LOCUS       NM_183186               2611 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus forkhead box N3 (Foxn3), mRNA.
ACCESSION   NM_183186 XM_127089
VERSION     NM_183186.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Zhu,X., Huang,B., Zhao,F., Lian,J., He,L., Zhang,Y., Ji,L.,
            Zhang,J., Yan,X., Zeng,T., Ma,C., Liang,Y., Zhang,C. and Lin,J.
  TITLE     p38-mediated FOXN3 phosphorylation modulates lung inflammation and
            injury through the NF-kappaB signaling pathway
  JOURNAL   Nucleic Acids Res 51 (5), 2195-2214 (2023)
   PUBMED   36794705
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Zhang,H., Zhuang,P., Welchko,R.M., Dai,M., Meng,F. and Turner,D.L.
  TITLE     Regulation of retinal amacrine cell generation by miR-216b and
            Foxn3
  JOURNAL   Development 149 (2) (2022)
   PUBMED   34919141
  REMARK    GeneRIF: Regulation of retinal amacrine cell generation by miR-216b
            and Foxn3.
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Karanth,S., Adams,J.D., Serrano,M.L.A., Quittner-Strom,E.B.,
            Simcox,J., Villanueva,C.J., Ozcan,L., Holland,W.L., Yost,H.J.,
            Vella,A. and Schlegel,A.
  TITLE     A Hepatocyte FOXN3-alpha Cell Glucagon Axis Regulates Fasting
            Glucose
  JOURNAL   Cell Rep 24 (2), 312-319 (2018)
   PUBMED   29996093
  REMARK    GeneRIF: liver FOXN3 and glucagon control fasting glucose.
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Tribioli,C., Robledo,R.F. and Lufkin,T.
  TITLE     The murine fork head gene Foxn2 is expressed in craniofacial, limb,
            CNS and somitic tissues during embryogenesis
  JOURNAL   Mech Dev 118 (1-2), 161-163 (2002)
   PUBMED   12351180
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Schorpp,M., Hofmann,M., Dear,T.N. and Boehm,T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI448353.1, BE623611.1, BY717160.1 and AK046748.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_127089.2, NM_183186.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK046748.1, SRR1660811.196981.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AI448353.1         74-212
            140-202             BE623611.1         210-272             c
            203-607             BY717160.1         1-405
            608-2611            AK046748.1         883-2886
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 49.93 cM"
     gene            1..2611
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /note="forkhead box N3"
                     /db_xref="GeneID:71375"
                     /db_xref="MGI:MGI:1918625"
     exon            1..50
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..607
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1438
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /note="checkpoint suppressor 1"
                     /codon_start=1
                     /product="forkhead box protein N3"
                     /protein_id="NP_899009.2"
                     /db_xref="CCDS:CCDS26103.1"
                     /db_xref="GeneID:71375"
                     /db_xref="MGI:MGI:1918625"
                     /translation="MGPVMPASKKAESSGISVSSGLSQRYRGSGFSKALQEDDDLDFP
                     LPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSD
                     MPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKN
                     SVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPPPTPQAYQ
                     STSGPPIWPGSTFFKRNGALLQVSPGVIQNGARVLSRGLFPGVRPLPITPIGMTAAIR
                     NSITSCRMRTESEPPCGSPVVSGDPKEDHNYSSAKSSTARSTSPTSDSISSSSSSADD
                     HYEFATKGSQEGSEGSFQSHESHSEPEEEDRKPSPKEGKDALGDSGYASQHKKRQHFA
                     KARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKE
                     QKETAKN"
     exon            608..720
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..785
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..891
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..2611
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2533
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /note="major polyA site"
ORIGIN      
        1 cacctttgtc ctttctggag cgatgctgac ctggacccat tctgactcag gagccttcac
       61 gtaaatgggt ccagtcatgc ctgccagtaa gaaggccgag agctcaggaa tcagtgtgtc
      121 cagtggactg agtcagcgtt accggggcag cggtttctcc aaggccctcc aggaagacga
      181 tgatcttgac ttccctctgc ccgacatccg attagaagag ggggccatgg aagatgaaga
      241 gctgaccaac ctgaactggc tgcatgagag caagaacttg ctgaagagct ttggggagtc
      301 ggtccttagg agtgtcagtc ctgtgcagga cctagacgat gacaccccac catcccctgc
      361 ccactcggac atgccctatg atgccaggca gaaccccaac tgcaagcccc cctactcctt
      421 tagctgcctc atatttatgg ccatcgagga ctctccgacc aagcgccttc cagtgaagga
      481 catctacaac tggatcttag aacatttccc gtattttgca aatgcaccta ctgggtggaa
      541 gaactcagtg agacacaact tgtcattgaa taagtgtttc aagaaagtgg acaaagagag
      601 gagtcagagt attgggaaag ggtcattgtg gtgcatcgac ccagagtata gacaaaatct
      661 aattcaggct ctgaaaaaga caccttacca cccacctcct actcctcagg cttatcaaag
      721 cacatcaggt ccacccatct ggccgggcag taccttcttc aagagaaacg gagccctcct
      781 gcaagtttct ccaggagtga tacaaaatgg agcgagggtt ctgagtcgag ggctgtttcc
      841 tggtgtccgg ccgttaccaa tcactcccat tgggatgacg gcagccataa ggaatagcat
      901 caccagttgc aggatgcgga ctgagagcga gcccccatgt ggctccccag tggtcagtgg
      961 cgatccgaag gaggaccaca actacagtag tgccaagtcc tccactgccc ggagcacctc
     1021 tcccaccagc gactccatct cctcttcctc ctcctcagcc gacgaccact atgagtttgc
     1081 tacgaagggg agccaggagg gcagtgaggg aagcttccag agccatgaga gccacagtga
     1141 accagaggag gaggaccgga aacccagccc gaaggaaggc aaggatgccc tgggggacag
     1201 cggatacgca tcccagcaca agaagcgcca gcacttcgcc aaggccagga aggtccccag
     1261 cgacacactg cccctcaaaa agagacgcac ggagaagccg cccgagagcg atgacgagga
     1321 gatgaaggag gcggccggtt cactcctgca cttagcaggg attcggtcct gtttgaacaa
     1381 catcaccaat cggacggcca aggggcagaa agaacaaaag gaaaccgcaa aaaattgaaa
     1441 caagtctctg atttgttttg aacttatggc catttggttt cagcatgtca ggagatttct
     1501 aatgatttgt ggcaatatca gcaatttttt tcttttttct tttttttttt ttcttttttc
     1561 cttttgttgg tttggttttc ttttctttct ttctttcttt cttttgtttt ttaatttgcc
     1621 ccccactcct ttgtttttgg acccttaaaa ttttttctgt ttaaaggaga ttgaagccat
     1681 agaaactcat attgacactc agccgtttta caaaagcttt tctttatctg aatacaaaaa
     1741 ccgaaaggaa aaaaaaaaaa gccaaaatta accattgctt cctgcagcct gtcagaaacc
     1801 tgtggctaaa cccacagggc tgtccatgtt aatgccacag gaacatggag caccacctag
     1861 gaggcacaca cgcacacaga gtcagtcgtc actgctcagc ccaaccctta ggtttaagaa
     1921 gtcagttgtg tttggagtga ggctgggaag cagttacaga gactgaagag cccttgtccc
     1981 ctagaggata accccatgct ctggccctgg catcccaagg taccacaaat gccatcggcc
     2041 ttgctgtgtg gcaagcccag ggcctggctg ccagtcctct gtgtttctta gccttgagcc
     2101 tggtaacatc tcccaggctg aataccagac tgttcaggtg tattaggtgt cagtgactga
     2161 ggagggaaaa cagggatcgt cagagccatt gataaccact gagttctgct ctatgttaaa
     2221 ttaagaagac ttccaaagcc ataagcctga aggttggtcc tgtgtgtgtg tgtgtgtgta
     2281 tgtgtgtgcg cgtgcatgtg cacacaaaca cacaacttaa aggtgatgca gaaaataggc
     2341 tgtgccctct taactgccca aggaaaagca atcatgccca agaaatgaca gtagctgtta
     2401 agaaaaatgg tacagatttt tttcctccta aataaataat ctgacccaag ttgggagggg
     2461 gggtgctacg gaaactgcca ttagtattat ggtgtcttta tgagattaaa ggcacattga
     2521 tggactcaac aaagcaaaaa catgacaaac aatacaactc ctgtactgtc ctcaaaaagg
     2581 gtttgcaatt aatatcagta ctcatttttg c
//
