LOCUS       NM_010237               4669 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus fyn-related kinase (Frk), transcript variant 2, mRNA.
ACCESSION   NM_010237
VERSION     NM_010237.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4669)
  AUTHORS   Sasaki,Y., Taya,Y., Saito,K., Fujita,K., Aoba,T. and Fujiwara,T.
  TITLE     Molecular contribution to cleft palate production in cleft lip mice
  JOURNAL   Congenit Anom (Kyoto) 54 (2), 94-99 (2014)
   PUBMED   24206222
REFERENCE   2  (bases 1 to 4669)
  AUTHORS   Wang,D., Zhang,Z., O'Loughlin,E., Wang,L., Fan,X., Lai,E.C. and
            Yi,R.
  TITLE     MicroRNA-205 controls neonatal expansion of skin stem cells by
            modulating the PI(3)K pathway
  JOURNAL   Nat Cell Biol 15 (10), 1153-1163 (2013)
   PUBMED   23974039
REFERENCE   3  (bases 1 to 4669)
  AUTHORS   Akerblom,B., Anneren,C. and Welsh,M.
  TITLE     A role of FRK in regulation of embryonal pancreatic beta cell
            formation
  JOURNAL   Mol Cell Endocrinol 270 (1-2), 73-78 (2007)
   PUBMED   17416457
  REMARK    GeneRIF: These results show that FRK affects beta cell number
            during embryogenesis and early in life, but is probably redundant
            for beta cell number and function in adult animals under normal
            conditions.
REFERENCE   4  (bases 1 to 4669)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 4669)
  AUTHORS   Welsh,M., Welsh,C., Ekman,M., Dixelius,J., Hagerkvist,R.,
            Anneren,C., Akerblom,B., Mahboobi,S., Chandrasekharan,S. and
            Liu,E.T.
  TITLE     The tyrosine kinase FRK/RAK participates in cytokine-induced islet
            cell cytotoxicity
  JOURNAL   Biochem J 382 (Pt 1), 261-268 (2004)
   PUBMED   15186217
REFERENCE   6  (bases 1 to 4669)
  AUTHORS   Anneren,C.
  TITLE     Dual role of the tyrosine kinase GTK and the adaptor protein SHB in
            beta-cell growth: enhanced beta-cell replication after 60%
            pancreatectomy and increased sensitivity to streptozotocin
  JOURNAL   J Endocrinol 172 (1), 145-153 (2002)
   PUBMED   11786382
REFERENCE   7  (bases 1 to 4669)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   8  (bases 1 to 4669)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   9  (bases 1 to 4669)
  AUTHORS   Thuveson,M., Albrecht,D., Zurcher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     iyk, a novel intracellular protein tyrosine kinase differentially
            expressed in the mouse mammary gland and intestine
  JOURNAL   Biochem Biophys Res Commun 209 (2), 582-589 (1995)
   PUBMED   7733928
  REMARK    Erratum:[Biochem Biophys Res Commun 1995 Jun 26;211(3):1100]
REFERENCE   10 (bases 1 to 4669)
  AUTHORS   Oberg-Welsh,C. and Welsh,M.
  TITLE     Cloning of BSK, a murine FRK homologue with a specific pattern of
            tissue distribution
  JOURNAL   Gene 152 (2), 239-242 (1995)
   PUBMED   7835707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166379.1, AK028855.1, AK164460.1 and BP761286.1.
            
            On Apr 21, 2009 this sequence version replaced NM_010237.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166379.1, BC007137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK166379.1         1-61
            62-3181             AK028855.1         2-3121
            3182-4327           AK164460.1         727-1872
            4328-4669           BP761286.1         1-342               c
FEATURES             Location/Qualifiers
     source          1..4669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..4669
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /note="fyn-related kinase"
                     /db_xref="GeneID:14302"
                     /db_xref="MGI:MGI:103265"
     exon            1..189
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            190..814
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1988
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /EC_number="2.7.10.2"
                     /note="intestine tyrosine kinase; beta-cell Src-homology
                     tyrosine kinase; B-cell src-homology tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase FRK"
                     /protein_id="NP_034367.2"
                     /db_xref="CCDS:CCDS23781.1"
                     /db_xref="GeneID:14302"
                     /db_xref="MGI:MGI:103265"
                     /translation="MGSVCVRLWAYLQPFLPCWSQEADKSVVIENPGAFCPPEAPRSQ
                     EPERSHGQYFVALFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLARHLEKKGTGLGQQ
                     LQGYIPSNYVAEDRSLQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFS
                     LSVLDEGVVKHYRIRRLDEGGFFLTRRKVFSTLNEFVNYYTTTSDGLCVKLEKPCLKI
                     QVPTPFDLSYKTADQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSM
                     DPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIH
                     LIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNED
                     IYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVI
                     QMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYFETDCSYSDTN
                     NFIN"
     exon            815..936
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1100
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1269
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1428
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1610
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1776
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..4649
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3095
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
     regulatory      4612..4617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /note="hexamer: AATAAA"
     polyA_site      4649
                     /gene="Frk"
                     /gene_synonym="BSK; BSK/IYK; GTK; RAK"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgggaa agctgacctg ggagttcctt ttagatcaga caaaaagaaa ccaggaagtt
       61 aggaggaatt attacagtct gtacagctca ggatgttaaa ggcgataacc tccacggcct
      121 ggttattcat tagcaagaag gaaagctccg gagagagcag aactctctca gctgcaggct
      181 tgaagcaggg cagtcaggaa gaagcacctt cccactggac ctccagctca gtcctctctt
      241 ggttttgcct cagggcagca gctacaaaca gaaagccagc tgtgagtgtc ttggccaagc
      301 ccagatctgc cggagagagg agagatccga agcgggaggt atggtgagtt gcagctgatt
      361 tggaagctgc ctggtggagg accgtggctc tgtacagctt gtggggagag gactatcctc
      421 tcctacaact actaagctag aacaacacca tgggcagcgt ctgtgtgaga ctctgggcat
      481 acctgcagcc ttttctcccg tgctggtctc aagaggcaga caagtcagta gtaattgaga
      541 atccaggggc cttctgtccc ccagaggctc ccaggtcaca agagcccgag agaagccatg
      601 gccagtattt tgtggctctg tttgattacc aagcacgtac tgcagaggac ctgagcttcc
      661 gtgccggcga caaactccaa gtcttggaca cttcgcatga gggctggtgg ttggccagac
      721 atttggagaa gaagggaacc ggcttaggtc agcagctaca gggctacatt ccttccaatt
      781 acgtggcgga ggaccggagt ctccaggcag agccgtggtt ttttggagca atcaaaagag
      841 cagatgcaga aaaacaactt ctgtattcag aaaaccagac gggcgccttt ctaatcagag
      901 agagtgagag ccagaagggt gacttttccc tctcagtttt agatgaaggt gttgtaaaac
      961 actacagaat aagaaggttg gatgaaggtg gcttcttcct caccaggagg aaagtctttt
     1021 caaccctgaa tgaattcgtg aactactaca ccacaacaag tgacgggctg tgtgtcaagc
     1081 tggagaagcc atgcttaaag atccaggtac caaccccttt tgatttgtca tataaaactg
     1141 cagaccagtg ggagatagac cgcaactcca tacagctttt gaagcgactg ggatctggtc
     1201 agtttggaga agtttgggaa ggtctgtgga ataataccac tccagtggcc gtaaaaacgt
     1261 taaaaccagg ttcaatggat ccaaatgact tcctgaggga ggcacagata atgaagagcc
     1321 taagacaccc aaaactcatc cagctctatg ctgtttgcac tttagaagat cccatttata
     1381 ttattacaga gttgatgaga catggaagcc tgcaagaata tctccaaaat gatggtgggt
     1441 caaaaatcca tttgattcaa caggtagaca tggcggcaca ggtggcttct ggaatggcct
     1501 atcttgagtc gcagaactat attcacagag atctggctgc aagaaatgtc cttgttggtg
     1561 aacataatat ctacaaagta gcagattttg gacttgcaag agtttttaag gtagataatg
     1621 aagacatcta tgaatctaaa cacgaaataa agctgccagt gaagtggact gcacccgaag
     1681 ccattcgtac taataaattc agcattaagt ctgatgtgtg gtcttttgga atcctgctct
     1741 atgaaatcat tacttatggc aaaatgcctt acagtggtat gacaggtgct caagtaattc
     1801 aaatgttgag tcaaaactac agacttccac agccatctaa ctgcccacag caattctaca
     1861 gcatcatgct agagtgctgg aatgttgagc ctaagcaacg gccaacattt gagaccctgc
     1921 attggaaact tgaagactac tttgaaacag actgttccta ttcagataca aataacttca
     1981 taaactaaac atcaaggaaa agaagaaata taatgaagat atgaaaacgt ggggctcatc
     2041 agtccagaaa tactatctat tcaaccaact gtgaaatcag cttattttga catattcaag
     2101 tggtaggatg aactcagcca tgcattccat atcaaaaaga taatctgtgt attttattga
     2161 ctaggaaaca ctgcaggaca gtataagata atgtgtcatt tttcctcact gcctggtaaa
     2221 atcaatcaca ctaaatgaag ttattttttt tccttttgag aactcctcac atttctattt
     2281 attgtttgaa tgcccatcaa gagaatcaac agatgacagt gtttactcag ttactgttgt
     2341 ggcattttcc tgtttactaa ttagactggt tattcattat tcctcaaatt gctgaatacc
     2401 atcaggctgt tattatgaag gaatttgatt gctctgctgc acagcaggac ctgtgctttg
     2461 agatattttt tttcctctct tttaaaatat cctgtaacta caataatggt aaagccatgt
     2521 taaatgactt gattgtactt gaagtaattg cacatatttt tcctatgcat aagaaaatga
     2581 agcagctgtt gagaaaagga attaaaatct ttctcatttt gtagaaggaa atgatggagt
     2641 ttgctctata cctcagtatg tgtcattgga gaatcatctg cattagtttt aatctcttaa
     2701 tgtcaggaat caggttgcaa agccgatgaa ttgttatgta tgggaatata ggggaactac
     2761 cacattgcct accaggtctg agaaatagat attaaagtgg cttagagaag ctaacagaga
     2821 gagctagagg attgctgcag ctttctaagt aataataaaa agtttctttg gcatgcaggc
     2881 ctattttaaa ttggcttcaa aacaggccaa tcagcacctg aggctaggaa taatgtctga
     2941 atgtagttat gaactgtagc ttttgtctgt taagtctgga tgcttttcag tatcttaagt
     3001 ttttataacc ttgaagaact tccctgtttt cttaggtaat gtgtgtatca aatgttctgc
     3061 atcactggat ggttagcaag acttttctaa aatcagctcc atagattctg gaatcttcta
     3121 ttgtgcggca ccgaatgaac attccaaaag gaaactgagt ttatcaagtt tatttttcat
     3181 ccttctttaa gagagaaggg actatctaga tgctcacaag gatcccctgc aaattaaaaa
     3241 acatgccaat tctttcaact aggaactagg agggtaacag ggactaacca ttagccattt
     3301 ggtgatggca cttccctagc tgcatttctg ttaccatagt agaaatcctg aaaacaaaac
     3361 aaaacaaaac aaaaacaaaa acaaaaacaa aaaacaaaca aacaaaacca acttagaaga
     3421 gacaagtttt attctagctt accattctag gccattgcat cacagcagga agtcactgtg
     3481 acaagagagc ttgaaaatga tttcatcaca tccacagtct aagaggagaa agagacataa
     3541 ctacatgcac gcatgcatga cttgcttgtt tgcttacttg tgctcaggtc aatttctaca
     3601 ctcttaaaat gtttgggaca cctttgccta ggaaatagca tggcacacaa tgggctgagt
     3661 tttccaggat caattaactt aattaagaca attctgtaca gacatgccca caggcaagtc
     3721 taatataaag aatcattgtc aactcattgt gactctcttt cttgatgatt ctaggtgctg
     3781 acaaattgtc aattatagct agtcattaga ccacttaaga ctcaaacctt atcaaacttt
     3841 cccatctacc acaagcattt tctgtgttcc actagtcaca ggtggccacc agtggtaagt
     3901 gaggctcctt gttctcttat atttaagaag acaaaatgga taacttaact cttaggcatt
     3961 atcccaagct tgttaaacac acacacacaa accaacatcc cattcccatt tgagggggag
     4021 gaagcagatt gcaaacacag tcctgtggct aatggacaac aatcagcaca gtggatgtta
     4081 atgccaagtg ttgattggct tggaagaaag tctgcactga agctgggcat atgaacttct
     4141 ccaagataag ttgtttattc aaataaaatt agagatgagt agctggttat gtgatcatta
     4201 tcagaactat ttaagatgaa ttaactgttg gaattaatct agtacatgta tgcattcatt
     4261 tctcatctta aacatttctg aagactttaa tctggatcat atgaaaagac tatagatgtg
     4321 cttagagaag gaaaagcatt tgttagataa gctcactatt aatattttaa ttagttgaca
     4381 gagcaagtag tagcttcaat tgtttgtttc agattatctg gtctaatgta accaaggaga
     4441 agacattcaa cagctagtcg gctaaaatga aatttcaaaa aggactcctt ttcctgagtt
     4501 catttttttc agaacttttt ctgcttgagg catacgtaga aatgaggggc aatattccaa
     4561 tttcattgtg caaattcaaa tgctatgtac ttttatgtgg tagctgataa taataaattt
     4621 gtagtaagat ctggctttga aatataaaaa aaaaaaaaaa aaaaaaaaa
//
