LOCUS       NM_172475               6338 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FERM domain containing 4A (Frmd4a), transcript variant
            1, mRNA.
ACCESSION   NM_172475
VERSION     NM_172475.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6338)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6338)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6338)
  AUTHORS   Yan,X., Nykanen,N.P., Brunello,C.A., Haapasalo,A., Hiltunen,M.,
            Uronen,R.L. and Huttunen,H.J.
  TITLE     FRMD4A-cytohesin signaling modulates the cellular release of tau
  JOURNAL   J Cell Sci 129 (10), 2003-2015 (2016)
   PUBMED   27044754
REFERENCE   4  (bases 1 to 6338)
  AUTHORS   Rowton,M., Ramos,P., Anderson,D.M., Rhee,J.M., Cunliffe,H.E. and
            Rawls,A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   5  (bases 1 to 6338)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   6  (bases 1 to 6338)
  AUTHORS   Sasaki,N., Kurisu,J. and Kengaku,M.
  TITLE     Sonic hedgehog signaling regulates actin cytoskeleton via
            Tiam1-Rac1 cascade during spine formation
  JOURNAL   Mol Cell Neurosci 45 (4), 335-344 (2010)
   PUBMED   20654717
REFERENCE   7  (bases 1 to 6338)
  AUTHORS   Ikenouchi,J. and Umeda,M.
  TITLE     FRMD4A regulates epithelial polarity by connecting Arf6 activation
            with the PAR complex
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 748-753 (2010)
   PUBMED   20080746
REFERENCE   8  (bases 1 to 6338)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   9  (bases 1 to 6338)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 6338)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY138785.1, BC058672.1, BC082808.1 and BP768112.1.
            
            On Apr 29, 2010 this sequence version replaced NM_172475.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058672.1, ERR3363660.1365966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY138785.1         233-241
            10-5235             BC058672.1         1-5226
            5236-6316           BC082808.1         5683-6763
            6317-6338           BP768112.1         27-48               c
FEATURES             Location/Qualifiers
     source          1..6338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 2.31 cM"
     gene            1..6338
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /note="FERM domain containing 4A"
                     /db_xref="GeneID:209630"
                     /db_xref="MGI:MGI:1919850"
     exon            1..248
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3344
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 4A"
                     /codon_start=1
                     /product="FERM domain-containing protein 4A isoform 1"
                     /protein_id="NP_766063.3"
                     /db_xref="CCDS:CCDS15656.2"
                     /db_xref="GeneID:209630"
                     /db_xref="MGI:MGI:1919850"
                     /translation="MEGLLSPMRTKMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDL
                     VASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESI
                     SYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLK
                     KLPALPTQALKEHPSLAYCEDRVIEYYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYA
                     VKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRA
                     SVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIA
                     IDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQE
                     ALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKIL
                     PKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIEN
                     AINENRIKSGKKPTQRASLVIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLQSPHK
                     GLPPRPPSSHNRPPPPQSLEGLRQLHYHRTDYDKSPLKPKMWSESSLDEPYEKVKKRS
                     SHGHSSSHKRFPSTGSCTEAGVSSSLQNSPIRSLPHWNSQSSMPSTPDLRVRSPHYVH
                     STRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPM
                     DDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGALGSASSGSMP
                     NLAARSGAASTGGGVYLHSQSQPSSQYRIKEYPLYIEGSATPVVVRSLESDQEGHYSV
                     KAQFKTSNSYTAGGLFKESWRGGGDEGDAGRLTPSRSQILRTPSLGRDGAHDKGSGRA
                     AVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSRVTRMPQMC
                     KATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGSYSDSCFLDSSLYPELADVQW
                     YGQEKAKPGTLV"
     exon            249..314
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            315..409
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            410..502
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            503..587
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            588..644
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            645..667
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            668..751
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            752..817
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            818..875
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            876..962
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1039
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1178
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1320
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1454
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1577
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1806
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1863
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2104
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2269
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..3144
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3241
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..6318
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6293..6298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /note="hexamer: ATTAAA"
     polyA_site      6316
                     /gene="Frmd4a"
                     /gene_synonym="2700017I06Rik; 5330420J21; C230040M21Rik;
                     Frmd4; Gm13190; mKIAA1294"
                     /note="major polyA site"
ORIGIN      
        1 gaggagtgga gcagacttct ccccgtacat cctttctcgg gcacctcagg caccaagaat
       61 tcaagttaga ctgctcgcgg tgcagaggcg ccacccgcga gaggggagcc actggaggct
      121 ccaggcatgg ctcttttcat gtgggatgct taaggactgc aacacagaca gagtaacttg
      181 cagagaagag aaactggcat gaggattccg ccaaaatgga agggctccta tctccgatga
      241 gaaccaagat gacggagggc cgtcgatgtc aagtacatct ccttgatgac aggaagctgg
      301 agctgctagt acagcccaag cttttggcca aggagcttct tgacctcgtg gcctctcatt
      361 tcaacctgaa ggagaaggag tactttggaa tagcattcac agatgagacg ggacacttga
      421 attggctcca gctcgatcgg agagtcctgg agcatgactt ccccaaaaag tctgggccgg
      481 tggttctgta cttctgtgtc agattctaca tagagagcat ctcctacctg aaggacaatg
      541 ctaccattga gctcttcttc ctgaatgcca agtcctgcat ctacaaggag ctgattgatg
      601 ttgacagtga agtggtattt gaattagctt cctatatttt acaggaagca aaaggagatt
      661 tctctagcaa tgaggtggtg agaagtgatc tgaaaaagct gccagcgcta cccacccaag
      721 ccctgaagga acacccctcc ctggcctact gtgaagacag agtcattgag tactacaaga
      781 agctgaatgg ccagacgagg ggacaagcaa tcgtgaacta catgagtatc gtggagtctc
      841 tgccaaccta cggtgttcac tattatgcag tgaaagacaa gcaggggata ccatggtggc
      901 tgggactgag ctacaaagga attttccagt atgactacca tgataaagtg aagccaagga
      961 agatatttca atggagacag ttggagaatc tgtatttcag ggaaaagaag ttttccgtgg
     1021 aagttcatga ccctcgcagg gcttcagtga ccaggaggac ttttgggcac agtggcattg
     1081 ccgtgcacac ctggtatgcg tgtccggcat tgatcaagtc catttgggcg atggctatta
     1141 gccagcatca gttctatctg gacagaaagc agagtaagtc caagatccat gcggcccgaa
     1201 gtctgagcga gatcgccatt gacctgacgg aaacagggac cctgaagacc tcaaagctgg
     1261 ccaacatggg gagcaagggg aagatcatca gcgggagcag tgggagtctg ctgtcctcag
     1321 gttctcagga atcagatagc tcgcagtcgg ccaagaaaga catgttggct gccttgaaat
     1381 ccaggcagga agctctggag gagacgctgc gccagaggct ggaggaactg aagagattgt
     1441 gtctccggga agctgaactc acaggaaaat tgcctgtgga atatcccctg gatccaggcg
     1501 aggaaccacc tattgttcgg aggagaattg gaacagcctt caagctggat gaacaaaaaa
     1561 tcctgcctaa aggagaggaa gctgagctgg aacgcctgga acgagagttt gcgattcagt
     1621 cccagatcac agaggccgcc cgccgtctag ccagtgaccc caatgtcagc aaaaaactga
     1681 agaagcaaag gaagacctct tatttgaatg cactgaagaa gctgcaggag attgaaaatg
     1741 caatcaacga gaaccgcatc aagtcaggga agaaacccac ccagagggct tcacttgtca
     1801 tcgatgatgg aaatatcgcc agcgaagaca gctctctctc ggatgccctc gttctggaag
     1861 atgaagactc tcaggttacc agcacaatat cccccttaca gtcgccacac aagggactcc
     1921 ctcctcggcc accttcatca cacaacaggc ctcctccccc acagtccctg gagggactca
     1981 ggcagctgca ctatcaccgt accgactatg acaagtcacc cttaaagccc aaaatgtgga
     2041 gcgagtcatc tttagatgag ccttatgaga aggtgaagaa acgctcctcc cacggccatt
     2101 ccagcagcca caagcgcttc cccagcacag gaagctgtac cgaggcagga gtaagcagct
     2161 ccttgcagaa cagtcccatc cgaagcctcc cacattggaa ttcccagtct agcatgccat
     2221 ccaccccaga cctgcgcgtc cggagtcccc actatgttca ttccacaagg tcagtggaca
     2281 tcagccccac gagactgcac agccttgcac tgcactttag gcatcgaagc tccagcctgg
     2341 agtcccaggg caagctcctg ggctcggaga acgacaccgg aagccccgac ttctacaccc
     2401 cgaggactcg tagcagcaat ggctcagacc ccatggacga ctgctcgtcc tgcaccagcc
     2461 actcgagctc agagcactac tacccagcac agatgaacgc caactactca acgctggctg
     2521 aggactcgcc gtccaaggcg cggcagcgac agcggcagag gcagcgggca gcaggcgccc
     2581 tgggctcagc cagctctggc agcatgccca acctggcggc ccgcagcggg gctgcaagca
     2641 ctggaggtgg cgtgtacctg cacagccaga gccagcccag ctctcagtac cgcatcaagg
     2701 agtacccact atatatcgag ggcagtgcca cacccgtggt ggtacgcagc ctggagagcg
     2761 accaggaggg ccactacagc gtcaaagcgc agtttaagac ctccaactct tacacagctg
     2821 gcggcctgtt caaagagagc tggcgcgggg gtggcgacga gggggatgca ggccgcctta
     2881 caccatctcg gtctcagatc ctgcggactc cttcgttggg gcgtgacggc gcccacgaca
     2941 aaggctccgg ccgtgccgcc gtgtctgatg agctgcgcca gtggtaccag cgctccacag
     3001 cctcgcataa ggagcacagc cgtctgtcac acaccagctc cacctcctcg gacagcggct
     3061 ctcagtacag cacctcttcc cagagcacct tcgtggcgca cagcagggtc accaggatgc
     3121 cccagatgtg caaggccacg tcagctgcct tacctcaaag ccagagaagc tcaacaccgt
     3181 ccagtgaaat tggagccacc ccaccaagca gcccccacca catcctgacc tggcagactg
     3241 ggagctacag tgacagctgc ttcctggatt cctccctcta tccagagcta gctgatgtcc
     3301 aatggtacgg gcaggaaaaa gccaagcccg ggaccctcgt gtgagccggc caggctggat
     3361 gtgaccaccg ccacgccatt ccaagtcacc tcactgcctc tcatttgcct tacccagatg
     3421 cactgtcacc tgcaccagct tcggccctca gcacttttct tctcctgtct ccacatccct
     3481 ttcaccctca aaaacctgac tgaggagaca ttctggaagg ttccgaaccc actgtgtgtc
     3541 ccctggctct cttgcccaga gagccagaca acaatcctca atggcacctt ggtggtttcc
     3601 gtctgccatg atacccaggc cacaaactgt caggaaagcc aacacatgca attcctgtag
     3661 aagagaacaa gaaaaaagct agccctgcct gcagatactg aagctgtttc tggctgccac
     3721 cctataggcc ggccgagtgc ttctagagga gagtgctcag gggatatcag tttacacctg
     3781 aaataaatct gccatagtga gacagccagc aagagctcct aaggggacgt gtgagaaaga
     3841 agactggtgc ttcagagacg catcagagga tcacagttgg ttctatgctg ccaaagatta
     3901 gacacattca acaatgaaca gataggaggg gccaagagga acacactttt tctgcagcga
     3961 aatttcaatt ctaaactgct cctacgcagc acaagtgaaa gtcaaccatc ttagaccacg
     4021 tcctgtcgtg acccttctcc tggagcactc ctgagagctg ggaacaaacc caacgggaca
     4081 gtgaagatga aggaggctcg gctggcctgg cagactcgga ctctatctgt ctggacatgg
     4141 gaggagcagg gtaccattag gactgcccta tgcaggggct tcagcctacg cccccaaagc
     4201 ttccttcctt ttgggatggg gaggaagcca acggtgacca tagccaaaag cagttctctc
     4261 gttaaaacca ccagtaaaag tgtaaccttt ctgttttgta caaggccttt cagtttttgt
     4321 ttttgggaaa ccaagggaaa aagcacattg caatctactc aagtgtttta ccgttgtggt
     4381 tcattttatg tttgttaaca cttgtgtgca ctcggacaga cctcgcctgt gtgtcgctta
     4441 gtcagagaac tcacgtacgc ccttaggtag gaagactttt tacacacgtc taccagttgg
     4501 caggcagagc agagttgcaa caactcagct cccaaagggc ccagacccct ccagcagtat
     4561 ctgtgacctc gatacaccac ctccgtccac agataccaag aggataaaag gcaaaaaaca
     4621 taaaagcacg cgtgcaagct gcttgtttac atgtgttttg agctatgctt aacacacaac
     4681 caaaaagcca tcaatctcca aaggcctcag aaccacttct atactaacta accagtgcac
     4741 agtcttagtg gggcatggca ctaacgatgg cacaagagtc tctgtggagg tagtgtggct
     4801 tgcaggggtt accttgtcat gacttcctgt ggggaagaca tctaggacca ggagccaggg
     4861 tgggaagaaa gcaaatctaa aagttggctg tggcatcaaa agaaaaaaac ttcctcatgt
     4921 atttaaatcc aagaataaca atagacatta ccagactggg aaggtaagaa atgaacagca
     4981 gaaaggactg accctcactt tgcagtggct tggaaacctc tggaagtcaa gtgggagcat
     5041 tcatcccatg tggcctgagg ccttttctct cccattcaag gctgggtacc ccagagctgg
     5101 gcatggttgg cgtgatgagc ccagcttcca gaagcagtac tcttcccaga cacttgaggg
     5161 ataaccctgt agggtgagtg gggacgggat atgatggtac aaaatgaccc tggggctccg
     5221 tggagacggg gctacctttc ttgctcctag tatgatagtc ggagctacat aaagcaggtt
     5281 tatttgggga ctatttcttc cttccttagc taatggaaat gtgacacatt gtgccccatt
     5341 ttctttcttc caaaaggaga tgcctgaata atttgcctga acagaaaacg tccaaaagga
     5401 aacaaagaac aagacaaggt tacatggtta caggttataa cagagacagc agtttgaaaa
     5461 ttgattctga agtccttcgg atctatgaga gatgcagaaa gaatctaaat gtaatagatt
     5521 tggggagcag agggaaacgg aatgggagct gtgaacacca tcacgatagt ctggcagtaa
     5581 ggacagagat ttaagtaaaa caggttttac tgtttagctg tgttcggtta atacactgta
     5641 cataatataa tacgcattag tcctttgaga ctgacataat aaatggtcgc tgtggttggt
     5701 gatgaacgct ctaggtattg tatccaagca cctgcagatt ctttacacat ccctgtttct
     5761 tttaagggag atgaagtccc cagtttaaag cccctattgg attcgttgga tacatgtaag
     5821 aaattgcttg tttcagccag aagactatgt tgtgagccag gttggtttat tttgttatat
     5881 gcaggtgagt gttggagtgt tcaaagccca atttgttttc atccagtatt agtttagttc
     5941 taaatatagc aagcctcacc caggtgctat cagatgacca attactgctt agttaactag
     6001 gtgtaaagtt ttacatatcc attcatgtca atagtttatt acaagttgtg taaaacggac
     6061 tctagtttaa taattggggg ggtggtaaga ttaggttgct cctgaaactg actgtagagc
     6121 atgtaaaatg attttactgg attctgttca actgtaatca atgacaaaga tgtatgttgt
     6181 agacaaagtt gcagaattaa aaaaaaaagg aaatctgctt ttaatttatt ctttttgtat
     6241 taagaatttg tatagtacct ttacattttg cagaacagtg ttgtcaacac ttattaaagc
     6301 attttcaaaa tgaaaacaaa aaaaaaaaaa aaaaaaaa
//
