LOCUS       NM_018789               3162 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus forkhead box O4 (Foxo4), mRNA.
ACCESSION   NM_018789 XM_906079 XM_919666
VERSION     NM_018789.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3162)
  AUTHORS   Yu,T., Yu,Y., Ma,Y. and Chen,G.
  TITLE     FoxO4 mediates macrophage M2 polarization by promoting LXA4R
            expression in an ovalbumin-induced allergic asthma model in mice
  JOURNAL   Allergol Immunopathol (Madr) 51 (4), 19-30 (2023)
   PUBMED   37422776
  REMARK    GeneRIF: FoxO4 mediates macrophage M2 polarization by promoting
            LXA4R expression in an ovalbumin-induced allergic asthma model in
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3162)
  AUTHORS   Jiang,X., Wang,Y., Xiao,Z., Yan,L., Guo,S., Wang,Y., Wu,H.,
            Zhao,X., Lu,X. and Wang,H.
  TITLE     A differentiation roadmap of murine placentation at single-cell
            resolution
  JOURNAL   Cell Discov 9 (1), 30 (2023)
   PUBMED   36928215
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3162)
  AUTHORS   Leduc-Gaudet,J.P., Franco-Romero,A., Cefis,M., Moamer,A.,
            Broering,F.E., Milan,G., Sartori,R., Chaffer,T.J., Dulac,M.,
            Marcangeli,V., Mayaki,D., Huck,L., Shams,A., Morais,J.A.,
            Duchesne,E., Lochmuller,H., Sandri,M., Hussain,S.N.A. and
            Gouspillou,G.
  TITLE     MYTHO is a novel regulator of skeletal muscle autophagy and
            integrity
  JOURNAL   Nat Commun 14 (1), 1199 (2023)
   PUBMED   36864049
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3162)
  AUTHORS   Penniman,C.M., Bhardwaj,G., Nowers,C.J., Brown,C.U., Junck,T.L.,
            Boyer,C.K., Jena,J., Fuqua,J.D., Lira,V.A. and O'Neill,B.T.
  TITLE     Loss of FoxOs in muscle increases strength and mitochondrial
            function during aging
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (1), 243-259 (2023)
   PUBMED   36442857
REFERENCE   6  (bases 1 to 3162)
  AUTHORS   Furukawa-Hibi,Y., Yoshida-Araki,K., Ohta,T., Ikeda,K. and
            Motoyama,N.
  TITLE     FOXO forkhead transcription factors induce G(2)-M checkpoint in
            response to oxidative stress
  JOURNAL   J Biol Chem 277 (30), 26729-26732 (2002)
   PUBMED   12048180
  REMARK    GeneRIF: plays an important role in the regulation of GADD45 in
            response to oxidative stress and thereby contributes to G(2)-M
            checkpoint
REFERENCE   7  (bases 1 to 3162)
  AUTHORS   Tang,T.T., Dowbenko,D., Jackson,A., Toney,L., Lewin,D.A., Dent,A.L.
            and Lasky,L.A.
  TITLE     The forkhead transcription factor AFX activates apoptosis by
            induction of the BCL-6 transcriptional repressor
  JOURNAL   J Biol Chem 277 (16), 14255-14265 (2002)
   PUBMED   11777915
  REMARK    GeneRIF: The forkhead transcription factor AFX activates apoptosis
            by induction of the BCL-6 transcriptional repressor.
REFERENCE   8  (bases 1 to 3162)
  AUTHORS   Richards,J.S., Sharma,S.C., Falender,A.E. and Lo,Y.H.
  TITLE     Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary:
            evidence for regulation by IGF-I, estrogen, and the gonadotropins
  JOURNAL   Mol Endocrinol 16 (3), 580-599 (2002)
   PUBMED   11875118
  REMARK    GeneRIF: AFX (a Forkhead transcription factor = Foxo4) is expressed
            in the rodent ovary
REFERENCE   9  (bases 1 to 3162)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   10 (bases 1 to 3162)
  AUTHORS   Furuyama,T., Nakazawa,T., Nakano,I. and Mori,N.
  TITLE     Identification of the differential distribution patterns of mRNAs
            and consensus binding sequences for mouse DAF-16 homologues
  JOURNAL   Biochem J 349 (Pt 2), 629-634 (2000)
   PUBMED   10880363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671926.11.
            
            On Aug 13, 2009 this sequence version replaced NM_018789.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF114260.1, AB032770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AL671926.11        145404-146149
            747-1803            AL671926.11        149053-150109
            1804-3162           AL671926.11        150391-151749
FEATURES             Location/Qualifiers
     source          1..3162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.89 cM"
     gene            1..3162
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /note="forkhead box O4"
                     /db_xref="GeneID:54601"
                     /db_xref="MGI:MGI:1891915"
     exon            1..746
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1811
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /note="forkhead protein; fork head domain transcription
                     factor AFX1; myeloid/lymphoid or mixed lineage-leukemia
                     translocation to 7 homolog"
                     /codon_start=1
                     /product="forkhead box protein O4"
                     /protein_id="NP_061259.1"
                     /db_xref="CCDS:CCDS41077.1"
                     /db_xref="GeneID:54601"
                     /db_xref="MGI:MGI:1891915"
                     /translation="MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDLATEP
                     HEPSEVEPSLGQKVPTEGHSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWG
                     NQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSL
                     HSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMDSSSKLLRGRSKGPKKKPSV
                     LPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPMRP
                     ESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSGLSGFSLQHPG
                     LAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPILS
                     QAPTLLLLGGMPSSSKLGTGVSLCPTPLEGPGPSNLVPNLSVMAPPPVMAGAPIPKVL
                     GTPVLASPTEDSSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP"
     exon            747..1803
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..3162
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /note="hexamer: AATAAA"
     polyA_site      3162
                     /gene="Foxo4"
                     /gene_synonym="afx; Afxh; Mllt7"
                     /note="major polyA site"
ORIGIN      
        1 gcctcaggtt taaaagagca ggaagctgag tgagagggtg cagaaagtgc cttcgctagg
       61 cggaggttac aggtggtgcc tcagagcgct actctgaggc tgcagcccgg actccggagg
      121 ggatcggaga acggagtgaa agggacagtt taggagctag agtccggaga cgagggagaa
      181 gttcgtgact ttctgagaac tggaaagaat gtgtttcccc ccttggggga ggcatggtga
      241 gggactgtgg caggctccac tgatcgctga gctgcagagg ttcgacccca cgtatggatc
      301 cagagaataa gaagtcagcc acaggggctg ccgcgatcct agacctcgat cccgacttcg
      361 aaccccagag ccgtccgcga tcctgcacct ggccccttcc tcgaccagac ctcgctacgg
      421 agccacacga accgtccgag gtggagccca gtctgggaca gaaggtaccc acggagggac
      481 actccgaacc gatcctgttg ccctctcggc tcccagagcc ggcagggggc ccccagccgg
      541 gaatcctggg ggctgtaaca ggtcctcgga agggaggctc ccgccggaat gcctggggaa
      601 atcagtcata tgcagaactc atcagccagg ccattgaaag cgccccggag aagcggctga
      661 cactcgccca gatctacgaa tggatggtcc gcacggtgcc ctacttcaag gacaagggtg
      721 acagcaacag ctcggcagga tggaagaact ccatccgtca caacctgtcc ttgcacagca
      781 agttcatcaa ggttcacaac gaggccactg gcaagagctc ttggtggatg ctgaaccccg
      841 atggcggcaa gggtggcaag gcaccccgcc gcagggctgc ctccatggat agcagcagca
      901 agctgctccg gggccgcagc aaaggcccca agaagaagcc gtctgtcctg ccagctccac
      961 cggaaggtgc cacgccaagg agccctctgg gccactttgc caagtggtca agcagccctt
     1021 gtcctcgaaa tcgagaagaa gctgatgtgt ggaccacttt ccgtccacga agcagttcaa
     1081 atgctagcac cgtcagcacc cggctgtcgc caatgaggcc ggagtctgaa gtgctagcag
     1141 aagaggaaat gccagcctcg gccagcagct atgcaggggg ggtccctccc acgctcagtg
     1201 aagatctaga gctactggat gggctcaatc tcgcatctcc ccattccttg ctctctagga
     1261 gcggtctctc cggcttctct ttgcagcatc ctgggcttgc tggcccctta catagctatg
     1321 gtgcctccct ctttggccca atagatgggt ctttgtcagc aggagaaggg tgcttctcaa
     1381 gttcccagtc tctagaggct ctgctcacct ctgatacacc accacctcct gctgatgtcc
     1441 tcatgaccca ggtagatcct atcctgtctc aggctcctac acttctgtta ctgggaggaa
     1501 tgccttcctc tagcaagctg ggcacaggag tcagcctgtg tcctacgccg ctagagggtc
     1561 ctggtcccag caacctggtc cccaaccttt ctgtgatggc accaccccca gtcatggcag
     1621 gcgctcccat ccctaaggtc ctgggaaccc ctgtgctcgc atctcctact gaagattcca
     1681 gccatgacag aatgcctcag gatctggatc ttgatatgta tatggagaac ctggagtgcg
     1741 acatggataa catcatcagt gacctcatgg atggtgaggg actggacttc aactttgagc
     1801 cagatccctg agtcacagca agaagctttg tcccctgctt cggaggtgga ggtggagcca
     1861 ggcctgtcct tatccacttt tcctccttga gccctcccca ggagtttggg accctacttt
     1921 agagctaagg attggtggca acacactcaa gtgttgagga aattataaag ataaatctat
     1981 gacatgtagg gattgtagag gagggtgata ggaggaggga gggaaaaggg ctttgtctca
     2041 ctgtgccaat tagggggtag ttatggtcct ttctcagggg ccaccattga tttcctcatt
     2101 cccacctcct aggcctgtag caggggccag caatgctgtt gaaatgtgaa gtcaccagtg
     2161 gccttattac cctgcctttg ggagcaggat tattattttt tttggtagag agtcttacta
     2221 gagctgggcc aggctgggtt gagcctggat ttttatgcag tggggtgggt gggtgggggg
     2281 ggccggggga cctaaaaggg ccaagttttg agcactggag tggctcacca ggccaaatca
     2341 cttttggaag gatgcagata acagacaggc tttttataaa cttttaaaga aatataaaca
     2401 caaatataga gatttttaac agtggtgagg tgctagtgat ggggagaagg cttttttttt
     2461 tctttccgaa ggctttgtca tagtgacatg atacaaacac tacagactct atggaggaga
     2521 cacaggaagc tagggagagg tgggtagcaa gagttttaag caaagaaacc taagtcaggt
     2581 ccccacattc tgttcacttg tgcctagaag agagtgctgt tgtggggcaa gcacactctt
     2641 atttgaccag tgcaggttag tgctcccaga gagagcatcc aagtcctgaa attggcttgg
     2701 ggcctgggag gggcgtgaaa gaaggaagga tttagggtag taaagttagg tacagagacc
     2761 tcgctgttca aggcctggga cagctgtccc tgcccttctt ccctgttgtg gtctgccagg
     2821 gttatgtgga aggctgtgta gcagcaagca gggctgtgga gaggaacagg gaagggagag
     2881 cctgacgagt ttggctgagg gtctgggaaa tgagcagggt tggggggaat gtggatcagg
     2941 tttactagca cctgccagag aggccatctg gggctcctcc accccagccc ccaagcagcc
     3001 cctcccccag cgcctttgca ttgtcccctc ccccactcct gctgtgggtt cccatcattt
     3061 cctgtgtcag cgcctggcct acccagattg tatcatgtgc tagattggag tggggaagtg
     3121 tgtcaaatca ataaatgagt tcaataaatg tctataatca ga
//
