LOCUS       NM_180974               5109 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus forkhead box N2 (Foxn2), transcript variant 1, mRNA.
ACCESSION   NM_180974
VERSION     NM_180974.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5109)
  AUTHORS   Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C,
            Hjerling-Leffler J, Sundstrom E, Pachnis V and Marklund U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   2  (bases 1 to 5109)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 5109)
  AUTHORS   Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C and
            Yan W.
  TITLE     Two miRNA clusters, miR-34b/c and miR-449, are essential for normal
            brain development, motile ciliogenesis, and spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (28), E2851-E2857 (2014)
   PUBMED   24982181
REFERENCE   4  (bases 1 to 5109)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   5  (bases 1 to 5109)
  AUTHORS   Machold R, Klein C and Fishell G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
REFERENCE   6  (bases 1 to 5109)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 5109)
  AUTHORS   Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco
            G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T,
            Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
            Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ,
            Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A,
            Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso
            J, Hide W and Ko MS.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 5109)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5109)
  AUTHORS   Tribioli C, Robledo RF and Lufkin T.
  TITLE     The murine fork head gene Foxn2 is expressed in craniofacial, limb,
            CNS and somitic tissues during embryogenesis
  JOURNAL   Mech Dev 118 (1-2), 161-163 (2002)
   PUBMED   12351180
  REMARK    GeneRIF: The dynamic and specific expression of Foxn2 during
            embryonic development suggest multiple independent roles for Foxn2
            function during gestation
REFERENCE   10 (bases 1 to 5109)
  AUTHORS   Schorpp M, Hofmann M, Dear TN and Boehm T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ173433.1, CJ145725.1, CN698353.1, CB524750.1, BB042729.2,
            CO431378.1, AK162076.1, BU152350.1, AK086861.1 and AW495021.1.
            
            On Sep 26, 2017 this sequence version replaced NM_180974.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.125049.1, AK154401.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CJ173433.1         1-8
            9-79                CJ145725.1         1-71
            80-614              CN698353.1         3-537
            615-1335            CB524750.1         1-721
            1336-1807           BB042729.2         214-685
            1808-2390           CO431378.1         81-663
            2391-4137           AK162076.1         470-2216
            4138-4406           BU152350.1         539-807
            4407-5090           AK086861.1         287-970
            5091-5109           AW495021.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..5109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.97 cM"
     gene            1..5109
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /note="forkhead box N2"
                     /db_xref="GeneID:14236"
                     /db_xref="MGI:MGI:1347478"
     exon            1..181
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            182..732
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1485
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead homolog 19; forkhead box N1"
                     /codon_start=1
                     /product="forkhead box protein N2 isoform 1"
                     /protein_id="NP_851305.2"
                     /db_xref="CCDS:CCDS29022.2"
                     /db_xref="GeneID:14236"
                     /db_xref="MGI:MGI:1347478"
                     /translation="MGPVIGMTPDKRAETPGAEKVAGLSQIYKMGSLPEAGDAARPKA
                     TLVGSESADDELTNLNWLHESSNLLTNLRLGSEGLPMVSPLYDIEGDEMPSFGPSCYQ
                     NPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDRFPYFATAPTGWKNSV
                     RHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLMQALKKQPFSSPQSAALSPHC
                     LSSALKQSQVQTLQESDIDAATAMILLNTSIEQEILECEKPLPLKTSLQKKRSYGSAF
                     SAPGAVRLQESPSPTAGIDPKADHNYSANSVAAQRCASRASMSSLSSVDEVYEFIPKS
                     SHGGSDGSEGFHSDEETDAEDEEDPLGDSGYAPQARGHSTLKGQPGKKIPKQSCQEID
                     EELKEAAGSLLHLAGIRTCLGSLISTAKAQSQKHREK"
     exon            733..827
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            828..892
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            893..961
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            962..5092
                     /gene="Foxn2"
                     /gene_synonym="3230402J05Rik; 6030465J18Rik; Fkh19; Foxn1;
                     HTLF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggggtggg gggggggggg atgtggtgct gcggcggccg ccaccgcagc tgccactgcc
       61 tgctcgcgcc tgggtgtccc ggaggcggct gctgggagcc acgggagcag ctgcggtgct
      121 ctgccatatt gtgtctggcc cggcccggcc ctcgcctctg gttcgcggcg gctgagtgac
      181 gaaatatacg agtaaatggg tccagtaatt ggaatgactc cagataagag agctgagacc
      241 ccgggagctg agaaggttgc aggactgagt cagatttaca aaatgggaag tttgcctgaa
      301 gctggggatg ctgccaggcc aaaggccact cttgtgggca gtgagtcagc agatgacgag
      361 ctaacaaact tgaactggct tcatgagagc agtaaccttc taacaaacct cagacttgga
      421 agtgaaggcc ttcccatggt cagtccgctg tatgacatag agggagatga gatgccatcc
      481 tttggaccat cgtgctacca gaacccagaa aaaaaatcag caacttcaaa gcccccgtac
      541 tcctttagtc ttctcattta tatggctatt gaacactcgc caaataaatg tttgcctgtc
      601 aaagaaattt acagctggat tctggatcgc ttcccatact ttgccactgc acctacaggc
      661 tggaagaatt ctgttcggca taatctatcc ctgaataaat gttttcagaa agtggaaaga
      721 agtcatggca aggttaatgg aaaaggctcc ttgtggtgcg ttgatccaga atataagccc
      781 aatcttatgc aggccttaaa gaagcagcct ttttcttctc cacaaagtgc tgctttatca
      841 cctcactgct taagctctgc tctcaagcaa agccaagtgc aaactctcca agaatctgac
      901 attgatgcag ccactgcaat gatactttta aatacttcaa tagaacaaga gattttagaa
      961 tgtgagaagc cactgcctct taaaacatca ctgcagaaga agaggagtta cggcagcgcg
     1021 ttcagtgccc ccggtgctgt gcgactgcag gagagcccgt ctccaaccgc cggcatcgac
     1081 ccaaaagccg accataacta cagtgccaac agcgtggcgg cccagcgctg cgcatccagg
     1141 gcgagcatgt cttctctgtc ctctgtggat gaggtgtatg aattcatccc aaagagcagc
     1201 cacggcggga gcgacggtag cgaaggcttc cacagcgacg aggagacgga tgcggaggac
     1261 gaggaggatc ctctgggaga cagtggctac gcaccgcaag ctcgtggaca cagtactctg
     1321 aaagggcagc caggcaaaaa gatcccaaaa cagtcctgtc aagagattga tgaggagctc
     1381 aaagaggcag ccgggtcgct gctccacctt gctggaatcc gcacctgcct tggttccctg
     1441 ataagtactg cgaaggcaca gagtcagaag caccgggaaa agtagacatg cgcagagtgt
     1501 gaagttactc taaagttact ctaaagttac tcttctactc aacttttaca gggatgtcag
     1561 agccatagcg gacggacgga cggacggacc tcttcagctg agggtggggg agggggccac
     1621 ttgtttcttt ctaagtctgt tttggttgct tttctttttt tttgtttaat taatcagttg
     1681 ctcttaggat catgcctaat tgtaaatctg acataaatgg ccccacaatt taatttctgt
     1741 gaataagtgt ctcccagatt tggaaaattt tgtataggag aattctcagc ctctgtctta
     1801 aacttacagg aaaaaaagtc ccttttttta atcggtaaaa aattggtaac tcggactttt
     1861 catttttctt cccattctgc tattaactag ttactggcat ctttctcaca tgcttctctc
     1921 ctgacacact gcagaagggt ggaatgggga tcttttgtct ttgttttcag gttactcttt
     1981 gttacagcat gagcatagcc ttttgaattg gaaagatcct agatgcctag aaggttctct
     2041 ggtttgtaga gaatataact gctctaagga ttaggaaagg ccatttgggg atgtggccat
     2101 cttaagacta attcctcctg caatagttat ctttgaaatg tttttacctc gcagttaatg
     2161 catagcttca ctggggcctt taccttttcc cagaatactc tgcaagtgtt taagttttag
     2221 ctgctagctg tcttagttaa gtaagaattg tctgatgaga ggatacagcc agagcgtgtc
     2281 atggaatgac agtcatcgtg acacacttgt accgaaagag atccttgcat ttgttttctc
     2341 agcgtactgt aatgaagatg tgttatgaca tcataagtaa aggaaagtca tcgagggcaa
     2401 gactctccaa actttgtata attgaaatta aatgtgtaat gaattagatt taaaacatta
     2461 ttaaatgttc ccattaagga aaatacagag ataaatatct tcagggattt caaaatatat
     2521 gtaaaaattg gatcttacac aaaactcttt gagaaggcaa tgtaatacct gtatgtgcca
     2581 ttaatccacg ctaaaagatt tttttatact actatttcaa aagtgcattg gctaagatat
     2641 tttaagtatt tgaatggaac tgcttatata agtcagtttt catatcactt acagtttgat
     2701 tatagtattt agagcaggga tactaatact ataactcaca tatatatttt tttacagtgg
     2761 tgagagaaac tttgggaaag tttagtctta tttcatgata cgtcctgtat tctagacagc
     2821 aacctttgaa tttttctcat ttatatggat atatatacac ttgctatatg caacatacat
     2881 aggctcaggt tagtttcctg ctttcaaatg tttttatgac tatggacttt tttaaagaga
     2941 caaatgtttt tatttttact tctaatttct ttctgggcaa tactgtcaaa tgagaagaaa
     3001 aacagaagcc ctgtttctta attgacacca cttaagctat aacagtattg atatactccc
     3061 gtttccatgt tagttgtaat taaatctgga tagccgactt aatggaattg gtgctactaa
     3121 aatatagaca tttttctttt attgataatg caggatgaag aatttggaat ttttctaatt
     3181 cataaatgtc atctttctag aaaacagtta aatgaagtta gtttttactg cagtgaataa
     3241 aacaccaagc agaagtgtga agtgtggtct tatcgtggta caagtcttaa agagatggta
     3301 gagttcagtg gatagcaggg aattgtgaag caggtcacca cgcccttctg ggtggacctg
     3361 tcacagggtc accacattcc gtgcttcacc agcagtatgt ctctcaaggc cctgtgcagc
     3421 gggcatgttg ttctgcaaat ggaggaaaat ggtctgaagt aggaggaaag agttgttctc
     3481 agctccaaga gaaagacctc tccagaattc gtgtttaggc agtaacttaa attcctttcc
     3541 ctcctccttc aaatggcctc ttacttaaag caacagccat tagcaaggat gatgcatgcc
     3601 cgtgcactca agactaataa gcagtgttct ctaacacctt gcacttggct ctcttacaag
     3661 gattcgattt ctcacttttc atttgctgct gtgtctaagc atcctccttc aaggggagag
     3721 agagcctttg agatctggtc ccttgtgatg ttcttagaga cagattatgc tcctgtttgg
     3781 tgtgctcaga ttgaagcctg gcttggaacc atccaggcga cgaattgtat gggctagaaa
     3841 ttcccaatag ataacaagct ttgtgtatga agtaaacacg gcttagaaat ccagggacag
     3901 cccaggtctc agtgatttaa agctggtgtt ggctaaggta tactctgcct tacaccgaaa
     3961 caagaatttg gttggaacga attccatttc taagggatgc ctaaaagaag ttgtgtccta
     4021 cttagcactg ttagcttcat tttccacttt gccaagagaa tcagtgtttc ttgagtatga
     4081 ctttgaaatt tgtgcaatat attactaaaa tagttgattt tttttttttt ttttttttgc
     4141 tttcaaattt agaacgaaac attgcctaga tcagtagaaa agcaaggggt gtgtcacccc
     4201 ctttccttgg agccttttct gctctcatag ccagctctac ttctcttgac tgggattcct
     4261 ttgtacattg taaagttgag catatgttct cagtgctttc tgaggcatta tgtaaagggt
     4321 tcatactaga tggtcagtta gatacatgtt agcattagcg tagttcaaag ctggagcagg
     4381 cgttgaggga atgcttgtgt cttgtagact ggaggccttt tcagtagctt aggctgttgt
     4441 cccagatgga cagcagctta atgccttttg aaaactatat aaagcgactt ttgaggcttt
     4501 caggtttaca tgtatgtcgt aggtattttt ttttaatttt gaaatgttta agttttaatt
     4561 aaagtttact ccagtatgtt aatgatgtag tcaaatattt attgaaaggc aaaatagaat
     4621 attttaatgt tatccctgcc atttttcaag aatattcttt gcatctaact gccagtgcca
     4681 ttgtcaaact tgttttcaaa attgttgtac ttttttatta aacagagtgc ttaattttaa
     4741 agtattatgt tgccatcata tagtgtataa aatgtaaaat tgccaattca ttgtacctat
     4801 tatttatttt taaactaaag tataagaata ccttttgatt gaagaaattt gttattaaat
     4861 tgtttttttt ctgatgtagc ataaaatctt ctgagtttaa ctgccaatag atgaccagcc
     4921 acaagtgaac cacttctcag ttgccagcct tgcttatagc agaagcaact tacaaacatt
     4981 tagtttttgt atctaatctc tgactattaa aatgtttata aagtttattt ttaccaaaga
     5041 gatgcaattc attatgataa agttgcagaa taaatgtcgt tttataacac ttaaaaaaaa
     5101 aaaaaaaaa
//
