LOCUS       NM_001368936            8064 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus FERM and PDZ domain containing 4 (Frmpd4), transcript
            variant 5, mRNA.
ACCESSION   NM_001368936 XM_006528887
VERSION     NM_001368936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8064)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8064)
  AUTHORS   Funk,O.H., Qalieh,Y., Doyle,D.Z., Lam,M.M. and Kwan,K.Y.
  TITLE     Postmitotic accumulation of histone variant H3.3 in new cortical
            neurons establishes neuronal chromatin, transcriptome, and identity
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2116956119 (2022)
   PUBMED   35930666
REFERENCE   4  (bases 1 to 8064)
  AUTHORS   Luo,P., Li,X., Wu,X., Dai,S., Yang,Y., Xu,H., Jing,D., Rao,W.,
            Xu,H., Gao,X., Fei,Z. and Lu,H.
  TITLE     Preso regulates NMDA receptor-mediated excitotoxicity via
            modulating nitric oxide and calcium responses after traumatic brain
            injury
  JOURNAL   Cell Death Dis 10 (7), 496 (2019)
   PUBMED   31235685
  REMARK    GeneRIF: Uncoupling the linkage between Preso and PSD-95 attenuated
            the stability of this complex and suppressed the regulatory effect
            of Preso on the NO response. In addition, phosphorylation of NMDAR
            by cyclin-dependent kinase 5 (CDK5) was shown to be responsible for
            the Preso-mediated Ca(2+) response, which was dependent on the
            interaction between Preso and CDK5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8064)
  AUTHORS   Lavado,A., Park,J.Y., Pare,J., Finkelstein,D., Pan,H., Xu,B.,
            Fan,Y., Kumar,R.P., Neale,G., Kwak,Y.D., McKinnon,P.J.,
            Johnson,R.L. and Cao,X.
  TITLE     The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and
            Controls Neural Progenitor Number
  JOURNAL   Dev Cell 47 (5), 576-591 (2018)
   PUBMED   30523785
REFERENCE   6  (bases 1 to 8064)
  AUTHORS   Piard,J., Hu,J.H., Campeau,P.M., Rzonca,S., Van Esch,H.,
            Vincent,E., Han,M., Rossignol,E., Castaneda,J., Chelly,J.,
            Skinner,C., Kalscheuer,V.M., Wang,R., Lemyre,E., Kosinska,J.,
            Stawinski,P., Bal,J., Hoffman,D.A., Schwartz,C.E., Van
            Maldergem,L., Wang,T. and Worley,P.F.
  TITLE     FRMPD4 mutations cause X-linked intellectual disability and disrupt
            dendritic spine morphogenesis
  JOURNAL   Hum Mol Genet 27 (4), 589-600 (2018)
   PUBMED   29267967
  REMARK    GeneRIF: The findings point to an important role of FRMPD4 in
            normal cognitive development and function in humans and mice, and
            support the hypothesis that FRMPD4 mutations cause ID by disrupting
            dendritic spine morphogenesis in glutamatergic neurons.
REFERENCE   7  (bases 1 to 8064)
  AUTHORS   Hu,J.H., Yang,L., Kammermeier,P.J., Moore,C.G., Brakeman,P.R.,
            Tu,J., Yu,S., Petralia,R.S., Li,Z., Zhang,P.W., Park,J.M., Dong,X.,
            Xiao,B. and Worley,P.F.
  TITLE     Preso1 dynamically regulates group I metabotropic glutamate
            receptors
  JOURNAL   Nat Neurosci 15 (6), 836-844 (2012)
   PUBMED   22561452
REFERENCE   8  (bases 1 to 8064)
  AUTHORS   Radulovic,J. and Tronson,N.C.
  TITLE     Preso1, mGluR5 and the machinery of pain
  JOURNAL   Nat Neurosci 15 (6), 805-807 (2012)
   PUBMED   22627790
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8064)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19210-19215 (2011)
   PUBMED   22074847
REFERENCE   10 (bases 1 to 8064)
  AUTHORS   Lee,H.W., Choi,J., Shin,H., Kim,K., Yang,J., Na,M., Choi,S.Y.,
            Kang,G.B., Eom,S.H., Kim,H. and Kim,E.
  TITLE     Preso, a novel PSD-95-interacting FERM and PDZ domain protein that
            regulates dendritic spine morphogenesis
  JOURNAL   J Neurosci 28 (53), 14546-14556 (2008)
   PUBMED   19118189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672186.7, AL807773.7 and BX546498.7.
            
            On Mar 8, 2019 this sequence version replaced XM_006528887.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL672186.7         198924-199079       c
            157-273             AL807773.7         170018-170134       c
            274-434             AL807773.7         51870-52030         c
            435-537             AL807773.7         45558-45660         c
            538-583             BX546498.7         103747-103792       c
            584-688             BX546498.7         97461-97565         c
            689-796             BX546498.7         93865-93972         c
            797-928             BX546498.7         89859-89990         c
            929-1048            BX546498.7         87103-87222         c
            1049-1185           BX546498.7         79470-79606         c
            1186-1312           BX546498.7         74530-74656         c
            1313-1402           BX546498.7         71356-71445         c
            1403-1585           BX546498.7         70644-70826         c
            1586-1724           BX546498.7         68453-68591         c
            1725-2783           BX546498.7         60121-61179         c
            2784-4073           BX546498.7         58444-59733         c
            4074-8064           BX546498.7         52964-56954         c
FEATURES             Location/Qualifiers
     source          1..8064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.36 cM"
     gene            1..8064
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="FERM and PDZ domain containing 4"
                     /db_xref="GeneID:333605"
                     /db_xref="MGI:MGI:3042378"
     exon            1..156
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..5398
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="isoform 5 is encoded by transcript variant 5; FERM
                     and PDZ domain-containing protein 4; PDZ domain-containing
                     protein 10; PSD-95-interacting regulator of spine
                     morphogenesis"
                     /codon_start=1
                     /product="FERM and PDZ domain-containing protein 4 isoform
                     5"
                     /protein_id="NP_001355865.1"
                     /db_xref="CCDS:CCDS90773.1"
                     /db_xref="GeneID:333605"
                     /db_xref="MGI:MGI:3042378"
                     /translation="MDVFSFVKIPKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTN
                     RDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVR
                     SVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKS
                     AFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSF
                     RFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRP
                     SSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLA
                     ALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQN
                     LVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHV
                     INTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLT
                     AGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQ
                     EAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRS
                     LAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEML
                     EKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDIC
                     YAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDF
                     LLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTS
                     AEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEM
                     TEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAAR
                     PATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLP
                     EGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDS
                     QRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGD
                     RFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEG
                     HFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEER
                     APGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTA
                     LTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGIQAFGEAV
                     SWWPADLRGGSPRTPPSQRALRHSSRILSGPVGLETFQERTKGVVSLKYPGITEAQEV
                     SSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLESSNW
                     RCRGPFSYCFLNQGQDEDGDEDEEEGEATLQVSCLYRPQITQAMSEPGNSSLVVGLQK
                     QGEELSRGTALKVWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEAQND
                     ANELLCLVRATKARKEESRPETYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEM
                     LLAMSSSFQVLCCLTEACMRLVKVVNTETQRQEIVAKIDEVVINYICLLKAAEAATGK
                     TTGDPNIGLSMRHSTTMAALVSTLTRSLKMLLNK"
     exon            157..273
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..434
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..537
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..583
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..688
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..796
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..928
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1048
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1185
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1312
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1402
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1585
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1724
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..2783
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..4073
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..8064
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8040..8045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="hexamer: AATAAA"
     regulatory      8044..8049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="hexamer: AATAAA"
     regulatory      8048..8053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="hexamer: AATAAA"
     polyA_site      8057
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="major polyA site"
     polyA_site      8061
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="major polyA site"
     polyA_site      8064
                     /gene="Frmpd4"
                     /gene_synonym="Gm196; Pdzd10; Pdzk10; PKAP1; preso;
                     Preso1"
                     /note="major polyA site"
ORIGIN      
        1 gccactcaaa ccccaggcgc actgaggtcc tggccatggg gctgctgagg ctgcctttgc
       61 tggtgtgaga aggggcaacg gagcctccag gctctggggt ccccaagctg cctacatgga
      121 tgtcttcagc tttgtgaaga ttccaaagct ttccagccac aggaccaagt cttcgggctg
      181 gccacctccc tcaggaacct ggggcttgaa ccaggtacca ccctatggat gggagatgat
      241 gacaaaccga gatggacgtg actacttcat caatcacatg acacaggcaa tcccatttga
      301 tgaccctcgg tttgacagct gccaaatcat ccccccagct ccacgaaagg tggagatgag
      361 gagagaccct gtgctgggct ttgggtttgt ggcagggagc gaaaagccag tggtcgttcg
      421 gtcagtaaca ccaggtggcc cctcagaagg caagctgatc ccaggagatc agattgtaat
      481 gattaatgat gaagcagtca gcgctgcacc aagagagaga gtcatcgacc tggtcaggag
      541 ctgcaaagaa tcgattctgc tcactgtcat tcagccctat ccatctccca aatcagcatt
      601 tatcagtgct gctaaaaagg caagattgaa gtccaatcca gtcaaagtgc gcttttccga
      661 agaggtcata atcaatggcc aagtgtcgga aactgttaaa gacaattcac ttctttttat
      721 gccaaatgtt ttgaaagtct atttggaaaa cggacagacc aaatcctttc gttttgactg
      781 cagcacctcc atcaaggatg tcatcttaac cctgcaagag aagttgtcta tcaaaggcat
      841 tgaacacttc tccctcatgc tggagcagag aattgaaggg gctggcacca agctgctctt
      901 gcttcatgaa caggagacac tcactcaggt gacacagagg cccagctccc ataagatgag
      961 gtgtcttttc cgaatcagtt ttgttcccaa agatcccatt gacctgttaa gaagagatcc
     1021 agttgctttt gagtatctct atgttcagag ttgtaacgat gtcgttcagg agcgatttgg
     1081 accagagctg aaatatgaca ttgccttgcg gctggccgcg ttacaaatgt acattgctac
     1141 tgtcaccacc aaacagacgc agaaaatctc cctcaaatac attgagaaag aatggggact
     1201 agagactttt cttccatctg ctgtgctgca gagcatgaaa gagaagaaca tcaagaaagc
     1261 actctcccac cttgtcaaag caaatcaaaa cttggtacca ccgggtaaaa agctctctgc
     1321 actacaagct aaggtccact atctcaagtt cctcagcgac ctgcgactat atgggggccg
     1381 tgtattcaag gcaacattag tgcaggcaga gaagcgctca gaagtaactc ttctggttgg
     1441 tccccggtat ggcataagcc atgtcataaa caccaaaacc aatctggtgg ctcttttagc
     1501 tgacttcagc catgtcaaca ggattgaaat gtttactgaa gaggagagct tggtgagggt
     1561 ggagttgcat gtgctagatg tgaagcccat tacactactt atggagtcat cagacgccat
     1621 gaacctggcc tgtctgacag ctggatacta ccggctgctt gtggactcca ggaggtcaat
     1681 atttaacatg gccaacaaga aaaacgcagg cacgcaggac acaggatcag aaaataaagg
     1741 caagcataat ctccttggtc ctgattggaa ctgtatgccc cagatgacca ccttcattgg
     1801 tgaaggcgaa caagaagccc aaatcacata tatagattct aagcagaaga cagttgagat
     1861 gacagacagc accttgtgtc ccaaagagca ccggcactta tatatcgaca actcatacag
     1921 ttcagatgaa cttaaccagc cgctgactca gccaggtgat gccccctgtg aggccgacta
     1981 tagaagtcta gctcagcggt cccttttgac cctctcagga ccagacactc tgaagaaagc
     2041 acaggaatct ccgcgaggag ctaaagtgtc ctttattttt ggagatcttg ccttagatga
     2101 tggcatgagt cccccaacta taggctatga aagaatgtta gaggagaatc cagaaatgct
     2161 ggagaagcag aggaatctct acatcagcag tgccaatgac atgaagaacc tggacctcac
     2221 tccagacaca gacagcatcc agtttgtggc aaattctgta tatgcaaaca taggtgatgt
     2281 gaagaacttt gaggcccctg aggggataga ggagcccctc ttacatgaca tctgttatgc
     2341 agaaaatacg gacgatgcag aagatgaaga tgaggtgagc tgcgaggagg acctcgtggt
     2401 gggtgaaatg aaccaaccag ccatccttga cctgtccggg tcaagtgatg acattattga
     2461 cctcacaacc ctgcctcctc cagaaggaga tgacaatgag gatgacttcc tcctgcgttc
     2521 tctgaacatg gccatcgctg ctcccccacc tggctttaga gacagttctg atgaagagga
     2581 cactcagagc caggcaacgt ccttccatga ggacaaagaa caaggcagca gcctgcagaa
     2641 tgaggagatc cctgtgtccc tcattgatgc tgtgcccacc agtgcagagg gcaagtgtga
     2701 gaagggactg gaccctgccg tcgtttccac actggaagcc ctagaagctc tttcagaaga
     2761 acagcagaag agtgaaaatt caggtgtagc catcttgcga gcttatagtc ccgagtcttc
     2821 atcagactcg ggcaatgaga ctaactcttc tgaaatgaca gagggttctg agctagctgc
     2881 agcacagaag cagtcggaaa gcctctcccg catgttcttg gccactcatg aaggctatca
     2941 ccctctggca gaagagcaga cagagttccc cacctccaaa gccccctcag tgggcttgcc
     3001 tccaaagtcc tcccatggcc tggctgctcg cccagcgacc gacctcccac ccaaagttgt
     3061 gccttccaag cagatccttc actcagacca catggaaatg gagccagaaa ccatggagac
     3121 caagtctgtc actgactatt ttagcaaact gcatatgggg tcagtagcat attcctgtac
     3181 cagcaaaagg aaaagcaagc ttcctgaggg agaggggaaa tcccccctga gtgggaatat
     3241 accagggaaa aaacagcagg gaaccaaaat agcagagata gaggaggaca ccaaaggcaa
     3301 agctggcact gtgtcttcaa gagacaatcc acacctcagc acttttaacc tagagagaac
     3361 tgcctttcgc aaggacagcc aaagatggta tgtggcctct gatggtgggg tggtagagaa
     3421 aagtggaatg gaagcaccag ccatgaaagt ctttcccaga ggtccaggct tgggtaacag
     3481 agaggctgaa gggaaagagg atggcactgt ggaaggaggg gctgatgatg cttcagtact
     3541 tggccaaggg gaccgcttcc tcacagacat ggcctgtgta gcctcagcca aagacttaga
     3601 taaccccgaa gatactgact ctccctcttg tgaccatgcc actaagcttt ctgaggctga
     3661 agacaatgtg gcccgccttt gtgactacca tttggccaag cgaatgtcat ccctgcagag
     3721 tgagggccat ttttctctac agagctctca aggctcttca gtggacacag gctgtggacc
     3781 gggcagcagt agcagtgcct gtgccactcc tgtggaatcg cccctctgcc cgtccatggg
     3841 gaagcacatg attccagatg cttctgggaa aggagggaga tatatttcac cagaggagag
     3901 agcccctggc catcccaacc atggagccac cttcgaggaa ctgcacccac agacagaagg
     3961 gatgtgtcca cgcatgacag tgcctgctct gcacacagcc attaatgccg accccctgtt
     4021 tggcactttg agagatggat gccatcgact gcccaagatt aaggaaacca cagctttgac
     4081 agagcctggg aaggagagac aaggaggcat gccttcagct tggtctccac atcctgaagc
     4141 tgatcccatc ctgctaccat caaatattca cttggaatca aaggtgccaa gcccaaatca
     4201 agaccctaat gatttctccc aaggaatcca ggcattcgga gaggctgtga gctggtggcc
     4261 agcagatctg agagggggga gccccaggac accccccagc cagagggctc tcagacatag
     4321 cagcagaatc ctctcaggac ccgtaggttt ggagaccttc caagagagaa ccaagggtgt
     4381 agtcagcttg aagtatccag gtatcacaga agcacaggag gtcagttcag aaagacgagc
     4441 agaactccct ctggggaaga agctcaccaa aagtttttcc caaagctcaa tgcactttat
     4501 ctctgaggga aagtttcaca aaaggtcccc catgtctcat aaagactcaa aggtgtatag
     4561 gaccctaccc ttacggaagc tggaaagcag caactggaga tgtcgaggac ccttcagcta
     4621 ctgttttcta aaccaaggac aggatgaaga tggggatgag gatgaagagg aaggagaggc
     4681 cacccttcag gtctcttgtc tctatcgacc acagataacc caagccatgt cggaaccagg
     4741 taactcatcc ctggttgttg gactgcagaa gcaaggggaa gaactgtcca gagggacagc
     4801 tctgaaggtc tggacagaag acccagatgg cccagatgac ttggacttca gcagtctggc
     4861 ttttgatgcc cggattgcaa gaataaatgc cctaaaggca aacacatatg gaatgcccga
     4921 tgggtttctc gaagcccaaa atgatgccaa tgagctgctc tgccttgtga gggcaaccaa
     4981 ggcaaggaag gaggagtcac gccctgaaac atatgacctt acactttctc agtacaagca
     5041 actgttatcc attgagtcca gacagttggg aagtgcctgt aggaaaatgg caatggccga
     5101 gaaaagccca gaagagatgc tcctagctat gagttccagt tttcaagtgc tctgttgcct
     5161 aacagaagct tgcatgcggt tagtgaaagt cgtgaacact gaaacacagc ggcaagaaat
     5221 tgtagcaaag attgatgaag tggtcataaa ctatatttgt ctcctgaaag ctgctgaggc
     5281 agccactggc aagaccactg gggatcctaa tattggacta tcgatgcgac attcaaccac
     5341 catggccgct cttgtaagca cactaacacg ttctctcaag atgcttttaa ataaataaat
     5401 atggaagtca catcataatc tatctttgca aagccataca tgaacttttc tttactttct
     5461 gtgtacaatg aacagatgtc tcctttcttc tctctgtata ttttgttctt ttatataaaa
     5521 taggagatag aagttacatt gatgaaatgt tgaaaagtct caatcagata tattctgttt
     5581 atattataca aatatacatg tagaaggaat atatgagaaa atgatgacat ttgactattt
     5641 ttcatgtagt caaaactcta agcatatgat atgaaatttt aaattctaca ttgttagagg
     5701 aaaacaatga atcctatccc ctttccttcc aaatggatac ttggagaccc tatcattcat
     5761 atttagaaga aaagccaaaa gaaacagaat agaaaagaaa tcaaaatgta tataaaatag
     5821 ttcccgtgtt ttaaaatcat aatttttaaa cattggaagt agcaaaaata tatttaaaat
     5881 tcaagaagct aatatgaatt actagaaaat atataataaa ttaacttttt gctcatagtg
     5941 ttttgttatt ggatgctttc ttccaagaat ccccacatat tcaattttgg tttatgctat
     6001 ttgggctaca gattggcagg ggtgggcaga ttccattgtg tcagcataaa tgctttttat
     6061 agtatttcta gacttaaaaa gttcccccaa ataaaagaac aggggaaatt atgggcagga
     6121 tcctaggcaa taactaaagg tataggttgt ctaattacat aaaataaatg gaattagtaa
     6181 tgccaaaatt aaattgtttg atgaaaagag agatctgctt tgactcaatg tcaaaataca
     6241 taaaccgaag gcattatttc cttccaactc aaccatgaag cttactattt cctttcaaga
     6301 acacctagta aagtgtttgt agaattacac aaaagcagat ttaatgagca caaaaagtgc
     6361 agacccagca atgtaaatca gagcgcaccc cagcacctgg gaagcacagc tcagccttca
     6421 actcttagtc ctcagctcca tgaagggctt cctgttgccc ctctctgaca ggagcatggc
     6481 tagcaacaaa acgtggaaag acagcctact actgggacaa aatttcaaat ctagagtgtt
     6541 ccagaaaatc aagtagagat gactactctc ataattgaaa ccatgattca aaaggtagta
     6601 tttacctaat gagtacttca tttggcagat agaaatacaa aatctgacag aaacatggca
     6661 aatttgacta ttttaagtga aactaaggga atacaaaggt gtgttctgaa ctgtcatcac
     6721 tcaaattata tctttgggtc aaaacaaaag aaggcaaact cttcaatcat aagttaaatt
     6781 gatatgtaca tatgtagttt ctggatcact ctgtagtcaa gctccccaat tcctatttct
     6841 gtaaatggct tagaataaga gtagtatagc aagaatcaat atttcccatt ttgtagcctg
     6901 ccatgcagga gacctagcaa ggtctacagt tgctatttct ctctggtcag ccattcattc
     6961 cacagagact cagcaaatgc aacaccacag atttacagat tgtaaccaat gaaaggagtt
     7021 cagatatacg ttgttataaa taatgtttga ttaaataata aaacattatt tcattacaat
     7081 tctaaatatt tggtgttttg ctgttgagag acattagtgg tgtttactgt ggaaaatctt
     7141 agcaaatatt ctgtgtacta taatacaaac aataatagga tgtgtgctct gtgtcagaca
     7201 atgtgctaaa cattattatc acatgtatta tctcatttaa tcatgtctat gatctcttgg
     7261 tttggacact atcattagtt ccttctggag gcattatggt ttactagtta tgaaatgtgg
     7321 ggcttgggat cagaaacatc ttgatttaaa ttttggtcct gccattccct agccctttca
     7381 tcttgggaaa gctatctttt ctttttcagt cttgatttcc ttattgtgaa atggacttca
     7441 atcatgagat ctatttccat agggttttca caagttttaa gtaaaattgt gtattgtaaa
     7501 gttcttacca caatatctga tggagaataa gtattcaatg ttagatatta taattatcat
     7561 aattgttgtg ttaaacatat tgcccaagat actgtgtgga ggatgtttgt tttcgatgca
     7621 tactgtatcc tgattgtgtg cagaacacat ttgtgtgtag tgcatactct gaaaagaagc
     7681 atacagggaa atgatggtct gttttcaaat tgcaaatcta gctagaacaa cttcctactc
     7741 cattgtggtt ctttgagaag cctcagggaa atagctctgg gtctttctag ccaatctcta
     7801 atttcctgtg actactccag taagtttctg ttctcctaaa gcaagtcttt actattcaaa
     7861 aatctcaaaa ggccccctca ccttcattaa gcatggggct cctaactgga gttcatgtcc
     7921 attagagtat aggaagaaca tactagaatg atacttgtgt ttatttttat ctagtttttt
     7981 tatgtttgtg tatgttttat aatggcataa tagtacagtg gtacatgtac ataattttaa
     8041 ataaataaat aaacaaataa acaa
//
