LOCUS       NM_172869               6721 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus FERM domain containing 3 (Frmd3), transcript variant
            1, mRNA.
ACCESSION   NM_172869
VERSION     NM_172869.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6721)
  AUTHORS   Ma,J., Gong,Y., Sun,X., Liu,C., Li,X., Sun,Y., Yang,D., He,J.,
            Wang,M., Du,J., Zhang,J., Xu,W., Wang,T., Chi,X., Tang,Y., Song,J.,
            Wang,Y., Ma,F., Chen,C., Zhang,H. and Zhan,J.
  TITLE     Tumor suppressor FRMD3 controls mammary epithelial cell fate
            determination via notch signaling pathway
  JOURNAL   Sci Adv 10 (27), eadk8958 (2024)
   PUBMED   38959315
  REMARK    GeneRIF: Tumor suppressor FRMD3 controls mammary epithelial cell
            fate determination via notch signaling pathway.
REFERENCE   2  (bases 1 to 6721)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX088570.6, BX957282.2 and AL844607.4.
            
            On Jan 3, 2023 this sequence version replaced NM_172869.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113795.1, AK034956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               BX088570.6         164216-164529
            315-419             BX088570.6         224658-224762
            420-462             BX957282.2         6528-6570
            463-541             AL844607.4         23551-23629
            542-639             AL844607.4         31951-32048
            640-763             AL844607.4         39580-39703
            764-851             AL844607.4         48786-48873
            852-940             AL844607.4         57319-57407
            941-1004            AL844607.4         62996-63059
            1005-1093           AL844607.4         64119-64207
            1094-1168           AL844607.4         65451-65525
            1169-1237           AL844607.4         65801-65869
            1238-1362           AL844607.4         74390-74514
            1363-6721           AL844607.4         91066-96424
FEATURES             Location/Qualifiers
     source          1..6721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 36.06 cM"
     gene            1..6721
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /note="FERM domain containing 3"
                     /db_xref="GeneID:242506"
                     /db_xref="MGI:MGI:2442466"
     exon            1..314
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1955
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 3"
                     /codon_start=1
                     /product="FERM domain-containing protein 3 isoform 1"
                     /protein_id="NP_766457.1"
                     /db_xref="CCDS:CCDS38789.1"
                     /db_xref="GeneID:242506"
                     /db_xref="MGI:MGI:2442466"
                     /translation="MFASCHCAPRGRRTMKMIHFRSSSIKSLNQEMKCTIRLLDDSEV
                     SCHIQRETKGQFLIEYICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKSHPP
                     YTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAEF
                     GDYYPDEHPENYISEFEIFPKQSQKLERKIMEIHNNELRGQSPAIAEFNLLLKAHTLE
                     TYGVDPHPCKDSRGATAFLGFTAAGFVVFQGNKRIHLRKWSDVCKLKFEGKTFYVIGS
                     QKEKNAVLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYS
                     GKVAKEVVEASSKIQRDPPEVHRVNITQSRSFHSLNKQLIINMEPLQPLLPSPTEQEE
                     EVPVGEGVPLPKMDVSEPLIASSPVKGAQCADPPDEEEDRVKEDPLTISELAYNPSAS
                     LLPTPVDDDEINMLFDCPSRLELEREDTDSFEELEADENAFLIAEEEELKEARQALSW
                     SYSILTGHIWVNPLVKSFSRLLVVGLGLLLFVFPLLLLLLESGIDLSFLCEIRQTPEF
                     EQFHYEYYCPLKEWVAGKVNIVLYMLGCS"
     exon            315..419
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            420..462
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            463..541
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            542..639
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            640..763
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            764..851
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            852..940
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1004
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1093
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1168
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1237
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1362
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..6721
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /note="major polyA site"
     regulatory      6702..6707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
                     /note="hexamer: AATAAA"
     polyA_site      6721
                     /gene="Frmd3"
                     /gene_synonym="4.1O; 9430066I12Rik; EPB41L4O; P410"
ORIGIN      
        1 ctcctcgcca ctcgccgctg gtggccgcag gcgccctgcg ctgccacggt ctccgggcgg
       61 agctgcaccc ggagctgcga ctgtattgag aacgtgtgaa tgtccgcgtg gaccagggcc
      121 gcgcgggtcc cgcgcctcct acggctgcct cccgcgtgct gctgtgtatg ttcgcttctt
      181 gtcactgtgc gccgagaggc agaaggacta tgaagatgat tcactttcgg agctccagta
      241 tcaaatcgct caaccaggag atgaaatgca ccattcgact gctggacgac tcggaggtct
      301 cctgccatat ccagagggaa acgaaagggc agtttctcat tgaatacatc tgcaactact
      361 atagcctgct ggaaaaggac tactttggaa ttcgctatgt ggacccagag aagcaaaggc
      421 actggcttga gcctaacaag tccatcttca agcaaatgaa atctcatcca ccatacacca
      481 tgtgctttag agtgaaattc tacccacatg aacccttgaa gattaaagaa gagctcacaa
      541 ggtacctatt atatttgcaa attaaaagag acatttttca tggtcgactg ctgtgttcct
      601 tttctgatgc tgcctatctg ggtgcttgta tcgttcaagc tgagtttggt gattactatc
      661 ctgatgagca tcctgagaat tatatcagtg agtttgagat ttttcccaag cagtcacaga
      721 aattggaaag aaaaatcatg gaaattcata acaacgaact aagaggtcag agcccagcaa
      781 ttgctgaatt caacttactc ttaaaagctc atacattgga aacttatgga gtggatcctc
      841 acccatgcaa ggattcaaga ggtgctacag catttttagg attcactgct gcaggtttcg
      901 tcgtattcca gggaaataaa agaatccatt tgagaaaatg gtcagatgtc tgcaaattga
      961 agtttgaagg gaagacattt tacgtgattg gttcccagaa agagaaaaat gctgttttgg
     1021 cattccatac atcaacacca gctgcctgca aacatttatg gaaatgtggg gtagaaaacc
     1081 aagcctttta taagtatgca aagtccagtc agatcaagac tgtgtcaagc agcaagatat
     1141 tttttaaagg aagtagattt cgatacagtg gtaaagttgc taaagaggtg gtagaggcaa
     1201 gctccaaaat ccagagggat cctcctgaag tgcatagagt caacattact cagagtcgca
     1261 gctttcactc cttgaacaaa cagctcatca tcaacatgga acctttgcag cccctgcttc
     1321 cttcccccac tgaacaggaa gaagaagttc ctgtgggtga gggtgtccca ctgcctaaaa
     1381 tggatgtgtc tgagccccta attgccagct caccagtgaa gggagcacag tgtgcagatc
     1441 ctccagatga agaggaagat agagtaaaag aagacccctt gaccatctct gaactagcgt
     1501 acaatcccag cgccagcctg cttcctaccc cagtggatga tgatgaaatc aacatgctct
     1561 ttgactgtcc atccaggctt gagttagaaa gagaagacac ggattcattt gaggaacttg
     1621 aagcagatga aaatgctttt ttgattgctg aagaggagga gctgaaggaa gctcgccaag
     1681 ctttgtcatg gagctattca atcctgaccg gccatatctg ggtcaacccc ctggtcaaga
     1741 gtttctccag gctccttgtg gtgggcctgg gactgctgct gtttgtattt cccctgctcc
     1801 tcctcctttt ggagtcaggt attgatctct ccttcttatg cgaaatccgt cagacaccag
     1861 agtttgagca gtttcactat gaatactatt gtcctctgaa ggagtgggtg gctgggaagg
     1921 tcaacatcgt cctctacatg ctgggttgtt cataaaatga atatctgata agacgaaggg
     1981 ctatcttcaa tactagtagt agcattttca gtagatgcta ggttttgatt ggccttcagt
     2041 tgtcaagagg tagtcttaac tcttgactct taactctctt aactgactgc tcaaaccttg
     2101 aaataagttt tctgtacttc attgaattta gtcgatttaa atcaaataca atacattgag
     2161 ttattcttca aaaatgcagt caggaagaaa aaaaatctcc atatcatacc ataataattt
     2221 aatacattgg aattaggtat tcttgtttct tttttgtgaa ctataatcaa attagaattt
     2281 tagtaaaaat acaaagtgaa tctttttaat ataacctttg gtgaaaataa tgacctctta
     2341 ctgatgccta tacaaataag ttgatgctga gtttttcttt cagttttttt aaaaaaaaat
     2401 atttttacgc gttctaacta ttttggtaaa tttttagcaa aacagaagct ttctggaatt
     2461 atttgagtat acctactgta aaaccaatgc acatggaatt ttttaatgtt ttggcacttg
     2521 atttttttaa agatattttt tggctaacta atccataatt tattacctgc atatgacttt
     2581 ggaaaaaaaa tgatagtaaa aaaactatag caagttctca aaaacagatg attaaactag
     2641 aagatgtaag catgaagaac attgagttga cattgtccgg tctagttttc agagttttgg
     2701 acatgataat cttattataa tttaatttgt gttcagtcca tatatttgga ctgggaaagc
     2761 agagtgtttt taaaagaaat taaaactaat tgtaatagta aaattgtaaa gaagatcaac
     2821 tagttaattg ttattgttga ctaatctgag taaaagcaag caggagtttg gcaaatagaa
     2881 ggtagcaaag aagagttctg ctgagactgc taggcaagtg atgctaagca tgtggttgcc
     2941 tttatggaag tgatgctgat atatggcact cattgtaaag tgatgtgcac tcactctctg
     3001 agttcacaaa atcatgttta gttaataaaa atggacaaaa ttttaaggtg aatttttggg
     3061 acccctcatg cttttcattg taattctctg ggtaaaattt caaggtggtg tgtgtgtgtg
     3121 tgtgtgtgtg tgtgagagag agagagagag agagagagag agagagagag agagagaaag
     3181 agagagagag agagagagag acaatgaaag tgggtgagaa aagacagaca gacaaacaga
     3241 aaggcagaga cagagatgga gagagaaaga gaatgatgag agagagagga tgatgagaga
     3301 gagagtgaat ttcctttatg aatctcttta agttctggac tcttgtgtaa ttgggacttt
     3361 aattgaaaca atgaatcatc agataataca tcaattctgt ttgggtaaaa tcaacaaagg
     3421 aagataaaaa aagacaaaag aaatgataaa tcctgagaca caatccttca tgtcagtgaa
     3481 cccaagacag aaaaatatct ggtgctttcc attgctggcc acttaccaac actgtgttat
     3541 aactaagaaa aaaaggagta taggaatatt tttagggaaa gagagaataa ggactcttca
     3601 attaaaagaa taacccataa agcctaacac tgggatttta aaaatatttc ttcgatttgt
     3661 ttttatttgt tttttgttta ttttatgtat ttattttctc agtaagtgct ctgctgcagg
     3721 tacaattacc tgtcagaaga gggtatcaga tccttttata gatggccttg aaacaccatg
     3781 ttgagactag gaattgaact caggtcctct ggaacaatac ctggtactct taaccattga
     3841 gccatctctc tagcttcaca aatatatatt ttaaaaacta gcagtttggc caaaaagaat
     3901 aaagtataga caagtgcatg cttgtgaaag aaattagggt ctttaaaaag aaaccaatga
     3961 gttttcattg aaacattaaa aaaaaaaaaa accttgaggg caccttaagt attgccacat
     4021 taaagtacac ctatagcagg ctcctgggta tcaaagagaa aagattctga gcagaaagat
     4081 ctggtggatc ctccttttct caaggtttag tcactcagga actcagaggc aactccagtc
     4141 aaggtccaaa ggaagattgg cagactatcg tatcatccaa ataatgctcg tttttcaaac
     4201 atgcaaaatt catgagttaa gaagttatga agattttacc tctatttcag cagaagatct
     4261 ggaggtcagg cagcaaatga cagagaaggc aatccctaag agaagatgta aagctgtaga
     4321 tgtgaagcct tagctgaaat ggagacttga ttcccattac actttcacac ccttatttcc
     4381 ttgaggcagg gtctctaact gaacctcaag ctaacttagc aagtcccaaa ctactttcct
     4441 aagcatcagc atcactggca ttacagatgt gcaaccacac ctgactttct acatgggcac
     4501 tggaaatttg gactcaggta ctcatgcttc ctcatgctgc caagccttct cagctgccaa
     4561 caaaatttct gaatcaagtt ctttttattt tcttctgttg tttgtgaatg ctggcatcat
     4621 atttgaagct atttcctaac tcagagtcat aaatatttat ttctataact tttgtaagag
     4681 ttttattatc atactagcaa cttaacttat gactgtggtg acagggtata ctgtgactta
     4741 gttgttctct attgaagata gaaaagaggt gtagcatacg tgagcagagg aggggagggc
     4801 agaggagagg aaagaagagg agggaagggg aaaggagggg aggagaggag aggagaggag
     4861 aggagaggag aggagaggag aggagaggag aggagagggg ggaggggagg agaggggagg
     4921 gagagggaga gggaaaggga gagggggaag agggagagag gagaggagag gagaggagag
     4981 gagaggagag gagaggagag gagtcttggg agggaaaaaa cagaatggat cagagaaatt
     5041 ctgtgtaact tctttatgaa ctgtatcaaa tgctggatat aatcccatat caaaagctta
     5101 aaggagatgg gtgagtatag agttatagtc ccctacctgc aggcagcttg cctgatagaa
     5161 gtgtgagaca agcattggtc ctgtttcctc ggggttggat attcgcccat gaaataaacc
     5221 atgaaacaaa gcaaactagg atagtatact tgaaaagacc aagaaatgaa ggtgtcatgt
     5281 tggtgactgt ctatagaaag ataagtttag gtcctactgg gtctgagatg gttggtaatg
     5341 gaaatagtat ctacagcttc ctgtggtgac ctcaaagtaa agagggaagc caacagtggg
     5401 taagggtgct tacttcacac atatgagggc ttgaacttga atcctcagca tctgtgtaaa
     5461 acactcaaca taactatgta ttccagtaac cctaggggag tggaaatagg caatctcagt
     5521 gaagcccagg ccagccagcc taactgacac agtggccttt tggatcagtg agagacccta
     5581 tcaaggccat aatctggaaa atgacagagg gaggcatcca gtgtcctgct ctggttctgt
     5641 aagcatatgc aacactcata tgcaccacaa acatacatca tgtatatgcc acagcaactt
     5701 tgttcactac taagtgtgaa tagctcactg ggttttattt tgttccttgg aaaatgtcaa
     5761 ggggcagctt attggttact tctgcattct gtgaccacag tacccaacat aaattaagga
     5821 gaggagacag actttatttt gatttatggt ttctgtggtg caacagagaa tcatatatca
     5881 caacattttc cctgattttc tgcatacttt tcaagatact cacattgaca gtaagataaa
     5941 aaatcacttg ttcttttatg agtttgacat ccaaatgtaa cactggaatc ttataatgtc
     6001 atttattcac tataaaagta aagcctttaa gaaatatcca tatttattag aaagcttcat
     6061 cagttgtttg agtcaaatga agaggggaat ttgtcaacac ataaaatata aaatagtgag
     6121 attgaggctt caaagcaagc acacaagtat gtcaatattc catattattg atatatgtat
     6181 atttataaaa gatgtgtata tgtgtgttta tatagatata gctcatatgc ctttcacaca
     6241 tacttacttg ttcttatttt gtcccaagtg aggaatttat ggaaccttat tattcttttc
     6301 tctctcagtt atcatgaaat atagactccc aagtgattat tttatgaaag tgttttatgt
     6361 acatttgtga atttgtgtat acccagagag agagaaagag agagagcaag taagtgtaca
     6421 cacacttatc tttagtgcta atatgagctt tataatgaga atgatatagg taaaggatca
     6481 tatatttcta tctgagtttg gaacatatgt gttatgtatt tacagtatat tttgtagttt
     6541 gtctaatatt atgaacataa cgctgaaaag atttacaatg agttgatttc tttatggggg
     6601 ctataatatg gttattggag ctgtatcttt gtatagtgaa attagcattt ctatgtcaac
     6661 atccagattg cttgtctgtt aatatggtag taggaatctc taataaaata atctggggca
     6721 a
//
