LOCUS       NM_172862              12368 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Fras1 related extracellular matrix protein 2 (Frem2),
            mRNA.
ACCESSION   NM_172862 XM_619899 XM_619900
VERSION     NM_172862.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12368)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 12368)
  AUTHORS   McLaughlin,M.T., Sun,M.R., Beames,T.G., Steward,A.C.,
            Theisen,J.W.M., Chung,H.M., Everson,J.L., Moskowitz,I.P.,
            Sheets,M.D. and Lipinski,R.J.
  TITLE     Frem1 activity is regulated by Sonic hedgehog signaling in the
            cranial neural crest mesenchyme during midfacial morphogenesis
  JOURNAL   Dev Dyn 252 (4), 483-494 (2023)
   PUBMED   36495293
REFERENCE   3  (bases 1 to 12368)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Schwaderer,A.L., Hains,D.S. and Calve,S.
  TITLE     FOXD1 is required for 3D patterning of the kidney interstitial
            matrix
  JOURNAL   Dev Dyn 252 (4), 463-482 (2023)
   PUBMED   36335435
REFERENCE   4  (bases 1 to 12368)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Hains,D.S., Schwarderer,A.L. and Calve,S.
  TITLE     3D Mapping Reveals a Complex and Transient Interstitial Matrix
            During Murine Kidney Development
  JOURNAL   J Am Soc Nephrol 32 (7), 1649-1665 (2021)
   PUBMED   33875569
REFERENCE   5  (bases 1 to 12368)
  AUTHORS   Zhang,X., Wang,R., Wang,T., Zhang,X., Dongye,M., Wang,D., Wang,J.,
            Li,W., Wu,X., Lin,D. and Lin,H.
  TITLE     The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in
            Cryptophthalmos Development
  JOURNAL   Front Cell Dev Biol 8, 625492 (2021)
   PUBMED   33490088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12368)
  AUTHORS   Center,E.M. and Polizotto,R.S.
  TITLE     Etiology of the developing eye in myelencephalic blebs (my) mice
  JOURNAL   Histol Histopathol 7 (2), 231-236 (1992)
   PUBMED   1515706
REFERENCE   7  (bases 1 to 12368)
  AUTHORS   Eicher,E.M. and Lane,P.W.
  TITLE     Assignment of LH XVI to chromosome 3 in the mouse
  JOURNAL   J Hered 71 (5), 315-318 (1980)
   PUBMED   6160178
REFERENCE   8  (bases 1 to 12368)
  AUTHORS   Center,E.M.
  TITLE     Genetical and embryological comparison of two mutations which cause
            foetal blebs in mice
  JOURNAL   Genet Res 29 (2), 147-157 (1977)
   PUBMED   405279
REFERENCE   9  (bases 1 to 12368)
  AUTHORS   Davisson,M.T., Eicher,E.M. and Green,M.C.
  TITLE     Genes on chromosome 3 of the mouse
  JOURNAL   J Hered 67 (3), 155-156 (1976)
   PUBMED   820740
REFERENCE   10 (bases 1 to 12368)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138112.4, CN536459.1, CN534900.1, CN530725.1, CF742372.1,
            BC068185.1 and BE864729.1.
            
            On Jul 28, 2006 this sequence version replaced NM_172862.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB236662.1, AJ833643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5411              AC138112.4         82150-87560
            5412-5879           CN536459.1         77-544
            5880-6114           CN534900.1         443-677
            6115-6753           CN530725.1         1-639
            6754-7159           CF742372.1         74-479
            7160-11439          BC068185.1         62-4341
            11440-11882         BE864729.1         53-495
            11883-12368         BC068185.1         4785-5270
FEATURES             Location/Qualifiers
     source          1..12368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.24 cM"
     gene            1..12368
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /note="Fras1 related extracellular matrix protein 2"
                     /db_xref="GeneID:242022"
                     /db_xref="MGI:MGI:2444465"
     exon            1..5411
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..9754
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /note="FRAS1-related extracellular matrix protein 2; NV
                     domain containing protein NV1; ECM3 homolog; NV
                     domain-containing protein 1"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 2
                     precursor"
                     /protein_id="NP_766450.2"
                     /db_xref="CCDS:CCDS17348.1"
                     /db_xref="GeneID:242022"
                     /db_xref="MGI:MGI:2444465"
                     /translation="MASRARRTAKFSSFQPILAQSPRLLLLLLLLSLVSYVSTQAAGP
                     GAALQSLGLSGTSGVPTEEAIVVANRGLRVPFGREVWLDPLRDLVLQVQPGDRCTVTV
                     LDNDALAQRPGHLSPKRFACDYGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAIVLP
                     LALEVEVVFTQLEIVTRNLPLVVEELLGTSNALDDRSLEFAYQPETEECRVGILSGLS
                     ALPRYGELLHYPQVQGGAGDRGTSKTLLMDCKAFQELGVRYRHTAPSRSPNRDWLPMV
                     VELHSRGAPEGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPD
                     MLAAEDAESDPDLLIFNLTSAFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPS
                     EDSDQERLFELELEIVDPEGAASDPFAFMVVVKPMNTLAPVVTRNTGLILYEGQYRPL
                     TGPIGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGSPSSDSAPKTFTVAELAAG
                     QVVYQHDDKDGSLSDNLVLRMSDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTVAE
                     GETVPIPPLTLSATDIDSDDSQLVFVLLPPFSSLGHLLLRQRHVPQEEQGLWQKQGSF
                     YERTVTEWRQQDITEGKLFYRHSGPHSPGPVMDQFMFRVQDNHDPPNQSGIQRFVIRI
                     HPVDRLPPELGSGCPLRMVVQESQLTPLRKRWLHYTDLDTDDRELQYTVTQPPTDTDE
                     NHSPAPLGTLVFTDNPSVVVSHFTQAQVNHHKIAYRPPGQELGVAARVAQFQFQVEDR
                     AGNVAPGTFTLYLQPVDNQPPEIVNTGFTVEEKGHHILRETELHVSDVDTDVTHISFT
                     LTQAPKHGHMQISGRPLHVGGQFHLEDIKHGRISYWNSGDESLTDSCSLEVSDRHHVV
                     PITLRVNVRPGDREGPMSVLPAGTLESYLDVLENGATEVTANIIKGAYQGTDDLMLTF
                     LLEGPPSYGEILVNGAPAEQFTQRDILEGSVVYAHTSGEIGLLPKADSFNLSLSAMSQ
                     EWRIGSSIVQGVTVWVTILPVDSQAPEISLGEQFVVLEGDKSVISLTHLSAEDMDSLK
                     DDLLCTIVIQPTSGYVENISPAPGSEKSRAGVAISAFTLKDLRQGHINYVQSVHRGVE
                     PVEDRFIFRCSDGINFSERQIFPIVIIPTNDEQPEMFMREFMVMEGMSLVVNRLILNA
                     ADADIPRDDLTFTITRFPTHGHVMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQ
                     EDSFVIKLTDGKHSVEKMVLIVVIPVDDETPRMTINNGLEIEIGETKVINNKVLMATD
                     LDSDDKSLVYIIRYGPGHGLLQRQKPLGAFENITLGMNFTQDEVDRNLIQYVHFGQEG
                     IRDLIKFDVTDGTNALIDRYFYVTIGSVDIVFPDVVSKGVSLKEGGKVTLTTDLLSTS
                     DLNSPDENLVFTITRAPMRGHLECTDRRGLSITSFTQLQLAGNKIYYIHTAEDEVKMD
                     SFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHNLVVSESESKLITPFELTVEDRDT
                     PDRLLKFIVTQVPVHGHLLFNNTRSVMVFTKQDLNENLISYKHDGTESTEDSFSFTVT
                     DGTHSDFYVFPDTVFETRRPQVMKIQVLPVDNSVPQIVVNKGASTLRTLATGHLGFMI
                     TSKILKVEDRDSLHFSLRFIVTEAPQHGYLLNLGQGNHSVTQFTQADIDDMKICYVLR
                     ERANATSDMFHFIVEDDGGNRLTNQHFRLNWAWISFEKEYYLINEDSKFLDIVLTRRG
                     YLGETSFISIGTRDGTAEKDRDFKGKAQKQVQFNPGQTRASWRVRILSDGEHEHSETF
                     QVVLSEPVLAILEFPTVTTVEIIDPGDESTVFIPQSEYSVEEDVGELFIPIRRSGDIS
                     RELMVICYTQQGTATSTVRTSVLSYSDYISRPEDHSSVIRFDKDEREKMCRILVIDDS
                     LYEEEETFQVLLSMPMGGRIGDKFPGANVTILTDRDDEPAFYFGDTQYSVDESAGYVE
                     LQVWRTGTDLSKPSSVTVRSRKTESLSADAGTDYVGISRNLDFAPGVNMQTVRVVILD
                     DLGRPILEGIEKFELVLRMPMNAALGEPSKATVSINDSASDLPKMQFKERVYTCNEND
                     GRVVAMIYRSGDIQHRSSVRCYTRQGSAQVMMDFEERPNTDVSTVTFLPGEMEKPCVL
                     ELMDDAVYEDVEELRLVLGTPQGSSAFGAAVGEQNETLIKIQDEADKAVIKFGETKFS
                     VTEPSRPGESVVVKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGET
                     QHTVEIEVIFDGVREMREAFTVHLKPDENMVAETQATKAIVYIEEIHSMADVTFPSVP
                     HIVSLLIYDDPSKGREDTGPVSGYPVVCITACNPKYPDYEKTGSICASENINDTLTRY
                     RWLISAPAGPDGVTSPMREVDFDTFFTSSKMITLDSIYFQPGSRVQCAARAVNTNGNE
                     GLELMSPIVTIGREEGLCQPRVPGVVGAEPFSAKLRYTGPEDPDFANLIKLTVTMPHI
                     DGMLPAISTRELSNFELTLSPDGTRVGNHKCSNLLDYNEVKTHHGFLTNATKNPEVIG
                     ETYPYQYSVPVRGSSTLRFYRNLNLEACLWEFVSYYDMTELLADCGGTIGTDGQVLNL
                     VQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNHGIGSPPEAE
                     LQGSLYPTSMRIGEEGRLAVNFKTEAQFHGLFVLSHPASFTSSLIVSADHPGLTFSLR
                     LIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTTPSNQEYRLPVTCNPREPVT
                     FDLDIRFQQVSDPVATEFSLNTHMYLLSKKNLWLSDGSMGFGQESDVAFAEGDVIYGR
                     VMVDPVQNLGDSFYCSIEKVFLCTGDDGYVPKYSPANAEYGCLADSPSLLHRFKIVDK
                     AQPETQATSFGDVLFNAKLAVDDPEAVLLVNQPGSDGFKVDSTPLFQVALGREWYIHT
                     IYTVKSKDNTHRGIGKRSLEYQYHSVVHPGPPQATTKSWKKRAVRSTPSLAGEIGAEN
                     NRGTNIQHISLNRRGKRQVPHGRIPPDGILPWELNSPSSEVSLVTVLGGLTVGLLTVC
                     LAVAAAVMCRNRSTKGKDTPKGSGSTEPMMSPQSHYNDSSEV"
     exon            5412..5501
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..5648
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            5649..5879
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            5880..6005
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6006..6257
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6258..6407
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6408..6617
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6618..6815
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6816..6980
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            6981..7163
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            7164..7294
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            7295..7453
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            7454..7757
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            7758..7889
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            7890..8221
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8222..8414
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8415..8519
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8520..8647
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8648..8782
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8783..8909
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            8910..9097
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            9098..9244
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     exon            9245..12348
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10404..10409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
                     /note="hexamer: AATATA"
     polyA_site      10426
                     /gene="Frem2"
                     /gene_synonym="6030440P17Rik; 8430406N05Rik; b2b1562Clo;
                     Gm409; my; ne; nv1"
ORIGIN      
        1 gacgtaggga ctctcctgac tgctacacgc ccgggacgcg ctggaagtgt ttagtgcctt
       61 ggattgcggc tccaaggagg gaccgtgcgg tgcatttggc catcctcctg gtccagccct
      121 gccactggga gggccccgca ggcaccgcgc cgagttcccg gcccttccca ccgtgctctc
      181 taggagcctg caaagtctag ctttgcatac ccgccgggtg aactgtcgga actctaaggc
      241 cggcagcctg cataccacaa gggctcccgg gatggccagc cgtgcgcgca ggacagccaa
      301 gttctccagc ttccagccga tactcgcaca gtcgcctagg ctgctgctgc tgctgctgct
      361 cctgtcactg gtaagctacg tctccacaca ggctgctggc cccggtgcag cacttcagtc
      421 cctgggtctc tccgggactt cgggagtccc tacagaggaa gctatagtgg tggcaaaccg
      481 cgggctccgt gtgcccttcg gtcgcgaagt ctggctggat ccgttgcgtg acttggtgct
      541 gcaggtgcag ccaggagacc gctgcacagt gaccgtgtta gacaacgacg cgctggccca
      601 gcggccgggc cacttgagtc ccaagcgttt tgcgtgcgac tatggcccgg gtgaggtgcg
      661 ctactcgcac ctgggtgctc gcagcccttc ccgcgaccgc gtccgcctgc agctgcgcta
      721 cgatgctcca ggaggggcga tagtcctgcc actggcacta gaggtggaag tggtcttcac
      781 ccagctggag attgtgactc ggaatttacc tctggtcgtg gaagaactgc tagggaccag
      841 taatgccttg gacgatcgga gcttagagtt cgcctaccag cctgagaccg aggagtgccg
      901 cgtgggcatc ttgtcaggtc tgagcgcttt gcctcgttac ggagaactcc ttcactaccc
      961 acaggtccag ggaggggccg gagatagagg gacctctaag acccttttga tggactgcaa
     1021 agcattccag gagctgggag tccgctaccg ccacacagcc cccagccgct cgcctaacag
     1081 ggactggctg cctatggtgg tcgagctgca ttcgcgaggg gctccagagg gcagcccggc
     1141 tctaaaacgc gaacacttcc aggtgcttgt gaggattcga ggaggagcgg agaacactgc
     1201 acccaagccc agtttcgtgg ccatgatgat gatggaggtg gaccagtttg tactgactgc
     1261 tctcactcca gacatgctag cagccgagga tgctgaatcc gacccagacc ttttgatttt
     1321 caacctcacc tctgccttcc agcctgggca gggctacctg gtgagcacgg atgacagaag
     1381 cctgcctctc tcctccttta cacagcggga tttgcgcctg ctgaagattg cctaccagcc
     1441 tccctctgaa gactcggatc aggagcgtct gtttgaacta gagctggaga tagtggaccc
     1501 tgaaggagca gcctcagacc ctttcgcctt catggtggtg gtgaaaccca tgaacacact
     1561 ggctcccgtg gtcacacgaa acactggcct tattctctat gagggtcaat atcggccgct
     1621 cacgggtccc ataggcagtg gaccccagaa cttggtcatc agtgatgaag atgacctaga
     1681 agctgtgagg ctggaggtgg tggctgggct ccggcatggc caccttgtta ttctgggttc
     1741 tcccagtagc gactctgctc ccaagacctt cacagtggcg gagctggcgg ctggccaggt
     1801 tgtgtatcag catgatgaca aagacggttc actgagtgac aacttggtgc tgcgcatgtc
     1861 cgatggagga ggcaggcacc aggtccagtt cctgttccct atcactttag tgcctgtgga
     1921 tgaccagccg ccggtcctga acgccaacac tgggctgaca gtggctgagg gggaaactgt
     1981 gcctatccca cccttgactc tcagtgcaac cgatatagat tcagatgact ctcagctggt
     2041 ttttgtcctg ttgccaccct tctcaagctt ggggcacctg cttctccgcc aaaggcatgt
     2101 cccccaggaa gagcagggtc tgtggcagaa gcaagggtca ttttacgagc gaacggtgac
     2161 agagtggcgg caacaggata taacagaggg gaagctcttc tataggcact cggggcccca
     2221 cagccctggg ccggtgatgg accagttcat gtttagagtc caagacaatc atgatccccc
     2281 taaccagtct gggatccaga ggtttgtaat acgcattcat cccgtggacc gtctccctcc
     2341 agaactgggc agtggctgtc cccttcggat ggtggtacag gaatcccagc tcacaccact
     2401 gaggaaaagg tggctgcact acactgacct ggacacagat gaccgagagt tacagtacac
     2461 agtgacccag cctcccacgg acacagatga gaaccactcg ccggctccac tgggcacgtt
     2521 ggtcttcact gataatccct cagtggtggt gagccatttt acccaagccc aggtcaatca
     2581 tcataaaatt gcttacaggc ccccagggca ggagctagga gtcgcagccc gagtggctca
     2641 gttccagttc caagtagagg atcgagctgg gaatgtggct cctggcacct tcacccttta
     2701 cctgcagcct gtggataacc agccccccga gattgtcaac actggcttca ccgttgagga
     2761 gaagggccac cacatcctgc gtgagaccga gctgcatgtg agtgatgttg acacggatgt
     2821 gacccacatc tcgttcactc tcacacaggc ccccaaacac ggccacatgc aaatatctgg
     2881 acggccactg catgtaggcg gacaattcca cttggaggac ataaagcatg gcagaatttc
     2941 ctactggaat agcggggatg agtctttgac tgacagctgc tccctggagg tcagcgacag
     3001 acaccatgtg gtgccaatca ctctcagagt gaacgttcgg ccaggggacc gtgaaggtcc
     3061 tatgtcagtc cttcctgctg gtactctgga gtcctatcta gacgtcttag agaatggggc
     3121 tactgaagtc actgccaata tcattaaggg ggcctatcag ggtaccgatg atttgatgct
     3181 gaccttcctg ttagaaggcc caccctccta tggggaaatc ttagtcaacg gagctccagc
     3241 tgagcagttc acccagaggg acatcctgga gggctctgtt gtctacgctc acaccagtgg
     3301 tgagattggc ctgttgccca aagctgactc ttttaacctg agtctatcag ctatgtctca
     3361 agaatggaga atcggtagca gcatcgttca aggcgtcact gtgtgggtga ccatcctccc
     3421 cgtggacagc caagcccctg agatttctct tggtgaacag tttgtagtgc tggaaggtga
     3481 caagagtgtg ataagcctga cccacctaag tgctgaggac atggactccc tgaaggatga
     3541 cctcttgtgc acaatagtca ttcagccaac ctcaggctat gtagagaaca tttctccagc
     3601 accaggctca gagaaatcaa gagccggggt tgccataagt gccttcacgc tgaaggatct
     3661 caggcaagga cacattaact atgtccagag tgtccacaga ggagtggagc ctgtcgaaga
     3721 ccgctttata ttccgttgtt ctgacggtat taacttctct gagagacaga tattccccat
     3781 tgtcatcatt cctaccaatg acgagcagcc agaaatgttc atgagggaat tcatggtgat
     3841 ggaaggcatg agtctggtgg tcaacagact catcctcaac gctgctgatg ccgacattcc
     3901 cagggatgat ctaacgttta ctattacccg gtttccaact cacggtcatg tcatgaacca
     3961 gttaatcaat ggtacagtgt tggttgaaag cttcaccctg gatcagatta tagagagttc
     4021 cagcattatt tatgagcacg atgactctga gacacaagag gacagttttg tgattaaact
     4081 gacagatggc aagcactccg tggagaagat ggtcctcatt gtggtcatcc ctgttgatga
     4141 cgagacaccc agaatgacca tcaataatgg gctagaaata gaaattgggg aaaccaaagt
     4201 tatcaacaac aaagtcctaa tggcaaccga tctagactct gatgacaaat cactggttta
     4261 tattatccgt tatggaccag ggcatggctt gttacagaga caaaaacctc taggtgcctt
     4321 tgaaaatatc actctaggca tgaattttac ccaggacgaa gtggacagga acttgattca
     4381 atatgtccac tttgggcaag aaggtattcg agacctgatt aaattcgatg tgacagatgg
     4441 aacaaatgct cttatagatc gctactttta cgtgactatt ggaagtgttg acattgtctt
     4501 ccctgatgtg gtaagtaagg gcgtgtcctt gaaagaaggt ggcaaagtca ctctgacaac
     4561 ggatctgctg agcacaagtg acttgaacag ccctgatgag aacttagttt tcaccattac
     4621 cagggctcct atgagaggtc acttggagtg cacggatcga aggggactgt ccatcacttc
     4681 tttcactcag ctccagctgg ctggtaacaa aatctactac atacacacgg ctgaggatga
     4741 ggtcaaaatg gacagcttcg agtttcaagt caccgatggg cggaaccctg tcttccgaac
     4801 tttccggatc tcaatcagtg acgtagacaa caaaaagcca gtggtcacca tccacaacct
     4861 ggtggtcagt gaaagtgaaa gtaagctgat cacccccttt gaactcactg tggaggacag
     4921 agatacccct gacaggctcc taaaattcat tgtcacccag gtccctgttc acggtcacct
     4981 cctcttcaac aataccagat ctgtcatggt tttcaccaag caagacttga atgaaaactt
     5041 aatcagctac aaacacgatg gcacagaatc cacggaagac agcttctcct tcaccgtgac
     5101 tgacggcacc cactcggact tctatgtttt tcctgataca gtgtttgaaa ccaggagacc
     5161 tcaagtgatg aaaatccagg tgttacctgt tgacaacagt gtcccccaaa ttgtggtgaa
     5221 caaaggagct tctacccttc gtaccctggc cactggccat ttagggttca tgatcacaag
     5281 caaaatactc aaagtggagg acagagacag cctgcatttt tctctcaggt tcattgtgac
     5341 agaagccccc caacatggct accttctcaa cctgggccaa ggaaaccaca gtgtcacaca
     5401 gttcacccaa gctgacattg atgacatgaa aatatgctat gtcttgagag agagagcaaa
     5461 tgccacaagt gatatgttcc atttcatagt ggaagatgac ggtggaaaca ggttaaccaa
     5521 ccagcatttt cgactgaatt gggcgtggat ctcctttgaa aaagagtatt acttgatcaa
     5581 cgaagactcc aaatttctag atattgttct tacacgcaga ggatacttgg gagaaacttc
     5641 atttataagt atcggcacca gggatgggac tgcggaaaaa gacagagact tcaagggtaa
     5701 agctcagaaa caggtacagt tcaaccccgg ccagaccagg gcctcgtgga gagtgcgcat
     5761 cctgagcgac ggggaacacg agcactcgga gaccttccaa gtggttctct cggagcctgt
     5821 gctggcaatc ctggagttcc ccacagtgac tacagtggag atcatcgacc caggagacga
     5881 atcaaccgtg ttcattcccc agtctgagta ctctgttgaa gaagatgtgg gtgagctgtt
     5941 cattcccatc aggagaagtg gagacatcag ccgggagctg atggtgatct gctacacaca
     6001 gcaagggaca gccaccagca ctgtgcggac gtccgtgctc tcttactctg actacatctc
     6061 caggcccgag gaccacagca gcgtgatccg ctttgacaaa gacgaacgag agaaaatgtg
     6121 tcgtattttg gtaattgatg actctttgta cgaagaggag gagactttcc aggtcctttt
     6181 gagcatgccc atgggcggga ggatcggtga caagtttcca ggagccaatg tgaccatcct
     6241 cacagacagg gatgatgagc ctgccttcta ctttggggac acccagtact ccgtggatga
     6301 gagtgccggc tacgtggagc tgcaggtgtg gaggacgggg accgacctct ctaagccttc
     6361 cagtgtcaca gtgaggtccc ggaaaacaga atccctctct gcagatgctg gaacagacta
     6421 tgtgggaatc agtcgcaatt tagattttgc gcctggcgtc aacatgcaga ctgttcgagt
     6481 ggtcattctg gatgaccttg gacgaccaat actggaggga attgagaagt ttgaactggt
     6541 acttcgaatg cctatgaacg ctgcccttgg ggagcccagc aaggccaccg tgtccataaa
     6601 tgactctgcc tcagacttgc ctaaaatgca attcaaagag agagtgtaca cttgcaacga
     6661 gaatgacggg cgtgtagtgg ccatgatcta caggagcggt gacatccagc acaggtcttc
     6721 tgtgagatgt tacacgaggc aggggtctgc gcaggtgatg atggacttcg aggaacgccc
     6781 aaataccgat gtttccactg tcacattcct ccctggtgag atggagaagc cgtgtgtcct
     6841 cgagctgatg gatgatgctg tctatgagga tgtagaggag ctgcgcctgg tacttggcac
     6901 gcctcagggc agctctgcct ttggagctgc agtgggcgag cagaacgaaa ccctgataaa
     6961 gatccaggat gaggctgaca aagctgttat caaatttgga gaaaccaaat ttagtgtcac
     7021 tgagcccagc agaccaggag agtcggtggt tgtcaaaatc ccggtcatcc gtcaaggaga
     7081 cacttcaaag gtctccatcg tgagagtcca caccaaggat ggctcggcta cctccggaga
     7141 ggattatcac cctgtgtcag aagaaatcga gtttaaggag ggagaaaccc aacacactgt
     7201 tgaaattgaa gtaatcttcg acggggtgag agagatgagg gaggccttca ctgttcacct
     7261 aaaaccagat gaaaatatgg tggcagagac acaggcaacc aaggccattg tatatataga
     7321 agaaatccac agcatggcag atgtcacctt tccttctgtc cctcacattg tgtccttgct
     7381 gatatacgat gatccctcca aaggcagaga ggacactgga cctgtgtctg gctacccggt
     7441 tgtctgcatt acggcctgca accccaaata tccagactat gagaaaacag gctctatttg
     7501 tgccagtgag aacatcaacg acactttgac ccgatacaga tggctgatca gcgctcccgc
     7561 tggccctgac ggtgtgacca gccccatgag agaggtcgac ttcgacacct tcttcacatc
     7621 atccaaaatg attacattag actccatata ctttcagcct ggctcccggg tccaatgtgc
     7681 ggcccgagca gtgaacacca atgggaatga aggcctggaa ctaatgagcc ccatcgttac
     7741 catcggcaga gaggaaggtc tctgtcagcc ccgtgtgcct ggggtagtgg gggcagagcc
     7801 attctccgct aagttgcgct acactggccc agaggaccca gactttgcca acctcatcaa
     7861 actcactgtc actatgccgc acatagacgg catgctccct gccatctcca caagagagct
     7921 gtccaacttt gagctgaccc tcagccctga cggcacgaga gttgggaatc acaaatgctc
     7981 caacctgctg gactacaatg aagtaaagac ccaccatggc ttcctgacca acgccacaaa
     8041 gaacccagag gtcattggag agacctatcc ttaccagtac agtgtgccgg tcaggggttc
     8101 cagcacctta cgcttctacc gaaacctgaa cctggaagca tgtctgtggg agtttgtcag
     8161 ctactatgac atgacggagc tcctggctga ctgtggagga accatcggga ccgatggcca
     8221 ggtcctcaac ctcgtgcagt cctacgtgac ccttcgagtt cctctgtacg tttcctacgt
     8281 gttccactcc cccgtgggcg tgggcggctg gcagcatttc gacttgaagt cagagctccg
     8341 actcacattc gtgtacgaca ctgccatctt gtggaaccat gggatcggca gccccccgga
     8401 agctgagctg caaggctctc tttacccaac cagcatgcgc attggtgagg agggacgcct
     8461 ggctgtgaac ttcaaaacag aggctcagtt ccatggcttg tttgtgctgt cccatcctgc
     8521 ttcctttacc agctcactga tcgtgtcagc tgaccatccg ggcctcacat tttccctccg
     8581 ccttatacgg agtgaaccaa cctacaatca gccagtccag cagtggagtt tcgtgtcaga
     8641 ctttgcggtc cgtgactact cgggcaccta cacagtaaag ttggtaccct gcaccactcc
     8701 atccaaccag gagtaccgtc tgccagtcac ctgcaacccc agagagcctg tcacctttga
     8761 ccttgacatt cgattccaac aggtcagcga tcccgtggcg actgagttca gcctgaacac
     8821 ccacatgtat ctgctgtcta agaagaatct ctggttgtct gatgggtcca tgggatttgg
     8881 gcaggaaagc gacgtggctt ttgcagaagg ggatgtgatt tatggccgtg tcatggtcga
     8941 tcctgtccag aacctcggtg actcctttta ctgcagcatt gagaaggtgt tcttatgcac
     9001 gggggatgac ggctacgtgc ccaagtacag cccagcgaat gcggaatatg gctgcctggc
     9061 tgattctcct tcactcttac atagattcaa aatcgtggat aaggctcagc cagagacaca
     9121 agccaccagc tttggagatg tcctgtttaa cgccaaactg gcagtggatg accctgaagc
     9181 tgttctctta gtgaatcagc ctggatccga tggttttaaa gtagactcaa caccactctt
     9241 tcaggttgcc ttgggccgag agtggtacat acacacaatc tatacggtaa agtctaagga
     9301 caacacccat cgaggcattg gcaagaggag cctggagtac cagtatcact cagtggtgca
     9361 tcccggacca ccgcaggcaa ccaccaagag ctggaagaag agagcagtca ggagcacgcc
     9421 ctccctcgca ggggagatcg gtgctgagaa caaccgggga acaaacatcc aacatatctc
     9481 cctgaaccgc cgtggcaaga ggcaggtccc ccacggaaga attcctcctg acggcatcct
     9541 gccctgggag ctcaatagtc ccagctctga agtgagcctt gtcactgtcc tgggaggcct
     9601 cacggtgggc ttgctcacag tctgcctggc tgtggctgcg gccgtcatgt gcaggaacag
     9661 gagcactaag ggcaaggata ctccaaaggg ctctggaagc actgagccca tgatgtcccc
     9721 gcagagccac tacaacgaca gctcggaggt gtgatggcct tctcttccgt gtgcctcaga
     9781 agatggggca ggacccccga ctgcttggga gcagcagcag agaactgaga gctttccgtg
     9841 acaaaggtgc taagagcccc tgactgtatt aaaagatttt gatttgattt gaactctatt
     9901 gcgccatgca tgcatcaaag gacaaattca ggccacatct ttcctgctgc ccagaaggca
     9961 tccaggatgc ttagagcctt ggtgggcggg caggggaggt gcttcttgta ttaggcagcg
    10021 ggtaagatga accagctccg aggtgctcaa aggtgctcaa ggactctctg ggaagtctga
    10081 gaggagatag ctatcactct gttttgttag tgtgaaattt gaaggtgctg ttatcatttg
    10141 tttattcttt gtataactga actgtttgaa ttggtaggcc cgaagcgtga caaacacacg
    10201 gaaatgacaa gttgtctaat ccgtgaagac aacatgaagt catgaccagg gctagttcaa
    10261 cccacgaatc acctcttact gatgggaaaa catagaagga atgactagaa aaaaaggaaa
    10321 atttgtttgg atctgaattg cttctcattc ccctcagacc tcctttgtct cacttgctta
    10381 tttaacattc acttaaacca aagaatatat taattctgga aacggatttt taagagacta
    10441 acgtcttcgg gatatatttg cagccaggct ctcgttaatc ggcctcactg ataacccagc
    10501 cttggtgtga agcaagagag ttgtagacgt gccggcaaag agacaccata gagttagatt
    10561 cgccacacga caaggttctc aagaactgag cctagatgtt tacagtattg aacccgtgca
    10621 tagtgagaaa cagctttacc aatggtgaag ggtgagagtg atatttatta acatgctttg
    10681 gaccaccaga atgcctcttg ggcgcgtttt ctagaacagt gatggcaaat gagattagtc
    10741 ttagaggaac agccgcacga caccatccgg agcttatatc agccacagga aattgtatta
    10801 ggctaaaatc tgctctaaat aatgggaatc tctctagaca tgtcactcca gaaattgact
    10861 tggaggtggc catggctgtc aatcattctc ttcagtgatc caggaagaga acatctctgt
    10921 ctggcctccc ccagttcagc gagccggtgc tatgaggttg ccctctggga ccttatctgt
    10981 gttctgtcac tttgatcgtt cactgtgtaa aaacctcttc agaagagtat gttagaaatt
    11041 ctgtttagaa caggaacact tcagcagagt aatggccatt tcctaaaacc cagtgaatac
    11101 atttatacca aaatgaatgc cttcacatag ccctcaaagg ctgcatgaag cccctcacgc
    11161 ttcagccaca ccctggccaa gctgaaccat cctggtagaa tggagatact cggaagcaaa
    11221 cttcatctca ggtcattcct gtatgtcagt gggtatcaac ctgtgagtgc cagcctgtct
    11281 atcagtgggt gcctgtgagt gccagcctgt ctatcagtgg ggagtgggtg cctgtgagtg
    11341 ccagcctgtc tatcagtggg tagtgggtgc ctatgagtgc cagcctgtct atcagtgggt
    11401 agtggatgcc tgtgagtgcc agcctgtcta tcagtgggta gtgggtgcct gtgagtgcca
    11461 gcctgtctat cagtgagtag tgggtgcctg tgagtgccag cctgtctatc agtgggtgcc
    11521 tgtgagtgcc agcctgtcta tcagtaggtg cctgtgaata ccaaccatat cttgactgag
    11581 aaagggaagc tgcactggtc ctgaaggaga aatgcctgtt gcctgcttcc ctctccatcc
    11641 agtgtctttc aagagatgag acacactgta gcacccttct gttggggagc ttagcgagtc
    11701 ctatctatag cacaagtgtc ccccagggga ctgactcaca ggggcagaaa gcgttgtcag
    11761 cccaggggtc cacttatcag atggagtggt tcattatcat cctttctttg ttttacctcc
    11821 agcagaccct tagctccatg tttggctacc tcagaatttg ggaatgacca tgttgccaac
    11881 agtataggaa cttccactgc ttagctttca gttcatcttc tgaagatagt cagagcaatt
    11941 gttctcaact ggcttgctgt ttctagtggt tgagcacttc caagcctgac tgccctgtgg
    12001 ccttcagctc aggaagtgaa tatagcaacg aatggcacat tatcatatat tgtgaccagg
    12061 atgcgtctat gccaaatctc actcggctgt gcattgttct attgaagcta ttgtctataa
    12121 gttagatgtt atattaagta caagataagc ctagcctcct gcaataggaa atgtcagtat
    12181 tctttctctc tctcccatct cttcttcctc ctcttactgg tatttttttt tcataatttt
    12241 aaaagtatct atttactaaa tatgtggctt aaaatacagt aatcgtttta aaaatctttt
    12301 caataagaaa aaaaaatgtt ttttaaataa agtaagtctt tgttttcaaa aaaaaaaaaa
    12361 aaaaaaaa
//
