLE     An ER Assembly Line of AMPA-Receptors Controls Excitatory
            Neurotransmission and Its Plasticity
  JOURNAL   Neuron 104 (4), 680-692 (2019)
   PUBMED   31604597
  REMARK    GeneRIF: Our results provide mechanistic insight into the stepwise
            biogenesis of AMPA-receptors in native endoplasmic reticulum
            membranes and establish FRRS1l as a powerful regulator of synaptic
            signaling and plasticity.
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL,
            Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE,
            Corrochano S and Nolan PM.
  TITLE     Loss of Frrs1l disrupts synaptic AMPA receptor function, and
            results in neurodevelopmental, motor, cognitive and
            electrographical abnormalities
  JOURNAL   Dis Model Mech 12 (2) (2019)
   PUBMED   30692144
  REMARK    GeneRIF: Frrsl1 deletion results in an increased proportion of
            immature AMPA receptors, indicated by incomplete glycosylation of
            GLUA2 (also known as GRIA2) and GLUA4 (also known as GRIA4) AMPA
            receptor proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Han W, Wang H, Li J, Zhang S and Lu W.
  TITLE     Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with
            Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission
  JOURNAL   Front Mol Neurosci 10, 402 (2017)
   PUBMED   29276473
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Madeo M, Stewart M, Sun Y, Sahir N, Wiethoff S, Chandrasekar I,
            Yarrow A, Rosenfeld JA, Yang Y, Cordeiro D, McCormick EM, Muraresku
            CC, Jepperson TN, McBeth LJ, Seidahmed MZ, El Khashab HY, Hamad M,
            Azzedine H, Clark K, Corrochano S, Wells S, Elting MW, Weiss MM,
            Burn S, Myers A, Landsverk M, Crotwell PL, Waisfisz Q, Wolf NI,
            Nolan PM, Padilla-Lopez S, Houlden H, Lifton R, Mane S, Singh BB,
            Falk MJ, Mercimek-Mahmutoglu S, Bilguvar K, Salih MA,
            Acevedo-Arozena A and Kruer MC.
  TITLE     Loss-of-Function Mutations in FRRS1L Lead to an
            Epileptic-Dyskinetic Encephalopathy
  JOURNAL   Am J Hum Genet 98 (6), 1249-1255 (2016)
   PUBMED   27236917
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3854)
  AUTHORS   Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR
            and Chen ZF.
  TITLE     Molecular mapping of developing dorsal horn-enriched genes by
            microarray and dorsal/ventral subtractive screening
  JOURNAL   Dev Biol 292 (2), 555-564 (2006)
   PUBMED   16516881
REFERENCE   9  (bases 1 to 3854)
  AUTHORS   Ferguson DA, Chiang JT, Richardson JA and Graff J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132345.1 and AK078331.1.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_001142965.2.
            
            On or before Jan 2, 2009 this sequence version replaced
            XR_001563.2, XR_001596.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.135096.1,
                                           SRR1660817.190227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1183              BC132345.1         28-1210
            1184-2159           AK078331.1         847-1822
            2160-3854           AK078331.1         1824-3518
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..3854
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /note="ferric-chelate reductase 1 like"
                     /db_xref="GeneID:230235"
                     /db_xref="MGI:MGI:2442704"
     exon            1..358
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1002
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /note="ferric-chelate reductase 1-like protein; DOMON
                     domain-containing protein FRRS1L"
                     /codon_start=1
                     /product="DOMON domain-containing protein FRRS1L
                     precursor"
                     /protein_id="NP_001136437.1"
                     /db_xref="CCDS:CCDS51179.1"
                     /db_xref="GeneID:230235"
                     /db_xref="MGI:MGI:2442704"
                     /translation="MAGQPLRRPAWVPLLLRLLLAGIAACDASPADDSAGPGGRGPRG
                     RARGDAGADEAVPRHDSSYGTFASEFYDLRYLSEEGYPFPTAPPVDPFAKIKVEDCGR
                     TKGCFRYGKPGCNAETCDYFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVM
                     ACVHDDNGRVRIQHFYNVGQWAKEVQRNPARDEEGVFENNRVTCRFKRPVNVPRDETI
                     VDLHLSWYYLFAWGPAIQGAITRHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPF
                     CLLLIVALTFYLLMGTP"
     exon            359..443
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            444..582
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            583..829
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..3854
                     /gene="Frrs1l"
                     /gene_synonym="6430704M03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgggtgc gggcgctccg cggctgcgcg gcgcgtgctg gcggcggctc ggtcccggcc
       61 cgcgcccgcg gggtccccgc tgcggccgga gcggcctggc tgcgggatcc gtgcgcagcg
      121 atggcggggc aacccctgcg gcgcccggcc tgggtaccac tgctcctgcg actgctgctg
      181 gcggggatcg ctgcctgcga tgccagcccc gcggacgaca gcgcgggccc ggggggccgg
      241 ggaccccggg gacgcgcgcg aggggacgcg ggcgcggacg aggcagtgcc gcgccacgac
      301 tcctcctacg gcaccttcgc cagcgagttc tacgacctgc gctacctgtc agaggagggt
      361 taccctttcc ccactgctcc tcctgtggac ccattcgcca aaatcaaggt ggaagactgt
      421 ggaagaacta agggatgctt cagatacggg aagccaggct gtaatgcaga aacctgtgac
      481 tacttcctta gctaccggat gataggcgct gacgtggagt ttgagctgag tgcagacaca
      541 gatggttggg tcgcggttgg attctcttca gacaaaaaga tgggtggtga cgatgtcatg
      601 gcctgcgtcc atgatgacaa tggcagagtc cgcatacagc acttctataa tgtgggtcag
      661 tgggcaaagg aggttcagag aaatcctgcc cgagatgaag aaggagtttt cgagaacaac
      721 cgcgtcacct gcaggtttaa gcgtcccgtg aatgttccca gggatgaaac gatcgtggat
      781 ctgcacctga gttggtacta cctgtttgct tggggtccgg ccattcaggg cgccatcact
      841 cgtcacgaca tagactctcc accggcttca gagcgcgttg tcagtattta caagtacgaa
      901 gacattttca tgccgtcggc tgcctaccag accttctcct cgccattttg tctgcttctc
      961 attgtcgccc tgaccttcta cctgctgatg ggaacccctt aaccaccgct gccagccaca
     1021 gactagatgg agtgaaaacc cttcagtatc tatttttcag taaccgcctg tataattttc
     1081 gcttctatga tctaaaaaca agtcatgatt tcaacatttt tgggagaaga aaaaaaaaag
     1141 cgcaagcctc tctcctggtc aggcaggatt gtcaaggcaa cgctactttc gggaagcact
     1201 taaaacattt gcaaacactt ccaaatatgt tctctgtttg agctttacaa tgtctatgca
     1261 ttggcttggt aaaactgtga gggccatcat attgatttaa acccagacaa agggtgcctt
     1321 ttgctgaccc acgtgtctca cagccttggc taacatgatc agacaacata cagtacggta
     1381 gggagaacta gacatggaaa gtagacctca gaacagtctt tgctttgagc agtctttact
     1441 ttcagtcctg aacaagaggg tcaccttgca tgtggccgtg gagatcttta taggatgtca
     1501 cggtgtatca tcaggctctc gagaactttt ctgtggcgca taaatgcttt tagatagtca
     1561 cacggttgat agggaatatg ggagagattc tagggataag cgagtggttt gtatttatct
     1621 aaaatatctt ctcaattagt gtggagttat ggaaaaacga ttatatatcg ctgttaggaa
     1681 aaattaaaaa tgtggatgtc cctgaagctg taaaattatt ataatgatta aaaataggag
     1741 aattcttagt agttagaatt tgctctcttc tgccactgta ttctaccaag taaggtgttc
     1801 atgggtgact gtagccaatg gtgtttttca agttagaata cactaagtat aactgaatat
     1861 ccattataac agaatagtca tcttaaggaa aacaaggcat tttaatcata tatcaacgtt
     1921 tttaaaggct gtagacacca ggagcaaaag atggggcagg gggcctaagg taaatttacc
     1981 aagagtatat gtttaaaatg ttcaattctt tgtttccttt tgtcaaaaga gccagatact
     2041 cttttagtcc aaatacctat gctagcagcc tgccaagagg cgagagtgta gctgtgggcg
     2101 cttacaccgc tgggccagtc ccattgtggc attccagaat tctctgattt tttttttttc
     2161 ccattgcttc cgagctggct ccagctttat aggtgagcaa cagcagatta tagtttctaa
     2221 aattgtcttc aagattcagg tcagaggtga aggtctgcgt gtgggaaagt gttcagattc
     2281 ttctgggctg gcgccaaaac aaagtaagta ttgctatttt gtgacaccac ccacacccgg
     2341 tttccaactc aaagttcaag cagaaggcct cacctcactc caattatctc ttcactaaac
     2401 cctctgatct tattcaggct tggctccagc atggccgtgc accagctttg cagcattagg
     2461 ggctggttta gaagtgaggg ttgggagtag atagagacac ccttgttgta aataagaagc
     2521 ctgatatttt tataaccctt atgtgtacaa tagtcgatct acaactagca gagccaatag
     2581 agacagactt cagttatgag taggagcaga gcgagcggtg tctcccttcc acatacgttt
     2641 caaatcaagt ttcactgggt cttttgactt tggtgactag ttttgtctat tttttttgcc
     2701 tggaactttc agagttatcc ttgtccttac agtaacatgc aagtgaccct actaagcgtc
     2761 ggtcttctct gcttcaggac cactacttgt gccagcaagt cgaaggggcc ttgaggtcct
     2821 ccctcctgtg gacgatgctc tcatctgaaa ggctctaact taattatctc gtcctcaggt
     2881 cctctggact agttttagga cttactcaag tgctcccgaa gcccactggg cttcctcagc
     2941 agacacttca ggctttagtg aaatcacagg ttttggctgc taagccatca tagaggaact
     3001 atttctcagt gcttgccctt gtgacagaca ttacttctta gtaagtgttc agcaaactga
     3061 tgggccaagt tacaaaccgt ctcgatgttg tgagtttatt gcagccagag ggatctcttt
     3121 tatatagtct acccgacgag taatgttttt atgtcctctc cttgtgatca catcatgtct
     3181 tccaaaaaca taaatgacag aatccttagt gattttgttg gttttgcttt tccatggaca
     3241 tcagttggca ttttcaacaa taaatcattg tcctggaata agaatttaca gactagggat
     3301 gcatcacaac ggttgaccgc agagagctag ccactgatag acctgctgga gttaaaagca
     3361 gataaactca aactagttca ttcttaccta ccgtaagaga aagaccttca cccctccact
     3421 ctttctctct ttcagcagag cctcacaatc ctcctcctcc agcctcctga ctcctggctg
     3481 ctgctatctc aagcacacac cacagattgg acagtgcgtt ttcctttcta atatgatgtt
     3541 tgtcctgagg gagacgccta tcaatgcttt ttgcttaaaa agaaaaaaaa ccaagtgaag
     3601 tataagtggc agaaaaacgt acactagttt aatgcactta tcttgcaaga gacagcctag
     3661 gctaagggag gcaacatgac tttctccatc tcatgcagag tcattaaaac ttccattaaa
     3721 tagaacctac tatccatact taaaccaact ggttgccttt gcctgcctcc tggtacttca
     3781 catcaagcag agaacttctt acagctgtat ttgaggaaag aaacacagtt taaggaagaa
     3841 agaaagaaag aaag
//
