LOCUS       NP_683737                521 aa            linear   ROD 24-DEC-2024
DEFINITION  forkhead box protein N4 [Mus musculus].
ACCESSION   NP_683737
VERSION     NP_683737.2
DBSOURCE    REFSEQ: accession NM_148935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Katreddi,R.R., Taroc,E.Z.M., Hicks,S.M., Lin,J.M., Liu,S., Xiang,M.
            and Forni,P.E.
  TITLE     Notch signaling determines cell-fate specification of the two main
            types of vomeronasal neurons of rodents
  JOURNAL   Development 149 (13) (2022)
   PUBMED   35781337
REFERENCE   3  (residues 1 to 521)
  AUTHORS   Wu,M., Deng,Q., Lei,X., Du,Y. and Shen,Y.
  TITLE     Elavl2 Regulates Retinal Function Via Modulating the
            Differentiation of Amacrine Cells Subtype
  JOURNAL   Invest Ophthalmol Vis Sci 62 (7), 1 (2021)
   PUBMED   34061953
REFERENCE   4  (residues 1 to 521)
  AUTHORS   Wu,F., Bard,J.E., Kann,J., Yergeau,D., Sapkota,D., Ge,Y., Hu,Z.,
            Wang,J., Liu,T. and Mu,X.
  TITLE     Single cell transcriptomics reveals lineage trajectory of retinal
            ganglion cells in wild-type and Atoh7-null retinas
  JOURNAL   Nat Commun 12 (1), 1465 (2021)
   PUBMED   33674582
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 521)
  AUTHORS   Iwagawa,T., Honda,H. and Watanabe,S.
  TITLE     Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born
            Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells
  JOURNAL   Invest Ophthalmol Vis Sci 61 (11), 43 (2020)
   PUBMED   32986815
REFERENCE   6  (residues 1 to 521)
  AUTHORS   Li,S., Misra,K., Matise,M.P. and Xiang,M.
  TITLE     Foxn4 acts synergistically with Mash1 to specify subtype identity
            of V2 interneurons in the spinal cord
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10688-10693 (2005)
   PUBMED   16020526
  REMARK    GeneRIF: Foxn4 acts synergistically with Mash1 to specify subtype
            identity of V2 interneurons in the spinal cord.
REFERENCE   7  (residues 1 to 521)
  AUTHORS   Kim,J., Wu,H.H., Lander,A.D., Lyons,K.M., Matzuk,M.M. and
            Calof,A.L.
  TITLE     GDF11 controls the timing of progenitor cell competence in
            developing retina
  JOURNAL   Science 308 (5730), 1927-1930 (2005)
   PUBMED   15976303
REFERENCE   8  (residues 1 to 521)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
REFERENCE   9  (residues 1 to 521)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (residues 1 to 521)
  AUTHORS   Gouge,A., Holt,J., Hardy,A.P., Sowden,J.C. and Smith,H.K.
  TITLE     Foxn4--a new member of the forkhead gene family is expressed in the
            retina
  JOURNAL   Mech Dev 107 (1-2), 203-206 (2001)
   PUBMED   11520680
  REMARK    GeneRIF: expressed during neural development in the retina, the
            ventral hindbrain and spinal cord and dorsal midbrain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY039039.1 and AC127255.4.
            
            On Apr 8, 2006 this sequence version replaced NP_683737.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092242.1, BC130222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     Protein         1..521
                     /product="forkhead box protein N4"
                     /calculated_mol_wt=55990
     Region          192..297
                     /region_name="FH_FOX"
                     /note="Forkhead (FH) domain found in Forkhead box (FOX)
                     family of transcription factors and similar proteins;
                     cl00061"
                     /db_xref="CDD:469596"
     Site            order(202,220..221,224,243..244,246..247,250,257,268..270,
                     272)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410788"
     Region          321..>401
                     /region_name="FAM75"
                     /note="FAM75 family; pfam14650"
                     /db_xref="CDD:464237"
     Region          371..406
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3Q3.1)"
     CDS             1..521
                     /gene="Foxn4"
                     /coded_by="NM_148935.2:78..1643"
                     /db_xref="CCDS:CCDS19562.1"
                     /db_xref="GeneID:116810"
                     /db_xref="MGI:MGI:2151057"
ORIGIN      
        1 miesgiwsrm semirssghs hhcspqeyrf lppvgdddlp gdlqslswlt avdvprlqqm
       61 angridlgss gvthphpgal agtadlhvga aprpllrrsq tavvprgvlg lspignhras
      121 aeqmnqfpag gqassglqem pqlyspatqi pfplplgsqq cppaglygsp fsarpsypqa
      181 hgamhasqep hpkhypkpiy syscliamal knsktgslpv seiysfmkeh fpyfktapdg
      241 wknsvrhnls lnkcfekvet kssgssrkgc lwalnlarid kmeeemhkwk rkdlaaihrs
      301 manpeeldkl isdrpescrr pgkrgepkap mlthattvam ahsclaisql ppkplmtlsl
      361 qsvplhhqlq pqahlapdsp apaqtpplha lpslspgplp qpamgrvpgd flninsdmnt
      421 evdaldpsim dfalqgnlwe emkedsfsld tleafgdspl gcdlgapslt pvsgnsdqsf
      481 pdvqvtglya aystaadgva psaansaqyl gtpgnkpial l
//
