LOCUS       NM_183193               2598 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus forkhead box I2 (Foxi2), mRNA.
ACCESSION   NM_183193
VERSION     NM_183193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Fan,Y., Sheng,S., Guo,C., Qiao,W., Jin,Y., Tan,L., Gao,Y.,
            Zhang,L., Dong,X., Zhang,J., Li,X., Shen,H., Liao,Y. and Chang,Y.
  TITLE     Forkhead Box i2 Transcription Factor Regulates Systemic Energy
            Metabolism Via Neuropeptide AgRP
  JOURNAL   Diabetes 71 (10), 2106-2122 (2022)
   PUBMED   35856496
  REMARK    GeneRIF: Forkhead Box i2 Transcription Factor Regulates Systemic
            Energy Metabolism Via Neuropeptide AgRP.
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Birol,O., Ohyama,T., Edlund,R.K., Drakou,K., Georgiades,P. and
            Groves,A.K.
  TITLE     The mouse Foxi3 transcription factor is necessary for the
            development of posterior placodes
  JOURNAL   Dev Biol 409 (1), 139-151 (2016)
   PUBMED   26550799
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Kimura-Yoshida,C., Mochida,K., Ellwanger,K., Niehrs,C. and
            Matsuo,I.
  TITLE     Fate Specification of Neural Plate Border by Canonical Wnt
            Signaling and Grhl3 is Crucial for Neural Tube Closure
  JOURNAL   EBioMedicine 2 (6), 513-527 (2015)
   PUBMED   26288816
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Jayasena,C.S., Ohyama,T., Segil,N. and Groves,A.K.
  TITLE     Notch signaling augments the canonical Wnt pathway to specify the
            size of the otic placode
  JOURNAL   Development 135 (13), 2251-2261 (2008)
   PUBMED   18495817
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Ohyama,T., Mohamed,O.A., Taketo,M.M., Dufort,D. and Groves,A.K.
  TITLE     Wnt signals mediate a fate decision between otic placode and
            epidermis
  JOURNAL   Development 133 (5), 865-875 (2006)
   PUBMED   16452098
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Identification of forkhead transcription factors in cortical and
            dopaminergic areas of the adult murine brain
  JOURNAL   Brain Res 1068 (1), 23-33 (2006)
   PUBMED   16376864
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Cloning and analysis of the murine Foxi2 transcription factor
  JOURNAL   Biochim Biophys Acta 1731 (2), 133-138 (2005)
   PUBMED   16289364
  REMARK    GeneRIF: we describe the cloning and analysis of the murine Foxi2
            gene, coding for a putative 311 amino acid protein
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Ohyama,T. and Groves,A.K.
  TITLE     Expression of mouse Foxi class genes in early craniofacial
            development
  JOURNAL   Dev Dyn 231 (3), 640-646 (2004)
   PUBMED   15376323
  REMARK    GeneRIF: examined the expression patterns of the Foxi class genes
            from embryonic day 6.5 to 10.5; Foxi2 is expressed throughout the
            cranial ectoderm adjacent to the neural plate from the 4-somite
            stage, later becoming excluded from the otic placode
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151838.6.
            
            On Feb 12, 2019 this sequence version replaced NM_183193.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045276.1, BC096623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC151838.6         163105-163678       c
            575-2598            AC151838.6         160423-162446       c
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 81.27 cM"
     gene            1..2598
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /note="forkhead box I2"
                     /db_xref="GeneID:270004"
                     /db_xref="MGI:MGI:3028075"
     exon            1..574
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1008
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /codon_start=1
                     /product="forkhead box protein I2"
                     /protein_id="NP_899016.2"
                     /db_xref="CCDS:CCDS21942.2"
                     /db_xref="GeneID:270004"
                     /db_xref="MGI:MGI:3028075"
                     /translation="MAGFCDSLGSCSVPHGLTRAIAHPPSYGRTDLSSGRRLWVNSAA
                     LSPAPYATGPGPAPSYAAATLAVPGSLLGASGGLAGADLAWLSLSGQQELLRLVRPPY
                     SYSALIAMAIQSAPLRRLTLSQIYQYVAGNFPFYKRSKAGWQNSIRHNLSLNDCFKKV
                     PRDENDPGKGNYWTLDPNCEKMFDNGNFRRKRRRRGETSEAAVPGASSPEGTALEPRG
                     STPQDPQTSPSPSEATTTCLSGFSTAMGALAGGFGALPDGLAHDFSLRRPPPTAAAHS
                     PQIPNTAPGFAPGHQTGATGFRMGHLIYSRDGTEV"
     exon            575..2598
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2575..2580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2596
                     /gene="Foxi2"
                     /gene_synonym="B130055A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agggtgaatg gagctcccat gagcttcagc acggagccac ctgcaccggc ccaggccggg
       61 ggagagctgg acatggctgg gttctgcgac agcctgggtt cctgctcagt cccgcacggc
      121 ctgacccggg ccatcgcgca tcccccgagc tacggccgaa cggatctgag ctctggccgg
      181 cgcctgtggg tgaactcggc cgcgctcagc ccggcgccct acgcgacggg accagggccg
      241 gctccatcct acgctgcagc gactctcgcc gtcccgggtt cgcttcttgg cgcttcaggc
      301 ggtctggcag gcgctgatct cgcttggctg agcctgtccg gacagcagga gctgctgagg
      361 ctggtacggc cgccctactc ctactcagca ctgatcgcca tggccatcca aagcgcgccg
      421 ctacgcaggt tgacgctcag ccagatctac cagtatgtgg cgggcaactt ccccttctac
      481 aagcgcagca aggcgggctg gcagaactcc atccgccaca acctgtcgct caatgattgc
      541 ttcaagaagg tgccccgaga tgagaacgat ccaggaaaag gcaattattg gacgctggat
      601 ccaaactgtg agaagatgtt tgacaatggg aacttccgaa ggaagaggag acggagagga
      661 gagactagcg aggccgctgt gcctggagcc agcagcccag agggaactgc actggagccc
      721 cgtggctcca ctccccagga cccacagacc tcaccatccc cgtctgaggc caccactact
      781 tgcctctcgg gcttctccac ggccatggga gccctggccg gcggctttgg cgccctccct
      841 gatggtctgg cccatgactt ttctttgcga aggccaccac caaccgcggc tgcccacagc
      901 cctcagattc ctaacaccgc gccaggcttc gctccgggcc atcagacagg ggctacaggc
      961 tttaggatgg ggcacctcat ctacagccgg gatgggactg aagtttgaag gaaagctaga
     1021 gactggccag gtgctctgtt ccaacattga gctaaggtcc tgaatcagtc cttcctggga
     1081 gccccacagg tgctgcatag gaaatggcgg ggctcctgtg tggattggct gaggcaggtt
     1141 gagcttgctg tgttctcatc aacctgggga atataccctc ttcttaagct ggttctctgc
     1201 ctatagatcc agctctgggc tctctgacag agcgccccag agagccttct taaaggggta
     1261 ataggttcct aaagaagcct gttggtctcc agtctccaga gagatgtctg gcagctggtg
     1321 agaggatggg aggaaactgg gctgcaagag catccagagc gcccttcagt gattggcccc
     1381 atctctggcc cacctgtttc agggcagcta gggaatggga tgggggtgca gcatgaggac
     1441 aggtggctgc cttccaccct catgagattg cacattgagg ggactctcat acttaggcaa
     1501 gagctgtctc agcagaggga gatccccgag gacaccagct ccctcccctg tcactgtgct
     1561 cctggcatca tcagtgctcc tgttacagaa cctcgctgtc cccagaccac agagaggctg
     1621 gcacttagga aaccctgggc agctttgggt ttgccttact tgaccgctgc tcccaccccc
     1681 tacccccacc atcgccatca ccgcccacac tcactaaagc tcacctgagg caggtgggtg
     1741 accacacctg tttttggttt ctctctactc ctgcctcctc ccttgctgtg actgctctca
     1801 ggcagaatcc tgagaacttc ctccagaatt taactctcca gcctttccaa gcctgtttat
     1861 attcagtgac tggcttttgg acctctgtgc tttcaggagc tccttgaggt cccagctgtt
     1921 ataagtcttt gtgtcacctg gcattttctg gggacatgga cactggccat ggacccatac
     1981 tatgccagga cagatgggag gagtactttc cctggaagag agcagagagg gaagtcttaa
     2041 gccagaccag tcttgccctt tagtgagccc agccccactt gcaccaacag ggcaagtctg
     2101 ccttggacta tctccaatct gcctactggg agagccatgg tcctctgaac ctgcggtgct
     2161 caggatgcag gaatggggtc ctgctcccca accctgcctc ctgtttgctg cgtgttgttc
     2221 ctacctggtg tgctgtggtt aaccaagctt acagtcaacc catactctct ttccaaatgt
     2281 aatgcgattt ttaaaattca ggaaaatata aattatttaa aatataaata aaaaaggttt
     2341 ttcgatttgg gggcatattt taatagaata acacactaaa aaggaacatc ccacttttta
     2401 ttctatcttt gcaagaaaat tggaaagaaa gaaataacta gctacaacaa gaagaaatac
     2461 agtgtaactt tcgtcagggc ttccacaaag ttggatacat ccaggtgtct tggctgtgtg
     2521 gcagctgcat catggaaatt gtgtttgttt tctacttctg atgctggatt ttctattaaa
     2581 attaagaaaa ggaaaata
//
