LOCUS       NM_008043               2614 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus frequently rearranged in advanced T cell lymphomas
            (Frat1), mRNA.
ACCESSION   NM_008043
VERSION     NM_008043.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Bechard,M., Trost,R., Singh,A.M. and Dalton,S.
  TITLE     Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant
            of glycogen synthase kinase 3beta subcellular localization in
            pluripotent cells
  JOURNAL   Mol Cell Biol 32 (2), 288-296 (2012)
   PUBMED   22064483
  REMARK    GeneRIF: Gsk3b is exported from the nucleus in a complex with Frat.
            Loss of PI3K/Akt activity results in dissociation of this complex
            and retention of Gsk3b in the nucleus.
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   van Amerongen,R., Nawijn,M.C., Lambooij,J.P., Proost,N., Jonkers,J.
            and Berns,A.
  TITLE     Frat oncoproteins act at the crossroad of canonical and
            noncanonical Wnt-signaling pathways
  JOURNAL   Oncogene 29 (1), 93-104 (2010)
   PUBMED   19802005
  REMARK    GeneRIF: Data show that that Frat synergizes with Diversin in the
            activation of JNK/AP-1 signaling.
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Martinez,G., Wijesinghe,M., Turner,K., Abud,H.E., Taketo,M.M.,
            Noda,T., Robinson,M.L. and de Iongh,R.U.
  TITLE     Conditional mutations of beta-catenin and APC reveal roles for
            canonical Wnt signaling in lens differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 50 (10), 4794-4806 (2009)
   PUBMED   19515997
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Hay,E., Faucheu,C., Suc-Royer,I., Touitou,R., Stiot,V.,
            Vayssiere,B., Baron,R., Roman-Roman,S. and Rawadi,G.
  TITLE     Interaction between LRP5 and Frat1 mediates the activation of the
            Wnt canonical pathway
  JOURNAL   J Biol Chem 280 (14), 13616-13623 (2005)
   PUBMED   15699046
  REMARK    GeneRIF: Data suggest that recruitment of Axin and Frat1 to the
            membrane by LRP5-triggered Wnt3 signaling leads to both Axin
            degradation and Frat1-mediated inhibition of glycogen synthase
            kinase-3.
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   Hansen,G.M. and Justice,M.J.
  TITLE     Activation of Hex and mEg5 by retroviral insertion may contribute
            to mouse B-cell leukemia
  JOURNAL   Oncogene 18 (47), 6531-6539 (1999)
   PUBMED   10597256
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Jonkers,J., van Amerongen,R., van der Valk,M., Robanus-Maandag,E.,
            Molenaar,M., Destree,O. and Berns,A.
  TITLE     In vivo analysis of Frat1 deficiency suggests compensatory activity
            of Frat3
  JOURNAL   Mech Dev 88 (2), 183-194 (1999)
   PUBMED   10534617
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Jonkers,J., Weening,J.J., van der Valk,M., Bobeldijk,R. and
            Berns,A.
  TITLE     Overexpression of Frat1 in transgenic mice leads to
            glomerulosclerosis and nephrotic syndrome, and provides direct
            evidence for the involvement of Frat1 in lymphoma progression
  JOURNAL   Oncogene 18 (44), 5982-5990 (1999)
   PUBMED   10557087
REFERENCE   9  (bases 1 to 2614)
  AUTHORS   Hansen,G.M., Tackles,D., Schwartz,C. and Justice,M.J.
  TITLE     A mouse chromosome 19 genetic map including the Lvis1 viral
            insertion site
  JOURNAL   Genomics 56 (2), 228-231 (1999)
   PUBMED   10051411
REFERENCE   10 (bases 1 to 2614)
  AUTHORS   Jonkers,J., Korswagen,H.C., Acton,D., Breuer,M. and Berns,A.
  TITLE     Activation of a novel proto-oncogene, Frat1, contributes to
            progression of mouse T-cell lymphomas
  JOURNAL   EMBO J 16 (3), 441-450 (1997)
   PUBMED   9034327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145557.3.
            
            On Oct 21, 2009 this sequence version replaced NM_008043.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U58974.2, AK015680.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2614              AC145557.3         73235-75848         c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.3 cM"
     gene            1..2614
                     /gene="Frat1"
                     /note="frequently rearranged in advanced T cell lymphomas"
                     /db_xref="GeneID:14296"
                     /db_xref="MGI:MGI:109450"
     exon            1..2614
                     /gene="Frat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1023
                     /gene="Frat1"
                     /note="frequently rearranged in advanced T-cell lymphomas
                     1"
                     /codon_start=1
                     /product="proto-oncogene FRAT1"
                     /protein_id="NP_032069.2"
                     /db_xref="CCDS:CCDS84438.1"
                     /db_xref="GeneID:14296"
                     /db_xref="MGI:MGI:109450"
                     /translation="MPCRREEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDQLIV
                     QIGETLQLDAAHDRPASPCAAPGPPPPQVLAALPADKTGTPARRLLRPTGSAETGNPA
                     PPGAVRCVLGERGRVRGRSAPYCVAEISPGASALPQQPGLDGPPGTGKLSTPQPLSGP
                     CRRGWLRNAAASRRLQQRRGSQPETRTGDDDDPHRLLQQLVLSGNLIKEAVRRLHSRQ
                     LQLHAKLPAHPFLGPLSAPVHEPPSPGSPRAACSDPGAFMGRAQLRTGDDLLVPGS"
     polyA_site      1572
                     /gene="Frat1"
                     /note="major polyA site"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frat1"
                     /note="hexamer: AATAGA"
     polyA_site      1655
                     /gene="Frat1"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Frat1"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="Frat1"
                     /note="major polyA site"
ORIGIN      
        1 attgtttaca aatcaaccca agccggcagc gttccggctc ccgcggctct aaggcgcgcg
       61 gtgccactgc ccggtggtcc ctgcctagcc cggcttgggc ctccgcctcg ctcccgcccc
      121 agccgcggct cgccgagccc gcggccaacc gagctgccag cgacgcccgc acagccgcgg
      181 gggcccgggc ggggggccat gccttgccgg agggaggagg aggaggaagc cggcgacgag
      241 gcggaggggg aggaggacga cgacagcttc ctcctgctgc agcagtcggt gactctgggt
      301 ggctcgaccg acgtggacca gctcatcgtc cagatcggcg agacgctgca gctggacgca
      361 gcgcacgatc gcccggcctc gccgtgtgcc gccccgggtc ccccgccccc gcaggtcctg
      421 gcggcgctgc cggcggacaa gaccgggacc ccagctagga ggctgctgcg gccgacgggg
      481 tcagcggaga ccgggaaccc tgcgcccccg ggggccgtgc gctgcgtgct aggggagcgc
      541 gggcgcgtgc ggggacggtc ggcgccctac tgcgtggcgg agatctcccc cggcgccagc
      601 gcgctgcccc agcagccggg ccttgacgga cccccgggga ccggcaaact aagcaccccg
      661 cagccactgt cgggcccgtg ccgccggggt tggctccgga acgcagccgc gtcccgccgc
      721 ttgcaacagc gacgcggatc tcagccggag acccgcactg gcgacgacga cgacccgcac
      781 cggctcctgc agcagctcgt gctctcggga aacctcatca aggaggcggt gcgcagactt
      841 cattcgcgac agctacagtt acacgcaaag cttcccgcac acccgttcct cgggcctctg
      901 tcagccccag tgcatgagcc gccttcgccc gggagccctc gcgcggcctg cagcgaccct
      961 ggcgctttca tggggagggc gcagctcaga actggggacg accttcttgt ccctggcagc
     1021 taacaaccta agtggccaca gcaccagcct gtagccgggg accaagggat ttacccaggg
     1081 cttcacccag ccggagctgg tggtggactc gagcattatt tggaaacggg aaaataagct
     1141 aaggaagaca gccgaaatat cgcagatatt ttcatgggta actgaaattg aaagccccga
     1201 actgtttgaa acccaggact taggtttgtt taaagcagaa tctacagagc gcaccgcagg
     1261 ctgtcagcag ggctcctttt tttttttttt tttttttttt ttttggcgtg attcaacctg
     1321 gtcgctgcaa ttccacgcag actctcctgg ccaagcgggg accacgtggc cacggtgcat
     1381 gctctcagga tcggctcagc ctgctatgga acgaaggacg atgatcccca ttacttgctg
     1441 tactttttca gggctggttc ctgatccatt ttcggggagg gggaaacaag agtggactta
     1501 atttcggggg gcgccccccc tccaaaatgc cacacttgaa catttaacga cagttaaaag
     1561 accatctcat catcctttgc ggtgctggtt tcaatgtaaa acatgcggta caacgagagg
     1621 accctcttgg ggctgaatag aagtaaccgt ttttttgtcc gttccctttt tctttcaaag
     1681 ggttgctgtt agcagagtgt tgagggaaag ctgcacccca tgagtgtaag gtggagacag
     1741 cagtgagctg tgttgggtaa tggaagggta tggcgaagca aggagtgacc ccctcctgcc
     1801 ttcgtaaagt gtgtttttaa aggagaccca tccctttggg ggttcaaggt cactgtttcc
     1861 tgggtgtgca ccgtgtagtg ggactccaac acggagacaa ccgaatggcc ttgctaggaa
     1921 gagagcacac tgttttgcaa atgcaagagt cccctaagga cgctcccgcc acatcccaga
     1981 ggaggtgggg atggcgagtg ctgagtgtgc ttcccgtccg aggccaccgc ccctgcccct
     2041 ccacctggct tgcagacaaa ctgccttgag acagtgaccg agtaccacct ttcccccttg
     2101 gttctgctgc cctactcaag cagggtggcg ctgatgatgc taggggccag ggtaggggat
     2161 tggggagatt ccacataatg ggcactccag ggacacagct tgggacacag tctcacacag
     2221 cctcttctaa tgggctctcg gggccatttg taataacagc tgcagttccc tggatagaca
     2281 gagttgattt cctcctgacc ctcccccagc tgtgccagct ggcctttgta agggaaggaa
     2341 ccctagtaga aaatgtgacc ctccaaatgg gaaagctgca ggtttttctg ctattgtgac
     2401 tgtgaagtgc ttggaaacac tgttcactct gagcgaccat ttcgttttag ttttctggag
     2461 tcaatggctt gttcagcatc cagatgtggc tgttgacata tctacacttc gcaccggagt
     2521 gactggaatt gtggctgtcc tgattatagg attttaactg aaataactgt ttttgaataa
     2581 atgtgttggg ttcccctcac acacaccccc acac
//
