LOCUS       NM_148935               2970 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus forkhead box N4 (Foxn4), mRNA.
ACCESSION   NM_148935
VERSION     NM_148935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Katreddi,R.R., Taroc,E.Z.M., Hicks,S.M., Lin,J.M., Liu,S., Xiang,M.
            and Forni,P.E.
  TITLE     Notch signaling determines cell-fate specification of the two main
            types of vomeronasal neurons of rodents
  JOURNAL   Development 149 (13) (2022)
   PUBMED   35781337
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Wu,M., Deng,Q., Lei,X., Du,Y. and Shen,Y.
  TITLE     Elavl2 Regulates Retinal Function Via Modulating the
            Differentiation of Amacrine Cells Subtype
  JOURNAL   Invest Ophthalmol Vis Sci 62 (7), 1 (2021)
   PUBMED   34061953
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Wu,F., Bard,J.E., Kann,J., Yergeau,D., Sapkota,D., Ge,Y., Hu,Z.,
            Wang,J., Liu,T. and Mu,X.
  TITLE     Single cell transcriptomics reveals lineage trajectory of retinal
            ganglion cells in wild-type and Atoh7-null retinas
  JOURNAL   Nat Commun 12 (1), 1465 (2021)
   PUBMED   33674582
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Iwagawa,T., Honda,H. and Watanabe,S.
  TITLE     Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born
            Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells
  JOURNAL   Invest Ophthalmol Vis Sci 61 (11), 43 (2020)
   PUBMED   32986815
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Li,S., Misra,K., Matise,M.P. and Xiang,M.
  TITLE     Foxn4 acts synergistically with Mash1 to specify subtype identity
            of V2 interneurons in the spinal cord
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10688-10693 (2005)
   PUBMED   16020526
  REMARK    GeneRIF: Foxn4 acts synergistically with Mash1 to specify subtype
            identity of V2 interneurons in the spinal cord.
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Kim,J., Wu,H.H., Lander,A.D., Lyons,K.M., Matzuk,M.M. and
            Calof,A.L.
  TITLE     GDF11 controls the timing of progenitor cell competence in
            developing retina
  JOURNAL   Science 308 (5730), 1927-1930 (2005)
   PUBMED   15976303
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Gouge,A., Holt,J., Hardy,A.P., Sowden,J.C. and Smith,H.K.
  TITLE     Foxn4--a new member of the forkhead gene family is expressed in the
            retina
  JOURNAL   Mech Dev 107 (1-2), 203-206 (2001)
   PUBMED   11520680
  REMARK    GeneRIF: expressed during neural development in the retina, the
            ventral hindbrain and spinal cord and dorsal midbrain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY039039.1 and AC127255.4.
            
            On Apr 8, 2006 this sequence version replaced NM_148935.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092242.1, BC130222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1643              AY039039.1         47-1689
            1644-2970           AC127255.4         120215-121541
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..2970
                     /gene="Foxn4"
                     /note="forkhead box N4"
                     /db_xref="GeneID:116810"
                     /db_xref="MGI:MGI:2151057"
     exon            1..74
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            75..163
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1643
                     /gene="Foxn4"
                     /codon_start=1
                     /product="forkhead box protein N4"
                     /protein_id="NP_683737.2"
                     /db_xref="CCDS:CCDS19562.1"
                     /db_xref="GeneID:116810"
                     /db_xref="MGI:MGI:2151057"
                     /translation="MIESGIWSRMSEMIRSSGHSHHCSPQEYRFLPPVGDDDLPGDLQ
                     SLSWLTAVDVPRLQQMANGRIDLGSSGVTHPHPGALAGTADLHVGAAPRPLLRRSQTA
                     VVPRGVLGLSPIGNHRASAEQMNQFPAGGQASSGLQEMPQLYSPATQIPFPLPLGSQQ
                     CPPAGLYGSPFSARPSYPQAHGAMHASQEPHPKHYPKPIYSYSCLIAMALKNSKTGSL
                     PVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNL
                     ARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKRGEPKAPMLTH
                     ATTVAMAHSCLAISQLPPKPLMTLSLQSVPLHHQLQPQAHLAPDSPAPAQTPPLHALP
                     SLSPGPLPQPAMGRVPGDFLNINSDMNTEVDALDPSIMDFALQGNLWEEMKEDSFSLD
                     TLEAFGDSPLGCDLGAPSLTPVSGNSDQSFPDVQVTGLYAAYSTAADGVAPSAANSAQ
                     YLGTPGNKPIALL"
     exon            164..309
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..437
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..557
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..685
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            686..782
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..990
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1383
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..2970
                     /gene="Foxn4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxn4"
                     /note="hexamer: AATAAA"
     polyA_site      2970
                     /gene="Foxn4"
                     /note="major polyA site"
ORIGIN      
        1 gggcgagcga aagggagtcc ccccctaccg cagcgccacc cgcccccagc cagccaaccc
       61 aggacctgct ccaggaaatg atagaaagtg gcatttggtc cagaatgtca gaaatgatca
      121 gaagctcggg gcacagccac cactgctctc cacaggaata caggtttctg cctcccgtgg
      181 gtgacgacga cctccctggg gaccttcagt cgctgtcctg gctcacggcc gtggacgtgc
      241 ctcgactgca gcagatggca aatgggcgga tagacctggg cagttcaggt gtgacacatc
      301 cacacccagg tgccttggct gggacagcag acctgcatgt gggtgcggcc ccacgtcccc
      361 tgctccgccg cagccagact gccgtggtcc ccaggggtgt gctgggcttg agccctatag
      421 gcaaccacag agccagcgct gagcagatga accagttccc tgcaggaggc caggcatcat
      481 cgggcctcca ggaaatgcca cagctgtact ccccagctac ccaaatcccg ttccctctgc
      541 ctctggggtc ccagcagtgc cctcctgccg gcctctatgg ttctccgttt tcggctcggc
      601 cttcctaccc acaggcccac ggggcaatgc atgcgtctca ggagccacac cccaaacact
      661 accccaagcc catctactcc tacagctgtc tgatcgccat ggccttgaag aacagcaaaa
      721 caggcagctt gcccgtgagt gagatctaca gcttcatgaa ggagcacttc ccctacttca
      781 agacagcacc tgacggctgg aagaactccg tgaggcacaa cctgtccctg aacaagtgct
      841 tcgagaaggt ggaaaccaag tccagcggct cctcacgcaa gggctgcctg tgggccctga
      901 acctggctcg catcgacaag atggaggagg agatgcacaa gtggaaacga aaggacctcg
      961 ctgccataca ccgcagcatg gccaaccctg aggagttgga caagctcatc tcagaccgcc
     1021 cggaaagctg ccggcgtcct ggaaaacgag gagagcctaa agcccccatg ctaactcatg
     1081 ccaccacggt ggccatggcc cacagctgcc tggccatctc ccaactccca ccaaagccac
     1141 tgatgaccct gtccctgcag tcagtgcctc tgcaccacca gctccagccc caggcacacc
     1201 tggccccaga ctccccggca ccagcacaga ccccacctct tcatgcccta cccagtctca
     1261 gcccagggcc tctcccgcag ccagccatgg gtagggttcc tggggacttc ctcaacatca
     1321 acagtgacat gaacacagag gtggacgccc tggaccccag catcatggac ttcgctctac
     1381 agggtaacct gtgggaagag atgaaggagg acagcttcag cctagacacg ctggaggcct
     1441 ttggagactc cccgcttggc tgcgacctgg gagccccaag cctgacccct gtctctggca
     1501 acagtgacca gtccttccct gatgtgcagg tgacaggtct ctatgctgcc tactccactg
     1561 ccgcagacgg tgtggcccca tcagcggcca actctgcgca gtacctgggt acaccaggga
     1621 acaagcctat tgctctgctt tgagctgtcg gcctggaaga aagggcacct tggctgtacc
     1681 gtgtctcgag ccaattgctg acgggggaaa tgacagcttg tggttcctcc tgcaccccaa
     1741 catgctgcca caggacactc ctggggcact caacagaagc aaggcgggga tggcaagccc
     1801 tctacctccc catcttctgc aggacttgag acagaggcat ggccatggtg agacccggct
     1861 cttaatagcc tgactcctgg cagagcccac cttgggacac agtagtgtgt cctggagaca
     1921 caggagggga aactctgagc acacacattc tcctaggaga ggaacctctg actatgcctc
     1981 agagcatggc ctacagctgg agaaaggccc tggtcagcct tggaagtgac atgattaacc
     2041 tccgccatag acttctgccc cttgctccta gggtgtccag agccatgcta ttgagactgt
     2101 gtgtacattt atttatattt attgtgactc cagctaagat ccctaaaaag agacccatgt
     2161 tagactcccc actgctcagc aaacctaact ccctagtgac cccgagtcat gaatcacatc
     2221 tccagcatgc tcaggcagcc cccgccccca cccctgtgat tcagagagcg agcgagcact
     2281 ttggtgactg ggtagcaccc catcattttc ctattaggac agatcttttt tggggggttt
     2341 atcatggctc acatctgctc ctggggatat acgggagagg aggtaccata gcatcaagtt
     2401 tggggaggac tgtggtgcta agacaagagg aaaaagtaga gacctgtctg tgccaggtta
     2461 gagacatgaa acaggaagat gggaaccttg ggctcgagcg ctcaccactc tttgtagcac
     2521 cagtgtagcg ccctgtcggt gcccgctgcc tcttcttggc tatgtctgtc ctcacactac
     2581 cctcttgtcc tgtgactgat ttttccaagt gagagttcta caggcaggtg ggccactggg
     2641 gagaggggtg ggggccccct ccacctgctc ttttccatct tgatgtctga ccccatgcct
     2701 gagagttcac aaccccaggt tgttcagaag acccagcagg caggccagcc atctgtaagg
     2761 gcagcgtgag gtcttgtcat caggggccat ctttcaggtc tccccactga gacagtgcag
     2821 cccagcccag ccggccagcc ttgctcagca gctgtgtgcc gggccctcag aaagtcatgc
     2881 agtttaagtg tgaagacccc gtgtccgggt agtgccaaga ctctgtaggt gtagtgctga
     2941 atgtctgctg tcaataaagg ctgaacagca
//
