LOCUS       NM_008238               3273 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus forkhead box N1 (Foxn1), transcript variant 1, mRNA.
ACCESSION   NM_008238
VERSION     NM_008238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Rathore,M., Curry,K., Huang,W., Wright,M., Martin,D., Baek,J.,
            Taylor,D., Miyagi,M., Tang,W., Feng,H., Li,Y., Wang,Z., Graor,H.,
            Willis,J., Bryson,E., Boutros,C.S., Desai,O., Islam,B.N.,
            Ellis,L.M., Moss,S.E., Winter,J.M., Greenwood,J. and Wang,R.
  TITLE     Leucine-Rich Alpha-2-Glycoprotein 1 Promotes Metastatic Colorectal
            Cancer Growth Through Human Epidermal Growth Factor Receptor 3
            Signaling
  JOURNAL   Gastroenterology 168 (2), 300-315 (2025)
   PUBMED   39393543
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Ito,J., Nakamura,T., Toyama,T., Chen,D., Berndt,C., Poschmann,G.,
            Mourao,A.S.D., Doll,S., Suzuki,M., Zhang,W., Zheng,J., Trumbach,D.,
            Yamada,N., Ono,K., Yazaki,M., Kawai,Y., Arisawa,M., Ohsaki,Y.,
            Shirakawa,H., Wahida,A., Proneth,B., Saito,Y., Nakagawa,K.,
            Mishima,E. and Conrad,M.
  TITLE     PRDX6 dictates ferroptosis sensitivity by directing cellular
            selenium utilization
  JOURNAL   Mol Cell 84 (23), 4629-4644 (2024)
   PUBMED   39547222
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Muro,R., Nitta,T., Nitta,S., Tsukasaki,M., Asano,T., Nakano,K.,
            Okamura,T., Nakashima,T., Okamoto,K. and Takayanagi,H.
  TITLE     Transcript splicing optimizes the thymic self-antigen repertoire to
            suppress autoimmunity
  JOURNAL   J Clin Invest 134 (20), e179612 (2024)
   PUBMED   39403924
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Labra,B., Parag-Sharma,K., Powers,J.J., Srivastava,S., Walker,J.R.,
            Kirkland,T.A., Brennan,C.K., Prescher,J.A. and Amelio,A.L.
  TITLE     Optimized in vivo multispectral bioluminescent imaging of tumor
            biology using engineered BRET reporters
  JOURNAL   iScience 27 (9), 110655 (2024)
   PUBMED   39252965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Segre,J.A., Nemhauser,J.L., Taylor,B.A., Nadeau,J.H. and
            Lander,E.S.
  TITLE     Positional cloning of the nude locus: genetic, physical, and
            transcription maps of the region and mutations in the mouse and rat
  JOURNAL   Genomics 28 (3), 549-559 (1995)
   PUBMED   7490093
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Nehls,M., Pfeifer,D., Schorpp,M., Hedrich,H. and Boehm,T.
  TITLE     New member of the winged-helix protein family disrupted in mouse
            and rat nude mutations
  JOURNAL   Nature 372 (6501), 103-107 (1994)
   PUBMED   7969402
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Sharkey,F.E. and Fogh,J.
  TITLE     Incidence and pathological features of spontaneous tumors in
            athymic nude mice
  JOURNAL   Cancer Res 39 (3), 833-839 (1979)
   PUBMED   427772
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Haaijman,J.J., Slingerland-Teunissen,J., Benner,R. and Van
            Oudenaren,A.
  TITLE     The distribution of cytoplasmic immunoglobulin containing cells
            over various lymphoid organs of congenitally athymic (nude) mice as
            a function of age
  JOURNAL   Immunology 36 (2), 271-278 (1979)
   PUBMED   571405
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Stutman,O.
  TITLE     Spontaneous tumors in nude mice: effect of the viable yellow gene
  JOURNAL   Exp Cell Biol 47 (2), 129-135 (1979)
   PUBMED   446837
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Benner,R., van Oudenaren,A. and Haaijman,J.J.
  TITLE     Deficient antibody formation in the bone marrow of nude mice
  JOURNAL   Immunology 35 (4), 619-626 (1978)
   PUBMED   361546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591131.9, BC108981.1,
            BX521706.1, W97983.1 and AI429806.1.
            
            On Mar 29, 2013 this sequence version replaced NM_008238.1.
            
            Summary: The protein encoded by this gene is part of the forkhead
            family or 'winged-helix' transcription factors that are important
            in developmental processes, immune system regulation, metabolism,
            cancer and aging. This gene family has over 100 members, subdivided
            into classes (A-Q) based on phylogeny. The encoded protein is
            proposed to regulate development of the thymus and differentiation
            of keratinocytes. Mutations in this gene cause severe primary
            T-cell immunodeficiency and congenital alopecia. In mouse mutations
            of this gene underlie the phenotype of the nude mouse, which has
            been widely used as a model system in oncology, immunology,
            dermatology, and transplantation studies. In humans mutations in
            this gene have been correlated with T-cell immunodeficiency, the
            skin disorder congenital alopecia, and nail dystrophy. Alternative
            splicing results in multiple transcript variants that encode
            different protein isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL591131.9         38506-38619         c
            115-2483            BC108981.1         3-2371
            2484-2904           BX521706.1         112-532
            2905-3050           W97983.1           108-253
            3051-3273           AI429806.1         1-223               c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..3273
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /note="forkhead box N1"
                     /db_xref="GeneID:15218"
                     /db_xref="MGI:MGI:102949"
     exon            1..114
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            115..266
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2090
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead box protein N1; winged-helix transcription factor
                     nude; hepatocyte nuclear factor 3 forkhead homolog 11;
                     HNF-3/forkhead homolog 11"
                     /codon_start=1
                     /product="forkhead box protein N1 isoform 1"
                     /protein_id="NP_032264.1"
                     /db_xref="CCDS:CCDS25102.1"
                     /db_xref="GeneID:15218"
                     /db_xref="MGI:MGI:102949"
                     /translation="MVSLLPPQSDVTLPGSTRLEGEPQGDLMQAPGLPDSPAPQNKHA
                     NFSCSSFVPDGPPERTPSLPPHSPSIASPDPEQIQGHCTAGPGPGSFRLSPSEKYPGF
                     GFEEGPAGSPGRFLKGNHMPFHPYKRHFHEDIFSEAQTAMALDGHSFKTQGALEAFEE
                     IPVDMGDAEAFLPSFPAEAWCNKLPYPSQEHNQILQGSEVKVKPQALDSGPGMYCYQP
                     PLQHMYCSSQPAFHQYSPGGGSYPVPYLGSPHYPYQRIAPQANAEGHQPLFPKPIYSY
                     SILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEN
                     KSGSSSRKGCLWALNPSKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKL
                     GSPLLGCPPPGLAGPGPIRPMAPSAGLSQPLHPMHPAPGPMPGKNPLQDLLGGHAPSC
                     YGQTYPHLSPSLAPSGHQQPLFPQPDGHLELQAQPGTPQDSPLPAHTPPSHGAKLMAE
                     PSSARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSP
                     TSSSMLPPPPAAHCFPPGPCLAETGNEAGELAPPGSGGSGALGDMHLSTLYSAFVELE
                     STPSSAAAGPAVYLSPGSKPLALA"
     exon            267..728
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            729..842
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            843..973
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1070
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1278
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1770
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..3264
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /note="hexamer: AATAAA"
     polyA_site      3261
                     /gene="Foxn1"
                     /gene_synonym="D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude;
                     Whn"
                     /note="major polyA site"
ORIGIN      
        1 ccctcacctg atgtcagccc agacccagga caatcaggct gacggactga cagacggtcg
       61 gagctcctgg ccccccagac ccaggccccc acgccgacct gcttcactga gcagctggct
      121 ttcttcgagg ccaggactgg gtgatggtgt cgctactccc tccgcagtct gacgtcacac
      181 ttccaggctc cacccgactg gagggcgaac cccaagggga cctcatgcag gctccgggcc
      241 tcccagactc ccctgcccca cagaacaagc atgctaactt cagctgctcg tcgtttgtgc
      301 ctgacggccc tccagagagg acaccctcac tgcccccaca cagccccagc atcgcatctc
      361 cagacccaga gcagatccag ggccactgca cagccggacc cggcccgggc tccttccgcc
      421 tttctccttc agaaaagtat cctggctttg gctttgagga gggcccagca ggcagcccag
      481 ggcgcttcct caagggcaac cacatgcctt tccaccccta caagaggcac ttccatgagg
      541 acatcttctc tgaggcccag acggccatgg cacttgatgg acactccttt aagactcagg
      601 gggcactgga agcctttgag gagatccctg tggacatggg cgatgctgag gccttcctgc
      661 ctagcttccc agcagaggct tggtgcaata aactccctta ccccagccag gaacacaacc
      721 aaattctgca ggggtcagag gtcaaggtca agccccaagc tctggacagt ggtcctggga
      781 tgtactgcta ccagcctccc ttgcaacata tgtactgttc ttctcagcct gccttccatc
      841 agtactcccc gggtggaggc agctaccctg tgccctacct gggctcacct cactatccct
      901 atcagaggat tgcaccccag gccaacgccg aaggtcacca gccactcttc ccaaagccca
      961 tctactctta cagcatcctc atcttcatgg cccttaagaa cagtaagacc ggaagccttc
     1021 cagtcagtga aatctacaat ttcatgacgg agcacttccc ttacttcaag actgctcctg
     1081 atggctggaa gaattctgtt cgccataacc tgtccctcaa caagtgcttt gagaaggtgg
     1141 agaataaatc cggaagttcc tctcgaaagg gctgtctgtg ggccctcaat ccttccaaaa
     1201 tcgacaagat gcaggaagaa ctgcagaagt ggaagaggaa agaccccatt gctgtgcgca
     1261 aaagcatggc caaaccagaa gagctggaca gcctcattgg agacaaaagg gaaaaactgg
     1321 gctctccgct gctgggctgt ccaccccctg ggctggcagg cccaggtccc atccggccca
     1381 tggcaccatc agctggtctt tcccagcctc tgcacccaat gcatccagct ccaggcccca
     1441 tgcctggcaa gaaccccctg caggacctac tgggtggcca tgctccctcc tgctatgggc
     1501 agacctaccc acacctttcc cccagcctgg ccccttctgg acaccagcag ccattgttcc
     1561 cacagccaga tgggcatctt gagctgcagg cccagccagg caccccccag gactcacctc
     1621 tacctgccca cacaccaccc agccacggtg ccaagctgat ggctgagcct tcctcagcca
     1681 ggaccatgca cgatactcta ctgccagatg gagaccttgg gactgacctg gatgctatca
     1741 acccttctct cactgacttc gacttccagg gaaatctgtg ggagcagctg aaggatgaca
     1801 gcttggccct ggaccccctc gtattggtga cctcgtcgcc gacgtcatcc tccatgttgc
     1861 cacccccacc agcagcccat tgcttccccc cagggccttg tctggcagaa acaggcaatg
     1921 aggcaggtga actggcacct ccaggcagcg gcggctccgg tgctctggga gacatgcacc
     1981 tcagcactct ctactccgcc tttgtggaac tggagtccac gccctcctca gcagctgccg
     2041 gccctgccgt gtacctcagt cccggctcaa agccattggc tctggcttga gctatgccca
     2101 acatcagctg cggcctttgc ctagctggct gccccatatt gggctcacct taaaggtcaa
     2161 agaaggaaaa cactacctgt ctcctatgcc actcagccaa cttatttgtt agccagaagt
     2221 tgggggcatc catctaggat gctacctggt ggacccgcat ctcacacggg gcccccagca
     2281 aggaaagtgt cggaaaagaa gcaacagcgc gccccctagc gccagctcac tcgaacttca
     2341 gctctcgagc gtgaactcaa gctctacaca cctgctcatc atgtgcctta cactcagagg
     2401 aagccttggg tcacagagtc tgatttgatt tctggggcag ctgagagcta aaagctttag
     2461 ttagcaaagc tcagggccag tgtgacaggt caaagatcac ccctccaaac ctcatcccaa
     2521 tccccatgtg ctctacagac ttggccctct cccagaaatc tctatttatt ctcccatctt
     2581 acacccttaa agcctacagg ggctcctccc gtatgacctg tgaacccctt agggagacaa
     2641 ctacttcata gaatttatct atacatcttc agtatatact ctggttggcc atctccaagg
     2701 tgacacacag aaggggcagc atctaccctg ggaccaaact gagcccaaat ccaacacaac
     2761 atgtttggaa aaaaaaaaaa aaacttgtcc tcagaaactt gaaccccctc tcttagtctc
     2821 agccacagga aaggccccct tcaggttgcc aagtctcact ctttctcaat gagaggttca
     2881 tatagttcaa gccccagcct attggatgcg gtcaactgtc ttaagcatcc tgagtaacta
     2941 gggtttgcaa cccgctacag gatgatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgata
     3001 cccccccaca cacacacaca catacacaca cctgcatagc agacttgggg ctcccaggga
     3061 gccggcagaa tgtccgtgga gctgagctgt gactcagatg cccaccatga cccaccaaat
     3121 gggatcccca gctttcccag ggcctgaggg caaccagaac ctccataggt tgtccccaag
     3181 ctcacacgag ggtgggcgga tccctcagtc atctaccatt gtcccctgtc ctggaacaat
     3241 aaagtaagcg cctgatggtt gcaaaaaaaa aaa
//
