LOCUS       NP_034366                587 aa            linear   ROD 02-MAY-2024
DEFINITION  folylpolyglutamate synthase, mitochondrial isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_034366
VERSION     NP_034366.2
DBSOURCE    REFSEQ: accession NM_010236.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 587)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 587)
  AUTHORS   Yang,C., Xie,L.Y., Windle,J.J., Taylor,S.M. and Moran,R.G.
  TITLE     Humanizing mouse folate metabolism: conversion of the dual-promoter
            mouse folylpolyglutamate synthetase gene to the human
            single-promoter structure
  JOURNAL   FASEB J 28 (5), 1998-2008 (2014)
   PUBMED   24532667
REFERENCE   4  (residues 1 to 587)
  AUTHORS   Sakamoto,E., Tsukioka,S., Oie,S., Kobunai,T., Tsujimoto,H.,
            Sakamoto,K., Okayama,Y., Sugimoto,Y., Oka,T., Fukushima,M. and
            Oka,T.
  TITLE     Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate
            leucovorin-enhanced 5-fluorouracil anticancer activity
  JOURNAL   Biochem Biophys Res Commun 365 (4), 801-807 (2008)
   PUBMED   18035049
  REMARK    GeneRIF: These results suggest that FPGS and GGH expression levels
            in tumors are determinants of the efficacy of LV in enhancing the
            antitumor activity of 5-FU.
REFERENCE   5  (residues 1 to 587)
  AUTHORS   Racanelli,A.C., Turner,F.B., Xie,L.Y., Taylor,S.M. and Moran,R.G.
  TITLE     A mouse gene that coordinates epigenetic controls and
            transcriptional interference to achieve tissue-specific expression
  JOURNAL   Mol Cell Biol 28 (2), 836-848 (2008)
   PUBMED   17998333
REFERENCE   6  (residues 1 to 587)
  AUTHORS   Roy,K., Mitsugi,K., Sirlin,S., Shane,B. and Sirotnak,F.M.
  TITLE     Different antifolate-resistant L1210 cell variants with either
            increased or decreased folylpolyglutamate synthetase gene
            expression at the level of mRNA transcription
  JOURNAL   J Biol Chem 270 (45), 26918-26922 (1995)
   PUBMED   7592937
REFERENCE   7  (residues 1 to 587)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (residues 1 to 587)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   9  (residues 1 to 587)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   10 (residues 1 to 587)
  AUTHORS   Fournier,R.E. and Moran,R.G.
  TITLE     Complementation mapping in microcell hybrids: localization of Fpgs
            and Ak-1 on Mus musculus chromosome 2
  JOURNAL   Somatic Cell Genet 9 (1), 69-84 (1983)
   PUBMED   6687641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772271.11.
            
            On Apr 5, 2008 this sequence version replaced NP_034366.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U32197.1, U33557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     Protein         1..587
                     /product="folylpolyglutamate synthase, mitochondrial
                     isoform 1 precursor"
                     /EC_number="6.3.2.17"
                     /note="folylpolyglutamate synthase, mitochondrial;
                     tetrahydrofolate synthase; folylpoly-gamma-glutamate
                     synthetase; tetrahydrofolylpolyglutamate synthase"
                     /calculated_mol_wt=60627
     transit_peptide 1..42
                     /note="Mitochondrion; propagated from UniProtKB/Swiss-Prot
                     (P48760.3)"
                     /calculated_mol_wt=4347
     mat_peptide     43..587
                     /product="Folylpolyglutamate synthase, mitochondrial.
                     /id=PRO_0000010099"
                     /note="propagated from UniProtKB/Swiss-Prot (P48760.3)"
                     /calculated_mol_wt=60627
     Region          44..581
                     /region_name="PLN02881"
                     /note="tetrahydrofolylpolyglutamate synthase; cl47075"
                     /db_xref="CDD:481415"
     Site            539
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q05932; propagated from
                     UniProtKB/Swiss-Prot (P48760.3)"
     CDS             1..587
                     /gene="Fpgs"
                     /coded_by="NM_010236.3:7..1770"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15926.1"
                     /db_xref="GeneID:14287"
                     /db_xref="MGI:MGI:95576"
ORIGIN      
        1 mswarsrlcs tlslaavsar gattegaarr gmsawpapqe pgmeyqdavr tlntlqtnas
       61 yleqvkrqrs dpqaqleame mylarsglqv edlnrlniih vtgtkgkgst cafterilrn
      121 yglktgffss phmvqvreri ringkpispe lftkhfwcly nqleefkdds hvsmpsyfrf
      181 ltlmafhvfl qekvdlavve vgiggafdct niirkpvvcg vsslgidhts llgdtvekia
      241 wqkggifkpg vpaftvvqpe gplavlrdra qqigcplylc pplealeevg lplslglega
      301 hqrsnaalal qlahcwlerq dhqdiqelkv srpsirwqlp lapvfrptph mrrglrdtvw
      361 pgrtqilqrg pltwyldgah ttssvqacvh wyrqslersk rtdggsevhi llfnstgdrd
      421 saallkllqp cqfdyavfcp nvtevssign adqqnftvtl dqvllrclqh qqhwnglaek
      481 qassnlwssc gpdpagpgsl llaphppqpt rtsslvfsci shallwisqg rdpifqpqsl
      541 prnllnhpta nsgasilrea aaihvlvtgs lhlvggvlkl ldpsmsq
//
