LOCUS       NM_026169               3166 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus FERM domain containing 8 (Frmd8), mRNA.
ACCESSION   NM_026169
VERSION     NM_026169.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3166)
  AUTHORS   Yu,M., Wu,W., Sun,Y., Yan,H., Zhang,L., Wang,Z., Gong,Y., Wang,T.,
            Li,Q., Song,J., Wang,M., Zhang,J., Tang,Y., Zhan,J. and Zhang,H.
  TITLE     FRMD8 targets both CDK4 activation and RB degradation to suppress
            colon cancer growth
  JOURNAL   Cell Rep 42 (8), 112886 (2023)
   PUBMED   37527040
  REMARK    GeneRIF: FRMD8 targets both CDK4 activation and RB degradation to
            suppress colon cancer growth.
REFERENCE   2  (bases 1 to 3166)
  AUTHORS   Badenes,M., Burbridge,E., Oikonomidi,I., Amin,A., de Carvalho,E.,
            Kosack,L., Mariano,C., Domingos,P., Faisca,P. and Adrain,C.
  TITLE     The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates
            inflammation and tumor growth
  JOURNAL   Life Sci Alliance 6 (4), e202201644 (2023)
   PUBMED   36720499
  REMARK    GeneRIF: The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates
            inflammation and tumor growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3166)
  AUTHORS   Haxaire,C., Hakobyan,N., Pannellini,T., Carballo,C., McIlwain,D.,
            Mak,T.W., Rodeo,S., Acharya,S., Li,D., Szymonifka,J., Song,X.,
            Monette,S., Srivastava,A., Salmon,J.E. and Blobel,C.P.
  TITLE     Blood-induced bone loss in murine hemophilic arthropathy is
            prevented by blocking the iRhom2/ADAM17/TNF-alpha pathway
  JOURNAL   Blood 132 (10), 1064-1074 (2018)
   PUBMED   29776906
  REMARK    GeneRIF: results suggest that blood entering the joint activates
            the iRhom2/ADAM17/TNF-alpha pathway, thereby contributing to
            osteopenia and synovitis in mice.
REFERENCE   4  (bases 1 to 3166)
  AUTHORS   Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and
            Freeman,M.
  TITLE     FRMD8 promotes inflammatory and growth factor signalling by
            stabilising the iRhom/ADAM17 sheddase complex
  JOURNAL   Elife 7, e35012 (2018)
   PUBMED   29897336
  REMARK    GeneRIF: FRMD8 promotes inflammatory and growth factor signaling by
            stabilizing the iRhom2/ADAM17 sheddase complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3166)
  AUTHORS   Oikonomidi,I., Burbridge,E., Cavadas,M., Sullivan,G., Collis,B.,
            Naegele,H., Clancy,D., Brezinova,J., Hu,T., Bileck,A., Gerner,C.,
            Bolado,A., von Kriegsheim,A., Martin,S.J., Steinberg,F.,
            Strisovsky,K. and Adrain,C.
  TITLE     iTAP, a novel iRhom interactor, controls TNF secretion by policing
            the stability of iRhom/TACE
  JOURNAL   Elife 7, e35032 (2018)
   PUBMED   29897333
  REMARK    GeneRIF: iTAP (FRMD8) is a novel iRhom2 interactor that controls
            TNF-alpha secretion by policing the stability of iRhom2/ADAM17
            complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3166)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (bases 1 to 3166)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083902.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026169.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083902.1, AK148434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3166              AK083902.1         3-3168
FEATURES             Location/Qualifiers
     source          1..3166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3166
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="FERM domain containing 8"
                     /db_xref="GeneID:67457"
                     /db_xref="MGI:MGI:1914707"
     exon            1..118
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            119..203
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            204..371
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            372..473
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            474..532
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            533..699
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            700..924
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1048
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1397
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..3166
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2836..2841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="hexamer: AATAAA"
     polyA_site      2854
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="major polyA site"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="hexamer: AATAAA"
     polyA_site      2899
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="major polyA site"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
ORIGIN      
        1 gaatcgaccc tgggcaggac cggagacccc gccggccggt gtggtggtgg gtccagaact
       61 ggaggcctga gtcgggtggc attctggagt gaggcagtgg gctctgcgac cctgcaagat
      121 ggagggggca gaaggcaacg cggggcagcc cggccctgcg gagcggtccc accgaagtag
      181 cgtctcttca gtgggtgccc gagcagccga tgtcctggtg tacctggcgg atgatacagt
      241 agtgcccctg gccgtggaga atttgtcctc aatcagtgcc catgagctgc accgcgcagt
      301 ccgtgaagtc ctgcagctcc cagacgtggc tttggaggcc tttgcactct ggctcgtctc
      361 ccctctcttg gaggtgcaat tgaaacccaa gcaccagccc tataaactgg gccgccagtg
      421 gccggagctg ctgctgcgct tcaccaacgc ctccgatgat gatgtcgcca tggatgagcc
      481 ttcccttcag ttccgaagga atgttttttt cccaaggcgc cgagagctcc agatccatga
      541 tgaggaggtc ttgcggctgc tctatgagga agccaagggc aatgtgctga ccgctcggta
      601 cccttgtgac ttggaggact gcgaggtgct gggtggcctt gtgtgccgtg tgcagcttgg
      661 gccctaccag cctggccagc ctgccgcctg cactctgaga gagaagctgg actccttcct
      721 ccctgcccac ctctgcaagc gagggcatgg cctctttgct gccttccggg gccgtggggc
      781 caagactggg ccaggtgagc aaggcctgct gaatgcctac cgccaggtaa aggaagtgac
      841 aggcaacaac agtgaacgtg aggccacctt gggctcccac taccgcgcat acctcctcaa
      901 gtgccacgag ctgcccttct acgggtgtgc cttcttccat ggcgaggttg acaagccagc
      961 ccagggcttc ttgcatcgag gtgggcgcaa accagtgact gtggccatca gtctggaggg
     1021 tgtgcacgtc atcgacaaca gggagaagca tgtgctgctg ggcctgcgct ttcaggagct
     1081 gtcgtgggat cacacttccc ctgaggagga agagcctgtc ctgtggctgg agttcgatgg
     1141 tgacagtgag ggcacgcctg tcaacaagct gctaaggatc tactccaagc aggctgagct
     1201 gatgagcggc ctcattgagt actgcattga gctgagccag gctgccgagc ctactctttc
     1261 ccaggagagt gcatccggcc ctcacgaagc tcccagcccc tctccacctc ccacccagcg
     1321 ccccaagctg cgaaggcagg gtagcgtggt gtgtagccgg attcagcatc tctctaccat
     1381 tgactatgtg gaagacggca aggggatcaa gcgggtgaaa ccaaagcgaa ccacctcctt
     1441 cttcagccga cagctctcct ccagccaggg aagctacacc gtggtgcagc ccaccgacga
     1501 cagcctggag cagagctgag ggaagccacg gccagcagca ggaggacatc tgggtgccct
     1561 agacacaacc aggcacagcc ctaggcaggg ccaggccaca ctcgtctcag atgctgtggg
     1621 cctgggtggg gtgctgtgca gggtctgctg gagtttcaga ccatggaaaa ctgacatcca
     1681 agccttccct gagcctggtg tgggtagagc tgtgctccag ccctttctac agcctgcctc
     1741 ttcctctgct ccaggctggc agctgacaaa ccctgctgcc ctcctgctct tccccaagtg
     1801 cactggtctt ccctctggag ggactgctgg cggttccgat ggcaggtgac tgaaggcaga
     1861 gcttgggacc tgcaagttca gtgtttgcct tcggtcatgg gcccttggtg actttatctt
     1921 gcattccttc tgctgacatt ccaccatgct ggccggccag gctgccacct tttcccctaa
     1981 gttatgttgg aactggaggg cacctctgca ggctaacccc tttcttgttg gcctttactg
     2041 atgtctctgt gctgaatggt ggctctccta ggaaccggtt ccatgctgca cataggaaaa
     2101 gcccttacat gtccctgggc tggattggct gtcccatacc aaccagttcc tttgttttcc
     2161 tgtgatctgg gtttaagggt tagattttgc cttgtctcct gtgctctgag ctgataaagc
     2221 ctggggcgtg gcaactccga attgcactgc actgtgggat tccctgaggc cagccacagc
     2281 ggctcaagcc acctctctcc gaaggacatc gcaaaggcct atctgtcccc agctctgcac
     2341 ccctggcagc cttgactgct cctgggaaga gctagttctg ggagtggagc tgtcctggcc
     2401 cttaagccct ttgtactccc tgggaatccc cactggatcc cagagacata gcttagcttt
     2461 gtcttcttgg tggaaagcca cagaaatgga aaccatcatc tctgaaaatg aaaccagttt
     2521 gcctgccagt gagctccaga agttttggca gcagagagaa agaaaaggct gacctcacta
     2581 taaggcattg tctgtaagat gatgtcacct gccactgtag ttaacccttt aggagccttg
     2641 tgtgttccct gagctaccag cccactcttg gcaaccttta ggtcatcttg actgctgttg
     2701 atggcttcag atcattatgt gaggggccca gatgcgtgtg cacaggtaca caaactctac
     2761 atttccattt gagcctttga gttttttaat taccacatgt gccttaaccc tctaggacag
     2821 agcactgttt tactaaataa atgtcttgag tgttcccagt ctttcctatc actggactta
     2881 ataaaatcat cacctagcac actttggaat ggttataata tggaatagcc agagtatggt
     2941 aaccacacgt gtcctgtgtg cccatggtat agcctcaggt cttcacccca gtaaaatctc
     3001 atctggtagc tcctggggac cggtctccag gtctccatag gaaccaggtc tgggaagact
     3061 tgggctcact tctgtctggg aggaacctgt acttccccca ctgcaagctg tggcagcagc
     3121 gatgtttgga gctttggccc tatggaataa agaccagagg ttgcag
//
