LOCUS       NP_080445                466 aa            linear   ROD 27-APR-2025
DEFINITION  FERM domain-containing protein 8 [Mus musculus].
ACCESSION   NP_080445
VERSION     NP_080445.1
DBSOURCE    REFSEQ: accession NM_026169.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Yu,M., Wu,W., Sun,Y., Yan,H., Zhang,L., Wang,Z., Gong,Y., Wang,T.,
            Li,Q., Song,J., Wang,M., Zhang,J., Tang,Y., Zhan,J. and Zhang,H.
  TITLE     FRMD8 targets both CDK4 activation and RB degradation to suppress
            colon cancer growth
  JOURNAL   Cell Rep 42 (8), 112886 (2023)
   PUBMED   37527040
  REMARK    GeneRIF: FRMD8 targets both CDK4 activation and RB degradation to
            suppress colon cancer growth.
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Badenes,M., Burbridge,E., Oikonomidi,I., Amin,A., de Carvalho,E.,
            Kosack,L., Mariano,C., Domingos,P., Faisca,P. and Adrain,C.
  TITLE     The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates
            inflammation and tumor growth
  JOURNAL   Life Sci Alliance 6 (4), e202201644 (2023)
   PUBMED   36720499
  REMARK    GeneRIF: The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates
            inflammation and tumor growth.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Haxaire,C., Hakobyan,N., Pannellini,T., Carballo,C., McIlwain,D.,
            Mak,T.W., Rodeo,S., Acharya,S., Li,D., Szymonifka,J., Song,X.,
            Monette,S., Srivastava,A., Salmon,J.E. and Blobel,C.P.
  TITLE     Blood-induced bone loss in murine hemophilic arthropathy is
            prevented by blocking the iRhom2/ADAM17/TNF-alpha pathway
  JOURNAL   Blood 132 (10), 1064-1074 (2018)
   PUBMED   29776906
  REMARK    GeneRIF: results suggest that blood entering the joint activates
            the iRhom2/ADAM17/TNF-alpha pathway, thereby contributing to
            osteopenia and synovitis in mice.
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and
            Freeman,M.
  TITLE     FRMD8 promotes inflammatory and growth factor signalling by
            stabilising the iRhom/ADAM17 sheddase complex
  JOURNAL   Elife 7, e35012 (2018)
   PUBMED   29897336
  REMARK    GeneRIF: FRMD8 promotes inflammatory and growth factor signaling by
            stabilizing the iRhom2/ADAM17 sheddase complex.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Oikonomidi,I., Burbridge,E., Cavadas,M., Sullivan,G., Collis,B.,
            Naegele,H., Clancy,D., Brezinova,J., Hu,T., Bileck,A., Gerner,C.,
            Bolado,A., von Kriegsheim,A., Martin,S.J., Steinberg,F.,
            Strisovsky,K. and Adrain,C.
  TITLE     iTAP, a novel iRhom interactor, controls TNF secretion by policing
            the stability of iRhom/TACE
  JOURNAL   Elife 7, e35032 (2018)
   PUBMED   29897333
  REMARK    GeneRIF: iTAP (FRMD8) is a novel iRhom2 interactor that controls
            TNF-alpha secretion by policing the stability of iRhom2/ADAM17
            complex.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 466)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083902.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083902.1, AK148434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     Protein         1..466
                     /product="FERM domain-containing protein 8"
                     /note="iRhom tail-associated protein"
                     /calculated_mol_wt=51697
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZ67; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5U2R3; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Region          136..273
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          379..409
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZ67; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZ67; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            420
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZ67; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Region          442..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UFK8.2)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZ67; propagated from
                     UniProtKB/Swiss-Prot (Q3UFK8.2)"
     CDS             1..466
                     /gene="Frmd8"
                     /gene_synonym="1200004M23Rik; 2310035N23Rik;
                     4931429L16Rik; iTAP"
                     /coded_by="NM_026169.4:119..1519"
                     /db_xref="CCDS:CCDS29481.1"
                     /db_xref="GeneID:67457"
                     /db_xref="MGI:MGI:1914707"
ORIGIN      
        1 megaegnagq pgpaershrs svssvgaraa dvlvyladdt vvplavenls sisahelhra
       61 vrevlqlpdv aleafalwlv spllevqlkp khqpyklgrq wpelllrftn asdddvamde
      121 pslqfrrnvf fprrrelqih deevlrllye eakgnvltar ypcdledcev lgglvcrvql
      181 gpyqpgqpaa ctlrekldsf lpahlckrgh glfaafrgrg aktgpgeqgl lnayrqvkev
      241 tgnnsereat lgshyrayll kchelpfygc affhgevdkp aqgflhrggr kpvtvaisle
      301 gvhvidnrek hvllglrfqe lswdhtspee eepvlwlefd gdsegtpvnk llriyskqae
      361 lmsglieyci elsqaaeptl sqesasgphe apspsppptq rpklrrqgsv vcsriqhlst
      421 idyvedgkgi krvkpkrtts ffsrqlsssq gsytvvqptd dsleqs
//
