LOCUS       NM_028767               3797 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus forkhead box P4 (Foxp4), transcript variant 3, mRNA.
ACCESSION   NM_028767 NM_027313
VERSION     NM_028767.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3797)
  AUTHORS   Li,X., Zou,S., Tu,X., Hao,S., Jiang,T. and Chen,J.G.
  TITLE     Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial
            Glial Cells, Leading to Abnormal Differentiation and Migration of
            Cortical Neurons in Mice
  JOURNAL   Neurosci Bull 39 (7), 1131-1145 (2023)
   PUBMED   36646976
  REMARK    GeneRIF: Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of
            Radial Glial Cells, Leading to Abnormal Differentiation and
            Migration of Cortical Neurons in Mice.
REFERENCE   2  (bases 1 to 3797)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3797)
  AUTHORS   Yang,Q., Zhang,J., Bao,Q., Zhong,J., Wang,X., Tao,Y., Xu,X., Lv,K.,
            Wang,Y., Li,B., He,L., Guo,X. and Ma,G.
  TITLE     Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell
            Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell
            Apoptosis
  JOURNAL   Stem Cells 40 (9), 843-856 (2022)
   PUBMED   35759955
  REMARK    GeneRIF: Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem
            Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell
            Apoptosis.
REFERENCE   4  (bases 1 to 3797)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3797)
  AUTHORS   Wang,F., Xu,S., Chen,T., Ling,S., Zhang,W., Wang,S., Zhou,R.,
            Xia,X., Yao,Z., Li,P., Zhao,X., Wang,J. and Guo,X.
  TITLE     FOXP4 differentially controls cold-induced beige adipocyte
            differentiation and thermogenesis
  JOURNAL   Development 149 (7) (2022)
   PUBMED   35297993
  REMARK    Erratum:[Development. 2022 May 1;149(9):dev200853. doi:
            10.1242/dev.200853. PMID: 35543268]
REFERENCE   6  (bases 1 to 3797)
  AUTHORS   Li,S., Zhou,D., Lu,M.M. and Morrisey,E.E.
  TITLE     Advanced cardiac morphogenesis does not require heart tube fusion
  JOURNAL   Science 305 (5690), 1619-1622 (2004)
   PUBMED   15361625
REFERENCE   7  (bases 1 to 3797)
  AUTHORS   Li,S., Weidenfeld,J. and Morrisey,E.E.
  TITLE     Transcriptional and DNA binding activity of the Foxp1/2/4 family is
            modulated by heterotypic and homotypic protein interactions
  JOURNAL   Mol Cell Biol 24 (2), 809-822 (2004)
   PUBMED   14701752
  REMARK    GeneRIF: complex regulatory mechanism underlying Foxp1, Foxp2, and
            Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the
            first Fox proteins reported whose activity is regulated by homo-
            and heterodimerization
REFERENCE   8  (bases 1 to 3797)
  AUTHORS   Teufel,A., Wong,E.A., Mukhopadhyay,M., Malik,N. and Westphal,H.
  TITLE     FoxP4, a novel forkhead transcription factor
  JOURNAL   Biochim Biophys Acta 1627 (2-3), 147-152 (2003)
   PUBMED   12818433
  REMARK    GeneRIF: In adult tissues FoxP4 is expressed in heart, brain, lung,
            liver, kidney, and testis.In situ hybridization revealed expression
            of FoxP4 in the developing lung and gut
REFERENCE   9  (bases 1 to 3797)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3797)
  AUTHORS   Lu,M.M., Li,S., Yang,H. and Morrisey,E.E.
  TITLE     Foxp4: a novel member of the Foxp subfamily of winged-helix genes
            co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues
  JOURNAL   Mech Dev 119 Suppl 1, S197-S202 (2002)
   PUBMED   14516685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164306.3 and AC113536.10.
            
            On Apr 7, 2022 this sequence version replaced NM_028767.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052766.1, SRR13422597.1530747.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC164306.3         105458-105695
            239-477             AC113536.10        12424-12662
            478-573             AC113536.10        28738-28833
            574-696             AC113536.10        36066-36188
            697-783             AC113536.10        36609-36695
            784-931             AC113536.10        38204-38351
            932-1142            AC113536.10        38464-38674
            1143-1247           AC113536.10        38926-39030
            1248-1335           AC113536.10        39730-39817
            1336-1419           AC113536.10        41035-41118
            1420-1588           AC113536.10        41270-41438
            1589-1665           AC113536.10        41527-41603
            1666-1767           AC113536.10        42222-42323
            1768-1889           AC113536.10        45607-45728
            1890-1956           AC113536.10        47167-47233
            1957-2126           AC113536.10        47685-47854
            2127-3797           AC113536.10        48155-49825
FEATURES             Location/Qualifiers
     source          1..3797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..3797
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="forkhead box P4"
                     /db_xref="GeneID:74123"
                     /db_xref="MGI:MGI:1921373"
     exon            1..238
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            239..477
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2274
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="isoform 3 is encoded by transcript variant 3;
                     forkhead box protein P4; fork head-related protein like A"
                     /codon_start=1
                     /product="forkhead box protein P4 isoform 3"
                     /protein_id="NP_083043.2"
                     /db_xref="CCDS:CCDS50135.1"
                     /db_xref="GeneID:74123"
                     /db_xref="MGI:MGI:1921373"
                     /translation="MMVESASETIRSAPSGQNGVGSLSAQADGGGGAGTAGTAPAAGR
                     DASGREAASGGADSNGEMSPAELLHFQQQQALQVARQFLLQQASSLNSPGNNDSKQSA
                     SAVQVPVSVAMMSQQMLTPQQMQQILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLH
                     LQLLTQQQAGKQQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPSQASG
                     PLQALPQAVCPTDLPQLWKGEGAPGQPAEDSGRQEGLDLASTAVTATSFASPPKVSPP
                     LSHHPLPNGQPTVLTSRRDSSSHEETPSSHPLYGHGECKWPGCETLCEDLGQFIKHLN
                     TEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPVTVS
                     ADPFPDGLVHPPTSAAAPVTPLRPPGLGSASLHSGGPARRRSNDKFCSPISSELAQNH
                     EFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVR
                     HNLSLHKCFVRVENVKGAVWTVDEREYQKRRPPKMTGSPTLVKNMISGLSYGALNASY
                     QAALAESSFPLLSNPGMLNPGSASSLLPLSQEDLGVPGEPLPSNGSSSPPRLSPPQYS
                     HQIQVKEEPAEAEEDRRPGPPLGAPNPSTVGPPEDRDLEEDLGGEDMS"
     exon            478..573
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            574..696
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            697..783
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            784..931
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1142
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1247
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1335
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1419
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1588
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1665
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1767
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1889
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1956
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2126
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..3797
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3166
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="major polyA site"
     regulatory      3775..3780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="hexamer: ATTAAA"
     polyA_site      3797
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
ORIGIN      
        1 aggagcgtcg ccggagcccg gggaaggacg atcggaagct ggagagagcc aagccatcct
       61 ccaaagtgcg atgcccccaa ggggctaagg cgcgcggcga tcggcgctag aaagatcgct
      121 tcggagcgca ggggcagccc cggcgagtgg cggcgggccc gggctgcgac ccgagcgagc
      181 cccatgcccc gtgcgggctg acgggccgga gcccgcactg agcggccggg ccggacaggt
      241 cccgattgag cggcaatgat ggtggagtct gcatcggaga caatcaggtc ggctccgtct
      301 ggtcagaacg gcgtgggcag cctctctgcg caggctgatg gcggcggtgg ggccgggacc
      361 gcgggcacgg ccccggctgc cggtagggat gcctcaggca gggaagcagc cagcggagga
      421 gccgacagca atggcgagat gagccccgcg gagcttctgc acttccaaca gcaacaggct
      481 ctccaggtgg cccggcagtt cctgttgcag caagcctcca gcctgaactc cccggggaac
      541 aatgacagta aacagtcggc ctctgcggtg caggtgcctg tgtctgtggc catgatgtcc
      601 cagcagatgc ttacccccca gcagatgcag cagatcctgt cgccacctca gctgcaggcc
      661 ttgctgcagc agcaacaggc tctcatgctc cagcagctgc aggagtatta caagaagcag
      721 caagagcagc tccacctgca gctcctcacc cagcagcagg ctggaaaaca gcagcccaaa
      781 gaggccctgg ggaacaagca gctggccttc cagcagcagc tcctgcagat gcaacagttg
      841 cagcaacagc acttgctcaa cctccagagg caggggctgg tcagcctgca gccaagccaa
      901 gcctcagggc ccctccaggc cctcccgcaa gccgtgtgcc cgacagacct gccccagctg
      961 tggaaaggcg agggtgcccc ggggcagccc gctgaggaca gcggcaggca ggaggggctg
     1021 gacctcgcca gcacagctgt tactgctacc tcgtttgcca gccctcccaa ggtctccccg
     1081 cccctctccc accacccctt acccaacgga caacccactg tgctcacatc tcggagagac
     1141 agctcctccc atgaggagac ccccagttcc caccctcttt atggacatgg ggagtgcaag
     1201 tggccaggct gtgagaccct gtgtgaagac ctgggccagt ttatcaaaca cctcaacaca
     1261 gaacacgctt tggatgaccg gagcacggcc caatgccgcg tgcagatgca ggtggtccaa
     1321 cagctggaga tccagctggc caaggagagt gagcggctgc aggccatgat ggcacatctg
     1381 cacatgcggc cttcagagcc caagcccttc agccagccag tgaccgtctc cgcagacccg
     1441 ttcccggatg gcctcgtgca ccccccaact tcagccgctg cccccgtcac acccctgcgt
     1501 ccccctggcc tgggctctgc ctctttgcac agtgggggcc ctgcccgcag gagaagtaat
     1561 gacaaattct gctcccccat ctcctcagag cttgcccaga atcatgagtt ctacaagaac
     1621 gctgacgtca ggcccccctt cacctacgct tcccttatcc gccaggccat tctggaaact
     1681 ccagatcggc agctgacgct aaatgagatt tataactggt tcaccaggat gttcgcctac
     1741 ttccgaagaa acacggccac ctggaagaat gccgtgcgcc acaacctcag cctgcacaag
     1801 tgtttcgtcc gtgtggagaa cgtcaagggg gccgtgtgga ctgtggatga gcgggaatat
     1861 cagaaacgga gaccgccaaa gatgacaggg agtcccactc tggtgaagaa catgatctcg
     1921 ggcctcagtt acggggcact taacgccagc taccaggctg ccctggcaga gagcagcttc
     1981 cctcttctca gcaaccccgg catgctgaac cctggctcag ccagcagcct tctgcccctc
     2041 agccaggagg acctgggtgt ccctggggaa ccactaccca gcaatgggag cagcagcccg
     2101 cctcgtcttt cccctcctca gtacagccac cagatacaag tcaaagagga gcctgcagag
     2161 gcagaggaag accgacggcc ggggcctccc ttgggcgccc ccaaccccag cactgtgggg
     2221 cctccagaag acagggacct ggaggaggac ctgggaggag aggacatgtc ctaagggcag
     2281 ggtgggcggg cagggcaggc caagaccctg ccgcccagtg gaccccggcc tacccacccc
     2341 actctacagc ccctccaacc tcaaggcact tcggggactc agacggggga gatccgggcc
     2401 agtagctccc atgccacctg actgacagac gcctggggac aggcatatcc ctgctccccg
     2461 cagagaacac agaacccttg gactgggacc cgtagaggac atggagggcc cagaccctct
     2521 cagcccctcc ctgtattccc aaccaccacc agcagcagca gcagggctct ccttccccac
     2581 cagtgctccc ctccaagacc ccttagcaca aggggagacc cgcaggcggg gctgagccac
     2641 ccccacaacc ctaccttctt catcccctct gtcccgtctg tggcagaggt ttctggccag
     2701 aggacccttc ccggttcatc tcccctcatc ttcttttccc aactgtgaaa attagttctc
     2761 cggtcccagc ttcctgctca aaggggcaag caggctgggg gcggggcacc tgcagaccag
     2821 ccccctcagc tgcgggagcg gagcaagttg tgccctgccc ttccctccct gacctgaggc
     2881 agaacccaga ttaagcaggt ctccacccca ccctgtttgc tgggcactcc tgcggcaccc
     2941 cgagagggac ccccatgctg gacaccttca gagcgtgtgc ataggtggtc tctgacctga
     3001 acatcacagt gcggagaaag cccggctgga aacaccctcg cccccagcct acgggtcccc
     3061 gaaatggggt cctctcaccc cgccccctca cctcctcctg tccttccctc tcccagttaa
     3121 aacggatgac caaagacctt tcttatgccg gaagcaaaaa ccaaaacttt ttgttggctt
     3181 tttcttttgc cgcctcccga gcaccctgcc ctcccaaccc tgccccctga tcccgggctg
     3241 gaagccttcc ctccttcact taagttattg tgttaaacca aagtttacag tgtctgttgg
     3301 tagcaagacc ccctcctccc ctctaccacc ccccccaagg gtccaggggt cctactcgct
     3361 tcccccctgc tcataccttg cctatggaga catgagaggg cagaatcctg cccccagccc
     3421 tgggctgctt tcgggggtcg ggggagggct cttcagatgc ctccatagga ccaagtcccc
     3481 atcattgccg ggagtgtgga ttctagcagc agagctggaa acgatgagat tccacagacc
     3541 ccctatgggg gacccacaac ccaagaccgc agactgggtg taagggatgc ccggaacacc
     3601 ctgaccaggc ccctccccta agacttcttg gatatttccc aggagaatcc cacattcacc
     3661 gccaaacccc tatccctacc caacacaagc tgccctcctg aaaggcaagg gcgccccgcc
     3721 cccggccttc ccccatgtac ccccacctgt gttccgtttg accagcacag aaatattaaa
     3781 gtcctctatt taccggg
//
