LOCUS       NM_194060               2528 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus forkhead box O6 (Foxo6), mRNA.
ACCESSION   NM_194060 XM_906986
VERSION     NM_194060.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Kim,M.E., Lee,J.S., Kim,T.W., Park,M.H. and Kim,D.H.
  TITLE     FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver
            through NLRP3 Inflammasome Activation
  JOURNAL   Endocrinol Metab (Seoul) 39 (1), 127-139 (2024)
   PUBMED   38417829
  REMARK    GeneRIF: FoxO6-Mediated TXNIP Induces Lipid Accumulation in the
            Liver through NLRP3 Inflammasome Activation.
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Stallings,C.E., Kapali,J., Evans,B.W., McGee,S.R. and
            Ellsworth,B.S.
  TITLE     FOXO Transcription Factors Are Required for Normal Somatotrope
            Function and Growth
  JOURNAL   Endocrinology 163 (2) (2022)
   PUBMED   34971379
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Zhang,L., Zhang,Y., Zhou,M., Wang,S., Li,T., Hu,Z. and Jin,C.
  TITLE     Role and mechanism underlying FoxO6 in skeletal muscle in vitro and
            in vivo
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   34080654
  REMARK    GeneRIF: Role and mechanism underlying FoxO6 in skeletal muscle in
            vitro and in vivo.
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Kim,D.H., Kim,B.M., Chung,K.W., Choi,Y.J., Yu,B.P. and Chung,H.Y.
  TITLE     Interaction between CHOP and FoxO6 promotes hepatic lipid
            accumulation
  JOURNAL   Liver Int 40 (11), 2706-2718 (2020)
   PUBMED   32639626
  REMARK    GeneRIF: Interaction between CHOP and FoxO6 promotes hepatic lipid
            accumulation.
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Moon,K.M., Lee,B., Kim,D.H. and Chung,H.Y.
  TITLE     FoxO6 inhibits melanogenesis partly by elevating intracellular
            antioxidant capacity
  JOURNAL   Redox Biol 36, 101624 (2020)
   PUBMED   32863230
  REMARK    GeneRIF: FoxO6 inhibits melanogenesis partly by elevating
            intracellular antioxidant capacity.
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Kim,D.H., Perdomo,G., Zhang,T., Slusher,S., Lee,S., Phillips,B.E.,
            Fan,Y., Giannoukakis,N., Gramignoli,R., Strom,S., Ringquist,S. and
            Dong,H.H.
  TITLE     FoxO6 integrates insulin signaling with gluconeogenesis in the
            liver
  JOURNAL   Diabetes 60 (11), 2763-2774 (2011)
   PUBMED   21940782
  REMARK    GeneRIF: investigation of role of FoxO6 in liver: Data suggest that
            a FoxO6-dependent pathway in liver orchestrates insulin regulation
            of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in
            mouse tissues.
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Bouchard,C., Lee,S., Paulus-Hock,V., Loddenkemper,C., Eilers,M. and
            Schmitt,C.A.
  TITLE     FoxO transcription factors suppress Myc-driven lymphomagenesis via
            direct activation of Arf
  JOURNAL   Genes Dev 21 (21), 2775-2787 (2007)
   PUBMED   17974917
  REMARK    GeneRIF: FoxO factors mediate Myc-induced Arf expression and
            provide direct genetic evidence for their tumor-suppressive
            capacity.
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Identification of forkhead transcription factors in cortical and
            dopaminergic areas of the adult murine brain
  JOURNAL   Brain Res 1068 (1), 23-33 (2006)
   PUBMED   16376864
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Hoekman,M.F., Jacobs,F.M., Smidt,M.P. and Burbach,J.P.
  TITLE     Spatial and temporal expression of FoxO transcription factors in
            the developing and adult murine brain
  JOURNAL   Gene Expr Patterns 6 (2), 134-140 (2006)
   PUBMED   16326148
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Jacobs,F.M., van der Heide,L.P., Wijchers,P.J., Burbach,J.P.,
            Hoekman,M.F. and Smidt,M.P.
  TITLE     FoxO6, a novel member of the FoxO class of transcription factors
            with distinct shuttling dynamics
  JOURNAL   J Biol Chem 278 (38), 35959-35967 (2003)
   PUBMED   12857750
  REMARK    GeneRIF: cloning and characterization; structural and functional
            properties related to gene regulation
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ571690.1.
            
            On Dec 7, 2005 this sequence version replaced XM_906986.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ571690.1, BC086628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.1 cM"
     gene            1..2528
                     /gene="Foxo6"
                     /note="forkhead box O6"
                     /db_xref="GeneID:329934"
                     /db_xref="MGI:MGI:2676586"
     exon            1..423
                     /gene="Foxo6"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1689
                     /gene="Foxo6"
                     /function="transcription factor"
                     /codon_start=1
                     /product="forkhead box protein O6"
                     /protein_id="NP_918949.1"
                     /db_xref="CCDS:CCDS18588.1"
                     /db_xref="GeneID:329934"
                     /db_xref="MGI:MGI:2676586"
                     /translation="MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGA
                     GVAEGSEDCGPERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIE
                     SAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTG
                     KSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLHLPERSPDDSPPGA
                     PVPGPLSASAKWAASPASHASDDYEAWADFRGSRRPLLGEAAELEDDEALEALAPSSP
                     LMYPSPASALSPALGARCPGELPRLAELGGPLGLHGGGVAGLPDALLDGAQDAYGPRA
                     RAGTPSYFGSCKASAYGGGGGFGPPALGSLRRLPMQTIQENKQASFVQAAAPFRPGAL
                     PALLPPPPPAPRPGPLLGAPGELALAGAAAAYPGKGAAPYAPPAPSRSALAHPISLMT
                     LPGEAGAAGLAPPAHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAGPDRFPADLDLDM
                     FSGSLECDVESIILNDFMDSDEMDFNFDSALPPPPPGLAGAPPPNQSWVPG"
     exon            424..2528
                     /gene="Foxo6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo6"
                     /note="hexamer: AATAAA"
     polyA_site      2527
                     /gene="Foxo6"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggacca tggctgcgaa gctgcgagcg catcaggtgg acgtggaccc ggacttcgcg
       61 ccgcagagcc ggccgcgctc gtgtacctgg cctctgccgc agccggactt ggccggcgac
      121 gaggacgggg cgctgggtgc aggagtagcc gagggttccg aggactgcgg gccggaacgc
      181 agggcgacgg ccccagcgat ggccccagcg cctccgctgg gcgcagaggt cggacccttg
      241 cggaaagcga agagctcccg acggaacgcg tgggggaacc tttcctacgc cgacctcatc
      301 accaaagcca tcgagagcgc cccggacaag agactcacgc tctcgcagat ctacgactgg
      361 atggtccgct acgtgcccta cttcaaggat aaaggcgaca gcaacagctc ggccggctgg
      421 aagaactcca ttcggcacaa cctgtcgctg cacacccggt tcatccgcgt gcagaacgag
      481 ggcactggca agagttcatg gtggatgctg aaccccgagg gcggaaagac aggcaagacc
      541 ccgcggcgcc gggccgtgtc catggacaat ggggccaagt tcctgcgcat caagggcaag
      601 gcgagcaaga agaagcagct gcacctgccg gaacggagcc ccgacgacag ccctccgggc
      661 gcaccagttc cagggcccct gtcggcctcc gccaagtggg cggccagccc ggcctcacat
      721 gccagtgacg actacgaggc gtgggctgac ttccgcggca gcaggagacc cctgctcggg
      781 gaggcggctg agctggagga cgacgaggcc ctggaggccc tggcaccgtc ctcgccactc
      841 atgtacccaa gccctgcgag cgcgctgtcg cccgccctgg gcgcgcgctg cccgggcgag
      901 ctgccgcgtc tggccgagct gggaggtccg ctgggcctgc acggtggcgg cgtggccggg
      961 ctgccggacg ccctgctgga cggcgcgcag gacgcgtacg ggccgcgggc acgcgccggg
     1021 accccctcct acttcggcag ctgcaaggcg agcgcctacg gcgggggcgg gggcttcggg
     1081 ccgcccgctc tgggctcgct gcgccgcctg cccatgcaga ccatccagga gaacaagcag
     1141 gccagcttcg tgcaggccgc cgcgcccttc cgccccgggg cgctgcccgc gctgctgcct
     1201 ccgccgccgc ccgcgccgag gcccggcccg ctgctgggcg cgcccgggga gctggcgctg
     1261 gcgggcgcgg ccgccgctta cccgggcaaa ggagcggccc cgtacgcgcc gccggcgccc
     1321 tcgcgcagtg ccttagccca ccccatcagc cttatgacgc tgcccggcga ggcgggcgcc
     1381 gccggcctgg ccccgccggc ccacgccgca gccttcgggg gtccgcccgg cggcctcctg
     1441 ctggatgcgc tgcccgggcc ctacgcggcc gcagcagccg ggcctctggg tgcagggccg
     1501 gaccgcttcc cggcggatct ggacctcgac atgtttagcg ggagcctcga gtgtgacgtc
     1561 gagtccatca tcctcaacga cttcatggac agtgacgaaa tggacttcaa cttcgactca
     1621 gccctgcctc cgccaccccc gggcctggct ggggcgccgc cccctaacca gagctgggtg
     1681 ccgggctgag ggccacccta cacagcctgg gtgccccggt cccgtcccca tggggcctct
     1741 gtcttcccat cccgatcccc gggtccccac tcccccgacc cagctccacg ggaggatcca
     1801 ggaggcaacc ccagcccagc tggagacatc cctccgagct gagcgcagag ggaggttgga
     1861 aggagcgctg cgacaccttg ccattcccgc ccgagggctg gaggtctggg agggatggtt
     1921 gaagtcgggc taggtgggag tggggggaga gcgaggcgga tggcccactg tggatgctgg
     1981 ccctgcaagc cccctaggag gtggggcagg ggcgtttctg aatcttcagt tcctattgct
     2041 gggccctttg tgaggcctaa gccacccaac tccaatctgg ttctcaaatg acacgtttcc
     2101 ctcactggcc gtagccccac cacacgaagc cagcaaccct cttcgttcac accaatctta
     2161 gtcatccatt ctgctcagtc ctctggtcct cagctaccct ctggttcagt ctcccatctt
     2221 aaccagtcct ggcacctccc ctctcctgtc agtcaacccc acactcctcc agtactggcc
     2281 acagcctctc cagcgggcct cagttccaga tccatccccc aattcgacac ccccagtcct
     2341 ggcccctctc tcccatattt ataagtgtcc ggtcggggcg ggcggtgggc gcggcgtccc
     2401 cggcgcgtat cgtaggcagt gtactgtggc cgtgccgtca gcgtgtgcgt gtgcgtgtgt
     2461 gccgtgtcga ggccgtgtag agtgcattgt acagcatatt ttcatgaata aaattgtttt
     2521 aaatattt
//
