LOCUS       NM_010225               2480 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus forkhead box F2 (Foxf2), mRNA.
ACCESSION   NM_010225
VERSION     NM_010225.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Jia,D., Zhou,Z., Kwon,O.J., Zhang,L., Wei,X., Zhang,Y., Yi,M.,
            Roudier,M.P., Regier,M.C., Dumpit,R., Nelson,P.S., Headley,M.,
            True,L., Lin,D.W., Morrissey,C., Creighton,C.J. and Xin,L.
  TITLE     Stromal FOXF2 suppresses prostate cancer progression and metastasis
            by enhancing antitumor immunity
  JOURNAL   Nat Commun 13 (1), 6828 (2022)
   PUBMED   36369237
  REMARK    GeneRIF: Stromal FOXF2 suppresses prostate cancer progression and
            metastasis by enhancing antitumor immunity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Perez Sanchez,C., Casas-Tinto,S., Sanchez,L., Rey-Campos,J. and
            Granadino,B.
  TITLE     DmFoxF, a novel Drosophila fork head factor expressed in visceral
            mesoderm
  JOURNAL   Mech Dev 111 (1-2), 163-166 (2002)
   PUBMED   11804790
REFERENCE   7  (bases 1 to 2480)
  AUTHORS   Aitola,M., Carlsson,P., Mahlapuu,M., Enerback,S. and
            Pelto-Huikko,M.
  TITLE     Forkhead transcription factor FoxF2 is expressed in mesodermal
            tissues involved in epithelio-mesenchymal interactions
  JOURNAL   Dev Dyn 218 (1), 136-149 (2000)
   PUBMED   10822266
REFERENCE   8  (bases 1 to 2480)
  AUTHORS   Miura,N., Kakinuma,H., Sato,M., Aiba,N., Terada,K. and Sugiyama,T.
  TITLE     Mouse forkhead (winged helix) gene LUN encodes a transactivator
            that acts in the lung
  JOURNAL   Genomics 50 (3), 346-356 (1998)
   PUBMED   9676429
REFERENCE   9  (bases 1 to 2480)
  AUTHORS   Hellqvist,M., Mahlapuu,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Differential activation of lung-specific genes by two forkhead
            proteins, FREAC-1 and FREAC-2
  JOURNAL   J Biol Chem 271 (8), 4482-4490 (1996)
   PUBMED   8626802
REFERENCE   10 (bases 1 to 2480)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590625.16.
            
            On Jan 26, 2022 this sequence version replaced NM_010225.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132385.1, Y11148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1554              AL590625.16        16783-18336
            1555-2480           AL590625.16        21562-22487
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.48 cM"
     gene            1..2480
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /note="forkhead box F2"
                     /db_xref="GeneID:14238"
                     /db_xref="MGI:MGI:1347479"
     exon            1..1554
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1718
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /note="forkhead homolog 20"
                     /codon_start=1
                     /product="forkhead box protein F2"
                     /protein_id="NP_034355.2"
                     /db_xref="CCDS:CCDS26424.1"
                     /db_xref="GeneID:14238"
                     /db_xref="MGI:MGI:1347479"
                     /translation="MSTEGGPPPPPPRPPPAPLRRACSPAPGALQAALMSPPPAATLE
                     STSSSSSSSSASCASSSSNSVSASAGACKSAASSGGAGAGSGGTKKATSGLRRPEKPP
                     YSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIK
                     LPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGA
                     SLLPQGFDFQAPPSAPLGCHGQGGYGGLDMMPAGYDTGAGAPGHAHPHHLHHHHVPHM
                     SPNPGSTYMASCPVPAGPAGVGAAAGGGGGGGDYGPDSSSSPVPSSPAMASAIECHSP
                     YTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHPSMSSYSLEQSYLHQNAREDLS
                     VGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM"
     exon            1555..2480
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /note="hexamer: AATAAA"
     polyA_site      2480
                     /gene="Foxf2"
                     /gene_synonym="Fkh20; FREAC2; LUN"
                     /note="major polyA site"
ORIGIN      
        1 agagagaaga gcactcctga aagaagacga cgggctagtc cccggggtcc gggctgaggt
       61 cttggctcga gggcgcagct gtccagctct gggcagcgtc gcctcagtgg cttaggagac
      121 ggttgcgcaa ggagccggcc ggaggctcgg aagagggatg cgcggggcgt tgcctccgac
      181 ccgccgccgc cgccgccgcc cgaagcccca gaggagctga gggaggcgac gccgaagcgc
      241 tggcccgcag tggcccgggc tgcagcgcgg ccggcgcagt agggcactcg cccgatttgt
      301 ggaccgaccc ggctccggcg ccgccgatcc cggtccgggg tccgcccccc aggcccggcc
      361 tcgttcccga ttcccagatg agcaccgagg gcgggcctcc gccacccccg ccgcgcccgc
      421 cgcctgcccc actccgccgc gcgtgcagcc cggcgcccgg cgcgctccag gccgccttga
      481 tgagcccgcc acccgccgcc accctggagt ccacttcgtc gtcgtcatca tcatcctctg
      541 cctcctgtgc ctcgtcctct tctaactccg tcagcgcctc ggccggtgct tgcaagagtg
      601 cggctagcag cggcggcgcg ggcgccggga gtggaggcac caagaaggca acctcggggc
      661 tgcggcggcc ggagaagcct ccttactcgt acatcgcgct catcgtcatg gccatccaga
      721 gctcgcccag caagcgcctg acgctcagtg agatctacca gttcctacag gcgcgcttcc
      781 cctttttccg tggcgcctac cagggctgga agaactccgt gcgccacaac ctctcgctca
      841 acgagtgctt catcaagctg cccaagggcc tcgggagacc tggtaagggc cactactgga
      901 ccatcgaccc ggccagcgaa ttcatgtttg aggagggttc gttccgccgc cggccgcgcg
      961 gcttcaggcg gaagtgccag gctctcaaac ccatgtacca tcgcgtggtg agcggcttgg
     1021 gcttcggggc ctcgctgctg ccccagggct tcgacttcca agcgcccccg tcggcgcctc
     1081 tgggttgcca cggtcaaggc ggttatggtg gcctcgacat gatgcccgcg ggctatgata
     1141 caggggcggg tgctccgggc cacgcgcatc cacaccacct ccaccaccac cacgtccccc
     1201 acatgtcgcc caacccgggc tccacctata tggccagctg cccggtgccc gcaggtcctg
     1261 cgggcgtcgg tgcggcagcg ggtggcggcg gtggcggcgg ggactatggg ccggacagca
     1321 gcagcagccc tgtgccctca tccccggcta tggcaagcgc cattgagtgt cactcgccct
     1381 acactagccc tgcggcacat tggagctcgc ctggcgcttc accttacctc aagcagccgc
     1441 ctgccctgac gccaagcagt aatcccgcgg cctctgctgg tctgcacccc agcatgtctt
     1501 cctactcgtt ggagcagagc tacttgcacc agaacgcccg cgaggatctc tcagtcggac
     1561 tgccccgtta ccagcaccac tccactccag tgtgcgacag gaaagatttc gtcctcaatt
     1621 tcaatggcat ttcttctttc cacccttccg ctagtggctc ttattatcac catcatcacc
     1681 agagcgtgtg ccaagatatt aagccctgtg ttatgtgaat ggacagaggc cttgaaggcc
     1741 actctgctct ccctcttctg ccttcttctc ctctcccctc cgagaggggc agccaggaac
     1801 tgcaacggac tcacactgtg cacgctggat agcgaatagc agtaagtagc acacccatca
     1861 cttagacaaa tacccaaggg agttctgctc accgatattt gcccggcccc tggaagagga
     1921 aacctttcga aagctaatat cccagaagag cgacagacag aggaggtgac tacatgtaag
     1981 acatatgtta ctgtgtggag gacataaaac ttttcagttc tggggtggcc attgcattca
     2041 ctaatcaggg tctgaaaagg gaggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2101 cttttcaaaa ttgcagtgct aaaagcacac aatttcaaga aagccttctc tagttccctg
     2161 gctcagtagg acatttcttc cacccactcc cagtccccca acactccctt cttcggatac
     2221 aggtgccaaa gaacattgtg aagaaatgaa gaaccgatag tctagtttaa gaaagtggct
     2281 ctcagtattg tgacagtaca tttttacaag gttgtttttc taccaccgta tttttaaagt
     2341 atttttatga tcttcgtata ctcacacttc gcttgtattg taaaaggagg gtatatttgc
     2401 acttatgtat actttgacag tttgccaaga tattttgatg taaggttttt tttttttcaa
     2461 taaaatgtgt ataacaagta
//
