LOCUS       NM_010226               1311 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus forkhead box S1 (Foxs1), mRNA.
ACCESSION   NM_010226
VERSION     NM_010226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Bates,E.A., Kipp,Z.A., Lee,W.H., Martinez,G.J., Weaver,L.,
            Becker,K.N., Pauss,S.N., Creeden,J.F., Anspach,G.B., Helsley,R.N.,
            Xu,M., Bruno,M.E.C., Starr,M.E. and Hinds,T.D. Jr.
  TITLE     FOXS1 is increased in liver fibrosis and regulates TGFbeta
            responsiveness and proliferation pathways in human hepatic stellate
            cells
  JOURNAL   J Biol Chem 300 (3), 105691 (2024)
   PUBMED   38280429
  REMARK    GeneRIF: FOXS1 is increased in liver fibrosis and regulates TGFbeta
            responsiveness and proliferation pathways in human hepatic stellate
            cells.
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Wang,S., Ran,L., Zhang,W., Leng,X., Wang,K., Liu,G., Song,J.,
            Wang,Y., Zhang,X., Wang,Y., Zhang,L., Ma,Y., Liu,K., Li,H.,
            Zhang,W., Qin,G. and Song,F.
  TITLE     FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell
            proliferation and EMT in gastric cancer
  JOURNAL   Sci Rep 9 (1), 5281 (2019)
   PUBMED   30918291
  REMARK    GeneRIF: FOXS1 is regulated by GLI1 and miR-125a-5p and promotes
            cell proliferation and EMT in gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Reyahi,A., Nik,A.M., Ghiami,M., Gritli-Linde,A., Ponten,F.,
            Johansson,B.R. and Carlsson,P.
  TITLE     Foxf2 Is Required for Brain Pericyte Differentiation and
            Development and Maintenance of the Blood-Brain Barrier
  JOURNAL   Dev Cell 34 (1), 19-32 (2015)
   PUBMED   26120030
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Schillebeeckx,M., Pihlajoki,M., Gretzinger,E., Yang,W., Thol,F.,
            Hiller,T., Lobs,A.K., Rohrig,T., Schrade,A., Cochran,R., Jay,P.Y.,
            Heikinheimo,M., Mitra,R.D. and Wilson,D.B.
  TITLE     Novel markers of gonadectomy-induced adrenocortical neoplasia in
            the mouse and ferret
  JOURNAL   Mol Cell Endocrinol 399, 122-130 (2015)
   PUBMED   25289806
  REMARK    GeneRIF: Genome-wide methylation analysis showed that two genes
            with hypomethylated promoters, Igfbp6 and Foxs1, are upregulated in
            GDX-induced adrenocortical neoplasms.
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1311)
  AUTHORS   Hjerling-Leffler,J., Marmigere,F., Heglind,M., Cederberg,A.,
            Koltzenburg,M., Enerback,S. and Ernfors,P.
  TITLE     The boundary cap: a source of neural crest stem cells that generate
            multiple sensory neuron subtypes
  JOURNAL   Development 132 (11), 2623-2632 (2005)
   PUBMED   15872002
REFERENCE   7  (bases 1 to 1311)
  AUTHORS   Carlsson,P. and Mahlapuu,M.
  TITLE     Forkhead transcription factors: key players in development and
            metabolism
  JOURNAL   Dev Biol 250 (1), 1-23 (2002)
   PUBMED   12297093
  REMARK    Review article
REFERENCE   8  (bases 1 to 1311)
  AUTHORS   Zaret,K.
  TITLE     Developmental competence of the gut endoderm: genetic potentiation
            by GATA and HNF3/fork head proteins
  JOURNAL   Dev Biol 209 (1), 1-10 (1999)
   PUBMED   10208738
  REMARK    Review article
REFERENCE   9  (bases 1 to 1311)
  AUTHORS   Farrington,S.M., Belaoussoff,M. and Baron,M.H.
  TITLE     Winged-helix, Hedgehog and Bmp genes are differentially expressed
            in distinct cell layers of the murine yolk sac
  JOURNAL   Mech Dev 62 (2), 197-211 (1997)
   PUBMED   9152011
REFERENCE   10 (bases 1 to 1311)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK077935.1.
            
            On Apr 6, 2007 this sequence version replaced NM_010226.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK077935.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1311              AK077935.1         2-1312
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..1311
                     /gene="Foxs1"
                     /gene_synonym="Fkh3; Fkhl18; FREAC10"
                     /note="forkhead box S1"
                     /db_xref="GeneID:14239"
                     /db_xref="MGI:MGI:95546"
     exon            1..1311
                     /gene="Foxs1"
                     /gene_synonym="Fkh3; Fkhl18; FREAC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1067
                     /gene="Foxs1"
                     /gene_synonym="Fkh3; Fkhl18; FREAC10"
                     /note="FREAC-10; forkhead-like 18 protein; transcription
                     factor FKH-3; forkhead-related transcription factor 10"
                     /codon_start=1
                     /product="forkhead box protein S1"
                     /protein_id="NP_034356.1"
                     /db_xref="CCDS:CCDS16901.1"
                     /db_xref="GeneID:14239"
                     /db_xref="MGI:MGI:95546"
                     /translation="MQKQPSPESLAPSAEPTKPPYSYIALIAMAIQSSPGQRATLSGI
                     YRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMF
                     QHGSFLRRRRRFTKRTGAQGTKGPVKIDHRPHRATSPDPGAPKTTTGRLCPFPQEVPN
                     PKGLSFEGLMGSLPANMSSTTSDVRPQLPTGPKEMCSAKSGGPRELSEATSPSPCPAF
                     GFSSAFSDAESLGKAPTPGVAPESVGSSYQCRMQTLNFCMGTDPGLEHLLVSSVPTPG
                     SSTPSASHRAPLPLPADSKEPWVAGSFPVQGGSGYPLGLPPCLYRTPGMFFFE"
     polyA_site      1311
                     /gene="Foxs1"
                     /gene_synonym="Fkh3; Fkhl18; FREAC10"
                     /note="putative"
ORIGIN      
        1 aacagcctgg gcagcctgtg cagatcgcca gctctgaata ccgtgcctgg ctttgcggtg
       61 tcagcaacac agccagcatg cagaagcaac catcaccaga atccttggct ccttctgcag
      121 agcccaccaa gcccccttac agctacatag ccctgattgc catggctatc cagagttcac
      181 cgggtcagcg ggccaccctc agtggcatct accgctacat catgggccgc tttgcctttt
      241 accggcacaa ccggccgggc tggcaaaaca gcatccgcca taacctgtct ctcaacgagt
      301 gtttcgtcaa ggtgcctcgt gatgaccgca agccaggcaa gggcagctac tggaccctgg
      361 atccggactg ccacgacatg ttccagcatg gcagctttct ccgtcgccgc agacgcttca
      421 ccaaacgcac aggtgcgcag ggcaccaagg gccctgtcaa gatagaccac agaccccaca
      481 gagccaccag cccggaccca ggagccccca agaccacaac tggcagactg tgcccattcc
      541 cacaagaggt gccaaacccc aagggcttaa gctttgaggg tctgatgggg tctttgccag
      601 ccaacatgag ctcaacaacc agtgacgtca ggccccaact gcccactgga cccaaagaga
      661 tgtgctcggc aaagtctgga ggcccaaggg agctctctga agctacctcg ccctcaccgt
      721 gcccagcatt cggcttttca tctgccttct ctgacgctga gagtctcggc aaggccccca
      781 cacccggtgt ggctcctgag agcgttggga gcagctacca gtgccggatg cagacactga
      841 atttctgtat ggggactgac ccaggccttg aacacctcct ggtctcttca gtccccaccc
      901 ctggatcctc gacaccttca gcctctcacc gggccccact gcccctgccg gctgactcca
      961 aagaaccctg ggtggctggg agcttccctg tccagggagg ttctggctat ccactgggat
     1021 tacccccctg tctttaccgg actccgggaa tgttcttctt cgagtgattg gctgcagcgg
     1081 cccctctgta gggctcctgt caactgttct ctggagactc agactggcta tatgacctag
     1141 ggcactctgc aagaacccag ccctggcagg ccaaggactg tgaggatcag aaggcagaag
     1201 tgagcagtca ggcaggtccc ttgggggcct cctgacaaac ttgggatgtg gggaaatgga
     1261 acccttaagc ttttctctgt ggttctcagg gctaataaag ccggtgtggt g
//
