LOCUS       NM_177603               2176 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus frequently rearranged in advanced T cell lymphomas 2
            (Frat2), mRNA.
ACCESSION   NM_177603 XM_977206 XM_994444
VERSION     NM_177603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   van der Wal,T., Lambooij,J.P. and van Amerongen,R.
  TITLE     TMEM98 is a negative regulator of FRAT mediated Wnt/ss-catenin
            signalling
  JOURNAL   PLoS One 15 (1), e0227435 (2020)
   PUBMED   31961879
  REMARK    GeneRIF: TMEM98 reduces FRAT2 protein levels and, accordingly,
            inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Walf-Vorderwulbecke,V., de Boer,J., Horton,S.J., van Amerongen,R.,
            Proost,N., Berns,A. and Williams,O.
  TITLE     Frat2 mediates the oncogenic activation of Rac by MLL fusions
  JOURNAL   Blood 120 (24), 4819-4828 (2012)
   PUBMED   23074275
  REMARK    GeneRIF: Data show that MLL fusion oncogenes maintain
            leukemia-associated Rac GTPases activity by regulating Frat gene
            expression, specifically Frat2.
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Bechard,M., Trost,R., Singh,A.M. and Dalton,S.
  TITLE     Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant
            of glycogen synthase kinase 3beta subcellular localization in
            pluripotent cells
  JOURNAL   Mol Cell Biol 32 (2), 288-296 (2012)
   PUBMED   22064483
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   van Amerongen,R., Nawijn,M.C., Lambooij,J.P., Proost,N., Jonkers,J.
            and Berns,A.
  TITLE     Frat oncoproteins act at the crossroad of canonical and
            noncanonical Wnt-signaling pathways
  JOURNAL   Oncogene 29 (1), 93-104 (2010)
   PUBMED   19802005
  REMARK    GeneRIF: Data show that that Frat synergizes with Diversin in the
            activation of JNK/AP-1 signaling.
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   van Amerongen,R., Nawijn,M., Franca-Koh,J., Zevenhoven,J., van der
            Gulden,H., Jonkers,J. and Berns,A.
  TITLE     Frat is dispensable for canonical Wnt signaling in mammals
  JOURNAL   Genes Dev 19 (4), 425-430 (2005)
   PUBMED   15681612
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   van Amerongen,R., van der Gulden,H., Bleeker,F., Jonkers,J. and
            Berns,A.
  TITLE     Characterization and functional analysis of the murine Frat2 gene
  JOURNAL   J Biol Chem 279 (26), 26967-26974 (2004)
   PUBMED   15073180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK081171.1 and BC085510.1.
            
            On Sep 9, 2009 this sequence version replaced NM_177603.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK081171.1         4-27
            25-2176             BC085510.1         1-2152
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.33 cM"
     gene            1..2176
                     /gene="Frat2"
                     /note="frequently rearranged in advanced T cell lymphomas
                     2"
                     /db_xref="GeneID:212398"
                     /db_xref="MGI:MGI:2673967"
     exon            1..2161
                     /gene="Frat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..917
                     /gene="Frat2"
                     /note="FRAT-2"
                     /codon_start=1
                     /product="GSK-3-binding protein FRAT2"
                     /protein_id="NP_808271.1"
                     /db_xref="CCDS:CCDS29813.1"
                     /db_xref="GeneID:212398"
                     /db_xref="MGI:MGI:2673967"
                     /translation="MPCRREEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDRLIV
                     QIGETLQLDTAHDRPASPCAAPGPPPAPPRVLAALSADKTGTPARRLLRPTGSAETGD
                     PAPPGAVRCVLGERGRVRGRSAPYCVAEIAPGASALPGPGRRGWLPGSVASHRIQQRR
                     WTAGGARAADDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATSPASAPGSGGGRSG
                     PDSVTLQPSGAWL"
     polyA_site      1234
                     /gene="Frat2"
                     /note="major polyA site"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frat2"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="Frat2"
                     /note="major polyA site"
ORIGIN      
        1 tttacaaatc aacccaagcc ggcagcgttc cggctcccgc ggctctaagg cgcgcggtac
       61 ctctgcccgg tggtcccggc ttccgcatcc ccaggctcgg ccccctcctg gcccggcttg
      121 ggcctccgcc gcgctcccgc cccagccgcg gctcgccgag cccgcggcca accgagctgc
      181 cagcgacgcc cgcacagccg cgggggcccg ggcggggggc catgccttgc cggagagagg
      241 aggaggagga agccggcgac gaggcagagg gggaggagga cgacgacagc ttcctcctgc
      301 tgcagcagtc ggtgactctg ggcggctcga ccgacgtgga tcggctcatc gtccagatcg
      361 gcgagacgct gcagctggac acggcgcacg atcgcccggc ctcgccgtgt gccgccccgg
      421 gtcccccacc cgcgcctccg cgggtcctgg cggcgctgtc ggcggacaag accgggaccc
      481 cagcgaggcg gctgctgcgg ccgacggggt cagcagagac cggggaccct gcgcctccgg
      541 gggccgtgcg ctgcgtgctg ggggagcgcg ggcgtgtgcg gggccgatcg gcgccctact
      601 gcgttgcgga gatcgccccg ggtgccagcg cgcttcccgg gccggggcgg cgagggtggc
      661 tccccggctc cgtggcttct caccgaatcc agcagcggcg gtggacagca ggcggagcgc
      721 gcgcggccga cgacgacccg caccggctcc tgcagcagct cgtgctctcc ggaaacctca
      781 tcaaggaggc ggtgcgcaga ctccagcgag cggtcgccgc ggttgcggcc acgagccccg
      841 cgagcgctcc ggggtccggg ggtggccgaa gcggaccgga ctcagtcact ctgcagccct
      901 cgggcgcctg gctctgacag gggatccctg gaggaggaag aggacgccgc tacgctgatc
      961 caacagtgtc ttgcccggga ctgtgcggag caggagctgt cgtccatccc tcgggctaca
     1021 gcctcaaagt taccggccgc gagaggctgt tagagaaaac ggactctact gagtagcacc
     1081 agcagccgag gacctgggat ctaccggttg aactgtggca gctacttaat ccacttggac
     1141 ctgacttagc ccttatcgtg tgcttggatt gtttatagat gtggctcgca ggggcgggaa
     1201 tcgggagggc ttctaacaat acttgaaaaa ccaatagtag atatgatctc gttattttcg
     1261 ggtacagaag ctttctgaat atggtgctac aattgcagag cagagcggtt ctagggtgaa
     1321 gaacataagt tggcagattt atgttggtgg gttgacaacg cttgctttcc cctgcttaat
     1381 ttgtgattat gaaggttggg gacctggttg gtgaattctt gaaggtgggg agagatgagt
     1441 ttaaatgggg acatgcaatt gattcgacct tgccaacttg aactcaaggt caggttggta
     1501 gagtggagtg ttgtgggatt cttgggagcg ctcaccccag tgtctttttc tggagccaag
     1561 cacagaccgg agtgtccctt tgccaccgcg tggagtctcc cgaggacacg gccgacatgg
     1621 ccatccttgt aggaagagtt atttgcggtt tctgtgcttt gcttttccag aactacttct
     1681 gctaggccac tctttggcca tagctccagc tttctcagaa atggtcataa gcaacctcct
     1741 gatctccctg cggccattgt gtttgtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1801 taggggggaa agcagtgggc acacttttct gctcttttga ccctctgcag agttggaggg
     1861 cgcctctcct gctaaacctg tcagttcttg gtgagtgact gaaacttttt taaaatgtga
     1921 ctcccagagg agaaaatgct ggcttttcct cttgtgaacc ccgaggggca cctcaggtgc
     1981 catcccaaac tttaaggtag ctaaactttt ttttttttat gattcaatgg ctcggtcatc
     2041 ctccagatgt ggctgttgat gtacacttcg caacggagtg tctgaaattg tggtggtcct
     2101 gatttatagg attcataatt aaaatgtctg ctgaataaat ttggtttttg ttttgaaaaa
     2161 aaaaaaaaaa aaaaaa
//
