LOCUS       NM_019739               5552 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus forkhead box O1 (Foxo1), mRNA.
ACCESSION   NM_019739
VERSION     NM_019739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5552)
  AUTHORS   He,Z., Yan,R.G., Shang,Q.B. and Yang,Q.E.
  TITLE     Transcriptomic dynamics and cell-to-cell communication during the
            transition of prospermatogonia to spermatogonia revealed at
            single-cell resolution
  JOURNAL   BMC Genomics 26 (1), 58 (2025)
   PUBMED   39838296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5552)
  AUTHORS   Ren,C., Xi,L., Li,H., Pan,Z., Li,Y., Wang,G., Dai,J., He,D., Fan,S.
            and Wang,Q.
  TITLE     Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury
            under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control
  JOURNAL   Life Sci 357, 123084 (2024)
   PUBMED   39374570
  REMARK    GeneRIF: Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte
            injury under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control.
REFERENCE   3  (bases 1 to 5552)
  AUTHORS   Yang,X., Zheng,F., Yan,P., Liu,X., Chen,X., Du,X., Zhang,Y.,
            Wang,P., Chen,C., Lu,H. and Bai,Y.
  TITLE     S100A2 activation promotes interstitial fibrosis in kidneys by
            FoxO1-mediated epithelial-mesenchymal transition
  JOURNAL   Cell Biol Toxicol 40 (1), 86 (2024)
   PUBMED   39382800
  REMARK    GeneRIF: S100A2 activation promotes interstitial fibrosis in
            kidneys by FoxO1-mediated epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5552)
  AUTHORS   Wang,X., Xu,L., Meng,Y., Chen,F., Zhuang,J., Wang,M., An,W.,
            Han,Y., Chu,B., Chai,R., Liu,W. and Wang,H.
  TITLE     FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral
            Ganglion Neuron Ferroptosis via Ferritinophagy
  JOURNAL   Adv Sci (Weinh) 11 (40), e2402671 (2024)
   PUBMED   39206719
  REMARK    GeneRIF: FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea
            Spiral Ganglion Neuron Ferroptosis via Ferritinophagy.
REFERENCE   5  (bases 1 to 5552)
  AUTHORS   Santini,L., Kowald,S., Cerron-Alvan,L.M., Huth,M., Fabing,A.P.,
            Sestini,G., Rivron,N. and Leeb,M.
  TITLE     FoxO transcription factors actuate the formative pluripotency
            specific gene expression programme
  JOURNAL   Nat Commun 15 (1), 7879 (2024)
   PUBMED   39251582
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5552)
  AUTHORS   Nakae,J., Kitamura,T., Silver,D.L. and Accili,D.
  TITLE     The forkhead transcription factor Foxo1 (Fkhr) confers insulin
            sensitivity onto glucose-6-phosphatase expression
  JOURNAL   J Clin Invest 108 (9), 1359-1367 (2001)
   PUBMED   11696581
REFERENCE   7  (bases 1 to 5552)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   8  (bases 1 to 5552)
  AUTHORS   Anderson,M.J., Shelton,G.D., Cavenee,W.K. and Arden,K.C.
  TITLE     Embryonic expression of the tumor-associated PAX3-FKHR fusion
            protein interferes with the developmental functions of Pax3
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1589-1594 (2001)
   PUBMED   11171995
REFERENCE   9  (bases 1 to 5552)
  AUTHORS   Furuyama,T., Nakazawa,T., Nakano,I. and Mori,N.
  TITLE     Identification of the differential distribution patterns of mRNAs
            and consensus binding sequences for mouse DAF-16 homologues
  JOURNAL   Biochem J 349 (Pt 2), 629-634 (2000)
   PUBMED   10880363
REFERENCE   10 (bases 1 to 5552)
  AUTHORS   Nakae,J., Park,B.C. and Accili,D.
  TITLE     Insulin stimulates phosphorylation of the forkhead transcription
            factor FKHR on serine 253 through a Wortmannin-sensitive pathway
  JOURNAL   J Biol Chem 274 (23), 15982-15985 (1999)
   PUBMED   10347145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104932.22 and AC163092.4.
            
            On Jun 17, 2009 this sequence version replaced NM_019739.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ252157.1, AK154041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1086              AC104932.22        116091-117176
            1087-2438           AC163092.4         85384-86735
            2439-5552           AC163092.4         87341-90454
FEATURES             Location/Qualifiers
     source          1..5552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 23.19 cM"
     gene            1..5552
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="forkhead box O1"
                     /db_xref="GeneID:56458"
                     /db_xref="MGI:MGI:1890077"
     exon            1..1086
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2424
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="forkhead protein 1; forkhead box protein O1A;
                     forkhead in rhabdomyosarcoma; forkhead box O1a"
                     /codon_start=1
                     /product="forkhead box protein O1"
                     /protein_id="NP_062713.2"
                     /db_xref="CCDS:CCDS17343.1"
                     /db_xref="GeneID:56458"
                     /db_xref="MGI:MGI:1890077"
                     /translation="MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAP
                     SGGAAANPDAAASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCG
                     DFQGPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNL
                     SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHS
                     KFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQS
                     GQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDD
                     LGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSP
                     GSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGLN
                     QYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQA
                     SHNKMMNPSSHTHPGHAQQTASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHP
                     MQMSALGSYSSVSSCNGYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDT
                     LDFNFDNVLPNQSFPHSVKTTTHSWVSG"
     exon            1087..2438
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..5552
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3251..3256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="hexamer: TATAAA"
     polyA_site      3274
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="major polyA site"
     regulatory      4960..4965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="hexamer: TATAAA"
     polyA_site      4983
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="major polyA site"
     regulatory      5533..5538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="hexamer: CATAAA"
     polyA_site      5552
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgggg cggcgcgcgc gccgccgcgg gcggggagcc cgctgcagat cccgtaagac
       61 gggagtctgc ggagtcgctt cagtccccgc cgccgccaca ttcaacaggc agcagcgccg
      121 ctgtcgcgcg gccgcggaga gctagagcgg cccgcagcgt ccgcccgtct gccttggcgt
      181 ccgcggccct tgtcagcggg agcgcggtgc ccgagctgcc gggctccgcg gcctggtcgg
      241 tgccccgtcc taggcacgaa ctcggaggct ccttagacac cggtgaccca gcgaagttaa
      301 gttctgggcg cgtccgtccg ctgcgccccg ccgcgcctga ctccggcgtg cgtccgccgt
      361 ccgcggcccc ccaatctcgg agcgacactc gggtcgcccg ctccgcgccc ccggtggccg
      421 cgtctcccgg tacttctctg ctggtggggg aggggcgggg gcaccatggc cgaagcgccc
      481 caggtggtgg agaccgaccc ggacttcgag ccgctgcccc ggcagcgctc ctgtacctgg
      541 ccgctgccca ggccggagtt taaccagtcc aactcgacca cctccagtcc ggcgccgtcg
      601 ggcggcgcgg ccgccaaccc cgacgccgcg gcgagcctgg cctcggcgtc cgctgtcagc
      661 accgacttta tgagcaacct gagcctgctg gaggagagtg aggacttcgc gcgggcgcca
      721 ggctgcgtgg ccgtggcggc ggcggctgcg gccagcaggg gcctgtgcgg ggacttccag
      781 ggccccgagg cgggctgcgt gcacccagcg ccgccacagc ccccaccgac cgggccgctg
      841 tcgcagcccc cacccgtgcc tccctccgct gccgccgccg cggggccact cgcgggacag
      901 ccgcgcaaga ccagctcgtc gcgccgcaac gcgtggggca acctgtcgta cgccgacctc
      961 atcaccaagg ccatcgagag ctcagccgag aagaggctca ccctgtcgca gatctacgag
     1021 tggatggtga agagcgtgcc ctacttcaag gataagggcg acagcaacag ctcggcgggc
     1081 tggaagaatt caattcgcca caatctgtcc cttcacagca agtttattcg agtgcagaat
     1141 gaaggaactg gaaagagttc ttggtggatg ctcaatccag agggaggcaa gagcggaaaa
     1201 tcaccccgga gaagagctgc gtccatggac aacaacagta aatttgctaa gagccgaggg
     1261 cgggctgcta agaaaaaagc atctctccag tctgggcaag agggtcctgg agacagccct
     1321 gggtctcagt tttctaagtg gcctgcgagt cctgggtccc acagcaacga tgactttgat
     1381 aactggagta catttcgtcc tcgaaccagc tcaaatgcta gtaccatcag tgggagactt
     1441 tctcccatca tgacagagca ggatgacctg ggagatgggg acgtgcattc cctggtgtat
     1501 ccaccctctg ctgccaagat ggcgtctacg ctgcccagtc tgtctgaaat cagcaatcca
     1561 gaaaacatgg agaaccttct ggataatctc aaccttctct cgtccccaac atctttaact
     1621 gtgtccaccc agtcctcgcc tggcagcatg atgcagcaga caccatgcta ttcgtttgca
     1681 ccgccaaaca ccagtctaaa ttcacccagt ccaaactact caaagtacac atacggccaa
     1741 tccagcatga gccctttgcc ccagatgcct atgcagacac ttcaggacag caaatcaagt
     1801 tacggaggat tgaaccagta taactgtgcc ccaggactct tgaaagagtt gttgacttct
     1861 gactctcctc cccacaatga cattatgtca ccggttgatc ccggagtggc ccaacccaac
     1921 agtcgggtcc tgggccaaaa tgtaatgatg ggccctaatt cggtcatgcc agcgtatggc
     1981 agccaggcat ctcataacaa aatgatgaac cccagctccc acacccaccc tggacatgca
     2041 cagcaaacgg cttcggtcaa cggccgtacc ctgccccatg tggtgaacac catgcctcac
     2101 acatctgcca tgaaccgctt gacccccgtg aagacacctt tacaagtgcc tctgtcccac
     2161 cccatgcaga tgagtgccct gggcagctac tcctcggtga gcagctgcaa tggctatggt
     2221 aggatgggtg tcctccacca ggagaagctc ccaagtgact tggatggcat gtttattgag
     2281 cgcttggact gtgacatgga gtccatcatt cggaatgacc tcatggatgg agataccttg
     2341 gattttaact ttgataatgt gttgcccaac caaagcttcc cacacagtgt caagactaca
     2401 acacacagct gggtgtcagg ctaagagtta gtgagcaggc tacatttaaa agtccttcag
     2461 attgtctgac agcaggaact gaggagcagt ccaaagatgc ccttcacccc tccttatagt
     2521 tttcaagatt taaaaaaaaa aaaaaaaaaa aaaaaagtcc tttctccttt cctcagactt
     2581 ggcaacagcg gcagcacttt cctgtgcagg atgtttgccc agcgtccgca ggttttgtgc
     2641 tcctgtagat aaggactgtg ccattgggaa tcattacaat gaagtgccaa actcactaca
     2701 ccatgtaatt gcagaaaaga ctttcagatc ctggagtgct ttcaagtttt gtatatatgc
     2761 agtagataca gaattgtatt tgtgtgtgtg ttttttaata cctacttggt ccaaggaaag
     2821 tttatactct tttgtaatac tgtgatggtc tcaagtcttg ataaactttg ctttgtacta
     2881 cctgtgttct gctacagtga gaagtcatga actaagatct ctgtcctgca cctcggctga
     2941 atgactgaac ctggtcattt gccacagaac ccatgagagc caagtagcca gtgatcaatg
     3001 tgctgaatta atggacttgt caaactttgg ggcagaataa gattaagtgc cagctttgta
     3061 caggtctttt tctattgttt ttgttgttgt ttattttgtt atttgcaaat ttgtacaaac
     3121 aacttaaaat ggttctaatt tccagataaa tgacttttga tgttattgtt aggactcaac
     3181 atcttttgga atagataccg aagtgtaatg ttttcttaaa actagagtct actttgttac
     3241 attgtctgct tataaatttg tgaaatcaga ggtatttggg ggctgcattc ataattttca
     3301 ttttgtattt ctaactggat tagtactaat tttatatgtg ctcagctggt ttgtacactt
     3361 tgcgatgata cctgataatg tttctgacta atcgtaaacc attgtaatta gtacttgcac
     3421 actcaacgtt cctggccctt tgggcaggaa agttatgtat agttacagac actctgtttt
     3481 gtgtgtagat ttatgtgtgt attttaaaga aatttcacct gcttttatta ccctgtgagt
     3541 tgtgtacagc gcatagcacc aagtcttcag atagatgcca cgtgcttaca gccttctagg
     3601 gaagcctgcc agatgatgcc ctgtgtcacg ctgtcatagt tcccatggga actctgtctg
     3661 tcgctcagga aaggggaact tttatctaag gtgatgttct ttgtctgact ggggttcgcc
     3721 tcctactact ctgagctgtt ggcttttgtc acgatggagg tggctttgtg gctctgtcct
     3781 gaagaatcct gtcacttctc ggtccccacc tctgttctct ttggctctga acagtgtaaa
     3841 tctaaggagg aagtttacaa ataggacttc agtgatttat ggagtgctct gtgcgcctaa
     3901 gtacagacag tggcaggatt agttaaaaat gaaggcagta aacttggaaa ccagccagct
     3961 ataaatggac atttattttg aaatccttag cttaagaatt tgagaagttt tttcagcctt
     4021 gagcagccta atgtgtctca aacatttacg ttttttatac attctattta cctgaaatcc
     4081 tgccagacca ggataattgg ttttacctct cattccgtcc atcggtgttt cccagtctcc
     4141 cacagtttga ggaatagatg taccccagca cccctctttg cctttatgag aaggcctggt
     4201 ttgcatgaga agaccaaatt gcacttccat gagaagacca aattgtttgt agtgttactt
     4261 agctctcccc tcgtttgtta gtgtgtgtta acaagaataa aatgtccctg ctttcaccca
     4321 ccgttggcca gctttgtcat aggcttccca ccataacttt cactatttta aacacatatt
     4381 gagccactgc tcgtctgact acctttgttt gggcactcca aaacaggact tgttttagaa
     4441 atgaactcct ccaagtagag cctccttcaa acagagtaga atttcctggt gtcaaagaac
     4501 ccgggtctgt ctccctttcc tcctccctct gccatttctt accattgcgg aaagagagag
     4561 cctccgtgtg taatcattca gtagaggcag ctaccgccct ggcagtggtc tacctgctga
     4621 atgccactga atgactagga ggtgtctctc ccttcagaag ctgtcaattt cagcagcaac
     4681 ccctgttttc cttggtgtta agatcccagt gtgaatcatg ggcagttgtc tggggcacag
     4741 tgaactccag gaaaggcttc gtatctgttt tgaaaacaaa catcaaacgt gtgagctccg
     4801 agggtccttt tctgggagaa tgttcgcttt ctggtctatt attgtacatg attgctctgt
     4861 gaaaagactt catctatgca gccttgtttg attcatttcc tttggtgtgt tctgttgtta
     4921 agagcaaatt gtattataga gctatttgga tattttaaat ataaagatgt attgtttcca
     4981 taatatagat gtatggagta tatttaggtg atagatgtac aacttggaaa gttctgcttg
     5041 gacaaactga gtctaagtta attagcaaat aatatatcct gatgagcagg aagccctgaa
     5101 acctaacaac agtaagcgga gaaaatcact taaaatggaa acagttcccc aaaggtgttc
     5161 aatttgaact tgttcaactg cttaatatat ggtccccccc ccccccaaaa aaaaaacctt
     5221 gaagttctta gttttcagct ctccaagtta ctgattttaa gtgaagtttc tctgtggttt
     5281 cagctgggga gtgattgttc agtagagtgt gcattgtgct ttatgcaaac caaacagcct
     5341 ggccctgtgg ccggggacag acagacagcc cgtcaggata gagtcccgcc cttcgccacc
     5401 acagcggact tgagtaacag tgcagatgcc ttgctcctgt tccattgcta tctgagaagt
     5461 gcctgatgag gatggtaaac ttacagacac aagaacaatc cttactgtgc gttgtataaa
     5521 gccataaatg tacataaatc atcttaagtg gc
//
