LOCUS       NM_001360084            5065 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus FERM domain containing 5 (Frmd5), transcript variant
            1, mRNA.
ACCESSION   NM_001360084 XM_006499269
VERSION     NM_001360084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5065)
  AUTHORS   Lyu,T.J., Ma,J., Zhang,X.Y., Xie,G.G., Liu,C., Du,J., Xu,Y.N.,
            Yang,D.C., Cen,C., Wang,M.Y., Lyu,N.Y., Wang,Y. and Zhang,H.Q.
  TITLE     Deficiency of FRMD5 results in neurodevelopmental dysfunction and
            autistic-like behavior in mice
  JOURNAL   Mol Psychiatry 29 (5), 1253-1264 (2024)
   PUBMED   38228891
REFERENCE   2  (bases 1 to 5065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5065)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5065)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845286.8 and AL928678.16.
            
            On Jan 26, 2018 this sequence version replaced XM_006499269.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.60158.1,
                                           SRR1660815.220818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AL845286.8         46049-46376         c
            329-433             AL928678.16        102474-102578       c
            434-476             AL928678.16        97245-97287         c
            477-555             AL928678.16        96722-96800         c
            556-653             AL928678.16        87138-87235         c
            654-777             AL928678.16        84361-84484         c
            778-865             AL928678.16        79709-79796         c
            866-954             AL928678.16        73701-73789         c
            955-1018            AL928678.16        68640-68703         c
            1019-1110           AL928678.16        68133-68224         c
            1111-1185           AL928678.16        66386-66460         c
            1186-1254           AL928678.16        65081-65149         c
            1255-1361           AL928678.16        64154-64260         c
            1362-5065           AL928678.16        56345-60048         c
FEATURES             Location/Qualifiers
     source          1..5065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.42 cM"
     gene            1..5065
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /note="FERM domain containing 5"
                     /db_xref="GeneID:228564"
                     /db_xref="MGI:MGI:2442557"
     exon            1..328
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1939
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 5"
                     /codon_start=1
                     /product="FERM domain-containing protein 5 isoform 1"
                     /protein_id="NP_001347013.1"
                     /db_xref="CCDS:CCDS89547.1"
                     /db_xref="GeneID:228564"
                     /db_xref="MGI:MGI:2442557"
                     /translation="MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFD
                     LLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPA
                     ALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDPGKHPEGYSSK
                     FQFFPKHSEKLEKKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGN
                     AAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPT
                     PEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKI
                     KREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPV
                     RSSSHGDTFLPHVRSSRADSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQIN
                     GATCSIEEEKESEASTPTATEAEALGGELRALCQGHGGSEQEQVNKFVLSVLRLLLVT
                     MGLLFVLLLLLIILTESDLDVAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSL
                     LIDT"
     exon            329..433
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            434..476
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            477..555
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..653
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            654..777
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            778..865
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            866..954
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1018
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1110
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1185
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1254
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1361
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..5065
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2508
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
     regulatory      5044..5049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5065
                     /gene="Frmd5"
                     /gene_synonym="1500032A09Rik; A930004K21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtggggcgc ccgggagaga acccagcttg cttggggttt gggggaggcg gtggtggctc
       61 tgtagaagga agaagagtgg ggcgggagga agcagcggtg gcgatccggt cagggtgatg
      121 gtgcaggtgc taagggccgg cgcggagctg ccgcgctgag gggcgacggg tccggagtcc
      181 gcagcgccgc cgcgtcgctc ccgaggacgg gcgagcgggc gggaagatgc tgagcaggtt
      241 gatgagcggc agcagcagga gtctggagcg cgagtacagc tgcaccgtgc ggctgctgga
      301 cgacagcgag tacacctgca ccatccagag agatgccaaa ggccagtacc tgtttgacct
      361 cctttgccac cacctgaacc tacttgagaa agactacttt gggattcgtt ttgtggaccc
      421 agataagcag cggcattggt tggagtttac aaagtcagtg gtgaagcagc tgagatccca
      481 gcctccgttc accatgtgct tccgcgtgaa gttttaccct gccgaccccg ctgccctgaa
      541 agaggaaata accaggtact tagtcttcct tcagatcaaa agggatctct accacggccg
      601 tcttctctgt aaaacatcgg atgccgcctt gttagcggcc tatatccttc aagcggagat
      661 tggggattat gacccgggaa agcaccctga aggctacagc tccaagttcc aatttttccc
      721 gaaacattca gagaaactgg aaaagaaaat tgctgagatt cacaagaccg aactcagtgg
      781 tcaaacacca gcaacatcag agctgaattt cttaagaaag gcccagacgt tagagaccta
      841 cggagtggac cctcacccat gtaaggatgt gtcgggaaat gctgcgtttc tggccttcac
      901 tcctttcggg tttgttgttc ttcaaggaaa caagagggtc cacttcatta aatggaatga
      961 ggtgaccaag ctgaaatttg aaggaaagac tttctattta tatgtaagtc agaaagagga
     1021 aaaaaagatt attctcacat attttgcccc aactccagaa gcctgcaagc acctctggaa
     1081 atgtggaatt gagaaccaag ccttctacaa gctggaaaag tcaagccaag tccgcacagt
     1141 gtccagcagc aatttgttct ttaaggggag ccggttccga tacagtggcc gggtcgcaaa
     1201 ggaagtaatg gagtccagtg ccaagatcaa acgggagccg ccagaaatac acagagcagg
     1261 gatggtccct agccgcagct gtccttctat aacccatggc ccacgactga gcagcgtccc
     1321 caggacacga agaagagctg tgcacatctc tatcatggaa ggccttgagt cgctacgaga
     1381 cagtgcccat tccaccccag tgcggtcctc ttcccatggg gacaccttcc tgcctcacgt
     1441 gagaagcagc cgggcagaca gcaatgaacg tgtcgctgtg atagcggatg aggcctacag
     1501 ccccgcagac agtgtgctgc ccacccctgt agccgagcac agcctggagc tgatgctgct
     1561 ctcccggcag atcaacgggg ccacgtgcag cattgaggag gagaaggagt cggaggccag
     1621 caccccgact gcgacagagg cggaggccct gggaggagag ctgagggccc tgtgtcaggg
     1681 gcacggcggg tcagagcaag aacaggtgaa taagtttgtt ttaagtgttc tccgtttgct
     1741 ccttgtgacc atgggactcc tctttgtttt gctcctcctc ctgatcatcc ttactgagtc
     1801 tgaccttgac gttgcttttt tccgagatat ccgccagacc cccgagtttg aacaattcca
     1861 ctatcaatac ttttgtcccc tcaggcgatg gtttgcctgc aaaatccgct cagtggtgag
     1921 cctgctcatt gacacctgag aaggcatgac tcctcccaat aactagccgg gtggaccaag
     1981 gaacccggct acccattccc agcaatggga cccatcgcgg aaccatcggc acacacacca
     2041 agtcctctca tgactcaaag tccactgagc ctagcagggt tctttcccag cagaagaaag
     2101 ggatataggc taatgctctg taaaccggga acattcagtt tcttcagagg ctcttccgag
     2161 aaaggctcag caactcaaat gtttctcatc cttcaatatg cagaataatt tgggggtttg
     2221 aacttttagt ttttcataga tgtgtattat tttgaaagta tccaaataaa agtcacttat
     2281 tttactagac tgatgattgc agtagtgtca cccagtagat gggacactag ctgaagactc
     2341 agactgttgt cctctgtacc ctgcaatttt ctcactggtg ccagtgggtt ccgggagacc
     2401 cagcagggca ggccggggct gtgggcaggc aggaatggct tcctcgccag acaggaaggt
     2461 ttcacaaagt aaacggcgta gaatgattaa atagaaagtt gcttcttacg atagtctgag
     2521 ttggattttc tttccctttt gtttgttttt gttttttcaa atctgagcag agagtgcatc
     2581 tgaagggacc acagctacag cagcagcagt ggaaggggtg gggtaagtct gtccccttag
     2641 actagagcct agtgaacacc tgagttgtat ttaatgtttt gcttttcttt ctgaagaacc
     2701 tcaagacttt tagtgcttct ggggtgtcaa agtggtgcca gagtgtgcgg tcagagatgt
     2761 cccacagcac agttaccaga gacctgtgct gagtcacacg agagcctgca gagccgcagg
     2821 gagctgtgct tgtcttgtta cagtatgccc ctccccccaa aaaagactat ttcaagctct
     2881 attttaacag caaaatgtta ttttcctatc tattcctatt ttgttttcac tttatgaatc
     2941 aaaagatgca agagagagac agatctgagg aaggcatcga gaaggagcag cggccttgga
     3001 agggaccagg aagcactaag caggacctct aagcaatgcc tacaggtgac agaatttgac
     3061 catggcagag accagcactt actataggaa tgccaccctt agggtcaacc cctgctcctg
     3121 gaaacaaggt ctaagagcac ttagtgtcgt ccctcacagc agcatacgtg tacacacaca
     3181 cacacacaca cacacacaca cacacacacg cacgagctgc agtccctaag cctctacact
     3241 tcttaccacc aataacacac aagagcatgt tttcatctca gggagaccgc aagtcatctg
     3301 aggcccaagg actcacgtaa aggacagtca aagggcacac tcctgggacc agaaaacagt
     3361 ggagcggagc agccccaaca gattgggcgg tagaatattt gagcttccct tatttgttgc
     3421 ctggggtaga accatgtcca cattcagaat atgacagcca ttaaaagcaa caacaacacc
     3481 caaaaacaaa caaatggggt tttgaagatg ctgggagggc atttacataa ttttaaagaa
     3541 agatgacatc cttatctaga ccagaggtca acaaacctct tttaataaaa ttttgatttt
     3601 gtggaccatg ctctgccacc ctagcacgcc tctgataatg catgcataga agaacatggc
     3661 ttgctctgag aaaattttat aaaaacatag ggctgaggat gtgtagctca gagggtaaag
     3721 tatttttcta acatgtataa ggccctggat ttgacttcaa acaatacaca aaaccaggtg
     3781 tggtagcata tacccgtggt cccagcattc agcagggaga cgggaagatc agaagttcaa
     3841 ggcaatcctc agtcagtgag ttaatcccag tctgggatac atgaggtgtc tcagaccacc
     3901 ggcttcccac tccctaaaaa caaacctaaa tctgcaatat gctgagagac tggtccccag
     3961 cagtacgatg caaaccctgg tctacacagg gccagcttcc attgctgttt tgtgtaagct
     4021 acccagaacc atttcccaat gggcagggtg ctccaacaac caaccagcag tgatgtgtgt
     4081 catctgatac caagatcaag aagtactgcc actgtgaaca gcggtgacac tatgaacggg
     4141 tccaggccta tctgatcatt tccgtaccag caacaatttg tgtgagatct aaaacatata
     4201 ccacatgaca agacaaactg aggggatcct agtaaagacc agaggttact taaaagcaat
     4261 gagccactgc tgcttgtcaa ctgcataacc aaggtgtgta ctcagcacag gactgacagc
     4321 aaaggctact gggaaacagg gctgtgtgaa ctgggatttc tattcttatg caacatagca
     4381 gattgccttc tagagtggtg ctcctacctc agtctgtaga acacagtgtc tatgcagtga
     4441 gtggtagtct cgcctctgac ctttcatagc ctcgagagag gcagcctgcc attgcctggt
     4501 gtgtttcttg tgtctagagt cctaacagtg ctgcgatccg tgccatttcc aacatctgac
     4561 ccagaatctt caggtcattt tctccctcaa ggcttagccc agaaaataag gacagaaaag
     4621 gctcccttcg attcggtttc caaatagttt tcaatagttc agtaacaaac cccctttact
     4681 ggtgactagt gtttttcatc atttccccat cattacaaaa gtttctgttt tcgtctggtt
     4741 ttgccgtatt ctgtgtctct tctttcctct cagaattatt gatctcactg tagaaaagca
     4801 gatctgccta gcattattga tcagaggaaa tacttactga atagtggact gcatctttaa
     4861 gcagtagagg ataaactacc tacaaatgtg aatttcttag tttcacttaa aagtatacac
     4921 ctgttaacct ttcgtgtgcc aaatctaagt tacgttttcc ttcaaagcaa tgtactcttt
     4981 tctacatatg tagtatgtag ttagcataaa atcattggtg ccatgaagat tatttttaaa
     5041 tccaataaat atttaaatac cgtaa
//
