LOCUS       NM_008039               1296 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus formyl peptide receptor 2 (Fpr2), mRNA.
ACCESSION   NM_008039 XM_622087 XM_918657
VERSION     NM_008039.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Lim,J.H., Neuwirth,A., Chung,K.J., Grossklaus,S., Soehnlein,O.,
            Hajishengallis,G. and Chavakis,T.
  TITLE     Formyl peptide receptor 2 regulates dendritic cell metabolism and
            Th17 cell differentiation during neuroinflammation
  JOURNAL   Front Immunol 15, 1354074 (2024)
   PUBMED   39148732
  REMARK    GeneRIF: Formyl peptide receptor 2 regulates dendritic cell
            metabolism and Th17 cell differentiation during neuroinflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Wickstead,E.S., Elliott,B.T., Pokorny,S., Biggs,C., Getting,S.J.
            and McArthur,S.
  TITLE     Stimulation of the Pro-Resolving Receptor Fpr2 Reverses
            Inflammatory Microglial Activity by Suppressing NFkappaB Activity
  JOURNAL   Int J Mol Sci 24 (21), 15996 (2023)
   PUBMED   37958978
  REMARK    GeneRIF: Stimulation of the Pro-Resolving Receptor Fpr2 Reverses
            Inflammatory Microglial Activity by Suppressing NFkappaB Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Edwards-Glenn,J.M., Fontes,M.T., Waigi,E.W., Costa,T.J.,
            Maiseyeu,A., Webb,R.C., McCarthy,C.G. and Wenceslau,C.F.
  TITLE     Specialized Pro-resolving Mediator Improves Vascular Relaxation via
            Formyl Peptide Receptor-2
  JOURNAL   Am J Hypertens 36 (10), 542-550 (2023)
   PUBMED   37439351
  REMARK    GeneRIF: Specialized Pro-resolving Mediator Improves Vascular
            Relaxation via Formyl Peptide Receptor-2.
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Bhattacharya,P., Dhawan,U.K., Hussain,M.T., Singh,P., Bhagat,K.K.,
            Singhal,A., Austin-Williams,S., Sengupta,S. and Subramanian,M.
  TITLE     Efferocytes release extracellular vesicles to resolve inflammation
            and tissue injury via prosaposin-GPR37 signaling
  JOURNAL   Cell Rep 42 (7), 112808 (2023)
   PUBMED   37436891
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Mooney,S.M., Billings,E., McNew,M., Munson,C.A., Shaikh,S.R. and
            Smith,S.M.
  TITLE     Behavioral changes in FPR2/ALX and Chemr23 receptor knockout mice
            are exacerbated by prenatal alcohol exposure
  JOURNAL   Front Neurosci 17, 1187220 (2023)
   PUBMED   37483341
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Vaughn,M.W., Proske,R.J. and Haviland,D.L.
  TITLE     Identification, cloning, and functional characterization of a
            murine lipoxin A4 receptor homologue gene
  JOURNAL   J Immunol 169 (6), 3363-3369 (2002)
   PUBMED   12218158
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Cui,Y.H., Le,Y., Zhang,X., Gong,W., Abe,K., Sun,R., Van Damme,J.,
            Proost,P. and Wang,J.M.
  TITLE     Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42
            (A beta 42), in murine microglial cells by TNF alpha
  JOURNAL   Neurobiol Dis 10 (3), 366-377 (2002)
   PUBMED   12270697
  REMARK    GeneRIF: By selectively up-regulating FPR2 in microglia, TNF alpha
            has the capacity to amplify host response in inflammatory diseases
            in the central nervous system.
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Tiffany,H.L., Lavigne,M.C., Cui,Y.H., Wang,J.M., Leto,T.L.,
            Gao,J.L. and Murphy,P.M.
  TITLE     Amyloid-beta induces chemotaxis and oxidant stress by acting at
            formylpeptide receptor 2, a G protein-coupled receptor expressed in
            phagocytes and brain
  JOURNAL   J Biol Chem 276 (26), 23645-23652 (2001)
   PUBMED   11316806
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Hartt,J.K., Barish,G., Murphy,P.M. and Gao,J.L.
  TITLE     N-formylpeptides induce two distinct concentration optima for mouse
            neutrophil chemotaxis by differential interaction with two
            N-formylpeptide receptor (FPR) subtypes. Molecular characterization
            of FPR2, a second mouse neutrophil FPR
  JOURNAL   J Exp Med 190 (5), 741-747 (1999)
   PUBMED   10477558
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Gao,J.L., Chen,H., Filie,J.D., Kozak,C.A. and Murphy,P.M.
  TITLE     Differential expansion of the N-formylpeptide receptor gene cluster
            in human and mouse
  JOURNAL   Genomics 51 (2), 270-276 (1998)
   PUBMED   9722950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054286.1 and AC165361.3.
            
            On or before Feb 16, 2006 this sequence version replaced
            XM_622087.1, XM_918657.1, NM_008039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117066.1, BB849199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK054286.1         3-78
            77-1143             AC165361.3         10236-11302         c
            1144-1296           AK054286.1         733-885
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 10.66 cM"
     gene            1..1296
                     /gene="Fpr2"
                     /gene_synonym="E330010I07Rik; Fpr-rs2"
                     /note="formyl peptide receptor 2"
                     /db_xref="GeneID:14289"
                     /db_xref="MGI:MGI:1278319"
     exon            1..76
                     /gene="Fpr2"
                     /gene_synonym="E330010I07Rik; Fpr-rs2"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1296
                     /gene="Fpr2"
                     /gene_synonym="E330010I07Rik; Fpr-rs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtctatag tgagagccaa gtacttcatt tacaccacag gaaccgaaga gtgtaagaag
       61 gagacctcag ctggttgtgc agacaaaatg gaatccaact actccatcca tctgaatgga
      121 tcagaagtgg tggtttatga ttctaccatc tccagagttc tgtggatcct ctcaatggtg
      181 gttgtctcca tcactttctt ccttggtgtg ctgggcaatg gactagtgat ttgggtagct
      241 ggattccgga tgccacacac tgtcaccact atctggtatc tgaatctagc attggctgac
      301 ttttctttca cagcaactct accattcctt cttgttgaaa tggctatgaa agaaaaatgg
      361 ccttttggct ggttcctgtg taaattagtt cacattgtgg tagatgtaaa cctgtttgga
      421 agtgtcttct tgattgctct cattgccttg gaccgctgca tttgtgttct gcatccagtc
      481 tgggctcaga accaccgcac tgtgagcctg gctaggaagg tggttgttgg gccctggatt
      541 tttgctctga ttctcacttt gcccattttt attttcttga ctactgttag aattcctgga
      601 ggagatgtgt attgtacatt caactttgga tcctgggctc aaactgatga agaaaagttg
      661 aacacagcta tcacttttgt aacaactaga gggatcatca ggttccttat tggtttcagc
      721 atgcccatgt caattgttgc tgtttgctat ggactcattg ctgtcaagat caacagaaga
      781 aaccttgtta attccagccg tcctttacga gtccttacag cagttgtggc ttccttcttt
      841 atctgctggt ttccctttca gcttgtggcc cttttgggca cagtctggtt taaagagaca
      901 ttgcttagtg gtagttataa aattcttgac atgtttgtta acccaacaag ctcattggct
      961 tacttcaata gttgtctcaa tccgatgctc tatgttttca tgggccagga ctttcgtgag
     1021 agatttattc attccctgcc ttatagtctt gagagagccc tgagtgagga ttctggtcaa
     1081 accagtgatt caagcaccag ttctacttca cctcctgcag acattgagtt aaaggcccca
     1141 tgaagtctgt gataagggat ggttttcatt ccacttcagt cccattccac ttctgccttc
     1201 cttaccttat gctgtgtcct atagcatttt taatctgaaa aaaaaaaaaa aacttctgtg
     1261 tcccctgaat ctggaaaatg aaataaaagt caatgt
//
