LOCUS       NM_001190332            4708 bp    mRNA    linear   ROD 12-OCT-2024
DEFINITION  Mus musculus FERM domain containing 7 (Frmd7), mRNA.
ACCESSION   NM_001190332 NM_001037750 XM_001477880 XM_358204 XM_913833
VERSION     NM_001190332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Mullner,F.E. and Roska,B.
  TITLE     Individual thalamic inhibitory interneurons are functionally
            specialized toward distinct visual features
  JOURNAL   Neuron 112 (16), 2765-2782 (2024)
   PUBMED   38917805
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Arvin,S., Rasmussen,R.N. and Yonehara,K.
  TITLE     EyeLoop: An Open-Source System for High-Speed, Closed-Loop
            Eye-Tracking
  JOURNAL   Front Cell Neurosci 15, 779628 (2021)
   PUBMED   34955752
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Rasmussen,R.N., Matsumoto,A., Arvin,S. and Yonehara,K.
  TITLE     Binocular integration of retinal motion information underlies optic
            flow processing by the cortex
  JOURNAL   Curr Biol 31 (6), 1165-1174 (2021)
   PUBMED   33484637
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Salman,A., Hutton,S.B., Newall,T., Scott,J.A., Griffiths,H.L.,
            Lee,H., Gomez-Nicola,D., Lotery,A.J. and Self,J.E.
  TITLE     Characterization of the Frmd7 Knock-Out Mice Generated by the
            EUCOMM/COMP Repository as a Model for Idiopathic Infantile
            Nystagmus (IIN)
  JOURNAL   Genes (Basel) 11 (10), 1157 (2020)
   PUBMED   33007925
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Yonehara,K., Fiscella,M., Drinnenberg,A., Esposti,F., Trenholm,S.,
            Krol,J., Franke,F., Scherf,B.G., Kusnyerik,A., Muller,J., Szabo,A.,
            Juttner,J., Cordoba,F., Reddy,A.P., Nemeth,J., Nagy,Z.Z.,
            Munier,F., Hierlemann,A. and Roska,B.
  TITLE     Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a
            Neuronal Circuit Asymmetry for Direction Selectivity
  JOURNAL   Neuron 89 (1), 177-193 (2016)
   PUBMED   26711119
  REMARK    GeneRIF: FRMD7 as a key regulator in establishing a neuronal
            circuit asymmetry
REFERENCE   7  (bases 1 to 4708)
  AUTHORS   Pu,J., Mao,Y., Lei,X., Yan,Y., Lu,X., Tian,J., Yin,X., Zhao,G. and
            Zhang,B.
  TITLE     FERM domain containing protein 7 interacts with the Rho GDP
            dissociation inhibitor and specifically activates Rac1 signaling
  JOURNAL   PLoS One 8 (8), e73108 (2013)
   PUBMED   23967341
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4708)
  AUTHORS   Li,Y., Pu,J., Liu,Z., Xu,S., Jin,F., Zhu,L., Tian,J., Luo,J. and
            Zhang,B.
  TITLE     Identification of a novel FRMD7 splice variant and functional
            analysis of two FRMD7 transcripts during human NT2 cell
            differentiation
  JOURNAL   Mol Vis 17, 2986-2996 (2011)
   PUBMED   22128244
  REMARK    GeneRIF: A novel splice variant of FRMD7 (FRMD7-S) with a shortened
            exon 4 relative to the original form of FRMD7 (FRMD7-FL) was
            identified from the cDNA of the human NT2 cell line and mouse fetal
            brain.
REFERENCE   9  (bases 1 to 4708)
  AUTHORS   Betts-Henderson,J., Bartesaghi,S., Crosier,M., Lindsay,S.,
            Chen,H.L., Salomoni,P., Gottlob,I. and Nicotera,P.
  TITLE     The nystagmus-associated FRMD7 gene regulates neuronal outgrowth
            and development
  JOURNAL   Hum Mol Genet 19 (2), 342-351 (2010)
   PUBMED   19892780
  REMARK    GeneRIF: FRMD7 expression is spatially and temporally regulated in
            human and mouse brain during embryonic and fetal development.
REFERENCE   10 (bases 1 to 4708)
  AUTHORS   Self,J., Haitchi,H.M., Griffiths,H., Holgate,S.T., Davies,D.E. and
            Lotery,A.
  TITLE     Frmd7 expression in developing mouse brain
  JOURNAL   Eye (Lond) 24 (1), 165-169 (2010)
   PUBMED   19265863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670230.12.
            
            On Dec 6, 2019 this sequence version replaced NM_001190332.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.61493.1,
                                           SRR7345562.2519526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL670230.12        84321-84436         c
            117-221             AL670230.12        57845-57949         c
            222-264             AL670230.12        57013-57055         c
            265-343             AL670230.12        54247-54325         c
            344-441             AL670230.12        51418-51515         c
            442-556             AL670230.12        43662-43776         c
            557-704             AL670230.12        43346-43493         c
            705-800             AL670230.12        41993-42088         c
            801-964             AL670230.12        40391-40554         c
            965-1033            AL670230.12        39111-39179         c
            1034-1109           AL670230.12        38917-38992         c
            1110-4708           AL670230.12        34310-37908         c
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 27.82 cM"
     gene            1..4708
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /note="FERM domain containing 7"
                     /db_xref="GeneID:385354"
                     /db_xref="MGI:MGI:2686379"
     exon            1..116
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2171
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /codon_start=1
                     /product="FERM domain-containing protein 7"
                     /protein_id="NP_001177261.1"
                     /db_xref="CCDS:CCDS53067.1"
                     /db_xref="GeneID:385354"
                     /db_xref="MGI:MGI:2686379"
                     /translation="MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFG
                     LEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQI
                     KKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQ
                     FHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNT
                     KINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHA
                     FFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHE
                     RQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAE
                     LEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFAD
                     SHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRP
                     DSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDA
                     FAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTV
                     LIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETI
                     SFATPGAEDRTLLKPCNYFLA"
     exon            117..221
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            222..264
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            265..343
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            344..441
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            442..556
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            557..704
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            705..800
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            801..964
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1033
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1109
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..4708
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /note="major polyA site"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
                     /note="hexamer: ATTAAA"
     polyA_site      4708
                     /gene="Frmd7"
                     /gene_synonym="EG665849; Gm1533"
ORIGIN      
        1 gtcacagctc ccacagccat ctgaatctac ttgctcgcag cccaacggcc tcgctgagga
       61 tgctccattt aaaagtgcag tttttggatg attcccagaa gatttttgtg gttgatcaaa
      121 aatcatctgg aaaggcgctc ttcaacctga gctgcggcca tctcaatctt gctgaaaagg
      181 aatattttgg actagaattc tgcagccatt ctggaaataa tgtttggttg gaacttctga
      241 agcccataac gaagcaagtc aaaaatccta aggaggttgt tttcaaattt atggtgaaat
      301 ttttcccagt ggaccccgga catcttcggg aagaactcac aaggtatctt tttactcttc
      361 aaataaagaa ggatttggct ctgggaaggc ttccatgcag tgacaactgc acagctttaa
      421 tggtgtcgca catcttacag tcagaattag gagacttcca tgaagaaaca gttaggaaac
      481 atctggtgca aacacagtac ttaccaagcc aagccagttt agagagcaag atcatgcaat
      541 ttcatcagca gcacataggc cggagcccag ctgaatcaga cattctgcta ctggacatag
      601 caaggaagct ggatatgtat ggcatcagac cgcagcccgc cagtgatggt gaagggatgc
      661 agattcacct ggctgttgct cacatgggag tattggtgtt acggggaaac acaaagatta
      721 acaccttcaa ctgggctaag attcgcaagc tgagttttaa gagaaagcat tttctcatca
      781 aacttcatgc taatattttg gtgttgtgca aagacacttt ggagttcacc atggccagcc
      841 gagatgcatg caaggctttc tggaagactt gcgtagagta ccatgctttc ttcaggctct
      901 ccgaagagcc caaatcaaag cccaaaacac tactctgtag caaaggttcc agtttccgct
      961 acagtggaag aactcaaagg caacttttgg aatacgggaa aaaggggaga ttaaagagcc
     1021 tgccgtttga aaggaaacag tacccatctc agtatcatga acggcagtgc agatcatcac
     1081 cagacattct ctctgatgtg tcaaaacaag tggaagatct gagactgaca tatggcagca
     1141 gctactaccg aaatgtcaat ggggtgcatg catctgagtc tatgctagac agtaggagga
     1201 ggaactctgc agttgaagtg acctttgcag ccgagctgga gcattctaaa ccggaggcag
     1261 aggccacatc gctccaccca tcccaaagca gttcctcctt caccttcatt tatgcagatc
     1321 ctgtctttaa cactgaccct gagcccatag agttctttga ggagcggagt cctctaagct
     1381 ccttccaaac aacctccaag tttgcggata gtcacacaag caaagcgagt ccagcaaggc
     1441 agctaacata caccgatgta ccctatattc cttgtactag tcagaaggtt gatattatgc
     1501 ctccccaagt ctttttttat gtggacaagc caccccaggt acccagacgg tctctgatca
     1561 tggcagagga aaatatgaga ccagacagct atgtagatca tagtgcaata aaaccagcta
     1621 aaaggagccc aaggaatatg aggataaaaa gcttacagca agaccttcaa gaactccaag
     1681 aagctatggc tagaactagt ggtagaagca atatcaatgt agagccagag gaggaagatc
     1741 cacatttaga tgatgcattt gcatataacc ttcaagagca aactcctaaa cgatctcaaa
     1801 gccaatcaga catgaaaact atccgttttc cttttgggtc agaatttaga cctttaggac
     1861 catgtcctgc tctgactcgt aaaaccgatc tgtttgcatg tacgtttgca gagcaggagt
     1921 tcccaacagt cctaatagat cagagctcag cagaaaggta tgtagctagt gagtccagtg
     1981 attcagaatc agaaattatt aaaccagact actatttttt gtatggcaaa ggaacaaagt
     2041 cacccagggc ccgaatccgc ttgtcgtctg gtagtctgca gctagaagaa gaggatgaaa
     2101 ctatttcttt tgcgacgcca ggcgctgaag ataggacttt gctaaagcca tgcaattatt
     2161 tcttagctta aaagagtgac tctgtgaatg ttcctggccc agttctcagt taccacctta
     2221 ggtaagacat aagaagccct tttgatccat cttttcctta gtcatcttaa ttgatggtaa
     2281 gatggtgtga aagatcaagc tgcagcctct ttccatgagc ttctttcttt tatttcctcc
     2341 aaaaagactc ggaaccatgc cttcttctcc ccagcactat ggcagtgcaa catcagtgga
     2401 tgacatacca ctatacattt ccttgggcag ccattattag tgaagatcca ttcttcaatg
     2461 gcgaagaaca atgaagtggg ttggtacatg ggactggctt ctaaaaccac cttgtgattt
     2521 agtagtccat gactatgttg gttatttttg tgattaggta acttgtttgg gacccagtga
     2581 acagtcttgt tatatactaa gaatgtcaat ttttttaaac atatacatag gtgagtagca
     2641 taaatcctct cagcacatgg taagaatcaa tagaggattt aacagatttc tcaatgcagg
     2701 aaattcatgg attaggccca tttctcaagt gaactgtgtg cctgatgagg atattaaggt
     2761 gtttgacttc tgatttctcc taattactta ttatataagg tgtgatcaat gttaacaggc
     2821 aagtttgttt attaatttct cctgccagaa tttatttttt tgccgtaagt ttgttgcatg
     2881 catgtaggca aggatatgag gtgtgatttt aataaagagt agtggaaaat ccactcaaac
     2941 agaagttatg aatatggcct tctttttact ttaacaaaat ccagaagtag ttggtcctgg
     3001 cctatatcta acaagacaga gaatggacaa aggacagagt caagggaaaa aagtatggtc
     3061 aggggtagag aagtagcaat aggcgtgact gctatgaaaa gtggcagcag tcacatcaga
     3121 ctcagacaga gaaacaacat tttcttgtgt ggttgttgtt ttggattttt accaggagcc
     3181 aaggctgggc tccaactcat gatcctcttg cctcagcctc ctgtgtgctg ggggttccag
     3241 tgatggacta cagtgttaaa aatcaatttg agtcctctaa aaaaacgtta agtgcatgca
     3301 tatttaactg aatgcatgaa tagacaccat gtgcatgctt gctgcccata gaagccagaa
     3361 gatggggtgg gatcccctgg aaccggagtt agcagacagt tgtgaactgc catggtggca
     3421 tcgggaaccc aacctagatc ttctgttgac gtggccagtg gtcttaagca ctgaacaatc
     3481 tcttagccct caaaattcca ttcttgaccc attaaatatt tgcctttcag tcctcttggg
     3541 aggctactga agaaccttgt tgataatctt aaatcaacat attttgaaga ccacgttaag
     3601 tgtaaatgtc aaagaagtga attgattaca tagacaagca attttatgtg tgatttgata
     3661 agaaaaggta gactatacaa ttcttttgtc tctacatcag taataaaaac tttaatatac
     3721 cttattccac tccctttttc tcttcccgga cacaaattca ctaagacacg agtgtagagt
     3781 agttatttca aactgagaat acactgaaac ttgaccactt acacaaaatt tctgtaggtt
     3841 tttactttct taaaaaaaaa agtacctgta atcttttccc caggagaaac tcaaaatctt
     3901 gcgagttaga tgctatttct catcttattt tcatttgaaa acttttgcta aatgtatatt
     3961 ttccttaaga actataaagt ttaaatctgt atatgatctt ttattaaaat agtaattaag
     4021 gggatcgtta aattagccat ctgaagacac ttttaaaagt actattaaga gttttatggt
     4081 aggaggaaga aatcaggata tatatcttca gctatataaa tacagtcaat tcttagtaac
     4141 ttttagtttc aatggaagcc ttggttatgt tccaataata aaaaagaact attataaatt
     4201 aattagaata acatatcaga cccaccctca agaaaacaaa catcgaggat cataaaattt
     4261 aaatatttat ttttaaaatc ccccaaacag tgacatatgc ttcacataga aacaggtcta
     4321 cagaactaac gctataatga gtaagcaata ccagctgtat ttgggatgca ggcgtgtggt
     4381 acagttttcc ataatcaatt tatgaacttg tttttacttt cacaaaaata tgaatgtcac
     4441 ccattattca agtcacacaa ttatttttag agcactatgg agaacaaact gcgattgagt
     4501 gtcatttaca gcatggacaa aaaaactaaa aatctaacca agtcatcaat tcaaggtaca
     4561 gtcaactcaa agcaacaggt acaggatagg caccaatgaa aagaattttc ttggcataca
     4621 atgttctgcc tttcaaatgt ttgtatttct tttttaaaag aagggatgta attgacattt
     4681 caattaaaaa ctgcattggc tacttgta
//
