LOCUS       NM_001403970            3854 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus forkhead box P4 (Foxp4), transcript variant 5, mRNA.
ACCESSION   NM_001403970 XM_017317688
VERSION     NM_001403970.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Li,X., Zou,S., Tu,X., Hao,S., Jiang,T. and Chen,J.G.
  TITLE     Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial
            Glial Cells, Leading to Abnormal Differentiation and Migration of
            Cortical Neurons in Mice
  JOURNAL   Neurosci Bull 39 (7), 1131-1145 (2023)
   PUBMED   36646976
  REMARK    GeneRIF: Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of
            Radial Glial Cells, Leading to Abnormal Differentiation and
            Migration of Cortical Neurons in Mice.
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Yang,Q., Zhang,J., Bao,Q., Zhong,J., Wang,X., Tao,Y., Xu,X., Lv,K.,
            Wang,Y., Li,B., He,L., Guo,X. and Ma,G.
  TITLE     Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell
            Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell
            Apoptosis
  JOURNAL   Stem Cells 40 (9), 843-856 (2022)
   PUBMED   35759955
  REMARK    GeneRIF: Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem
            Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell
            Apoptosis.
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Wang,F., Xu,S., Chen,T., Ling,S., Zhang,W., Wang,S., Zhou,R.,
            Xia,X., Yao,Z., Li,P., Zhao,X., Wang,J. and Guo,X.
  TITLE     FOXP4 differentially controls cold-induced beige adipocyte
            differentiation and thermogenesis
  JOURNAL   Development 149 (7) (2022)
   PUBMED   35297993
  REMARK    Erratum:[Development. 2022 May 1;149(9):dev200853. doi:
            10.1242/dev.200853. PMID: 35543268]
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Li,S., Zhou,D., Lu,M.M. and Morrisey,E.E.
  TITLE     Advanced cardiac morphogenesis does not require heart tube fusion
  JOURNAL   Science 305 (5690), 1619-1622 (2004)
   PUBMED   15361625
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Li,S., Weidenfeld,J. and Morrisey,E.E.
  TITLE     Transcriptional and DNA binding activity of the Foxp1/2/4 family is
            modulated by heterotypic and homotypic protein interactions
  JOURNAL   Mol Cell Biol 24 (2), 809-822 (2004)
   PUBMED   14701752
  REMARK    GeneRIF: complex regulatory mechanism underlying Foxp1, Foxp2, and
            Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the
            first Fox proteins reported whose activity is regulated by homo-
            and heterodimerization
REFERENCE   8  (bases 1 to 3854)
  AUTHORS   Teufel,A., Wong,E.A., Mukhopadhyay,M., Malik,N. and Westphal,H.
  TITLE     FoxP4, a novel forkhead transcription factor
  JOURNAL   Biochim Biophys Acta 1627 (2-3), 147-152 (2003)
   PUBMED   12818433
  REMARK    GeneRIF: In adult tissues FoxP4 is expressed in heart, brain, lung,
            liver, kidney, and testis.In situ hybridization revealed expression
            of FoxP4 in the developing lung and gut
REFERENCE   9  (bases 1 to 3854)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3854)
  AUTHORS   Lu,M.M., Li,S., Yang,H. and Morrisey,E.E.
  TITLE     Foxp4: a novel member of the Foxp subfamily of winged-helix genes
            co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues
  JOURNAL   Mech Dev 119 Suppl 1, S197-S202 (2002)
   PUBMED   14516685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164306.3 and AC113536.10.
            
            On Apr 7, 2022 this sequence version replaced XM_017317688.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3765653.1118108.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC164306.3         105458-105695
            239-477             AC113536.10        12424-12662
            478-573             AC113536.10        28738-28833
            574-696             AC113536.10        36066-36188
            697-783             AC113536.10        36609-36695
            784-931             AC113536.10        38204-38351
            932-1142            AC113536.10        38464-38674
            1143-1247           AC113536.10        38926-39030
            1248-1335           AC113536.10        39730-39817
            1336-1419           AC113536.10        41035-41118
            1420-1645           AC113536.10        41213-41438
            1646-1722           AC113536.10        41527-41603
            1723-1824           AC113536.10        42222-42323
            1825-1946           AC113536.10        45607-45728
            1947-2013           AC113536.10        47167-47233
            2014-2183           AC113536.10        47685-47854
            2184-3854           AC113536.10        48155-49825
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..3854
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="forkhead box P4"
                     /db_xref="GeneID:74123"
                     /db_xref="MGI:MGI:1921373"
     exon            1..238
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            239..477
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2331
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="isoform 5 is encoded by transcript variant 5;
                     forkhead box protein P4; fork head-related protein like A"
                     /codon_start=1
                     /product="forkhead box protein P4 isoform 5"
                     /protein_id="NP_001390899.1"
                     /db_xref="GeneID:74123"
                     /db_xref="MGI:MGI:1921373"
                     /translation="MMVESASETIRSAPSGQNGVGSLSAQADGGGGAGTAGTAPAAGR
                     DASGREAASGGADSNGEMSPAELLHFQQQQALQVARQFLLQQASSLNSPGNNDSKQSA
                     SAVQVPVSVAMMSQQMLTPQQMQQILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLH
                     LQLLTQQQAGKQQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPSQASG
                     PLQALPQAVCPTDLPQLWKGEGAPGQPAEDSGRQEGLDLASTAVTATSFASPPKVSPP
                     LSHHPLPNGQPTVLTSRRDSSSHEETPSSHPLYGHGECKWPGCETLCEDLGQFIKHLN
                     TEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPHLPH
                     CSQLNPVPGSSSFSKVTVSADPFPDGLVHPPTSAAAPVTPLRPPGLGSASLHSGGPAR
                     RRSNDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWF
                     TRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEREYQKRRPPKMTGSP
                     TLVKNMISGLSYGALNASYQAALAESSFPLLSNPGMLNPGSASSLLPLSQEDLGVPGE
                     PLPSNGSSSPPRLSPPQYSHQIQVKEEPAEAEEDRRPGPPLGAPNPSTVGPPEDRDLE
                     EDLGGEDMS"
     exon            478..573
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            574..696
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            697..783
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            784..931
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1142
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1247
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1335
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1419
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1645
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1722
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1824
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1946
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2013
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2183
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..3854
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3223
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="major polyA site"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
                     /note="hexamer: ATTAAA"
     polyA_site      3854
                     /gene="Foxp4"
                     /gene_synonym="1200010K03Rik; 2310007G05Rik; mFKHLA"
ORIGIN      
        1 aggagcgtcg ccggagcccg gggaaggacg atcggaagct ggagagagcc aagccatcct
       61 ccaaagtgcg atgcccccaa ggggctaagg cgcgcggcga tcggcgctag aaagatcgct
      121 tcggagcgca ggggcagccc cggcgagtgg cggcgggccc gggctgcgac ccgagcgagc
      181 cccatgcccc gtgcgggctg acgggccgga gcccgcactg agcggccggg ccggacaggt
      241 cccgattgag cggcaatgat ggtggagtct gcatcggaga caatcaggtc ggctccgtct
      301 ggtcagaacg gcgtgggcag cctctctgcg caggctgatg gcggcggtgg ggccgggacc
      361 gcgggcacgg ccccggctgc cggtagggat gcctcaggca gggaagcagc cagcggagga
      421 gccgacagca atggcgagat gagccccgcg gagcttctgc acttccaaca gcaacaggct
      481 ctccaggtgg cccggcagtt cctgttgcag caagcctcca gcctgaactc cccggggaac
      541 aatgacagta aacagtcggc ctctgcggtg caggtgcctg tgtctgtggc catgatgtcc
      601 cagcagatgc ttacccccca gcagatgcag cagatcctgt cgccacctca gctgcaggcc
      661 ttgctgcagc agcaacaggc tctcatgctc cagcagctgc aggagtatta caagaagcag
      721 caagagcagc tccacctgca gctcctcacc cagcagcagg ctggaaaaca gcagcccaaa
      781 gaggccctgg ggaacaagca gctggccttc cagcagcagc tcctgcagat gcaacagttg
      841 cagcaacagc acttgctcaa cctccagagg caggggctgg tcagcctgca gccaagccaa
      901 gcctcagggc ccctccaggc cctcccgcaa gccgtgtgcc cgacagacct gccccagctg
      961 tggaaaggcg agggtgcccc ggggcagccc gctgaggaca gcggcaggca ggaggggctg
     1021 gacctcgcca gcacagctgt tactgctacc tcgtttgcca gccctcccaa ggtctccccg
     1081 cccctctccc accacccctt acccaacgga caacccactg tgctcacatc tcggagagac
     1141 agctcctccc atgaggagac ccccagttcc caccctcttt atggacatgg ggagtgcaag
     1201 tggccaggct gtgagaccct gtgtgaagac ctgggccagt ttatcaaaca cctcaacaca
     1261 gaacacgctt tggatgaccg gagcacggcc caatgccgcg tgcagatgca ggtggtccaa
     1321 cagctggaga tccagctggc caaggagagt gagcggctgc aggccatgat ggcacatctg
     1381 cacatgcggc cttcagagcc caagcccttc agccagccac acctacccca ttgctcacag
     1441 ctgaacccag tccctggctc ctcctcattc tccaaggtga ccgtctccgc agacccgttc
     1501 ccggatggcc tcgtgcaccc cccaacttca gccgctgccc ccgtcacacc cctgcgtccc
     1561 cctggcctgg gctctgcctc tttgcacagt gggggccctg cccgcaggag aagtaatgac
     1621 aaattctgct cccccatctc ctcagagctt gcccagaatc atgagttcta caagaacgct
     1681 gacgtcaggc cccccttcac ctacgcttcc cttatccgcc aggccattct ggaaactcca
     1741 gatcggcagc tgacgctaaa tgagatttat aactggttca ccaggatgtt cgcctacttc
     1801 cgaagaaaca cggccacctg gaagaatgcc gtgcgccaca acctcagcct gcacaagtgt
     1861 ttcgtccgtg tggagaacgt caagggggcc gtgtggactg tggatgagcg ggaatatcag
     1921 aaacggagac cgccaaagat gacagggagt cccactctgg tgaagaacat gatctcgggc
     1981 ctcagttacg gggcacttaa cgccagctac caggctgccc tggcagagag cagcttccct
     2041 cttctcagca accccggcat gctgaaccct ggctcagcca gcagccttct gcccctcagc
     2101 caggaggacc tgggtgtccc tggggaacca ctacccagca atgggagcag cagcccgcct
     2161 cgtctttccc ctcctcagta cagccaccag atacaagtca aagaggagcc tgcagaggca
     2221 gaggaagacc gacggccggg gcctcccttg ggcgccccca accccagcac tgtggggcct
     2281 ccagaagaca gggacctgga ggaggacctg ggaggagagg acatgtccta agggcagggt
     2341 gggcgggcag ggcaggccaa gaccctgccg cccagtggac cccggcctac ccaccccact
     2401 ctacagcccc tccaacctca aggcacttcg gggactcaga cgggggagat ccgggccagt
     2461 agctcccatg ccacctgact gacagacgcc tggggacagg catatccctg ctccccgcag
     2521 agaacacaga acccttggac tgggacccgt agaggacatg gagggcccag accctctcag
     2581 cccctccctg tattcccaac caccaccagc agcagcagca gggctctcct tccccaccag
     2641 tgctcccctc caagacccct tagcacaagg ggagacccgc aggcggggct gagccacccc
     2701 cacaacccta ccttcttcat cccctctgtc ccgtctgtgg cagaggtttc tggccagagg
     2761 acccttcccg gttcatctcc cctcatcttc ttttcccaac tgtgaaaatt agttctccgg
     2821 tcccagcttc ctgctcaaag gggcaagcag gctgggggcg gggcacctgc agaccagccc
     2881 cctcagctgc gggagcggag caagttgtgc cctgcccttc cctccctgac ctgaggcaga
     2941 acccagatta agcaggtctc caccccaccc tgtttgctgg gcactcctgc ggcaccccga
     3001 gagggacccc catgctggac accttcagag cgtgtgcata ggtggtctct gacctgaaca
     3061 tcacagtgcg gagaaagccc ggctggaaac accctcgccc ccagcctacg ggtccccgaa
     3121 atggggtcct ctcaccccgc cccctcacct cctcctgtcc ttccctctcc cagttaaaac
     3181 ggatgaccaa agacctttct tatgccggaa gcaaaaacca aaactttttg ttggcttttt
     3241 cttttgccgc ctcccgagca ccctgccctc ccaaccctgc cccctgatcc cgggctggaa
     3301 gccttccctc cttcacttaa gttattgtgt taaaccaaag tttacagtgt ctgttggtag
     3361 caagaccccc tcctcccctc taccaccccc cccaagggtc caggggtcct actcgcttcc
     3421 cccctgctca taccttgcct atggagacat gagagggcag aatcctgccc ccagccctgg
     3481 gctgctttcg ggggtcgggg gagggctctt cagatgcctc cataggacca agtccccatc
     3541 attgccggga gtgtggattc tagcagcaga gctggaaacg atgagattcc acagaccccc
     3601 tatgggggac ccacaaccca agaccgcaga ctgggtgtaa gggatgcccg gaacaccctg
     3661 accaggcccc tcccctaaga cttcttggat atttcccagg agaatcccac attcaccgcc
     3721 aaacccctat ccctacccaa cacaagctgc cctcctgaaa ggcaagggcg ccccgccccc
     3781 ggccttcccc catgtacccc cacctgtgtt ccgtttgacc agcacagaaa tattaaagtc
     3841 ctctatttac cggg
//
