LOCUS       NM_013521               1332 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus formyl peptide receptor 1 (Fpr1), mRNA.
ACCESSION   NM_013521
VERSION     NM_013521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Yang,X., Xiao,W., Le,Q., Zhang,Z., Wang,W., Lee,S.H., Dighe,A.,
            Kerrigan,J.R. and Cui,Q.
  TITLE     Knockout of formyl peptide receptor 1 reduces osteogenesis and bone
            healing
  JOURNAL   Life Sci 344, 122583 (2024)
   PUBMED   38508232
  REMARK    GeneRIF: Knockout of formyl peptide receptor 1 reduces osteogenesis
            and bone healing.
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Shao,S., Sun,Z., Chu,M., Chen,J., Cao,T., Swindell,W.R., Bai,Y.,
            Li,Q., Ma,J., Zhu,Z., Schuler,A., Helfrich,Y., Billi,A.C., Li,Z.,
            Hao,J., Xiao,C., Dang,E., Gudjonsson,J.E. and Wang,G.
  TITLE     Formylpeptide receptor 1 contributes to epidermal barrier
            dysfunction-induced skin inflammation through NOD-like receptor
            C4-dependent keratinocyte activation
  JOURNAL   Br J Dermatol 190 (4), 536-548 (2024)
   PUBMED   37979162
  REMARK    GeneRIF: Formylpeptide receptor 1 contributes to epidermal barrier
            dysfunction-induced skin inflammation through NOD-like receptor
            C4-dependent keratinocyte activation.
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Ma,G., Li,J., Wang,H., Lin,A.L., Yang,G. and Zuo,Z.
  TITLE     Formyl peptide receptor 1 is involved in surgery-induced
            neuroinflammation and dysfunction of learning and memory in mice
  JOURNAL   Behav Brain Res 452, 114577 (2023)
   PUBMED   37423318
  REMARK    GeneRIF: Formyl peptide receptor 1 is involved in surgery-induced
            neuroinflammation and dysfunction of learning and memory in mice.
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Le Naour,J., Montegut,L., Pan,Y., Scuderi,S.A., Cordier,P.,
            Joseph,A., Sauvat,A., Iebba,V., Paillet,J., Ferrere,G.,
            Brechard,L., Mulot,C., Dubourg,G., Zitvogel,L., Pol,J.G.,
            Vacchelli,E., Puig,P.L. and Kroemer,G.
  TITLE     Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis
  JOURNAL   Oncoimmunology 12 (1), 2237354 (2023)
   PUBMED   37492227
  REMARK    GeneRIF: Formyl peptide receptor-1 (FPR1) represses intestinal
            oncogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Gao,J.L., Lee,E.J. and Murphy,P.M.
  TITLE     Impaired antibacterial host defense in mice lacking the
            N-formylpeptide receptor
  JOURNAL   J Exp Med 189 (4), 657-662 (1999)
   PUBMED   9989980
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Abe,H., Takeshita,T., Nagata,K., Arita,T., Endo,Y., Fujita,T.,
            Takayama,H., Kubo,M. and Sugamura,K.
  TITLE     Molecular cloning, chromosome mapping and characterization of the
            mouse CRTH2 gene, a putative member of the leukocyte
            chemoattractant receptor family
  JOURNAL   Gene 227 (1), 71-77 (1999)
   PUBMED   9931443
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Gao,J.L., Chen,H., Filie,J.D., Kozak,C.A. and Murphy,P.M.
  TITLE     Differential expansion of the N-formylpeptide receptor gene cluster
            in human and mouse
  JOURNAL   Genomics 51 (2), 270-276 (1998)
   PUBMED   9722950
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Stubbs,L., Carver,E.A., Shannon,M.E., Kim,J., Geisler,J.,
            Generoso,E.E., Stanford,B.G., Dunn,W.C., Mohrenweiser,H.,
            Zimmermann,W., Watt,S.M. and Ashworth,L.K.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Gao,J.L. and Murphy,P.M.
  TITLE     Species and subtype variants of the N-formyl peptide chemotactic
            receptor reveal multiple important functional domains
  JOURNAL   J Biol Chem 268 (34), 25395-25401 (1993)
   PUBMED   8244972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY194974.1, BY750286.1, L22181.1, BY160621.1 and BX514917.1.
            
            On Jul 28, 2005 this sequence version replaced NM_013521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137714.1, BY750286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               BY194974.1         4-344
            342-692             BY750286.1         345-695
            693-722             L22181.1           955-984
            723-1057            BY160621.1         1-335
            1058-1332           BX514917.1         213-487
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 10.63 cM"
     gene            1..1332
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /note="formyl peptide receptor 1"
                     /db_xref="GeneID:14293"
                     /db_xref="MGI:MGI:107443"
     exon            1..57
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1323
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1163
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /note="lipoxin A4 receptor; fMLP receptor; N-formyl
                     peptide receptor; N-formylpeptide chemoattractant
                     receptor"
                     /codon_start=1
                     /product="fMet-Leu-Phe receptor"
                     /protein_id="NP_038549.1"
                     /db_xref="CCDS:CCDS28418.1"
                     /db_xref="GeneID:14293"
                     /db_xref="MGI:MGI:107443"
                     /translation="MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVT
                     FVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFG
                     WFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWIC
                     AFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFI
                     IGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALIST
                     IQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERA
                     LTEDSAQTSDTGTNLGTNSTSLSENTLNAM"
     regulatory      1304..1309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /note="hexamer: AATAAA"
     polyA_site      1323
                     /gene="Fpr1"
                     /gene_synonym="fMLF-R; FPR; LXA4R"
                     /note="major polyA site"
ORIGIN      
        1 ggcttctttc ttcaggagat cagctgtaga tctgtccaga gctgttggaa agttcaggag
       61 tctacaagat ggacaccaac atgtctctcc tcatgaacaa gtctgcagtg aacctcatga
      121 atgtatctgg gagtactcaa tcagtatctg ctggctacat cgttctggat gtcttctcat
      181 atttgatctt tgccgtcaca tttgtccttg gggttctggg caacgggctc gtgatctggg
      241 tggctggttt ccgcatgaaa cacactgtca ccaccatctc ttacttgaac ttggccattg
      301 ctgacttttg cttcacttcc actttgccat tttacattgc cagcatggtc atgggaggac
      361 attggccatt tggttggttc atgtgcaaat tcatatatac tgtaatagac ataaacctat
      421 ttggaagtgt cttcctgatt gccctcattg cactggaccg ctgtatttgt gttctgcatc
      481 cagtctgggc tcagaaccac cgcactgtga gcctagccaa gaaggtaatc atcgtaccct
      541 ggatttgtgc atttcttctt acattgccag ttatcattcg tttgaccaca gtccctaata
      601 gtagacttgg accagggaaa acagcctgta ctttcgactt ctccccctgg accaaagatc
      661 ctgtagagaa gaggaaggtg gccgtcacca tgctcactgt cagaggaatc atcaggttca
      721 tcattgggtt cagcactccc atgtccattg ttgccatttg ctatgggtta ataaccacta
      781 aaattcacag gcagggcctg atcaaatcca gccgtccttt gcgggttctc tcctttgttg
      841 tggctgcctt tttcctctgc tggtgcccat ttcaagtagt ggccctcata tccacaatcc
      901 aagtccgtga acggttgaag aacatgactc caggcattgt aactgctttg aaaatcacaa
      961 gccccttggc tttcttcaac agctgcctca atccaatgct ttatgtcttt atgggccagg
     1021 acttcagaga aagactaatc cactctttac ctgccagcct agagagggcc ctgactgagg
     1081 actcagctca gaccagtgat acaggcacca atttggggac caactctact tccctttctg
     1141 aaaacacttt aaatgcaatg taaagaacgg gctctaactt ccagcttcat ctgctttgag
     1201 ttccactgtg ctataggcat tccctgttga ccttcaggct acatgctcat taggaaaact
     1261 tgaaataacc ttttagactt ttttacctca acccaagata gtcaataaag aaaaaagaac
     1321 ataaaaaaaa aa
//
