LOCUS       NM_183112                420 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus Frey regulator of sperm-oocyte fusion 1 (Frey1), mRNA.
ACCESSION   NM_183112
VERSION     NM_183112.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Cai,R., Scott,O., Ye,G., Le,T., Saran,E., Kwon,W., Inpanathan,S.,
            Sayed,B.A., Botelho,R.J., Saric,A., Uderhardt,S. and Freeman,S.A.
  TITLE     Pressure sensing of lysosomes enables control of TFEB responses in
            macrophages
  JOURNAL   Nat Cell Biol 26 (8), 1247-1260 (2024)
   PUBMED   38997458
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 420)
  AUTHORS   Lu,Y., Shimada,K., Tang,S., Zhang,J., Ogawa,Y., Noda,T., Shibuya,H.
            and Ikawa,M.
  TITLE     1700029I15Rik orchestrates the biosynthesis of acrosomal membrane
            proteins required for sperm-egg interaction
  JOURNAL   Proc Natl Acad Sci U S A 120 (8), e2207263120 (2023)
   PUBMED   36787362
REFERENCE   4  (bases 1 to 420)
  AUTHORS   Hao,H., Shi,B., Zhang,J., Dai,A., Li,W., Chen,H., Ji,W., Gong,C.,
            Zhang,C., Li,J., Chen,L., Yao,B., Hu,P., Yang,H., Brosius,J.,
            Lai,S., Shi,Q. and Deng,C.
  TITLE     The vertebrate- and testis- specific transmembrane protein C11ORF94
            plays a critical role in sperm-oocyte membrane binding
  JOURNAL   Mol Biomed 3 (1), 27 (2022)
   PUBMED   36050562
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 420)
  AUTHORS   Contreras,W., Wiesehofer,C., Schreier,D., Leinung,N., Peche,P.,
            Wennemuth,G., Gentzel,M., Schroder,B. and Mentrup,T.
  TITLE     C11orf94/Frey is a key regulator for male fertility by controlling
            Izumo1 complex assembly
  JOURNAL   Sci Adv 8 (32), eabo6049 (2022)
   PUBMED   35960805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006499.1 and BC094251.1.
            
            On Nov 5, 2009 this sequence version replaced NM_183112.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006499.1, BY706534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AK006499.1         2-350
            350-420             BC094251.1         1052-1122
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.99 cM"
     gene            1..420
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /note="Frey regulator of sperm-oocyte fusion 1"
                     /db_xref="GeneID:75641"
                     /db_xref="MGI:MGI:1916742"
     exon            1..134
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..330
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /note="uncharacterized protein C11orf94 homolog"
                     /codon_start=1
                     /product="protein Frey"
                     /protein_id="NP_898935.1"
                     /db_xref="CCDS:CCDS16445.1"
                     /db_xref="GeneID:75641"
                     /db_xref="MGI:MGI:1916742"
                     /translation="MVLAMLGALYPRAGLSLFLFYLILAGALLRPQPQRSQQSVPEEF
                     SAPLELLQPLSGLVDDYGLRPKHPRPGGPRPLLSQAQQRKRDGPNMADYYYDVNL"
     exon            135..208
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /inference="alignment:Splign:2.1.0"
     exon            209..364
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /inference="alignment:Splign:2.1.0"
     regulatory      342..347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /note="hexamer: CATAAA"
     polyA_site      364
                     /gene="Frey1"
                     /gene_synonym="1700021K07Rik; 1700029I15Rik; Frey"
                     /note="major polyA site"
ORIGIN      
        1 agatagcccc cacagcaggg actggagaca atggttctcg ccatgcttgg ggctctgtac
       61 cccagggctg gactcagtct cttccttttt tacctcatct tggcaggcgc actccttcga
      121 cctcagcccc agaggtctca gcaatctgtt ccggaggaat tttcagcccc gctggaactg
      181 ttgcagcctc tctcaggcct ggtggatgac tatgggctca gacccaagca cccgaggcca
      241 ggtgggcccc gaccccttct ctcccaggcc cagcagcgca agcgggacgg gcccaacatg
      301 gctgactatt actatgatgt gaacctgtga tgggaacccc gcataaagct attctgggca
      361 gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
