LOCUS       NM_172699               4808 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus forkhead box J3 (Foxj3), transcript variant 1, mRNA.
ACCESSION   NM_172699
VERSION     NM_172699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4808)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4808)
  AUTHORS   Huang,J., Zhang,Y., Zhou,X., Song,J., Feng,Y., Qiu,T., Sheng,S.,
            Zhang,M., Zhang,X., Hao,J., Zhang,L., Zhang,Y., Li,X., Liu,M. and
            Chang,Y.
  TITLE     Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction
            of PGC-1alpha
  JOURNAL   Diabetes 73 (2), 178-196 (2024)
   PUBMED   37939221
  REMARK    GeneRIF: Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via
            Induction of PGC-1alpha.
REFERENCE   3  (bases 1 to 4808)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 4808)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
  REMARK    GeneRIF: FOXJ3 is required for the survival of spermatogonia and
            participates in spermatocyte meiosis.
REFERENCE   5  (bases 1 to 4808)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4808)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4808)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4808)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4808)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 4808)
  AUTHORS   Farrington,S.M., Belaoussoff,M. and Baron,M.H.
  TITLE     Winged-helix, Hedgehog and Bmp genes are differentially expressed
            in distinct cell layers of the murine yolk sac
  JOURNAL   Mech Dev 62 (2), 197-211 (1997)
   PUBMED   9152011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082840.1, AK139508.1, AK077346.1 and BP763140.1.
            
            On Mar 19, 2014 this sequence version replaced NM_172699.2.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1). Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058231.1, AK139508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK082840.1         2-68
            68-2167             AK139508.1         2-2101
            2168-2972           AK082840.1         2169-2973
            2973-4787           AK077346.1         365-2179
            4788-4808           BP763140.1         32-52               c
FEATURES             Location/Qualifiers
     source          1..4808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.43 cM"
     gene            1..4808
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /note="forkhead box J3"
                     /db_xref="GeneID:230700"
                     /db_xref="MGI:MGI:2443432"
     exon            1..185
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            186..246
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2074
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead box protein J3; forkhead domain gene 6"
                     /codon_start=1
                     /product="forkhead box protein J3 isoform 1"
                     /protein_id="NP_766287.1"
                     /db_xref="CCDS:CCDS18585.1"
                     /db_xref="GeneID:230700"
                     /db_xref="MGI:MGI:2443432"
                     /translation="MGLYGQACPSVTSLRMTSELESSLTSMDWLPQLTMRAAIQKSDA
                     TQNAHGTGISKKNALLDPNTTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLS
                     EIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKE
                     DTLPTRPKKRARSVERASTPYSIDSDSLGMECIISGSASPTLAINTVTNKVTLYNADQ
                     DGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTNHPEPVSQPLTPQQQQQPQYN
                     LPEREKQLLFTEYNFEDLSASFRSLYKSVFEQSLSQQGLMSIPSESSQQSHTSCSYQH
                     SPSSTVTSHPHSNQSSLPNNHSGLSATGSNSVAQVSLSHPQMHPQPSPHTPHRPHGLP
                     QHPQRPQHPAPHPQQHSQLQPPHSQHPPPHQHIQHHPNHQHQTLAHQPPPPPQQVSCN
                     SGVSSDWYATLDMLKESCRIASSVNWSDVDLSQFQGLMESMRQADLKNWSLDQVQFAD
                     LCSSLNQFFTQTGLIHSQSNVPQNVCHGAMHPAKPSQHIGAGNLYIDSRQSLPPSVMP
                     PPGYPHIPQALNTPGTTMAGHHGAMNQQHMMPSQAFPMRRPLPPDDIQDDFDWDSIV"
     exon            247..571
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            572..646
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            647..730
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            731..832
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            833..961
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1142
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1556
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1658
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1850
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1958
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..4789
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /note="hexamer: AATAAA"
     polyA_site      4789
                     /gene="Foxj3"
                     /gene_synonym="C330039G02Rik; Fhd6"
                     /note="major polyA site"
ORIGIN      
        1 agttccgggt gcgcggcccc ggatgttggc tgctcccgcc gccgctgccg ccgccgccgc
       61 cactctcggc gccgctccgg gcctgggccg ctctctgagg gcgccgttgg gacctttcgc
      121 ggggaacgga gacgcacgca gcggccggag gctcggccgg gccgtcccgg cctgcgtagc
      181 ctgagattct ctttgtggcc agatgggttt gtatggacaa gcttgtccat ctgtaacttc
      241 attaaggatg acatctgaac tggagagcag cctaacatct atggactggt taccccagct
      301 caccatgaga gcagccatcc agaaatctga tgctacacaa aatgcacatg gaacgggaat
      361 ttctaagaag aatgcactcc ttgacccaaa tacaacactg gaccaggaag aagtccaaca
      421 gcacaaagat ggaaaacctc cgtacagcta tgccagcctc atcacatttg caattaatag
      481 ctcacctaaa aagaagatga cattaagtga gatttaccaa tggatttgtg ataactttcc
      541 gtattataga gaagctggca gtggttggaa gaattctata cgacataatc tgtcactgaa
      601 caaatgtttc cttaaagtgc ctcggtccaa ggatgatccc ggaaagggtt cttactgggc
      661 aatagacacc aatccgaagg aagacacgct gcctactcgg ccaaagaaga gggcaagatc
      721 cgtagaacgg gcctcaactc catatagcat agattcagat tctttgggaa tggagtgtat
      781 tatttcggga agtgcctctc caactctggc aatcaacact gtgactaaca aagtaacatt
      841 gtacaacgct gaccaggatg gtagtgatag ccctcgaagc agccttaaca acagtctctc
      901 agaccagagt ttggcgtctg ttaatttgaa cagtgttgga agtgtacata gttatacacc
      961 ggtcactaac catccagaac cagtctctca gccattaaca cctcagcagc agcagcagcc
     1021 acagtacaac cttccagaac gagaaaaaca actccttttc acagaataca attttgaaga
     1081 tctcagtgcc tcatttcgga gtctttataa gtcagttttt gagcagtcac ttagtcaaca
     1141 aggtttaatg agcatccctt cggaatcttc ccaacagtcc cacacttcat gttcctatca
     1201 acactctcct agcagtacag tgacctctca cccacacagc aaccaaagca gcctgcccaa
     1261 caatcacagt ggcctcagtg ccacaggtag taattcggtt gcacaggtct cgctgtccca
     1321 cccccagatg cacccccagc cctctccaca tacaccccat agaccgcatg gtttacccca
     1381 gcacccacag cgtccccagc acccagcacc acacccacag caacacagcc agctacagcc
     1441 gcctcactcc cagcaccccc ctccacatca gcacatacaa caccatccga accatcagca
     1501 tcagacatta gcacatcagc caccgccacc cccgcaacag gtatcctgta attctggtgt
     1561 ttcaagtgat tggtatgcaa cactcgatat gctgaaggaa agctgtcgaa ttgccagcag
     1621 tgttaactgg tcagatgtag acctttcaca gttccaaggt ctgatggaga gtatgaggca
     1681 ggcggatctc aagaactggt cattagatca ggttcagttc gctgatctct gttcctctct
     1741 taatcagttc ttcacacaga ctggccttat ccactcgcag agtaatgttc cgcagaatgt
     1801 ctgtcacggt gccatgcacc cagcaaagcc ttcccaacac atcggggcag gaaatttgta
     1861 catagattcc aggcaaagtc tccctccctc agtgatgcca ccccctggtt atcctcatat
     1921 tccacaggcg ctcaacactc caggaactac gatggcaggt catcacggag ccatgaacca
     1981 gcagcacatg atgccttccc aagccttccc gatgcggcgc cctctgcctc cagatgacat
     2041 ccaggatgac tttgattggg attcaatagt gtaggcttgt ttctgcaaga cagcagactc
     2101 caggattctt tttgttcagt gaaaggacgg attagaggcc ggttgagaaa acaaagctat
     2161 gttaccagtg ctatctaaat tcctttcgaa gacaatcaga gattctagct gggtaactta
     2221 ctgcttttat ccaacccaag caagaactac atgtttgtct ccctgccagt accctctgta
     2281 gctcctaact gttgtgattt ggacagcttt ttgcatattt gtgtcagttt gatgttgacc
     2341 acaagtgcca gactgatttt tcagacagag cctattttgc tgcgagcagt ttatagatac
     2401 atatgtgtaa atatgtgtac aaatattact gaaaggcttc aagttttttc taattggatt
     2461 attgtatctt gaaaagaaag ttactgtcag tttttattcc ttgttaggcc attttctgca
     2521 ggatgctttc aaatgataca gagagctgaa aggaaatcag tttttcaaag cccagtttcc
     2581 tttatttaat cttcagaaat aggagtaatc atgaatccac cgagtaagtc aaagaatctg
     2641 gagttggtac tcaaaaacag tgcagagggc cgttgttcct gagcaagctt gtcacttgtc
     2701 attcggtgtt gtagagagag tgttgtacct gtcagtgtga ttcctcagct gcatcttggc
     2761 agctctgaaa tgtgtgggct gactgaaact gggtattgct tggctcttca aacaaaccaa
     2821 tgtctccata gtcacttatg tatttattat tcaaaagtgt tattttaata tttattgctc
     2881 tgtgaatgca cagttctgtt ggattcacta gggagggatt tgtctgaaag catggttatt
     2941 tttctggata aagtttacag acaaagacaa tcagaagcat tggtccttct cttttatcat
     3001 cactccttac caggtgagcg tgcttcctgt cttgcttagc cttcctgctg ggggagactt
     3061 aatagctaca taggaatttc ctggaatttg aatcagtcta tttaggcagc aagatacaga
     3121 ggctgggttt atacagcagt gtccctgctg ttggtaacgc tagcaggggc tgcatgcagc
     3181 tccagagtct tatctgcttc agtcttgagt gcagtgactg actgcgtgac ctgctgttgg
     3241 gtctgtgtgt ccccaacatg aagcacctca gagctttgat cagttgcttt gttttgtgtc
     3301 atgtcacagc tagcatgggt tgaatgtgtt gattttataa tgaaagtaaa gaaaggagat
     3361 tctcctcccc acagtgaata gatcgttaat tggttcttta cagagaggga aatccatttt
     3421 aatgagaaaa tagattctgt caaatcaaga agaaataact ggtcaccagt tgcttgttag
     3481 tgtctctggg ctaagcagtg cttaatcaca ttgactaacc tcagcgagtc tgtggatgag
     3541 taatctctac tggaacaaag gtttctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3601 gtgtgtgtgt gtgtaagtgc aagagatcat gaaagagacg gggcacgggg agagaatgag
     3661 aatatctgtg tatgtgttaa tggagtgttg tcttgaatga atccctggga agccatgggg
     3721 agtgcaggga agaagggaga gcctcgggct tcgctgttgc ttggaccccc acttggcatg
     3781 agagaaagaa gctcaggtac agaggattct caaccaatag ccaacaggcc tcactcggaa
     3841 ggactgggca agatgagatg gctgtctgca gagaaaaagc ttgggaaaat gaggtcctca
     3901 gtagtttgct caagtctctg ttttctagac accaaaatgg ctgctctgtg actaggattg
     3961 ctccgcagca gtgtgcactt taaatgattg ggtgttggag tatcgcagtc tgaaacagca
     4021 tggcttgatg aatttacaga ttatgtgaag ctaacttccc atttgacaat tactgatttg
     4081 cagtgatcga tatatttatg aatgtttaaa ctgaccaaga atggcacttg aggccactca
     4141 ccactcttct gtgattccct gtttccctgg ggctcagcaa gcctgagtgc ctgggcaggg
     4201 aaggctacct ggtgggcgca gagtccctct agtggccatt tctgatttat ttgatgacac
     4261 acagcaagtt ctctagggct gaaattaact ggagacttgg ggtaaggact aacaaacata
     4321 catacacaga tggggcgctc tgtccaggag aagagtccga ctggcatttg tggcagtgtt
     4381 tgaaatgtaa atgtactcct gtgtgttcct gtaaatattt aatatgtgtc tcagacgtcc
     4441 tttgaagtgg gaggggatcg atcttgggat aatttcaaat ggaatagagt attttgatat
     4501 gttcattgaa agggtgatgt gtacatactt atattgtata tatgtggtga catgcattgg
     4561 cttttgtgca gaaacaacct gctcttgtgc tgctgttgga cagtcaagtg ttttaatgtt
     4621 tctacagttt tcctattgca cgatttcata ttctgccaat ggtgagtggc acccattctt
     4681 tgtaaccgta tagtgctgta aagaaatatt ccaagtgtca ttaggattgt cgctgccaga
     4741 attgatatgc atggatggca cttaaaataa atatattatg ataactgtaa aaaaaaaaaa
     4801 aaaaaaaa
//
