LOCUS       NM_001376967            6787 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus forkhead box O3 (Foxo3), transcript variant 1, mRNA.
ACCESSION   NM_001376967 XM_006512806
VERSION     NM_001376967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6787)
  AUTHORS   Wang,R., Ji,L., Yuan,S., Liu,X., Liang,Z., Chen,W., Wang,B., Hu,S.,
            Liu,Z., Zeng,Z., Song,Y., Wu,T. and Chen,B.
  TITLE     Microglial forkhead box O3a deficiency attenuates LPS-induced
            neuro-inflammation and depressive-like behaviour through regulating
            the expression of peroxisome proliferator-activated receptor-gamma
  JOURNAL   Br J Pharmacol 181 (20), 3908-3925 (2024)
   PUBMED   38881194
  REMARK    GeneRIF: Microglial forkhead box O3a deficiency attenuates
            LPS-induced neuro-inflammation and depressive-like behaviour
            through regulating the expression of peroxisome
            proliferator-activated receptor-gamma.
REFERENCE   2  (bases 1 to 6787)
  AUTHORS   Wen,Y., Li,Y., Guo,J. and Shang,K.
  TITLE     Expression of FoxO3a in sepsis mice and its association with
            lymphocyte apoptosis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 253-257 (2024)
   PUBMED   38814205
  REMARK    GeneRIF: Expression of FoxO3a in sepsis mice and its association
            with lymphocyte apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6787)
  AUTHORS   Ribeiro,C., Ferreirinha,P., Landry,J.J.M., Macedo,F., Sousa,L.G.,
            Pinto,R., Benes,V. and Alves,N.L.
  TITLE     Foxo3 regulates cortical and medullary thymic epithelial cell
            homeostasis with implications in T cell development
  JOURNAL   Cell Death Dis 15 (5), 352 (2024)
   PUBMED   38773063
  REMARK    GeneRIF: Foxo3 regulates cortical and medullary thymic epithelial
            cell homeostasis with implications in T cell development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6787)
  AUTHORS   Yang,C., Kang,F., Huang,X., Wu,W., Hou,G., Zheng,K., Han,M.,
            Kan,B., Zhang,Z. and Li,J.
  TITLE     Spinal sirtuin 2 attenuates bone cancer pain by deacetylating
            FoxO3a
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167129 (2024)
   PUBMED   38513990
  REMARK    GeneRIF: Spinal sirtuin 2 attenuates bone cancer pain by
            deacetylating FoxO3a.
REFERENCE   5  (bases 1 to 6787)
  AUTHORS   Cheng,Y., Zhang,M., Xu,R., Fu,L., Xue,M., Xu,C., Tang,C., Fang,T.,
            Liu,X., Sun,B. and Chen,L.
  TITLE     p53 accelerates endothelial cell senescence in diabetic retinopathy
            by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
  JOURNAL   Exp Gerontol 188, 112391 (2024)
   PUBMED   38437929
  REMARK    GeneRIF: p53 accelerates endothelial cell senescence in diabetic
            retinopathy by enhancing FoxO3a ubiquitylation and degradation via
            UBE2L6.
REFERENCE   6  (bases 1 to 6787)
  AUTHORS   Nemoto,S. and Finkel,T.
  TITLE     Redox regulation of forkhead proteins through a p66shc-dependent
            signaling pathway
  JOURNAL   Science 295 (5564), 2450-2452 (2002)
   PUBMED   11884717
  REMARK    GeneRIF: redox regulation through a p66shc-dependent signaling
            pathway
REFERENCE   7  (bases 1 to 6787)
  AUTHORS   Richards,J.S., Sharma,S.C., Falender,A.E. and Lo,Y.H.
  TITLE     Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary:
            evidence for regulation by IGF-I, estrogen, and the gonadotropins
  JOURNAL   Mol Endocrinol 16 (3), 580-599 (2002)
   PUBMED   11875118
  REMARK    GeneRIF: expression in the ovary
REFERENCE   8  (bases 1 to 6787)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   9  (bases 1 to 6787)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   10 (bases 1 to 6787)
  AUTHORS   Furuyama,T., Nakazawa,T., Nakano,I. and Mori,N.
  TITLE     Identification of the differential distribution patterns of mRNAs
            and consensus binding sequences for mouse DAF-16 homologues
  JOURNAL   Biochem J 349 (Pt 2), 629-634 (2000)
   PUBMED   10880363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116179.6 and AC140402.2.
            
            On Dec 5, 2019 this sequence version replaced XM_006512806.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.12357.1,
                                           SRR11927932.2778312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC116179.6         49212-49381
            171-900             AC116179.6         50362-51091
            901-2336            AC140402.2         23716-25151
            2337-6787           AC140402.2         35322-39772
FEATURES             Location/Qualifiers
     source          1..6787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.79 cM"
     gene            1..6787
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /note="forkhead box O3"
                     /db_xref="GeneID:56484"
                     /db_xref="MGI:MGI:1890081"
     exon            1..170
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..900
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..2301
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /note="forkhead box O3a; forkhead protein FKHR2"
                     /codon_start=1
                     /product="forkhead box protein O3"
                     /protein_id="NP_001363896.1"
                     /db_xref="GeneID:56484"
                     /db_xref="MGI:MGI:1890081"
                     /translation="MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
                     AKPSGETAADSMIPEEDDDEDDEDGGGRASSAMVIGGGVSSTLGSGLLLEDSAMLLAP
                     GGQDLGSGPASAAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLS
                     YADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSR
                     FMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAA
                     PESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDD
                     VQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDN
                     IALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTI
                     QENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNV
                     MLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGS
                     AKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDME
                     SIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG"
     exon            901..2336
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..6787
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6765..6770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /note="hexamer: AATAAA"
     polyA_site      6787
                     /gene="Foxo3"
                     /gene_synonym="1110048B16Rik; 2010203A17Rik; Fkhr2;
                     FKHRL1; Foxo3a"
                     /note="major polyA site"
ORIGIN      
        1 gctcgtggaa gggaggagga ggaatgtgga aggcggcggc gcagcacagg ctgacaggcg
       61 gttcctccgg cgggctgcgg cggcggcccg agagtcccct cgtcgcggtg ccctgggctc
      121 gcgcggaatc gtacgccctc ccgcctcgtt cctgaaggga aggagccgag gtagctggag
      181 ctcgaacctt cgcggtgccc cgttcctccc ccgccgcacc cagcctgggc tcgagaggag
      241 agagcaagag cccaagccgc gggcggcggg caggcggcga agatggcaga ggcaccagcc
      301 tccccggtcc cgctctctcc gctcgaagtg gagctggacc cagagttcga gccacagagt
      361 cggccacgct cctgtacgtg gcccctgcag aggccggagc tgcaggcgag cccggccaag
      421 ccctcggggg agacggccgc agactccatg atccccgagg aggacgacga tgaagacgac
      481 gaggacggcg gcggccgagc cagctcggcc atggtgatcg gtggcggcgt gagcagcacg
      541 ctgggttccg ggctgctcct cgaggattcg gccatgctgc tggctccagg agggcaggac
      601 ctcgggtcgg ggccagcgtc cgccgcaggc gctctgagtg ggggcacgcc gacgcagctg
      661 cagcctcagc agccactgcc acagccgcag ccgggggcgg ctgggggctc tgggcaacca
      721 aggaaatgct cctcgcggcg gaatgcctgg gggaacctgt cctatgccga cctgatcacc
      781 cgcgccatcg agagctcccc ggacaaacgg ctcactttgt cccagatcta cgagtggatg
      841 gtgcgctgtg tgccctactt caaggataag ggcgacagca acagctctgc gggctggaag
      901 aactccatcc ggcacaacct gtccctgcac agccgcttca tgcgcgttca gaatgaaggc
      961 acgggcaaga gctcttggtg gatcatcaac cccgatgggg gaaagagcgg gaaggccccc
     1021 cggcggcgtg cggtctccat ggacaacagc aacaagtaca ccaagagccg aggccgggca
     1081 gccaagaaga aggcggccct gcaggctgcc ccagagtcgg cagacgacag tccttcccag
     1141 ctctccaagt ggcctggcag ccccacgtcc cgcagcagcg acgagctgga tgcgtggacc
     1201 gacttccgct cgcgcaccaa ttccaacgcc agcaccgtga gcggccgcct gtcgcccatc
     1261 ctggcaagca cggagctgga tgacgtccag gatgatgatg gacccctgtc ccccatgctg
     1321 tacagcagct ctgccagcct gtcgccctcc gtgagcaagc cgtgtactgt ggagcttccg
     1381 cggctgacgg acatggccgg caccatgaat ctgaatgatg ggctggccga gaacctcatg
     1441 gacgacctgc tggataacat cgcgctcccg ccatcgcagc catcgcctcc tggcgggctt
     1501 atgcagcggg gctccagctt cccatatacc gccaagagct ccggcctggg ctccccaacc
     1561 ggctccttca acagtaccgt gtttggacct tcgtctctga actccttgcg tcagtcaccc
     1621 atgcagacta tccaggagaa cagaccagcc accttctctt ccgtgtcaca ctacggcaac
     1681 cagacactcc aagacctgct tgcttcagac tcactcagcc acagcgacgt catgatgacc
     1741 cagtcggacc ccttgatgtc tcaggctagc accgccgtgt ccgcccagaa tgcccgccgg
     1801 aacgtgatgc ttcgcaacga tccaatgatg tcctttgctg cccagcctac ccaggggagt
     1861 ttggtcaatc agaacttgct ccaccaccag caccaaaccc agggcgctct tggtggcagc
     1921 cgtgccttgt caaattctgt cagcaacatg ggcttgagtg actccagcag ccttggctca
     1981 gccaaacacc agcagcagtc tcccgccagc cagtctatgc aaaccctctc ggactctctc
     2041 tcaggctcct cactgtattc agctagtgca aaccttcccg tcatgggcca cgataagttc
     2101 cccagtgact tggacctgga catgttcaat gggagcttgg aatgtgacat ggagtccatc
     2161 atccgtagtg aactcatgga tgctgacggg ttggatttta actttgactc cctcatctcc
     2221 acacagaacg ttgttggttt gaatgtgggg aacttcactg gtgctaagca ggcctcatct
     2281 caaagctggg taccaggctg aaggatcact gaggaaaggg gaaatgggca aagcagaccc
     2341 tcaaactgac ggaagaccta cagagaaaac cctttgccaa atctgctctc agcaagtgga
     2401 cagtgatccg tttacagctt gacacctttg agactcccac gccgcttccc taacccagca
     2461 gagactgtta gcagccctgg ccctgggtga agcccttacc cgtggaacag aactctataa
     2521 catatgcaaa atctaactca tctgcaagtg acctgccagc gtggacagca cccatcagca
     2581 ccccccactc cttcagagca caccgggacc ccgttggcga ctccgtcgtg ttttactatc
     2641 atgatggttt aggggatatt ttaagtgtcg tcttgtgttt gtttcctttg accctctgag
     2701 ttttctacac acagtaacct gcagtatttt tctgttgaaa atgttaactg tcctttccct
     2761 agcacactta aaagcagaag gaaggtgtta tatcagttcc cagtctggcc ttgagcatcg
     2821 caagcttttg agcctgtggg accccacaaa cttaacacat tgcataaact aatggggggg
     2881 ggggcgggta tttcttcttt tatttggtag aaaattatcc ttttctaaaa actgaacaat
     2941 ggcacaactg cttgccctgc gtgcccgacc aggaccgaac tatgcgtagg cgaagcaaac
     3001 agagccaggc atctgaccca gtagtttcca gttctgagtc ggggggtggt ctgtgggtgg
     3061 agaccttgat gcccactccg cagttgcctg ctcggtgggg ctgtggtctc ccgccatcct
     3121 ccgcggtagg cggtatctct gctcttagga actagggcct cttcaggaaa gcatcagctc
     3181 agcctctgcc cgttgccaaa tgccacgaat gggtttagtc ttgaggagaa aagagaaatg
     3241 tgtgcctgtt ctgcttcgta gaagacgtgg agttacaggt gagccattta gcatgcgtgt
     3301 gagagcgaca aaccacgtct gcaccagctg gtccaacggc actgtttgtg aaacgtgcat
     3361 atcttttgat tcttttcaac cttgctgtgt gtacgctgat cttcctagaa gtgtatgagt
     3421 gacaggcaat agtatacaag gtgagatatc tctatatata taggcttagt ttgtaattct
     3481 tcaagtgatt catggaaata caagataagg caatttaaac ttttttttaa aaaaaaactt
     3541 tttctgcttc tgtggaactc atttttgttg ttgttgttgt tgtttccaaa aagttatggt
     3601 gctgtatagg tgctttctgt tgagcctgca gagtgtgagt gtaggtggta ctctctttgg
     3661 tagacagcgt agttgggaac acctttggta catacaaaac tggtgtggcg atgctctgac
     3721 tagcacagca tatgcatatg tctccaaagt gatatctgaa ggctttcttc tttgcataaa
     3781 aagcactagg catttaagtg tataaaatat tttatcatgt acagcaaaga tggaactcta
     3841 tgcatggcgt caggaatgtg ggctaatgtt ctagcacagg cctccccgct tgagttctcg
     3901 ccattgcctg cactgtagct gtgaacacca acccaggcgt gccacccaat cccctgcctc
     3961 agcactggcc cccttgtgca cctttgcttc ctgagcactc tgggggtggt gaagatggcc
     4021 atcacagccc ctagcacagt gagagttcca ctgggtattg tcacaggtct ctcctgcctc
     4081 gcttggattc ttgtgtctga gcgatggccc tgttgattcc actctgcctt ttatggaatc
     4141 tgtacgttac cacgcggctg tggtcctgct aggcctgtgg cacgttgcct ttcccaagct
     4201 gctacatgtt tataaccttc atttttaaag tccagttttg aaaacgtgta taggagtcgt
     4261 gtgacctgct ggccagagag cccatacttg cttatccaat ccttgatggt gatgctagcc
     4321 acgccctgat gcttcagcca tcagctgtcc ccgcaactgt gtcattttgg tggaggacta
     4381 actggctttc tggcttccca gagtgctgca ccctgggtgg aatgtctcag ggtggcagct
     4441 gaaggaacag agaaagctca ggtacaaggg agaaccccaa gtgcttccaa catgagggcc
     4501 ctgagcattc tctgttgagt ttaaagaaac gcagaccagc tcacaagata atgtcttggc
     4561 tctgcagttt acaggcactg ggagtggaaa ggacaaccct ccggtgcatt cccctagtct
     4621 taaaacttgg atttcctttc agacatggta gctcgtttat tctccttccc agtgtttgtt
     4681 aggtttcagg caccagatct cacagaacgt cctagaaatc gactataagc tgaggcggga
     4741 acagggtgag acaagagtcg cctcggcaga gtgggagagc agaggcagag tgctttgatt
     4801 tactctacac acagaacacg tggagagctg aggcctgccg ggccctggag aggctcaggc
     4861 gagacttgga cggcaatgcc tactggggta tttgcactcc caccctcaga ctccccacac
     4921 agagaggcca agctctctta agaagcccaa ttgtgtgtca gacttgacag aggtatagcc
     4981 tgggccctct gtaccttctg ttgggaccct gctttcaggg tagcttggcc attggccacc
     5041 aagtagcatt ctcagtgtct taggtcccta acaaggaacc ggtctgttga gacatctgag
     5101 caggtgacct tgtggacctt ccagacttag aaccagccca tggagtcctg atgagaaaga
     5161 agtgtgcagt gagccctcct ggggagccct gcacgcctgt gacaatgtca cagaacgcca
     5221 aaggcccatg tggaagactg gcgttctctt caggctctag aacctgatac cttgtaccaa
     5281 agatagagaa gagcatgggg caagccttcg ccatcctagc tctaggactg actgggctca
     5341 gcatacccgg ttaactgtga ctgcattaga ggtgtgttct ccattgtatc ctctgcaaca
     5401 taatgacggc tgaagcacat agaactgttt tcctacgtct cctgctaatg gaggagcgtg
     5461 cactaggtgt agcacaaagc agacattggg gcttgatgat tagcgtcagc ctaaggagag
     5521 gtacacccca tctcaggtgt gacttcagcc aacttctgaa cccatgtaca ggttcatagg
     5581 gacagacaac tctgcctttt cttgaagcgc tccatccact gaacgagcaa gcagcctttg
     5641 aatctcttgg gaaagagctt taagagtaag gcggggagaa aacaagcctt ccctccctcc
     5701 gtcatccccc ggactaaggg aaaacaaaac aaaacgctac ctattcgcta aacacaaagg
     5761 aaaggtaata agagactggc tgagtcgtca tcttcttcct gtatttggga acatcatgat
     5821 taggtggacg agtgttgagt tttttaatta aaagcagacc ttttgtagaa aagcaatcac
     5881 tgatacagag gtacaaagaa gccagttctg ggggggaaga agtagtggga acacagggca
     5941 tgaggttaga gatgtctgtg gatcacgtct gtcaaacagg actagagaaa gatgcccaag
     6001 caactgacag gaataagtgg tgtttgaact aaatctcaag tgtatagcat acagattaga
     6061 tggatgaagt attttctctt gttgaatttt attcatttgt attctttcat gaatgaatga
     6121 ttgcaaggcc tcggtcacac tccaggaata cttgtgcgac tgtttttttt tttttttttt
     6181 taaagcgtgt gtctggtcac ttctctaaaa tgatctcctt gtctggcaat cagccttctc
     6241 tgtagacttg tcccggcaca ttatgtacgt gggaaatgtg gacaggtgtg aaggagacca
     6301 gaagaattgg tgaatactga aaagtgtgtt gtgcatttag gcttcacgtg gttaacgttt
     6361 tttgggtttt tttttttttt taagaaaaaa gttgcatgaa tgaaaacaac ctctgtacac
     6421 attacctgta aaaatggcct gttttgattt cttgcttcta ccccacacaa actagaattt
     6481 cgtgtggcgc gtggccatgt ttaaacacct gcagcagttg gtcgtctggt ttgaggcaga
     6541 cgcaatcctg ctgcattctg ggtactgagg accttgtcta accatacgct gccgtgagtt
     6601 agctctgccg cctttcttct caaggatcaa aaccagtttg atttgggaat ctgccccttc
     6661 ccggtggaat ggaggtgcgt acttcccgtg gcgtttgtag atattgcctg tgtattccat
     6721 ttaaaaccat aatctagttt gtaaaagaga tgatgacgca tgtaaataaa gctttggtga
     6781 cactcta
//
