LOCUS       NM_007989               1366 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus forkhead box H1 (Foxh1), mRNA.
ACCESSION   NM_007989
VERSION     NM_007989.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1366)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   2  (bases 1 to 1366)
  AUTHORS   Loizou,E., Banito,A., Livshits,G., Ho,Y.J., Koche,R.P.,
            Sanchez-Rivera,F.J., Mayle,A., Chen,C.C., Kinalis,S., Bagger,F.O.,
            Kastenhuber,E.R., Durham,B.H. and Lowe,S.W.
  TITLE     A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate
            Plasticity and Myeloid Leukemia through the Pluripotency Factor
            FOXH1
  JOURNAL   Cancer Discov 9 (7), 962-979 (2019)
   PUBMED   31068365
  REMARK    GeneRIF: FOXH1 was identified as a critical mediator of mutant p53
            function that binds to and regulates stem cell-associated genes and
            transcriptional programs in the context of mouse model of acute
            myeloid leukemia.
REFERENCE   3  (bases 1 to 1366)
  AUTHORS   Huang,X., Balmer,S., Yang,F., Fidalgo,M., Li,D., Guallar,D.,
            Hadjantonakis,A.K. and Wang,J.
  TITLE     Zfp281 is essential for mouse epiblast maturation through
            transcriptional and epigenetic control of Nodal signaling
  JOURNAL   Elife 6, e33333 (2017)
   PUBMED   29168693
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1366)
  AUTHORS   Simon,C.S., Downes,D.J., Gosden,M.E., Telenius,J., Higgs,D.R.,
            Hughes,J.R., Costello,I., Bikoff,E.K. and Robertson,E.J.
  TITLE     Functional characterisation of cis-regulatory elements governing
            dynamic Eomes expression in the early mouse embryo
  JOURNAL   Development 144 (7), 1249-1260 (2017)
   PUBMED   28174238
REFERENCE   5  (bases 1 to 1366)
  AUTHORS   Wang,G., Liu,L., Guo,S. and Zhang,C.
  TITLE     Expression and distribution of forkhead activin signal transducer 2
            (FAST2) during follicle development in mouse ovaries and
            pre-implantation embryos
  JOURNAL   Acta Histochem 118 (6), 632-639 (2016)
   PUBMED   27432806
  REMARK    GeneRIF: that FAST2 is expressed in a cell-specific manner during
            ovarian follicle development
REFERENCE   6  (bases 1 to 1366)
  AUTHORS   Yamamoto,M., Meno,C., Sakai,Y., Shiratori,H., Mochida,K., Ikawa,Y.,
            Saijoh,Y. and Hamada,H.
  TITLE     The transcription factor FoxH1 (FAST) mediates Nodal signaling
            during anterior-posterior patterning and node formation in the
            mouse
  JOURNAL   Genes Dev 15 (10), 1242-1256 (2001)
   PUBMED   11358868
REFERENCE   7  (bases 1 to 1366)
  AUTHORS   Saijoh,Y., Adachi,H., Sakuma,R., Yeo,C.Y., Yashiro,K., Watanabe,M.,
            Hashiguchi,H., Mochida,K., Ohishi,S., Kawabata,M., Miyazono,K.,
            Whitman,M. and Hamada,H.
  TITLE     Left-right asymmetric expression of lefty2 and nodal is induced by
            a signaling pathway that includes the transcription factor FAST2
  JOURNAL   Mol Cell 5 (1), 35-47 (2000)
   PUBMED   10678167
REFERENCE   8  (bases 1 to 1366)
  AUTHORS   Liu,B., Dou,C.L., Prabhu,L. and Lai,E.
  TITLE     FAST-2 is a mammalian winged-helix protein which mediates
            transforming growth factor beta signals
  JOURNAL   Mol Cell Biol 19 (1), 424-430 (1999)
   PUBMED   9858566
REFERENCE   9  (bases 1 to 1366)
  AUTHORS   Weisberg,E., Winnier,G.E., Chen,X., Farnsworth,C.L., Hogan,B.L. and
            Whitman,M.
  TITLE     A mouse homologue of FAST-1 transduces TGF beta superfamily signals
            and is expressed during early embryogenesis
  JOURNAL   Mech Dev 79 (1-2), 17-27 (1998)
   PUBMED   10349617
REFERENCE   10 (bases 1 to 1366)
  AUTHORS   Labbe,E., Silvestri,C., Hoodless,P.A., Wrana,J.L. and Attisano,L.
  TITLE     Smad2 and Smad3 positively and negatively regulate TGF
            beta-dependent transcription through the forkhead DNA-binding
            protein FAST2
  JOURNAL   Mol Cell 2 (1), 109-120 (1998)
   PUBMED   9702197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC119156.1 and AC156550.5.
            
            On Mar 30, 2013 this sequence version replaced NM_007989.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137781.1, AF110506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1306              BC119156.1         1-1306
            1307-1366           AC156550.5         45324-45383         c
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.24 cM"
     gene            1..1366
                     /gene="Foxh1"
                     /gene_synonym="fast-1; fast-2; Fast1; Fast2"
                     /note="forkhead box H1"
                     /db_xref="GeneID:14106"
                     /db_xref="MGI:MGI:1347465"
     exon            1..344
                     /gene="Foxh1"
                     /gene_synonym="fast-1; fast-2; Fast1; Fast2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1283
                     /gene="Foxh1"
                     /gene_synonym="fast-1; fast-2; Fast1; Fast2"
                     /note="forkhead activin signal transducer 1; forkhead
                     activin signal transducer 2; FAST1 transcription factor"
                     /codon_start=1
                     /product="forkhead box protein H1"
                     /protein_id="NP_032015.1"
                     /db_xref="CCDS:CCDS27584.1"
                     /db_xref="GeneID:14106"
                     /db_xref="MGI:MGI:1347465"
                     /translation="MASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPE
                     AESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFR
                     DDYEGWKDSIRHNLSSNRCFHKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCR
                     RWQNRGTHRAFAKDLSPYVLHGQPYQPPSPPPPPREGFSIKSLLGDPGKESTWPQHPG
                     LPGQSTAAQAGTLSKGEEGMGTGPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSP
                     VTPDQGSWPLHLLEDSADSRGVPRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPTTS
                     CPQCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAP
                     GWLLSWYSM"
     exon            345..449
                     /gene="Foxh1"
                     /gene_synonym="fast-1; fast-2; Fast1; Fast2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..1366
                     /gene="Foxh1"
                     /gene_synonym="fast-1; fast-2; Fast1; Fast2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccacagc ctctttctgt cacccctccc cctttcatca gaatgataaa gaaagggcct
       61 ggcctgcctg tcccagcatg gcctcgggct gggacctggc ctcaacttac actccgacta
      121 ccccgagccc ccagttagcc ctggctccgg cccagggcta cctcccttgt atggggcctc
      181 gcgacaactc tcagctgagg cctccagagg cagagtctct ttcgaagacc cccaagagga
      241 ggaagaagag atacctacgg catgacaagc ccccctacac ctacttggcc atgatcgcct
      301 tggtaattca ggccgcaccc ttccgcaggc tgaaactggc tcagattatc cgtcaggtcc
      361 aggcagtgtt ccccttcttc agggacgact atgagggctg gaaggactcc atccgccaca
      421 acctttcctc taatcggtgc ttccataagg tgcccaagga ccctgcaaag ccccaggcca
      481 agggcaactt ctgggcggtg gatgtgagcc tgattcctgc tgaggcgctg cgccttcaga
      541 acactgccct gtgccgtcga tggcagaacc ggggcaccca cagagctttc gccaaggacc
      601 tgagccccta cgtgctccac ggccagcctt atcagccacc cagtccccca ccaccaccta
      661 gggagggttt cagcatcaag tccctgctag gggaccctgg gaaagaatcc acatggcccc
      721 agcatcctgg gctccctgga cagagcactg cagctcaggc aggcaccttg tcaaaggggg
      781 aagaagggat gggcactgga ccctctagct cctctgagac gcctctgtgg cccctctgct
      841 cccttcctgg gcccacaatc atagaggggg agagttccca aggggaggta atcaggcctt
      901 ctcccgtcac cccagatcaa ggctcctggc ccctccactt acttgaggat tccgcagatt
      961 ccaggggagt gcccaggagg gggagcagag cctccttgtg gggacagcta cccacttctt
     1021 acttgcccat ctatacgccc aatgtagtaa tgcccttggc cacactaccg accacctctt
     1081 gtccccagtg cccatcttct gccagcccag cttactggag cgtaggcact gaatcccaag
     1141 ggtcccagga cctgctctgt gatctagact ccctcttcca gggagtacca cccaacaaga
     1201 gtatctatga tgtgtgggtc agccatccta gggacctggc agctcctgcc ccaggctggc
     1261 tcctttcctg gtacagcatg taatattcta gggcagaaag ggctgcttct ctcttccacc
     1321 catgaatatc attttgatga accagagcta ggagcatgtc cgcagc
//
