LOCUS       NM_001346637            4681 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FERM domain containing 4B (Frmd4b), transcript variant
            1, mRNA.
ACCESSION   NM_001346637 XM_006506004
VERSION     NM_001346637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Kong,Y., Zhao,L., Charette,J.R., Hicks,W.L., Stone,L., Nishina,P.M.
            and Naggert,J.K.
  TITLE     An FRMD4B variant suppresses dysplastic photoreceptor lesions in
            models of enhanced S-cone syndrome and of Nrl deficiency
  JOURNAL   Hum Mol Genet 27 (19), 3340-3352 (2018)
   PUBMED   29947801
  REMARK    GeneRIF: his study reveals a critical role of FRMD4B in maintaining
            ELM integrity and in rescuing morphological abnormalities of the
            outer nuclear layer in photoreceptor dysplasia.
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4681)
  AUTHORS   Ikenouchi,J. and Umeda,M.
  TITLE     FRMD4A regulates epithelial polarity by connecting Arf6 activation
            with the PAR complex
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 748-753 (2010)
   PUBMED   20080746
REFERENCE   5  (bases 1 to 4681)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 4681)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4681)
  AUTHORS   Klarlund,J.K., Holik,J., Chawla,A., Park,J.G., Buxton,J. and
            Czech,M.P.
  TITLE     Signaling complexes of the FERM domain-containing protein GRSP1
            bound to ARF exchange factor GRP1
  JOURNAL   J Biol Chem 276 (43), 40065-40070 (2001)
   PUBMED   11445584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155725.3, AF327856.1 and BC052390.1.
            
            On Oct 22, 2016 this sequence version replaced XM_006506004.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF327856.1, SRR9219379.30721.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC155725.3         107779-107793       c
            16-3174             AF327856.1         1-3159
            3175-4681           BC052390.1         3406-4912
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.93 cM"
     gene            1..4681
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /note="FERM domain containing 4B"
                     /db_xref="GeneID:232288"
                     /db_xref="MGI:MGI:2141794"
     exon            1..228
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..3174
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 4B; golgi-associated band
                     4.1-like protein; GRP1 binding protein GRSP1"
                     /codon_start=1
                     /product="FERM domain-containing protein 4B isoform 1"
                     /protein_id="NP_001333566.1"
                     /db_xref="CCDS:CCDS85102.1"
                     /db_xref="GeneID:232288"
                     /db_xref="MGI:MGI:2141794"
                     /translation="MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLR
                     TWCGLRDVYQMTEGRHCQVHLLDDRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGI
                     TFIDDTGQENWLQLDHRVLEHDLPKKPGPTLLHFAVRFYIESISFLKDKNTVELFFLN
                     AKACVHKGQIEVDSETIFKLAALVLQESKGDYTSDENARKDLKTLPVFPTKTLQEHPS
                     LAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISY
                     KGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQ
                     TWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETGTQRGSKLV
                     TLEAKSQFIMASNGSLISSGSQDSEGMEEQKREKILELKKKEKLLQEKLLQKVEELKK
                     ICLREAELTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDDNLLPTEEDPALQELESNFL
                     IQQKLVEAAKKLASEPDLCKTVKKKRKQDYTDAVKRLQEIENSINEYRIRCGKKPSQK
                     AAVVPPEDIIPSESSSLSDTTTYDDPNDSFTLAGQRPSSVPHSPRILPPKSLGIERIH
                     FRKSSINEQFMDTRHSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEP
                     DSSSQHCRQRSGSLESQSHLLSEMDSDKPFFTLSKSQRSSSTEILDDGSSYTSQSSSE
                     YYCVTPAASPYYTTQTLDTRARGRRRSKKHSVSTSNSGSMPNLAQKDPLRNGVYSKGQ
                     DPPPSGYYIAGYPPYAECDLYYSGGYVYENDTEGQYSVNPSYRSSAHYGYDRQRDYSR
                     SFHEDEVDRVPHNPYATLRLPRKAAVKSEHITKNIHKALVAEHLRGWYQRASGQKDQG
                     HSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSEY
                     ENPVHSPYTSYYGSIYNPLSSPSRQYAETTPLDGTDGSQLEDNLEGSEQRLFWHEDSK
                     PGTLV"
     exon            229..294
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..389
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..482
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..567
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..624
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..647
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..731
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..797
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..855
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..942
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1019
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1158
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1300
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1434
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1554
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1783
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1840
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1988
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2108
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2920
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3053
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..4667
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4644..4649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /note="hexamer: AATAAA"
     polyA_site      4667
                     /gene="Frmd4b"
                     /gene_synonym="6030440G05Rik; GOBLIN; GRSP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagctaca gcagagcgtg gcgagcccag gatcgcggaa tccaggctcc gagggaaagc
       61 agcggcatgg cttcggtgtt catgtgcgga gtggaggacc tgctgttcag cggcagccgc
      121 ttcgtgtgga acttgaccgt gtccacgctg cggagatggt acaccgagag gctgcgggct
      181 tgccaccagg tgctgcggac gtggtgcggg ctgcgggatg tgtaccagat gacagaaggc
      241 aggcactgcc aggttcacct gctggatgac agaagactgg agctgctggt tcagcccaag
      301 cttttatcaa gagagctgct ggacctcgtg gcgtcgcatt tcaacctgaa agagaaggag
      361 tactttggaa taacgtttat agacgacacg ggtcaagaga actggttgca gctggaccac
      421 agagttctgg aacatgattt acctaagaag cccggcccaa ctcttctgca cttcgctgtc
      481 aggttctaca tcgagagcat atccttccta aaggataaga acaccgtgga gctgtttttc
      541 ctgaacgcaa aggcctgtgt acacaagggg caaattgaag tagacagtga gaccatcttc
      601 aagttggcag ccctggtttt gcaggaaagc aagggagatt ataccagcga tgagaatgcc
      661 aggaaagact tgaagacact gccagtcttt ccaaccaaaa cccttcagga acatccatcc
      721 ctcgcttact gtgaggacag agtgattgag cattatttga aaatcaaagg tctcactcgg
      781 ggtcaagctg tggtccagta tatgaaaata gtagaagccc taccaacgta tggagtccat
      841 tactatgcag tgaaggataa gcagggactt ccatggtggc ttggtatcag ctacaaagga
      901 atcggccagt atgacttaca agacaaggtg aagcctcgca aactatttca atggaagcag
      961 ctggaaaatt tgtatttccg tgagaagaaa tttgctgtgg aggtgcacga tccccgaagg
     1021 atttcagtgt ctagaagaac ctttggacag agtggcctgt ttgtacaaac ctggtatgca
     1081 aactcttctc tcatcaagtc catctgggta atggccatta gccagcatca gttctacctg
     1141 gaccggaagc agagcaaagc aaaaattcct tcagccagaa gcttagacga catcgccatg
     1201 gacttaacag agactggaac acagaggggc tccaaactgg tgactctgga agcaaagagt
     1261 cagttcatca tggcaagcaa tggcagcctg atatcctcag gttctcagga ctcggaaggc
     1321 atggaggagc aaaagcggga gaagattctg gaactcaaga agaaggagaa gctgttgcaa
     1381 gaaaagctcc tgcagaaagt ggaggagctg aagaagatct gcctgcggga ggccgagctc
     1441 acgggcagaa tgccaaagga gtatccactg aacataggcg agaagccccc tcaggtcagg
     1501 aggcgagtgg ggaccacgtt caagttagat gacaacttac tgcctactga ggaggatccg
     1561 gctttacaag aactggagag caatttcctg atacagcaga agctggttga ggctgcaaag
     1621 aagctcgcca gtgagcccga cctttgtaaa accgtgaaga aaaagcgaaa gcaagattac
     1681 acagacgctg tgaaaagact gcaggagatt gaaaattcca tcaacgaata ccgaatccga
     1741 tgtggcaaga agcccagcca gaaggctgcc gttgtcccac cagaagacat cattccatcg
     1801 gaaagcagtt ctttgtccga caccaccacc tatgacgacc ccaatgactc cttcactctt
     1861 gctgggcagc gaccaagttc agtacctcat tctccaagaa ttctaccccc caagtctctc
     1921 ggaattgagc gaatccactt cagaaaatcc tccatcaacg aacagttcat ggacaccagg
     1981 cattccagag aaatgctgtc cacacacagc agcccttaca agactctgga gaggcggcca
     2041 cagggaggac ggagcatgcc cactacgccc gtcctgactc ggaatgccta cagcagcagc
     2101 cacctggaac ctgactcctc atctcaacac tgccgccagc ggagcggaag cctggagtcc
     2161 cagtcccacc tgctctccga gatggacagt gacaagccat ttttcaccct ctccaaatcc
     2221 caaagaagca gcagcacgga gatccttgac gacgggtctt cgtataccag ccagtcaagc
     2281 tccgagtatt actgtgtgac gcctgctgcc agcccttact acaccaccca gaccctagac
     2341 acccgtgcca gggggagaag aaggtccaag aaacacagtg tttctacttc caattcagga
     2401 agcatgccca acctagcaca aaaggatcct ttgaggaacg gtgtctactc caaaggtcag
     2461 gacccacctc cttccggtta ctatatcgct ggatatccac cgtatgcaga gtgtgacctg
     2521 tattacagtg gtggctacgt ctacgagaat gacactgagg gacagtacag tgtcaatcct
     2581 tcttaccgat cctcagctca ctatggatat gaccgccaga gggactacag caggtctttc
     2641 catgaagatg aagtagaccg cgtgccacat aacccatacg caactctccg gctgccaagg
     2701 aaggcggccg tgaaatctga gcacatcacc aaaaacatcc acaaggcctt agttgctgag
     2761 cacctgcgtg gctggtacca gagggcttct ggacaaaagg atcaggggca cagcccacag
     2821 acgagctttg actcagacag gggatcgcag aggtgcctgg gatttgcagg gctgcaggtc
     2881 ccctgttctc caagcagtcg agcatcttcc tactcttcag tgtcttccac aaatgcttct
     2941 gggaactgga ggacccagtt aaccattggg ctatctgaat atgaaaatcc agtgcattct
     3001 ccctacacca gctactatgg cagcatctac aatcccttgt cctctccgag cagacagtat
     3061 gcagagacca ctccactgga cggtacagac ggaagccagc tggaagacaa cctggagggt
     3121 agtgaacaga ggcttttttg gcacgaagac tccaagcctg gaacattagt ctgaatgcag
     3181 ctggacctcc tgaccaagca ctgcgcgtgc tcacactagt gtgccttgca gagtccgttc
     3241 atcttctaga aggcatcaaa ggctgaagac aagacttaaa tgtggtttga aagcaaagaa
     3301 tcacacagta aaccccacaa aaccctgggg gaggacttgc cttccaaact ccaggcacta
     3361 acctatcact aagtcagatc ccgttcgttg tgtgactctt gtcaagagga cccgcacgaa
     3421 gcccggatcc acagcgagct ttttggaagg gaataacagt tgtcgaaggc aaacctcgaa
     3481 gctgggaagg tggtcaggga gtttgtcccg ttggagagga ggatgggaga tttcagagca
     3541 cagttgagat gctgagagag agagcccaga agctcctgaa tcgtggctta tctccacaga
     3601 gtttgaactt gtgagctgac agaaaactca ccgtttctac aaagagatga ggacagttta
     3661 gacagtattg gaaacttact tgaagagaag ttagattttc atgaagttct gaatgagtgt
     3721 agatgtttta ggctattgca aagcaatgtt cttcataaga gccctaatat ggattctagt
     3781 cttctgattg ctatagcatc ctgtaactat aacttaacag tcactgacta gaggaaatga
     3841 agtcactggc cagctctgct tggagaatgt tcttaaggta catgccacca attcctgttg
     3901 tgcttcccaa cactgactgt tcagactggt gaccttgcct gtcacctgaa cggtgggctc
     3961 gaggtggcaa gtttatccag aaaaagtgtc tggagatgct aacagaaagg accccagagg
     4021 acaaagccaa cccacatcac cgtagatgaa ttgtgtgcct taaagtggtg aaccgtagaa
     4081 aatgaagcct acgacctgaa ctccagaagc aaatccgagt cacaaagtga caagccgaga
     4141 ttgacaggaa agaatttact ccgagctgca ggagattgaa ttatgaggat taaactacct
     4201 cataccccca ctggaggagc tcatttgcgt aggtttgtgg ttcataggat tttgcttgct
     4261 tctagaacag ccttgatctt tgtctcttta tttggcttcc aagtcccaca aaaggtgctc
     4321 ccttcccctc ccttttatac gagtttcttg ttcatattgt gaatagagac atttctcaac
     4381 aacttttctg gaacattttt tctacctgta ttccaaagca tgtaatatat acataaaaat
     4441 gatttgataa ctgctccttt gtcatttgta tcactagaaa tgaagttcgg ggaaattttt
     4501 ttggaaaaaa aaagacacaa gttaaaaaaa aataacttat tcctttttgc atatttgtat
     4561 agcctcctgg aattggaaat cgccttttgc atattctttc accgttttga ctttttgaga
     4621 cctattattt ttttatgtag gtcaataaac ttatggtgtg ctactgaaaa aaaaaaaaaa
     4681 a
//
