LOCUS       NP_899009                457 aa            linear   ROD 28-APR-2025
DEFINITION  forkhead box protein N3 [Mus musculus].
ACCESSION   NP_899009 XP_127089
VERSION     NP_899009.2
DBSOURCE    REFSEQ: accession NM_183186.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Zhu,X., Huang,B., Zhao,F., Lian,J., He,L., Zhang,Y., Ji,L.,
            Zhang,J., Yan,X., Zeng,T., Ma,C., Liang,Y., Zhang,C. and Lin,J.
  TITLE     p38-mediated FOXN3 phosphorylation modulates lung inflammation and
            injury through the NF-kappaB signaling pathway
  JOURNAL   Nucleic Acids Res 51 (5), 2195-2214 (2023)
   PUBMED   36794705
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Zhang,H., Zhuang,P., Welchko,R.M., Dai,M., Meng,F. and Turner,D.L.
  TITLE     Regulation of retinal amacrine cell generation by miR-216b and
            Foxn3
  JOURNAL   Development 149 (2) (2022)
   PUBMED   34919141
  REMARK    GeneRIF: Regulation of retinal amacrine cell generation by miR-216b
            and Foxn3.
REFERENCE   4  (residues 1 to 457)
  AUTHORS   Karanth,S., Adams,J.D., Serrano,M.L.A., Quittner-Strom,E.B.,
            Simcox,J., Villanueva,C.J., Ozcan,L., Holland,W.L., Yost,H.J.,
            Vella,A. and Schlegel,A.
  TITLE     A Hepatocyte FOXN3-alpha Cell Glucagon Axis Regulates Fasting
            Glucose
  JOURNAL   Cell Rep 24 (2), 312-319 (2018)
   PUBMED   29996093
  REMARK    GeneRIF: liver FOXN3 and glucagon control fasting glucose.
REFERENCE   5  (residues 1 to 457)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (residues 1 to 457)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (residues 1 to 457)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 457)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 457)
  AUTHORS   Tribioli,C., Robledo,R.F. and Lufkin,T.
  TITLE     The murine fork head gene Foxn2 is expressed in craniofacial, limb,
            CNS and somitic tissues during embryogenesis
  JOURNAL   Mech Dev 118 (1-2), 161-163 (2002)
   PUBMED   12351180
REFERENCE   10 (residues 1 to 457)
  AUTHORS   Schorpp,M., Hofmann,M., Dear,T.N. and Boehm,T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI448353.1, BE623611.1, BY717160.1 and AK046748.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XP_127089.1, NP_899009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK046748.1, SRR1660811.196981.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 49.93 cM"
     Protein         1..457
                     /product="forkhead box protein N3"
                     /note="checkpoint suppressor 1"
                     /calculated_mol_wt=50214
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q499D0.1)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q499D0.1)"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00409; propagated from
                     UniProtKB/Swiss-Prot (Q499D0.1)"
     Region          86..109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q499D0.1)"
     Site            97
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q499D0.1)"
     Region          114..203
                     /region_name="FH_FOXN3"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     N3 (FOXN3); cd20059"
                     /db_xref="CDD:410833"
     Site            order(119,137..138,141,160..161,163..164,167,174,185..187,
                     189)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410833"
     Region          285..422
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q499D0.1)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q499D0.1)"
     CDS             1..457
                     /gene="Foxn3"
                     /gene_synonym="5430426H20Rik; Ches1; Ches1l; HTLFL1"
                     /coded_by="NM_183186.2:65..1438"
                     /db_xref="CCDS:CCDS26103.1"
                     /db_xref="GeneID:71375"
                     /db_xref="MGI:MGI:1918625"
ORIGIN      
        1 mgpvmpaskk aessgisvss glsqryrgsg fskalqeddd ldfplpdirl eegamedeel
       61 tnlnwlhesk nllksfgesv lrsvspvqdl dddtppspah sdmpydarqn pnckppysfs
      121 clifmaieds ptkrlpvkdi ynwilehfpy fanaptgwkn svrhnlslnk cfkkvdkers
      181 qsigkgslwc idpeyrqnli qalkktpyhp pptpqayqst sgppiwpgst ffkrngallq
      241 vspgviqnga rvlsrglfpg vrplpitpig mtaairnsit scrmrtesep pcgspvvsgd
      301 pkedhnyssa ksstarstsp tsdsisssss saddhyefat kgsqegsegs fqsheshsep
      361 eeedrkpspk egkdalgdsg yasqhkkrqh fakarkvpsd tlplkkrrte kppesddeem
      421 keaagsllhl agirsclnni tnrtakgqke qketakn
//
