LOCUS       NM_008241               2948 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus forkhead box G1 (Foxg1), transcript variant 1, mRNA.
ACCESSION   NM_008241 XM_914980
VERSION     NM_008241.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Gil,Y., Ryu,J., Yang,H., Ma,Y., Nam,K.H., Jang,S.W. and Shim,S.
  TITLE     Molecular Characterization of Subdomain Specification of Cochlear
            Duct Based on Foxg1 and Gata3
  JOURNAL   Int J Mol Sci 25 (23), 12700 (2024)
   PUBMED   39684410
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2948)
  AUTHORS   Inskeep,K.A., Crase,B., Dayarathna,T. and Stottmann,R.W.
  TITLE     SMPD4-mediated sphingolipid metabolism regulates brain and primary
            cilia development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470011
REFERENCE   3  (bases 1 to 2948)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2948)
  AUTHORS   Artimagnella,O., Maftei,E.S., Esposito,M., Sanges,R. and
            Mallamaci,A.
  TITLE     Foxg1 regulates translation of neocortical neuronal genes,
            including the main NMDA receptor subunit gene, Grin1
  JOURNAL   BMC Biol 22 (1), 180 (2024)
   PUBMED   39183266
  REMARK    GeneRIF: Foxg1 regulates translation of neocortical neuronal genes,
            including the main NMDA receptor subunit gene, Grin1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2948)
  AUTHORS   Zheng,X., Wu,B., Liu,Y., Simmons,S.K., Kim,K., Clarke,G.S.,
            Ashiq,A., Park,J., Li,J., Wang,Z., Tong,L., Wang,Q., Rajamani,K.T.,
            Munoz-Castaneda,R., Mu,S., Qi,T., Zhang,Y., Ngiam,Z.C., Ohte,N.,
            Hanashima,C., Wu,Z., Xu,X., Levin,J.Z. and Jin,X.
  TITLE     Massively parallel in vivo Perturb-seq reveals cell-type-specific
            transcriptional networks in cortical development
  JOURNAL   Cell 187 (13), 3236-3248 (2024)
   PUBMED   38772369
REFERENCE   6  (bases 1 to 2948)
  AUTHORS   Xuan,S., Baptista,C.A., Balas,G., Tao,W., Soares,V.C. and Lai,E.
  TITLE     Winged helix transcription factor BF-1 is essential for the
            development of the cerebral hemispheres
  JOURNAL   Neuron 14 (6), 1141-1152 (1995)
   PUBMED   7605629
REFERENCE   7  (bases 1 to 2948)
  AUTHORS   Monaghan,A.P., Grau,E., Bock,D. and Schutz,G.
  TITLE     The mouse homolog of the orphan nuclear receptor tailless is
            expressed in the developing forebrain
  JOURNAL   Development 121 (3), 839-853 (1995)
   PUBMED   7720587
REFERENCE   8  (bases 1 to 2948)
  AUTHORS   Avraham,K.B., Fletcher,C., Overdier,D.G., Clevidence,D.E., Lai,E.,
            Costa,R.H., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of eight members of the hepatocyte
            nuclear factor 3/fork head winged helix family of transcription
            factors
  JOURNAL   Genomics 25 (2), 388-393 (1995)
   PUBMED   7789972
REFERENCE   9  (bases 1 to 2948)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   10 (bases 1 to 2948)
  AUTHORS   Tao,W. and Lai,E.
  TITLE     Telencephalon-restricted expression of BF-1, a new member of the
            HNF-3/fork head gene family, in the developing rat brain
  JOURNAL   Neuron 8 (5), 957-966 (1992)
   PUBMED   1350202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U36760.1, CA320871.1, BC046958.1 and AV226567.1.
            
            [WARNING] On Feb 11, 2025 this sequence was replaced by
            NM_008241.3.
            
            On May 12, 2009 this sequence version replaced NM_008241.1.
            
            Transcript Variant: This variant (1) represents the 2-exon
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36760.1, BQ443556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               U36760.1           1-246
            247-670             CA320871.1         172-595
            671-2935            BC046958.1         309-2573
            2936-2948           AV226567.1         267-279
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.78 cM"
     gene            1..2948
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /note="forkhead box G1"
                     /db_xref="GeneID:15228"
                     /db_xref="MGI:MGI:1347464"
     exon            1..380
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..2947
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..2011
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /note="forkhead-related protein FKHL1; HNF-3/forkhead
                     homolog, brain factor 1"
                     /codon_start=1
                     /product="forkhead box protein G1"
                     /protein_id="NP_032267.1"
                     /db_xref="CCDS:CCDS25899.1"
                     /db_xref="GeneID:15228"
                     /db_xref="MGI:MGI:1347464"
                     /translation="MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHH
                     PQHHHHHHHHHHPPPPAPQPPPPPPQQQQQQPPPAPQPPQARGAPAADDDKGPQPLLL
                     PPSTALDGAKADALGAKGEPGGGPAELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEG
                     GKEGDKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQ
                     NSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKL
                     AFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYS
                     SVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTY
                     SLNPCSVNLLAGQTSYFFPHVPHPSMTSQTSTSMSARAASSSTSPQAPSTLPCESLRP
                     SLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH"
     regulatory      2914..2919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /note="hexamer: AATAAA"
     polyA_site      2939
                     /gene="Foxg1"
                     /gene_synonym="2900064B05Rik; BF-1; Bf1; Hfh9; Hfhbf1"
                     /note="major polyA site"
ORIGIN      
        1 aaaaaacgga agtagacgcc cactcatatt ttcttcaatg tcaagcaaaa tgaaaatatt
       61 tccaggatga tcgatcgcgg ctaccggctt ccagtactgc ctagaagctg aagaggaggt
      121 ggagtgcccg aggagacaac tgccaccggg tcacccgcgc gtgagcgcga ctctgggagt
      181 gaagcgagac ggagggagaa cacacgtgtt acctgcttta tttcgggact gtttgggtct
      241 gtgctcgccc ggggcagctc tccgcccgcc cgcccgcgtg cgtggaaggc ctccacagaa
      301 cgcacccacc gctcagccgc ccccgctcgc cgccctcagc ccagcttcac agccgagctc
      361 gccgcgggcc gcaggaagct cttttgctac atgccttgcc agcgccggag cctgcggtcc
      421 aactgcgctg ctgccggagc gctcagtgcc gcctccgctg cccgctcccc ccgcgcccca
      481 ctccgaaccc gctggtcgcc cgccgcgctg ctgcccggct cccgtgccgc cgccgccgcc
      541 gccgccgccc cccgacgcct gggtgatgct ggacatggga gataggaaag aggtgaaaat
      601 gattcccaag tcctcgttca gcatcaacag cctggtcccc gaggccgtcc agaacgacaa
      661 ccaccacgcg agccacggcc accacaacag ccaccacccc cagcatcacc atcatcatca
      721 ccaccaccac cacccgccgc cgcccgcgcc ccagccgcct ccaccgccgc cccagcagca
      781 gcagcagcag ccgcccccgg ccccgcagcc cccgcaggcg cgcggcgccc cagcagccga
      841 cgacgacaag ggtccccagc cgctcctgct cccgccctcc accgccctgg acggggccaa
      901 ggctgacgca cttggagcca aaggcgagcc gggcggcggg ccggcggagc tggcgcccgt
      961 cgggccggac gagaaggaga agggcgcggg cgccgggggg gaggagaaga aaggggcggg
     1021 cgagggcggc aaggacgggg aggggggcaa ggagggcgac aagaagaacg gcaagtacga
     1081 gaagccgccg ttcagctaca acgcgctcat catgatggcc atcaggcaga gtcccgagaa
     1141 gcgcctgacg ctcaatggca tctatgagtt catcatgaag aacttcccct actaccgcga
     1201 gaacaagcag ggctggcaga actccatccg ccacaacctg tccctcaaca agtgcttcgt
     1261 gaaggtaccg cgccactacg acgacccggg caagggcaac tactggatgc tcgacccgtc
     1321 gagcgacgac gtgttcatcg gcggcacgac cggcaagctg cggcgccgct ccaccacgtc
     1381 tcgggccaag ctggccttta agcgcggggc gcgcctcacc tccaccggcc tcaccttcat
     1441 ggaccgcgcc ggctccctct actggcccat gtcgcccttc ctgtccctgc accacccccg
     1501 cgccagcagc actttgagtt acaacgggac cacgtcggcc taccccagcc accccatgcc
     1561 ctacagctcc gtgttgactc aaaactcgct gggcaacaac cactccttct ccaccgccaa
     1621 cgggctgagt gtggaccggc tggtcaacgg ggagatcccg tacgccacgc accacctcac
     1681 ggccgctgcg ctcgccgcct cggtgccctg cggcctgtcg gtgccctgct ccgggaccta
     1741 ctccctcaac ccctgctccg tcaacctgct cgcgggccag accagttact ttttccccca
     1801 cgtcccgcac ccgtcaatga cttcgcagac cagcacgtcc atgagcgccc gggccgcgtc
     1861 ctcctctacg tcgccgcagg ccccctcgac cctgccctgt gagtctttaa gaccctcttt
     1921 gccaagtttt acgacaggac tgtccggggg actgtctgat tatttcacac atcaaaatca
     1981 ggggtcttct tccaaccctt taatacatta acatccgggg gaccagactg taagtgaacg
     2041 ttttacacac atttgcattg taaatgataa ttaaaaaaat aagtccaggt attttttatt
     2101 aagccccccc tccccatttc tgtacgtttg ttcagtcttt agggttgttt actattctaa
     2161 cacggtgtgg agtgtcagcg aggtgcaatg tgggagaata cattgtagaa tataaggttt
     2221 ggacgtcaaa ttatagtaga atgtgtatct aaatagtgac tgctttgcca tttcattcaa
     2281 acctgacaag tctatctcaa caggctgcca gatttccatg tgtgcagtat tataagttat
     2341 catggagcta tctggtggac gcaggccttg agaacaacct aaattatgaa gagagtttta
     2401 aaatgttaaa ttgtaatttg tatttaagaa tttgtagtaa aggtgcccaa ggaattatat
     2461 tggccattta ttgttttgtc ctttttcttt aaagaactgt ttctttcctt ttgtttactt
     2521 ttagaccaaa gattggattc tagcaaatgc acttggtata ctaagtatta aaacaagtaa
     2581 acaaacaaac gaaaaaggaa ggttgtttag ttggcaacac tgcccattca attgaatccg
     2641 aaggagacaa aattaaggat tgccttcagt ttgtgttgtg tatatttcga tgtatgtggt
     2701 cactaacagg tcacttttat tttttctaaa tgtagtgaaa tgttaatacc tattgtactt
     2761 ataggtaaac cttgcaaata tgtaacctgt gttgcgcaaa tgccgcatca atttgagtga
     2821 ttgttaatgt tgtcttaaaa tttcttgatt gtgatactgt ggtcatatgc ccgtgtttgt
     2881 cacttacaaa aatgtttact atgaacacac agaaataaaa aataggctaa attcatatat
     2941 atcttgaa
//
