LOCUS       NP_001094934             399 aa            linear   ROD 05-DEC-2024
DEFINITION  forkhead box protein I3 [Mus musculus].
ACCESSION   NP_001094934 XP_001477807 XP_144880
VERSION     NP_001094934.1
DBSOURCE    REFSEQ: accession NM_001101464.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 399)
  AUTHORS   Xing,X.L., Zeng,Z., Wang,Y., Pan,B. and Huang,X.
  TITLE     Identification of potential molecular mechanism related to
            craniofacial dysmorphism caused by FOXI3 deficiency
  JOURNAL   Mol Genet Genomic Med 12 (3), e2411 (2024)
   PUBMED   38433559
  REMARK    GeneRIF: Identification of potential molecular mechanism related to
            craniofacial dysmorphism caused by FOXI3 deficiency.
REFERENCE   2  (residues 1 to 399)
  AUTHORS   Raymundo,J.R., Zhang,H., Smaldone,G., Zhu,W., Daly,K.E.,
            Glennon,B.J., Pecoraro,G., Salvatore,M., Devine,W.A., Lo,C.W.,
            Vitagliano,L. and Marneros,A.G.
  TITLE     KCTD1/KCTD15 complexes control ectodermal and neural crest cell
            functions, and their impairment causes aplasia cutis
  JOURNAL   J Clin Invest 134 (4), e174138 (2023)
   PUBMED   38113115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 399)
  AUTHORS   Ankamreddy,H., Thawani,A., Birol,O., Zhang,H. and Groves,A.K.
  TITLE     Foxi3GFP and Foxi3CreER mice allow identification and lineage
            labeling of pharyngeal arch ectoderm and endoderm, and tooth and
            hair placodes
  JOURNAL   Dev Dyn 252 (12), 1462-1470 (2023)
   PUBMED   37543988
REFERENCE   4  (residues 1 to 399)
  AUTHORS   Thawani,A., Maunsell,H.R., Zhang,H., Ankamreddy,H. and Groves,A.K.
  TITLE     The Foxi3 transcription factor is necessary for the fate
            restriction of placodal lineages at the neural plate border
  JOURNAL   Development 150 (19) (2023)
   PUBMED   37756587
  REMARK    GeneRIF: The Foxi3 transcription factor is necessary for the fate
            restriction of placodal lineages at the neural plate border.
REFERENCE   5  (residues 1 to 399)
  AUTHORS   Christensen,M.M., Hallikas,O., Das Roy,R., Vaananen,V.,
            Stenberg,O.E., Hakkinen,T.J., Francois,J.C., Asher,R.J.,
            Klein,O.D., Holzenberger,M. and Jernvall,J.
  TITLE     The developmental basis for scaling of mammalian tooth size
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2300374120 (2023)
   PUBMED   37307487
REFERENCE   6  (residues 1 to 399)
  AUTHORS   Shirokova,V., Jussila,M., Hytonen,M.K., Perala,N., Drogemuller,C.,
            Leeb,T., Lohi,H., Sainio,K., Thesleff,I. and Mikkola,M.L.
  TITLE     Expression of Foxi3 is regulated by ectodysplasin in skin appendage
            placodes
  JOURNAL   Dev Dyn 242 (6), 593-603 (2013)
   PUBMED   23441037
  REMARK    GeneRIF: Eda and activin A are upstream regulators of Foxi3 in skin
            appendage placodes
REFERENCE   7  (residues 1 to 399)
  AUTHORS   Urness,L.D., Paxton,C.N., Wang,X., Schoenwolf,G.C. and Mansour,S.L.
  TITLE     FGF signaling regulates otic placode induction and refinement by
            controlling both ectodermal target genes and hindbrain Wnt8a
  JOURNAL   Dev Biol 340 (2), 595-604 (2010)
   PUBMED   20171206
REFERENCE   8  (residues 1 to 399)
  AUTHORS   Drogemuller,C., Karlsson,E.K., Hytonen,M.K., Perloski,M., Dolf,G.,
            Sainio,K., Lohi,H., Lindblad-Toh,K. and Leeb,T.
  TITLE     A mutation in hairless dogs implicates FOXI3 in ectodermal
            development
  JOURNAL   Science 321 (5895), 1462 (2008)
   PUBMED   18787161
REFERENCE   9  (residues 1 to 399)
  AUTHORS   Zou,D., Silvius,D., Davenport,J., Grifone,R., Maire,P. and Xu,P.X.
  TITLE     Patterning of the third pharyngeal pouch into thymus/parathyroid by
            Six and Eya1
  JOURNAL   Dev Biol 293 (2), 499-512 (2006)
   PUBMED   16530750
REFERENCE   10 (residues 1 to 399)
  AUTHORS   Ohyama,T. and Groves,A.K.
  TITLE     Expression of mouse Foxi class genes in early craniofacial
            development
  JOURNAL   Dev Dyn 231 (3), 640-646 (2004)
   PUBMED   15376323
  REMARK    GeneRIF: Foxi3 expressed in a broad region of the pan-placodal
            ectoderm adjacent to the neural plate from E6.75 to first somite
            stage; expression restricted to ectoderm & endoderm of branchial
            pouches at E10.5
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH466523.1.
            
            On or before Oct 4, 2008 this sequence version replaced
            XP_001477807.1, XP_144880.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Mus musculus"
                     /strain="mixed"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     Protein         1..399
                     /product="forkhead box protein I3"
                     /calculated_mol_wt=41884
     Region          87..109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z120.2)"
     Site            99
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:30467319; propagated from
                     UniProtKB/Swiss-Prot (D3Z120.2)"
     Site            103
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:30467319; propagated from
                     UniProtKB/Swiss-Prot (D3Z120.2)"
     Region          126..218
                     /region_name="FH_FOX"
                     /note="Forkhead (FH) domain found in Forkhead box (FOX)
                     family of transcription factors and similar proteins;
                     cl00061"
                     /db_xref="CDD:469596"
     Region          <128..348
                     /region_name="COG5025"
                     /note="Transcription factor of the Forkhead/HNF3 family
                     [Transcription]"
                     /db_xref="CDD:227358"
     Site            order(134,152..153,156,175..176,178..179,182,189,199..201,
                     203)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410827"
     Region          219..225
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:30467319,
                     ECO:0000269|PubMed:37041148"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z120.2)"
     Region          221..287
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z120.2)"
     Site            258
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:30467319; propagated from
                     UniProtKB/Swiss-Prot (D3Z120.2)"
     Site            266
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:30467319; propagated from
                     UniProtKB/Swiss-Prot (D3Z120.2)"
     Site            268
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:30467319; propagated from
                     UniProtKB/Swiss-Prot (D3Z120.2)"
     Region          307..353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z120.2)"
     Region          385..393
                     /region_name="9aaTAD.
                     /evidence=ECO:0000269|PubMed:30467319"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z120.2)"
     CDS             1..399
                     /gene="Foxi3"
                     /coded_by="NM_001101464.1:4..1203"
                     /db_xref="CCDS:CCDS51804.1"
                     /db_xref="GeneID:232077"
                     /db_xref="MGI:MGI:3511278"
ORIGIN      
        1 malycgdnfv ysqpaaapga pptsrapygl sdyaappaaa anpylwlngp gvggpasaas
       61 ylgapppppg aapgpflqpp aapgtfagaq rgfaqpsasa paspagsaap gelgwlsmas
      121 redlmkmvrp pysysaliam aiqsaperkl tlshiyqfva dnfpfyqrsk agwqnsirhn
      181 lslndcfkkv prdeddpgkg nywtldpnce kmfdngnfrr krrrraeass nltvpsgtsk
      241 segqssrlrv sgklegdsps silrpsqspe ppegtkstas spgastltst pclntflstf
      301 ntlnvnssss mgnqrtlpgs rrhlggtqlp sstfpntsvp dsspdsmqls tvggsnqlss
      361 yynpfsggss gdqsspfssp fynfsmvnsl iyprdgsdi
//
