LOCUS       NP_076396                372 aa            linear   ROD 28-APR-2025
DEFINITION  forkhead box protein I1 [Mus musculus].
ACCESSION   NP_076396
VERSION     NP_076396.3
DBSOURCE    REFSEQ: accession NM_023907.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Kui,M., Pluznick,J.L. and Zaidman,N.A.
  TITLE     The transcription factor Foxi1 promotes expression of V-ATPase and
            Gpr116 in M-1 cells
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F267-F273 (2023)
   PUBMED   36603001
  REMARK    GeneRIF: The transcription factor Foxi1 promotes expression of
            V-ATPase and Gpr116 in M-1 cells.
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Szeto,I.Y.Y., Chu,D.K.H., Chen,P., Chu,K.C., Au,T.Y.K.,
            Leung,K.K.H., Huang,Y.H., Wynn,S.L., Mak,A.C.Y., Chan,Y.S.,
            Chan,W.Y., Jauch,R., Fritzsch,B., Sham,M.H., Lovell-Badge,R. and
            Cheah,K.S.E.
  TITLE     SOX9 and SOX10 control fluid homeostasis in the inner ear for
            hearing through independent and cooperative mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022)
   PUBMED   36343245
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Barone,S., Zahedi,K., Brooks,M., Henske,E.P., Yang,Y., Zhang,E.,
            Bissler,J.J., Yu,J.J. and Soleimani,M.
  TITLE     Kidney intercalated cells and the transcription factor FOXi1 drive
            cystogenesis in tuberous sclerosis complex
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33536341
  REMARK    GeneRIF: Kidney intercalated cells and the transcription factor
            FOXi1 drive cystogenesis in tuberous sclerosis complex.
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Mukherjee,M., DeRiso,J., Janga,M., Fogarty,E. and Surendran,K.
  TITLE     Foxi1 inactivation rescues loss of principal cell fate selection in
            Hes1-deficient kidneys but does not ensure maintenance of principal
            cell gene expression
  JOURNAL   Dev Biol 466 (1-2), 1-11 (2020)
   PUBMED   32800756
  REMARK    GeneRIF: Foxi1 inactivation rescues loss of principal cell fate
            selection in Hes1-deficient kidneys but does not ensure maintenance
            of principal cell gene expression.
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Montoro,D.T., Haber,A.L., Biton,M., Vinarsky,V., Lin,B.,
            Birket,S.E., Yuan,F., Chen,S., Leung,H.M., Villoria,J., Rogel,N.,
            Burgin,G., Tsankov,A.M., Waghray,A., Slyper,M., Waldman,J.,
            Nguyen,L., Dionne,D., Rozenblatt-Rosen,O., Tata,P.R., Mou,H.,
            Shivaraju,M., Bihler,H., Mense,M., Tearney,G.J., Rowe,S.M.,
            Engelhardt,J.F., Regev,A. and Rajagopal,J.
  TITLE     A revised airway epithelial hierarchy includes CFTR-expressing
            ionocytes
  JOURNAL   Nature 560 (7718), 319-324 (2018)
   PUBMED   30069044
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Hulander,M., Wurst,W., Carlsson,P. and Enerback,S.
  TITLE     The winged helix transcription factor Fkh10 is required for normal
            development of the inner ear
  JOURNAL   Nat Genet 20 (4), 374-376 (1998)
   PUBMED   9843211
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Overdier,D.G., Ye,H., Peterson,R.S., Clevidence,D.E. and Costa,R.H.
  TITLE     The winged helix transcriptional activator HFH-3 is expressed in
            the distal tubules of embryonic and adult mouse kidney
  JOURNAL   J Biol Chem 272 (21), 13725-13730 (1997)
   PUBMED   9153225
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Avraham,K.B., Fletcher,C., Overdier,D.G., Clevidence,D.E., Lai,E.,
            Costa,R.H., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of eight members of the hepatocyte
            nuclear factor 3/fork head winged helix family of transcription
            factors
  JOURNAL   Genomics 25 (2), 388-393 (1995)
   PUBMED   7789972
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Peterson,R.S., Porcella,A., Ye,H.,
            Paulson,K.E. and Costa,R.H.
  TITLE     Members of the HNF-3/forkhead family of transcription factors
            exhibit distinct cellular expression patterns in lung and regulate
            the surfactant protein B promoter
  JOURNAL   Dev Biol 166 (1), 195-209 (1994)
   PUBMED   7958446
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019994.1 and BF454473.1.
            
            On Apr 14, 2009 this sequence version replaced NP_076396.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019994.1, BC007475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.65 cM"
     Protein         1..372
                     /product="forkhead box protein I1"
                     /note="HNF-3/forkhead homolog 3; forkhead homolog 10"
                     /calculated_mol_wt=40667
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q922I5.2)"
     Region          114..213
                     /region_name="FH_FOXI1"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     I1 (FOXI1) and similar proteins; cd20053"
                     /db_xref="CDD:410827"
     Site            order(122,140..141,144,163..164,166..167,170,177,187..189,
                     191)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410827"
     Region          202..271
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q922I5.2)"
     CDS             1..372
                     /gene="Foxi1"
                     /gene_synonym="5830401E05Rik; Fkh10; FREAC6; HFH-3; Hfh3"
                     /coded_by="NM_023907.4:67..1185"
                     /db_xref="CCDS:CCDS24539.1"
                     /db_xref="GeneID:14233"
                     /db_xref="MGI:MGI:1096329"
ORIGIN      
        1 mssfdlpaps pprcspqfps igqeppemnl yyenffhpqg mpspqrptsf egggeygttp
       61 npylwlngpa mtpppylpgt naspflpqay gmqrqllpsd lgwlpipsqe elmklvrppy
      121 sysaliamai hgapdqrltl sqiyqyvadn fpfynkskag wqnsirhnls lndcfkkvpr
      181 deddpgkgny wtldpncekm fdngnfrrkr krksdsssst sslasekten gllasspkpt
      241 epqevldtas pdtttsspek rsspapsgtp clnnflstmt ayvsgtnpis rsvatpglss
      301 epidkmgqns lnfnsytplt nlsshgngge wanpvatnal gyggsvfnqf sphfynsint
      361 ngilfpregt ev
//
